シンシナティ小児病院濱田研究室では、ショウジョウバエをモデルとして温度感覚および痛みのメカニズム解明を目指しています。ハエの遺伝学を活用して、私達の開発したユニークな行動のアッセイ法、および、神経活性のイメージングなどを用いています (Hamada FN, Nature 2008)。また、最近はサーカディアンリズムおよび老化にも着目しています。

博士課程取得者、あるいは終了見込みの方で、分子生物学、またはショウジョウバエを用いた遺伝学の経験がある方を歓迎いたしますが、バックグランドは問いません。

興味のある方は、CV、今までの研究内容、推薦書2通もしくは照会可能な方の連絡先をfumika.hamada@cchmc.orgにお送り下さい。

連絡先

Fumika Hamada, Ph.D.
Assistant Professor
Visual Systems Group
Division of Pediatric Ophthalmology
Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue, ML 7003
Cincinnati, OH, 45229
Office: R2.2457/ (513)803-1662
Lab : R2.2455/ ((513)803-1673
Fax : (513)803-0740
fumika.hamada@cchmc.org

研究所ホームページ　http://www.cincinnatichildrens.org/

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私の留学時代のボスから，新しいグラントが取れたのでポスドクを募集したいという依頼があったので代理で投稿します．ラボは細胞生物学をメインにしてますが，生化学にも研究領域を広げたいということで，生化学のバックグラウンドを持った人を探しています．

研究室が所属するWeill Cornell Medical CollegeはNYのマンハッタンにあり，近隣のRockefeller UniversityやMemorial Sloan-Kettering Cancer Centerとの共同研究も活発に行われています．

研究内容に関しては直接Dr. Zhouに，そのほかアメリカ生活等に関して質問がありましたら石井(ishii.ryhi_at_gmail.com, _at_を@に置き換えてください)までご連絡ください．

[募集内容]
Postdoctoral Research Associate positions available immediately to study the ubiquitin-dependent proteolysis in controlling DNA repair and hematopoiesis, and the associated tumorigenic processes using a combination of biochemistry, cell and molecular biology and mouse and chemical genetic approaches. Please refer to the lab website http://www.med.cornell.edu/research/pez2001/.

We are looking for candidates with experiences in protein expression, purification, and structural and enzymatic analysis. Applicants familiar with X-ray crystallography as well as general protein purification procedures, including ion-exchange chromatography, gel filtration, affinity chromatography, and FPLC, are desirable. Experience in high throughput screening is a plus.

Cornell University will sponsor H1B visa if required.

Send curriculum vitae and references to:

Dr. Pengbo Zhou
Professor
Department of Pathology and Laboratory Medicine
Weill Cornell Medical College
1300 York Ave., C312
New York, NY 10065
E-mail: pez2001@med.cornell.edu

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私が所属しているHarvard School of Public Healthの Dr. Horng研究室にて、下記のClassified（Harvard School of Public Health postdoc募集　by Dr. Tiffany Horng）のようにポスドク研究員を募集しております。Dr. Horngは日本の研究を高く評価しており、是非日本の研究者と仕事がしたいと考えております。そこでDr. Horngの依頼で日本語にて募集の補足を致します。

Dr. Horngは炎症分子機構のexpertであり（Cell 2009, Nature Immunology 2007, Nature 2002, Nature Immunology 2001 (as a first or corresponding author)）、現在慢性炎症に着目し研究を進めております（Horng T et al Nature Medicine, 2011)。

他分野の方でも、炎症に興味があり、また分子細胞生物学に基本的な知識があれば、やる気のある方を優先するとのことです。受入れ時期は相談可です。Fellowshipの受入れ先としても可能ですので、留学受入れ先を探されている方もお気軽にお問い合わせ下さい。研究室は立ち上がって数年で小規模ですが、その分アットホームな雰囲気です。慢性炎症の分子機構解明を共に目指してくれます方、是非ご応募下さい。

研究内容・研究室などの御質問がございましたら、お気軽に日本語でお問い合わせ下さい。村上（日本語可　e-mail: tmurakam@hsph.harvard.edu)

