University of North Carolina at Chapel Hill (UNC) School of Medicine, Postdoctral Positions

Multiple Postdoctoral Positions of Gene Regulation, Bioinformatics and/or Cancer Biology

Job Description: Lineberger Comprehensive Cancer Center & the Department of Biochemistry, University of North Carolina at Chapel Hill (UNC) School of Medicine

Multiple postdoctoral associate research positions available for the highly motivated candidates with a fresh PHD training in molecular biology, biochemistry and cell biology to join the Lineberger Comprehensive Cancer Center and Department of Biochemistry, University of North Carolina at Chapel Hill (UNC) School of Medicine, USA. Our lab (webpage: http://www.gregwanglab.com) emphasizes on mechanistic understandings of gene regulation, chromatin, stem cells, and human disease notably cancer. We have recently published our findings on various gene regulatory mechanisms, including those related to DNA methyltransferase and histone modifying enzymes, at Molecular Cell 2013, Blood 2015, Cell Reports 2015; Cancer Cell 2016; Nature (2018); Stem Cell Reports (2018) and Molecular Cell (2018 in press).

With recent acquisition of funds from NIH and NCI, we have multiple positions available for
1) Postdoctoral associates focused on experimental biology
2) Bioinformatics associate focused on computation analysis of genomics dataset
These positions will be relatively long-term and supported by our recently secured 5-year funds from NIH/NCI, American Cancer Society and Leukemia & Lymphoma Society.

The on-going projects include (1) biochemical characterization of epigenetic factors/complexes that regulate gene expression in stem cells or cancer cells; (2) CRISPR/dCas9-based editing and screening of pathways crucial for cancer development; (3) knockout and knock-in mouse models with deficiency in histone /DNA methylation regulation in context of development and tumorigenesis, with a special focus on hematopoietic disease; (4) epigenomic and transcriptome analyses (ChIP-Seq and RNA-Seq) of normal versus cancer cells to understand 3D chromatin structure and to delineate pathways essential for tumor growth.

Applicants should be self-motivated with a track record of publication in the above area, have laboratory and analytical skills, and be a critical thinker. Application shall include CV, a cover letter (with summary of research experiences and future interests, and expected availability date), reprints of publications, and contact information of three references. These should be sent to gregwang.unc@gmail.com

The starting annual salary for this postdoc position is around $48,000 in addition to covered medical insurance.

Posted by greg wang(greg_wang@med.unc.edu)


Memorial Sloan-Kettering Cancer Centerポスドク募集

Memorial Sloan-Kettering Cancer CenterのEmily Cheng 研究室では、現在Postdoctoral Fellow 及びResearch Associateを募集しております。当研究室では、BCL-2ファミリーによるアポトーシス制御機構の解明、及びBCL-2ファミリーを標的とした新規癌治療法の確立を目指して研究をおこなっています。応募される方は、以下の英文広告をご参照の上、Dr. ChengまでCV及び推薦者3名の連絡リストをお送りください。なお、日本語でのご質問等ございましたら、当研究室出身の山内茜(ainoyama24@gmail.com)までお気軽にお問合せ下さい。

Postdoctoral fellow and research associate positions are available for highly motivated individuals interested in studying the BCL-2 family and the fundamental mechanisms of cell death, developing novel therapeutics targeting the BCL-2 family, and investigating the molecular control of mitochondrial metabolism by the BCL-2 family (Science 330: 1390-1393; Molecular Cell 36: 487-499; Nature Cell Biology 8: 1348-1358; Nature Cell Biology 17: 1270-1281; Nature Communications 7: 13131; Cell Reports 21, 2926–2939). We are particularly interested in the pathogenesis and targeted therapy of lung and kidney cancers.

Applicants should hold a Ph.D. degree and have a strong background in molecular/cellular biology, biochemistry, mouse genetics, or cancer biology, and a good publication record.

Full applications including curriculum vitae and a list of three references should be submitted through chenge1@mskcc.org to: Emily Cheng, M.D., Ph.D., Member, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.



