Postdoctoral Research Associate / Neurodegenerative Diseases, Aging, and CNS Regeneration. : COLUMBUS, OH, United States

Candidate should have recently obtained a doctoral degree in Molecular and Cell Biology, Biochemistry, Neurobiology, Cancer Biology, or related fields. This position requires strong research skills in cell biology and molecular signaling. Candidate is expected to lead projects in the field of neurodegenerative diseases, aging, and neuroregeneration. All communication will be in English.

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Visiting Scholar / Neurodegenerative Diseases, Aging, and CNS Regeneration.
COLUMBUS, OH, United States

This position requires strong research skills in cell biology and molecular signaling. Candidate is expected to lead projects in the fields of neurodegenerative diseases, aging, and neuroregeneration, and to generate high-impact research publications. He or she is also expected to mentor students and technicians in experimental design and implementation. A doctoral degree and previous postdoctoral training is required in Molecular and Cell Biology, Biochemistry, Neurobiology, Cancer Biology, or related fields. A qualified candidate should speak fluent English, and have sufficient funding to support living in the US for the first year. Promotion to research scientist position is optional after successful completion of projects, which allows grant application as independent researcher.

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Max Planck Florida Institute(MPFI)、谷口研究室では、現在新たにポスドク１名を募集しております。恵まれた研究環境を生かし、オリジナリティの高い研究を追求し、その過程を“いっしょに楽しめる方”を歓迎します。将来、研究室主宰者となり、神経回路研究の潮流を自分で作りたいと考えている方、この機会を利用してみませんか？

MPFIは、２年前、米国フロリダに設立された神経回路研究に特化した新しい研究所です。所内では米国内外の著名研究者によるセミナーが頻繁に行われ、キャンパス内のScripps Florida Institute, Florida Atlantic Universityとも活発な研究交流が行われています。また、ドイツMax Planck Societyの一部であることから、米国にいながら“Max Planck流”を体感できるというのも当研究所の大きな魅力の１つとなっています。

研究内容：大脳抑制性神経細胞には多くのサブタイプが存在します。それぞれのサブタイプは、多様な神経回路機能において、特有の働きをしていることが示唆されています。したがって、大脳抑制性神経細胞サブタイプ多様性の生成メカニズム、機能的意義を明らかにすることは、脳科学における最重要課題の１つとなっています。われわれは、マウス遺伝学、分子生物学、ウイルス学、イメージング技術を活用し、大脳抑制性神経細胞サブタイプの運命決定メカニズム、神経回路発達、高次機能における役割を理解しようとしています。今回の募集では、特に、大脳抑制性神経細胞サブタイプの学習、機能的回路発達における神経活動、構造的可塑性に興味を持たれている方を募集します。

(参考文献)
Taniguchi et al.,Neuron, 2011
Taniguchi et al.,Science, 2013
Taniguchi et al.,Front. Cell. Neurosci, 2014

勤務地：米国フロリダ州ジュピター。海と自然に囲まれた年中暖かな場所にあります。トップクラスの公立学校の学区内にあり、治安もよく、ご家族のおられる方も安心かと思います。

採用時期：2015年2月～4月（応相談）

待遇：MPFIの規定に準ずる。

応募資格：博士課程修了、もしくは修了見込み者。必須ではありませんが、生体内での脳機能研究、二光子顕微鏡イメージング経験者を歓迎します。

応募書類：1.CV（業績リスト、実験手技、推薦者３名の連絡先を含む）
2.これまでの研究内容（1-2ページ）
3.志望動機（1-2ページ）
以上を英文でまとめ、PDFをe-mailで送付してください。
質問等がありましたら、応募前のコンタクトも大歓迎です（日本語可）。

連絡先：谷口弘樹 (Hiroki Taniguchi, Ph.D)
e-mail: taniguchimpfi@gmail.com
tel:1-561-972-9260

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ベイラー医科大学Children's Nutrition Research Center (CNRC)の福田ラボでは、ポスドクを募集しております。当研究室は、過食や肥満において、視床下部ニューロンネットワークがレプチンやインスリンなどの代謝シグナルに応答しなくなるメカニズムを研究しています。この視床下部ニューロンの機能不全が肥満や糖尿病の病態基盤となっている可能性があり、その分子的実態をマウス遺伝学、薬理学、脳器官培養法、ならびに各種レポーターマウスを用いたアプローチを通して明らかにしようとしています。