Tiffany Horng, Ph.D.
Assistant Professor
Department of Genetics and Complex Diseases
Harvard School of Public Health
655 Huntington Ave, II-115
Boston, MA 02115
thorng@hsph.harvard.edu

Dr. Tiffany Horng in the Department of Genetics and Complex Diseases in Harvard School of Public Health is looking for an outstanding postdoctoral fellow to study the molecular mechanisms regulating chronic inflammation in inflammatory bowel disease (IBD). The project, for which funding has recently been obtained, involves use of a novel mouse model of IBD in which the inflammatory trigger is well-defined, thus enabling genetic manipulation of its signaling pathway. Block of the critical signaling pathway after development of inflammation can be used to test the hypothesis that chronic inflammation, once initiated, could become self-sustaining and self-amplifying. Thus this model can be used to 1) identify a unique transcriptional circuitry capable of driving chronic inflammation, and 2) delineate the pattern of chromatin modifications that maintains such transcriptional circuitry.

Candidates should have a solid background in molecular biology and cell biology; experience working with mice and mouse husbandry; and experience in studying inflammatory bowel disease or a related area, as demonstrated in their publication record. Candidates must have a Ph.D. or M.D. degree. The position is available immediately.

Please submit application, including a cover letter, CV and names and contact information of at least 3 references to:

Tiffany Horng, Ph.D.
Assistant Professor
Department of Genetics and Complex Diseases
Harvard School of Public Health
655 Huntington Ave, II-115
Boston, MA 02115
thorng@hsph.harvard.edu

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Signal Transduction Laboratory, Massachusetts General Hospital, Harvard
Medical Schoolでポスドクあるいは実験助手を募集しています。

[研究内容]　私たちの研究室では、protein farnesylation、S-nitrosylation、S-sulphydrationなどシステイン残基の翻訳後修飾を介する細胞内情報伝達の 生物学的、病気の成因における意義を解明することにより新しい治療・予防法の開発につなげようと、新しいプロジェクトを始めたところです。
　 Protein farnesylationの阻害が、高脂血症治療薬として主に用いられているスタチン（HMG-CoA reductase阻害薬）のコレステロール非依存性作用において主要な役割を果たしているというエビデンスに基づいて、protein farnesylationを介する細胞内シグナル伝達のとくに免疫細胞での作用を、敗血症（重症感染症）や糖尿病を疾患モデルとして、in vitro、培養細胞系、マウスを用いて研究しています。こうした研究に興味のある方は気軽に連絡して下さい。

[募集人数]　若干名　
[応募資格]　ポスドク：Ph.D.あるいはM.D.取得者、または、取得見込みの方。実験助手（テクニカルスタッフ)：大学卒業後研究経験のある方。
[待遇]　Massachusetts General Hospital の規定に準拠
[赴任時期]　随時（できるだけ早い時期が望ましいが、相談して下さい）
[提出書類]　E-mailあるいは郵送で、(1) CV(履歴書)、(2)研究業績、（３）照会可能な２名の氏名と連絡先　

Masao Kaneki (金木正夫), M.D., Ph.D.
Associate Professor
Harvard Medical School
Director, Signal Transduction Laboratory
Department of Anesthesia, Critical Care, and Pain Medicine
Massachusetts General Hospital
149 Thirteenth Street, Rm. 6604
Charlestown, MA 02129, USA
Tel: 617-726-8122 & 4179
Fax: 617-726-8134
E-mail: mkaneki@helix.mgh.harvard.edu

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Employer
INSERM U1053 is a French governmental laboratory located at Bordeaux Segalen University in Bordeaux, France. Its topics are Liver carcinogenesis, endoplasmic reticulum stress and angiogenesis.
http://www.gref-bordeaux.fr/
Christophe Grosset is a governmental researcher working at Bordeaux Segalen University. He is principal investigator and manage a team of six persons.