The University of Texas MD Anderson Cancer Centerポスドク募集

The University of Texas MD Anderson Cancer Center の高橋研究室では、癌ゲノミクス、バイオインフォマティクス、分子生物学、分子疫学などにバックグラウンドをもつポスドクの方を一名募集します。
最近の業績としては、治療関連性白血病の前白血病クローン性造血の同定(Lancet Oncology)、染色体コピー数異常としてのクローン性造血(Blood Advance)、レナリドマイド治療群のCLLの遺伝子解析(Blood)、遺伝子異常の微小残存性病変としての臨床的意義(JCO)、混合形質性白血病の網羅的遺伝子解析(Nature Comm)などがあります。
Department ChairのDr.Andrew FutrealのCo-mentor制度となります。


Koichi Takahashi, MD
Assistant Professor
Department of Leukemia
Department of Genomic Medicine
The University of Texas MD Anderson Cancer Center

投稿者:Koichi Takahashi(ktakahashi@mdanderson.org)


Southern Research Institute Postdoctral position

The NIH-funded Nakazawa lab is seeking an independent-thinking, highly motivated postdoctoral fellow to study in the Neuroscience Department at Southern Research (SR), which is focused on the cellular mechanisms underlying the positive, negative, and cognitive symptoms of schizophrenia. We utilize genetically-engineered mice to investigate hypofunction of N-Methyl-D-aspartate (NMDA)-type glutamate receptor (NMDAR), which interacts with the major excitatory neurotransmitter of the CNS, glutamate. This hypofunction model of schizophrenia, in which NMDARs are developmentally-deleted from cortical and hippocampal GABA neurons, enables study of the role of NMDARs in the pathogenesis of schizophrenia. The Nakazawa lab is particularly interested in (1) perinatal abnormalities leading to cortical GABAergic dysfunction, and (2) the circuitry mechanisms of hyper-excitable auditory cortex. The NIH-funded postdoctoral fellowship position suits candidates highly motivated to perform i!
n vivo Ca2+ imaging from awake behaving animals and interested in understanding neuronal circuitry function. A developmental neurobiologist with expertise of handling perinatal mouse brain organs are also welcome. Candidates should be capable of and willing to learn new techniques to perform delicate surgical procedures and must demonstrate abilities to think independently and work collaboratively. Prospective candidates should send the following in a single PDF: a statement of interest describing research experience and future goals, curriculum vitae, and contact information for two references willing to provide a letter of support to: Kazu Nakazawa, M.D., Ph.D., electronically to e-mail: knakazawa@southernresearch.org. Expect to join a growing cadre of supportive, outstanding, and collaborative neuroscientists in an exciting research environment. Southern Research provides a competitive benefits package, including insurance and retirement benefits, and is an Equal Opp!
ortunity/Affirmative Action Employer. Lab web site: https://s!

Posted by Kazu Nakazawa(knakazawa@southernresearch.org)




当研究室では、肥満によって発症リスクが増加する代謝性・炎症性疾患、特に2型糖尿病や肝臓疾患において、その発症機構を1)RNAサイレンス機構、2)細胞外小胞(エキソソームなど)、3)炎症性代謝ストレス、に注目して研究を行っています。新ラボメンバーの方とは、最近の知見 [Nature Comms (accepted), bioRxiv 2018, Cell Reports 2018, Cell Reports 2015, Diabetes 2014, Nature, 2012, Cell 2010]を更に発展させ、主に細胞外小胞の動態・機能変化の解析を通し、代謝性・炎症性疾患の発症機構の解明を目指します。意欲の高い方、そして、代謝、免疫、細胞外小胞などの研究経験を代謝性・炎症性疾患の病態モデルに応用したい方を大歓迎いたします。

応募資格:上記の研究に興味のある PhD, MD, MD-PhD 取得者、あるいは着任までに取得見込みの方。
応募書類:1) 履歴書、2) これまでの研究の概要、3) 信用照会3名以上の連絡先。
送付先:中村能久 (Takahisa Nakamura)

Takahisa Nakamura, Ph.D.
Assistant Professor
Divisions of Endocrinology and Developmental Biology,
Cincinnati Children's Hospital, MLC 7012
3333 Burnet Ave., Cincinnati, OH 45229
Office phone: 513-803-9230
Email: Takahisa.Nakamura@cchmc.org



