Karolinska Institutet ポスドク募集

スウェーデン王立カロリンスカ研究所(Karolinska Insitutet)、Department of Medical Biochemistry and BiophysicsでAssistant Professor（PI）Dr. Per Uhlen (per.uhlen@ki.se)が意欲的な日本人ポスドクを募集しております。分子生物学、細胞生物学、カルシウムシグナリング、細胞イメージングの分野に興味がある方は、下記要件を御参照の上、Dr. Per Uhlenにメール頂ければ幸いです。
カロリンスカ研究所（1810年設立）は、ノーベル医学・生理学賞の選考委員会を併せ持つヨーロッパ最大級の研究所です。研究所は、大学、大学院および病院を併設し、ストックホルムの中心より、バスで１５分程度のところに立地する開放的で緑豊かなキャンパスです。
私の知人Dr. Per Uhlenは、非常に明るく友好的な性格の持ち主です。日本人には非常に好意的で、日本人のポスドクとの仕事を望んでおります。御気軽に連絡を取られてみて下さい。

Post-doctoral positions - now available

Post-doctoral positions are currently available for self-motivated individuals to study the role of calcium signaling in mammalian signal transduction at the Karolinska Institute, Sweden.
A range of exciting and cutting-edge projects are available investigating the role of calcium signaling in mammalian cells as well as fundamental signaling mechanisms of calcium oscillations. A strong development and/or disease oriented emphasis is placed on many of these areas of study. Our interdisciplinary team consists of researchers with different backgrounds, spanning from physics to molecular biology. Sophisticated imaging techniques, such as ratiometric fluorescence microscopy and two-photon confocal microscopy, as well as a wide range of approaches from molecular biology to mouse genetic strategies are employed to tackle these problems.

Required background experience of applicant: PhD with experience/interest in molecular/cell biology and/or calcium signaling and/or cell imaging

Supervisor/host: Per Uhlen

Period: 1-4 year(s)

Position/project financed: Yes

Place: Department of Medical Biochemistry and Biophysics, Karolinska Institutet, STOCKHOLM, Sweden

Application: Selected applicants will be interviewed. Applicants should send their CV and indicate their scientific interests to per.uhlen@ki.se

Dr Per Uhlen
Laboratory of Molecular Neurobiology
Dept of Medical Biochemistry and Biophysics
KAROLINSKA INSTITUTET
Sheelesv. 1, A1:02
SE-171 77 STOCKHOLM, Sweden
Tel# +46-8-524-87677
Fax# +46-8-341-960
E-mail: per.uhlen@ki.se

Additional information:
http://www.mbb.ki.se/molneuro/uhlen/
http://www.cedb.se
http://www.sweden.se
http://ki.se/ki/jsp/polopoly.jsp?d=656&l=en
http://www.swejap.com

最近の主な論文
Uhlen P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM. Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. Proc Natl Acad Sci U S A. 2006

Jacob SN, Choe CU, Uhlen P, DeGray B, Yeckel MF, Ehrlich BE. Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons. J Neurosci. 2005; 16:2853-64.

Uhlen P. Spectral analysis of calcium oscillations. Sci STKE. 2004. 258:pl15.

Miyakawa-Naito A, Uhlen P, Lal M, Aizman O, Mikoshiba K, Brismar H, Zelenin
S, Aperia A. Cell signaling microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations. J Biol Chem. 2003; 278:50355-61.

Aizman O, Uhlen P, Lal M, Brismar H, Aperia A. Ouabain, a steroid hormone that signals with slow calcium oscillations. Proc Natl Acad Sci U S A. 2001; 98:13420-4.

Uhlen P, Laestadius A, Jahnukainen T, Soderblom T, Backhed F, Celsi G,
Brismar H, Normark S, Aperia A, Richter-Dahlfors A. Alpha-haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells. Nature. 2000; 405:694-7.

Aizman O, Brismar H, Uhlen P, Zettergren E, Levey AI, Forssberg H, Greengard P, Aperia A. Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons. Nat Neurosci. 2000; 3:226-30.