Selected publications:
1. Laloo B, D Simon, V Veillat, D Lauzel, V Guyonnet-Duperat, F Moreau-Gaudry, F Sagliocco, C Grosset. FunREG: a functional, integrated and quantitative method to measure post-transcriptional mechanisms. Mol and Cel Prot, 2009, Aug;8(8):1777-88.
2. Simon, D., Laloo, B., Barillot, M., Barnetche, T., Blanchard, C., Rooryck, C., Marche, M., Burgelin, I., Coupry, I., Chassaing, N., Gilbert-Dussardier, B., Lacombe, D., Grosset, C., and Arveiler, B. A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia, Hum Mol Genet, 2010, 19, 2015-2027.
3. Laloo, B., Maurel, M., Jalvy-Delvaille, S., Sagliocco, F., and Grosset, CF. Analysis of post-transcriptional regulation using the FunREG method, Biochem Soc Trans, 2010, 38, 1608-1614.
4. Jalvy-Delvaille S., Maurel M., Majo V., Pierre N., Chabas S., Combe C., Rosenbaum J., Sagliocco F. and Grosset CF. Molecular basis of differential target regulation by miR-96 and miR-182. Nucleic Acids Research, in revision.

Mission
Dr Christophe Grosset (INSERM U1053, Bordeaux, France) is currently looking for a post-doctoral candidate that would be interested in working in his research team.

Research is not funded yet but applications will be submitted with the candidate soon as post-doc application deadlines from French association (La Ligue Contre le Cancer", "ARC" and "FRM") occur on September and October 2011.

Dr Grosset's research project is focused on the role of microRNAs in the control of genes involved in liver carcinogenesis. The pathological models are the hepatocellular carcinoma, a primary liver cancer affecting adult subjects and the hepatoblastoma, a liver cancer affecting children.

If you are interested or if you know somebody who may be interested in applying to this position, please, directly contact Dr Grosset and send a complete CV by email (christophe.grosset@u-bordeaux2.fr).

Profile of candidates
Profile should be in accordance with information available on the French association websites below:
See ARC: http://www.arc-cancer.net/chercheurs/
See FRM: http://www.frm.org/images/pdf/aides_scientif/frm_peb2010.pdf
See Ligue contre le Cancer: http://www.ligue-cancer.net/article/1591_allocation-post-doctorale-pour-post-doctorant-confirme
The candidate should have either:
1- a French PhD and spend at least two years post-doc in a foreign country and in the same lab.
Or
2- a foreign or French PhD and spend less than 2 years in France as a post-doc at the time of the application.

In both cases, candidate should have:
1- a strong background in molecular and cellular biology in human cells.
2- performed at least one research program in human pathology field (cancer, genetic diseases, neurophysiopathology, hepatology...).
3- published one or more manuscripts as a first author per research program.

Please do not apply if the above points are not fulfilled (criteria for a post-doctoral application from French associations).

Knowledge in animal experimentations, FACS analyses, microRNA biology and RNA regulation will be appreciated but it is not mandatory. However the candidate should be highly motivated.

If interested, please send a complete CV to christophe.grosset@u-bordeaux2.fr

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特異的、機能的な神経回路形成の分子機構の研究

我々は、脳、特に記憶学習の中心である海馬に焦点を置いて、海馬のシナプスがどのような分子機構で作られ、成熟し、維持されるか、それぞれのシナプス結合の特異性はどのような分子によって発揮されるのか、そして、シナプスが神経活動に応じてどのように改変されていくのかを、分子細胞生物学、分子遺伝学、組織学、生化学、生理学的手法、そしてイメージングを使用し、遺伝子操作マウスや初代培養を用いて解析しています。これらの課題を追求することで、神経活動の基礎となる機能的な脳神経回路の形成のメカニズムの解明、また、シナプス形成異常による神経疾患の原因探求や治療につなげようとしています。

現在、ポスドクを募集中です。 我々の研究に興味を持ち、意欲のある人からの応募を歓迎します。 以下の要領で、応募して下さい。

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Postdoctoral positions are available at the University of Michigan Medical School (Ann Arbor, Michigan).