Weill Cornell Medical College Postdoctral Position

Postdoc Position Available in Weill Cornell Medical College, New York City

A Postdoctoral Associate position is available immediately in Ching-Hwa Sung’s Laboratory at the Weill Cornell Medical College, New York City. The Sung lab uses state-of-the-art mouse genetics, molecular cell biological, and ultrastructural techniques to address the molecular basis of retinal degenerative diseases including retinitis pigmentosa (RP), aged-macular degeneration (AMD) and ciliopathy (Cell 130:535; J Clin Invest 114:131; Nat Cell Biol. 13:402; J Cell Biol 190:953; Dev Cell 32:731). The postdoc will work on a new project related to the cell biology/signaling pathway/metabolism of cone photoreceptors and the exploration of therapeutic treatments to prevent cone cell death. PhD candidates are required to have a publication record in one of the following fields (biochemistry, cell biology, neuroscience, biomedicine) and strong communication skills. Experience in stem cell cultures and/or animal handling is preferred. Review of applicants will start immediatel!
y until the position is filled. The stipend levels follow the current NIH scale. Interested individuals should submit a single PDF file containing the following information to Ching-Hwa Sung (chsung@med.cornell.edu). (i) CV including 2-3 referees’ contacts. (ii) A 1-page cover letter summarizing your current research, general research interest, and personal goals. Weill Cornell Medical College is an equal opportunity/affirmative action employer.

投稿者:Ching-Hwa Sung(chsung@med.cornell.edu)


University of California, Davisポスドク募集

私のCold Spring Harbor Laboratory, Tuveson Labでの同僚であったChang-il HwangがUniversity of California, Davisでの独立に伴い、ポスドクを募集しております。


Position Description:

A postdoctoral fellow position in pancreatic cancer biology is available at the Department of Microbiology and Molecular Genetics, University of California, Davis. Our research interest is to study genetic and epigenetic alterations in pancreatic cancer progression using genetically engineered mouse models and patient-derived organoid models and exploit therapeutic vulnerabilities for pancreatic cancer. The position provides outstanding opportunities for building research career with recently developed organoid models in the interface of basic and translational pancreatic cancer research in close collaboration with UC Davis Comprehensive Cancer Center.

Outstanding individuals skilled in molecular biology, cell biology, mouse genetics, cancer (epi)genetics and/or next generation sequencing (RNA-seq, ChIP-seq, ATAC-seq) with bioinformatic analysis are encouraged to apply for a postdoctoral position in a dynamic interdisciplinary team studying pancreatic cancer.

Basic Qualifications:

The applicant must have a Ph.D. in biochemistry, cell biology, genetics, molecular biology, cancer biology, or related field, and must have proven productivity as a first author. In addition, the applicant should be proficient in tissue culture, mouse genetics and basic molecular biology techniques. It is preferable that the successful applicant has experience with either 1) cancer biology with mouse and tissue culture models , or 2) genomics approach (next generation sequencing and basic analysis). Finally, the applicant should be well versed in Microsoft Office, Excel, PowerPoint, and a graphing program such as Prism or R. The applicant must be attentive and reliable with various modes of communication and must have the motivation to pursue and drive a project independently. Candidates should be willing to apply for independent funding.

Please send an email with a cover letter, curriculum vitae with the names of three references to:

Chang-il Hwang, D.V.M., Ph.D.

Assistant Professor

241B Briggs Hall

Department of Microbiology and Molecular Genetics

College of Biological Sciences

University of California, Davis

One Shields Ave, Davis, CA 95616

Email : cihwang@ucdavis.edu



Washington University School of Medicine Postdoctral Position

Postdoctoral positions for projects examining T cell responses to viral infection, cancers and microbiota at Washington University School of Medicine

We are seeking for 2-3 postdoctoral fellows to study T cell immune responses to pathogens, cancers and intestinal microbiota. The goals are to understand cell intrinsic programs by which T lymphocytes differentiate into effector, memory or regulatory cells, and define the impact of these programs on antiviral host protection, control of tumor growth and establishment tolerance at host-microbiota interface. We are conducting collaborative research between the three labs of Takeshi Egawa (antiviral, anti-tumor T cell responses), Chyi-song Hsieh (Treg induction in response to microbiota) and Haina Shin (antiviral responses at mucosal tissues) with complementary expertise in T cell biology. We will use animal models (viral infection, tumor models, germ-free mice), genetic and epigenetic profiling, and the generation of genetically modified mice to address these questions.
Strong candidates are expected to have experience in mouse studies, flow cytometry, and molecular and cellular biology. Additional expertise in bioinformatics, epigenetic analyses and culture of microbes is preferred. The positions will be in either the Department of Pathology and Immunology or Department of Medicine at Washington University School of Medicine, located in Saint Louis, MO, USA. Washington University is a scientifically rich environment offering close interactions with leading immunologists and microbiologists as well as state-of-art core facilities, which will foster the development of a successful research career.

Selected Recent Publication:
Raju S. et al., PLoS Pathog. 2018;14:e1007053, PMID: 29734372
Chou, C. et al., Immunity, 2016; 45:570-582. PMID: 27566940
Ebihara, T. et al., Nat Immunol. 2015;16:1124-1133. PMID: 26414766
Chou, C. et al., Nat Immunol. 2014;15:884-893. PMID: 25029552

Perry, JSA., et al., Immunity, 2018;48:923-936. PMID: 29752065
Chai, JN. et al., Sci Immunol., 2017;2(13). PMID: 28733471
Nutsch K. et al., Cell Rep., 2016;17:206-220. PMID: 27681432
Perry, JSA., Lio CJ. et al., Immunity, 2014;41:414-426. PMID: 25220213
Lathrop et al., Nature, 2011;478:250-254. PMID: 21937990

Scott, JM. et al., J Virol. 2018; pii: JVI.00038-18. PMID: 29343577
Shin H., Curr Opin Virol. 2018;28:61-67. PMID: 29175730
Shin H., et al., Nat Commun. 2016;7:13346. PMID: 27827367
Shin H. and Iwasaki, A., Nature. 2012;491:463-7. PMID: 23075848

Please send your CV, a brief statement of your past accomplishment and prospective goal (1-2 pages each), and email addresses of two or more references to:

Takeshi Egawa
Department of Pathology and Immunology
Washington Universtity School of Medicine
Email: tegawa@wustl.edu

投稿者:Takeshi Egawa(tegawa@wustl.edu)


Johns Hopkins School of Medicine Postdoctral Position

Postdoctoral Fellowship: Genetic and Mechanistic Studies of X-linked Dystonia Parkinsonianism
The Lieber Institute and Johns Hopkins Department of Neurology, Baltimore, MD
A postdoctoral position is available within the Erwin lab (erwinlab.org) at the Lieber Institute for Brain Development and Johns Hopkins Department of Neurology to study the mechanisms leading to X-linked Dystonia Parkinsonism. The applicant would be working with a team of researchers on projects using human induced pluripotent stem cell (iPSC) models, brain tissue and single cell genomics to investigate the role of retrotransposons and Taf1 disruption in pathology. Individuals with stem cells, (epi)genomics, genetics, developmental neuroscience and/or computational experience would be particularly well suited.
The Lieber Institute for Brain Development (LIBD) is located in the new Johns Hopkins Bioscience Park in Baltimore, MD. LIBD was conceived from the realization that a new approach is needed to fully exploit the unprecedented opportunities to accomplish the critical goal of helping affected individuals and their families. The LIBD aims to transform the research landscape in two ways: by providing new tools for scientific discovery and by developing new collaborative approaches to achieve our ambitious mission. The mission of the Lieber Institute for Brain Development is to translate the understanding of basic genetic and molecular mechanisms of schizophrenia and related developmental brain disorders into clinical advances that change the lives of affected individuals.
To Apply: Submit your CV and cover letter to jennifer.erwin@libd.org

Posted by Jennifer Erwin(Jennifer.erwin@libd.org)


SUNY Upstate Medical University Postdoctral Position

A dynamic translational research laboratory at SUNY Upstate Medical University has a position available for a hematological translational researcher. The researcher will work on projects involving in genomic stability regulation and MDS/AML progression biomarker discovery research; novel combination target treatment in hematological malignancies diseases; and novel immunotherapy method development.

Prefer the candidate has an academic degree in scientific field and at least two years related research experience; has experience in performing PCR, RT-PCR, Cellular culture, Western blot, and flowcytometry. It will be a plus if the candidate has an experience in mouse model experiments. The candidate shall have interest in manuscript writing and grant application preparation.

To apply, please send the following to Dr. Jeffrey Pu (puj@upstate.edu)
• A full CV with publication list
• Cover letter including the names and contact details of 3 references
• PDF copies of your most recent publications

Posted by Jeffrey J. Pu, MD, PhD.(puj@upstate.edu)