In the brain, information processing occurs at synapses, and defects in synapse formation are likely to underlie many neurological and psychiatric diseases. We are therefore interested in the molecules and structures that regulate synapse formation and maintenance in the mammalian brain. We are particularly interested in the mechanisms underlying synapse specificity (e.g., Terauchi et al., Nature, 2010) and activity-dependent synapse refinement (e.g., Yasuda et al., Neuron, 2011).

M.D. and/or Ph.D. scientists trained in any fields of molecular and cellular biology are welcome to apply. Any interested individual should send their CV, a brief statement of scientific/research interests and contact information for three references to "umemoh@umich.edu".

Hisashi Umemori, M.D., Ph.D.
Molecular & Behavioral Neuroscience Institute and Department of Biological Chemistry
University of Michigan Medical School
Room 5065, BSRB
109 Zina Pitcher Place
Ann Arbor, MI 48109-2200

Tel: 734-763-5242
Fax: 734-936-2690
E-mail: umemoh@umich.edu

Representative Publications:

Yasuda M, Johnson-Venkatesh EM, Zhang H, Parent JM, Sutton MA, & Umemori H. Multiple forms of activity-dependent competition refine hippocampal circuits in vivo. Neuron 70, 1128-1142 (2011).

Terauchi A, Johnson-Venkatesh EM, Toth AB, Javed D, Sutton MA, & Umemori H. Distinct FGFs promote differentiation of excitatory and inhibitory synapses. Nature 465, 783-787 (2010).

Umemori H* & Sanes JR. Signal regulatory proteins (SIRPs) are secreted presynaptic organizing molecules. J. Biol. Chem. 283, 34053-34061 (2008).

Fox MA, Sanes JR, Borza DB, Eswarkumar VP, Fassler R, Hudson B, John SWM, Ninomiya Y, Pedchenko V, Pfaff SL, Rheault M, Sado Y, Segal Y, Werle MJ, & Umemori H. Distinct target-derived signals organize formation, maturation and maintenance of motor nerve terminals. Cell 129, 179-193 (2007).

Umemori H, Linhoff MW, Ornitz DM, & Sanes JR. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Cell 118, 257-270 (2004). [Cover Article]

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National Institutes of Health, U. S. A.

[classified ad]
Polo Kinase in Mitotic Controls and Tumorigenesis

Dr. Kyung Lee

A postdoctoral fellowship is available to study the function of mammalian polo-like kinase 1 (Plk1) and its interacting proteins in normal and cancer cell proliferation. Plk1 plays a pivotal role in proper mitotic progression and its deregulation is tightly associated with oncogenesis. We have been studying various centrosomal and kinetochore proteins that are critical for both subcellular localization and mitotic/non-mitotic functions of Plk1. Projects include, but are not limited to, the mechanisms of various Plk1-mediated cellular events and the physiological significance of Plk1 and its associated proteins during cell cycle progression, tumorigenesis, and stem cell proliferation.

Applicants should be a Ph.D. or M.D. with less than 3 years of postdoctoral experience. Expertise in cell biology, biochemistry, and stem biology is preferred. Visit https://ccrod.cancer.gov/confluence/display/CCRKLEE/Home for additional information. Salary starts at $49,400 plus health insurance with no previous postdoctoral training. To apply, send CV to Dr. Kyung Lee (kyunglee@mail.nih.gov). This position is subject to a background investigation.

Selected Publications:

Kang, Y.-H., et al. 2006. Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. Mol. Cell 24:409-422.

Soung NK, et al. 2009. Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells. Dev. Cell 16: 539-550.

Park JE, et al. 2009. Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay. PNAS USA. 106:1725-1730.

Yun SM, et al. 2009. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat. Str. & Mol. Biol. 16:876-882.

Park, J. -E., et al. 2011. Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate. PNAS USA. 108:8200-5.

Johmura Y, et al. 2011. A bifurcated spindle assembly pathway regulated by mammalian polo-like kinase 1 PNAS USA. Jun 20. [Epub ahead of print]

Liu F, et al. 2011. Structural basis of noncanonical phosphopeptide interactions with the polo-box domain of polo-like kinase 1 that provide unprecedented binding affinities. Nat. Chem. Biol. (In press).

The NIH is dedicated to building a diverse community in its training and employment programs.

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