神奈川県立がんセンター 常勤医師募集






〒241-8515 横浜市旭区中尾 2-3-2

応募案内は http://kcch.kanagawa-pho.jp/medical/recruit.html#doctor です。

〒241-8515 横浜市旭区中尾 2-3-2


免疫療法科・臨床研究所 部長
電話(045)520-2222(代表) 内線5063
e-mail: tsasada@kcch.jp



The University of Michigan Medical School Postdoctral position

We are seeking a postdoctoral fellow to join our group to work on genetically dissecting the epigenetic basis of X-chromosome inactivation. X-inactivation is an evolutionarily conserved paradigm of epigenetic regulation that equalizes X-linked gene expression between male and female mammals by silencing genes on one of the two X-chromosomes in females. X-inactivation lies at the nexus of functional long non coding (lnc) RNAs and chromatin-modifying factors. Our lab has discovered new lncRNAs and identified chromatin modifying proteins with a previously unknown function in X-inactivation. Projects involve functionally interrogating these lncRNAs and chromatin modifiers and their relationship in causing X-inactivation via both high- and low-throughput assays in cultured stem cells and in mice. There will be opportunities to take these or other projects with you. If your skills and career goals match these, please send a CV and a brief statement of your scientific backgro!
und and career goals. See our lab website (http://www-personal.umich.edu/~kalantry/Kalantry_Lab/Welcome.html) for more information.

Sundeep Kalantry, Ph.D. (kalantry@umich.edu)

Associate Professor
University of Michigan Medical School
Department of Human Genetics

The University of Michigan is an equal opportunity/affirmative action employer.

投稿者:Shigeki Iwase(siwase@umich.edu)


Cedars-Sinai Medical Centerポスドク募集

新たなグラント獲得に伴い、カルフォルニア州ロサンゼルス、Cedars-Sinai Medical Center, Yamashita Labでは意欲のある研究員をそれぞれ1名ずつ募集しています。
1. 糸球体腎炎の発病メカニズム、特にマクロファージや好中球(TLRやEGFRを介した)の半月体形成性糸球体腎炎における役割について、cell culture, animal model, そしてヒトの腎生検組織を用いて調べています。
また、これに加えて、糸球体内皮細胞特異的な分子の同定、innate immune tolerance, matrix metalloproteinase, inflammasomeそしてACEのRAS非依存的な腎炎への影響についても調べています。
Constitutively Bound EGFR-Mediated Tyrosine Phosphorylation of TLR9 Is Required for Its Ability To Signal. J Immunol. 2018; 200(8):2809-2818.
Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy. Am J Physiol Renal Physiol. 2018; 314(4):F531-F542.
Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling. Sci Signal. 2012 Jul 17; 5(233):ra50.
Antiviral innate immunity disturbs podocyte cell function. J Innate Immun. 2013; 5(3):231-41.
非常にsupportiveなCollaborator達(Drs. Moshe Arditi, Kenneth Bernstein, Ravi Thadhani, and Ananth Karumanchi)に囲まれて、ラボを運営しております。面白い数々のTransgenic/Knock-out miceや機材、試薬も揃っており、非常に恵まれた環境です。私達のグループには現在25人が働いており、私も含めて6人の日本人研究者が在籍しています。みなさんとても協力的で環境の変化にも適応しやすいかと思います。
2. 豊富な腎生検のデータ(2006以降だけでも37,000件)や臨床データを用いて、臨床研究を行っています。全体の内、70%が自己腎(Native Kidney)で30%が移植腎(Transplant Kidney)です。Transplant Centerでは腎移植自体も活発に行われており、年間200例ほど行われています。外来患者数は3,000人(年間の外来患者来院数8,000)で臨床情報はすべてそろってます。これだけ大きなデータがあれば、腎生検/腎病理に関係することであれば、臨床上の些細な疑問も含めてすべてプロジェクトになり、比較的簡単に論文化(少なくとも年3-4本)されると思います。今年の6月に1人腎臓内科医が加わりましたが、既に今年(2018年)のASNに演題 (Thymic disease-associated nephropathy: a report of 21 cases from a single institution)を提出し、論文の執筆も始めております。
Cedars-Sinai Medical Centerはビバリーヒルズにある、およそ900床の病院でそれに併設している研究所では活発にtranslational researchが行われております。ロサンゼルスは気候もよく、日本の食材も簡単に手に入り、また日本人も多いため、他の州に比べて非常に快適な生活が送れると思います。私が所属するRenal Pathologyは腎生検標本年間3600例を有し、私も含め5人のrenal pathologistsが所属するアメリカ西海岸最大の施設です。うち、移植腎生検も活発に行われており、年間700件以上あります。
また、2017年11月よりMGHのNephrologyのトップであったDr. Ravi ThadhaniとBeth Israel HospitalのDr. Ananth Karumanchi(両者ともHarvardのProfessor)がCedars-Sinaiに移ってきており、共同研究を行っています。腎臓研究はますます活発になってきています。
給与:Cedars-Sinai Medical Centerの内規に沿ったものとなります。
Michifumi Yamashita, MD, PhD, FASN
Assistant Professor
Department of Pathology & Laboratory Medicine
Cedars-Sinai Medical Center
8700 Beverly Blvd. PACT 500
Los Angeles, CA 90048
Email: Michifumi.Yamashita@csmc.edu



New York University College of Dentistry Postdoctral Position

Post-doctoral fellowship
New York University College of Dentistry

Dr. Shoshana Yakar at the New York University College of Dentistry is searching for a post-doctoral fellow to study skeletal growth, development and aging in animal models with impaired growth hormone and insulin-like growth factor 1 axis. Candidate should be highly motivated cell biologist who is capable of carrying on independent research with an expertise in confocal microscopy, live cells imaging, and other standard cell biology methods.

Desired Skills and Qualifications:
• Candidates must be within 5 years of completing a PhD.
• Experience in mitochondria biology.
• Competence in planning and multitasking, and excellent organizational skills.
• Both written and oral communication are required. 
NYU offers excellent benefits. Salary will be commensurate with qualifications and experience. Interested candidates should send a CV, names with contact information of three references, and a statement summarizing prior research experience and future goals by email to: Dr. Shoshana Yakar at sy1007@nyu.edu.
NYU is an Equal Opportunity/Affirmative Action Employer.

私、Emi Shimizuの共同研究者であるDr. Shoshana Yakarがポスドクを募集しています。Dr. Yakarは、ニューヨーク大学(NYU, Department of Basic Science and Craniofacial Biology)所属で、詳細は上記に記載されていますが、骨格の成長と老化の関係を成長ホルモンとインスリン様成長因子などを組織特異的にノックアウトしたネズミを用いて研究を行っています。Ph.Dを取得されてから、5年以内の方でCell biologyやmolecular biologyのバックグラウンドがあり、Mitochondrial Biologyの経験のある方を希望しています。
ご希望の方はCVと3名の推薦者の連絡先、これまでの研究内容などを書かれたstatementを添付の上、上記までemail(sy1007@nyu.edu)にご連絡下さい。また、質問等がありましたら、Emi Shimizu (shimize1@sdm.rutgers.edu)に遠慮無くご連絡下さい。

Posted by Shoshana Yakar(sy1007@nyu.edu)






共同利用・共同研究拠点運営委員長 教授 田村智彦 付



 本研究センター内に開設を検討しているエピゲノム解析センターの担当教員(医学研究科免疫学)や技術員らとともにChIP-seq, ATAC-seq, scRNA-seqなどクロマチン解析・遺伝子発現解析を用いる共同研究に携わっていただきます。(https://www.yokohama-cu.ac.jp/amedrc/news/kyoudoukenkyuboshu.html)。


公立大学法人横浜市立大学 先端医科学研究センター




大学院医学研究科免疫学・教授 田村智彦


公募による選考(書類選考の後、面接選考 ※海外からの応募場合Skypeでも可)。



投稿者:西山 晃(nishiyaa@yokohama-cu.ac.jp)


University of Oxford postdoc position

A postdoc position is available in my group at the Department of Biochemistry, University of Oxford.

We are seeking to appoint an outstanding individual to reveal the function of unconventional kinetochore proteins in Trypanosoma brucei, the causative agent of sleeping sickness. Although it was widely believed that all eukaryotes would have a conserved set of kinetochore proteins, we recently identified 20 uncharacterized kinetochore proteins (named KKT1–20) in Trypanosoma brucei and discovered that they constitute unconventional kinetochores specific to kinetoplastids, a group of evolutionarily-divergent eukaryotes (Akiyoshi and Gull, Cell 2014, Nerusheva and Akiyoshi Open Biol 2016). We are currently characterizing these KKT proteins using various techniques including cell biology, bioinformatics, advanced microscopy, biochemistry, biophysics, and structural biology.

For more information, please click on the link below:

Please contact me if you have any question.

Bungo Akiyoshi

Group leader
Sir Henry Dale Fellow, EMBO Young Investigator
Department of Biochemistry
University of Oxford,
South Parks Road,
Oxford OX1 3QU
United Kingdom
Email: bungo.akiyoshi@bioch.ox.ac.uk

投稿者:Bungo Akiyoshi(bungo.akiyoshi@bioch.ox.ac.uk)

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