最近の論文：
1. Williams et al., (2014) Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metabolism, 1–12. PMID: 25017942
2. Jia et al., (2014) Hepatocyte Hepatocyte Toll-like Receptor 4 Regulates Obesity-Induced Inflammation and Insulin Resistance. Nature Communications 12, 3878-3889. PMID: 24815961
3. Asterholm et al., (2014) Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 57,1209-1218. PMID: 24623101
4. Shi et al., (2013) Central GLP-2 Enhances Hepatic Insulin Sensitivity via Activating PI3K Signaling in POMC Neurons. Cell Metabolism. 18, 86-98. PMID: 23823479
5. Fukuda et al., (2011) Induction of Central Leptin Resistance by cAMP-Related Signaling. Cell Metabolism. 13, 331-339. PMID: 2135652

このポスドクポジションは、下記のCNRCポスドクプログラムに応募していただく必要があります。興味のある方は福田(fukuda@bcm.edu)までご連絡ください。

Postdoctoral positions are available (starting from early 2015) at the Children’s Nutrition Research Center (CNRC) at Baylor College of Medicine (Houston).
Candidates should have a PhD or MD degree in a relevant discipline. Graduates within the last 12 months are preferred. All candidates need to identify a potential mentor in the CNRC (http://www.bcm.edu/cnrc/faculty) and contact the mentor directly. Candidates and their mentors are expected to assemble an application package (see below) and submit it to CNRC by September 30 of 2014.
Application package:
1. Candidate’s curriculum vitae.
2. Transcripts of candidate’s undergraduate and graduate degree (directly from the registrar if possible).
3. Recommendation letters from candidate’s Ph.D. or M.D. mentor and two other people who know the candidate well.
4. Candidate statement, explaining why he or she would like to work with the proposed mentor, what is expected to be learnt from our program, and how it would help accomplish stated goals.
5. A short research proposal (2-5 pages) to be developed jointly by the candidate and the potential mentor. The proposal should include background materials describing the rationale for and relevance of the research, hypotheses to be tested, experimental approaches, and methods for evaluating the results.

[問い合わせ]
Makoto Fukuda Ph.D.
Assistant Professor
Children's Nutrition Research Center
Department of Pediatrics
Baylor College of Medicine
Email: fukuda@bcm.edu

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Postdoctoral Position in Angiogenesis Research and Drug Targeting Technology

Postdoctoral positions are available in the laboratory of Dr. Masanobu Komatsu at Sanford-Burnham Medical Research Institute (formerly Burnham Institute). One research project is to investigate the regulatory mechanism of blood vessel maturation and stabilization. Our laboratory has shown that the small GTPase R-Ras promotes quiescence of vascular cells and normalizes newly forming vessels in the pathologically regenerating vasculature (Nature Medicine 2005, Cancer Cell 2012. http://www.ncbi.nlm.nih.gov/pubmed/22897853). The goal of this study is to exploit the R-Ras pathways in order to modulate blood vessels for therapeutic advantage, for instance 1) to block metastasis and improve drug delivery in cancer, or 2) to improve blood perfusion in ischemic heart disease.

The other area of research focus is to develop novel drug delivery technologies using peptide-directed vascular targeting. We have worked primarily on targeting tumors, organ fibrosis, and pulmonary arterial hypertension for delivery of therapeutics and imaging probes (American Journal of Pathology 2010 and 2014, Biomaterials 2012). In particular, we pioneered the method to target pulmonary arterial hypertension for lung-specific delivery of therapeutics (http://www.ncbi.nlm.nih.gov/pubmed/21549345).

Visit our website for more information on research focuses of the laboratory. http://www.sanfordburnham.org/Talent/Pages/MasanobuKomatsu.aspx
Interested applicants should submit a single PDF file containing CV, a brief description of research interests and accomplishments to Dr. Komatsu.
Masanobu Komatsu, Ph.D.
Associate Professor
Sanford-Burnham Medical Research Institute at Lake Nona
mkomatsu@sanfordburnham.org
Tel 407-745-2067

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A postdoctoral position is available at the Division of Biological Sciences, Harvard University School of Public Health to study molecular mechanisms of metabolic regulation and diseases. Major research interests of the lab include immunometabolism (Cell Metab 7:485; JCI 123:261; Nat Med 18:1665) and hepatic control of peripheral fat metabolism (Nature 502:550). Candidates must have a PhD or equivalent degree. Preference will be given to recent graduates with a strong publication record and relevant research experience in molecular biology and mouse disease models.

To apply, please submit CV, a brief statement of research experience/interests and contact information for three references to:

Chih-Hao Lee, PhD
Department of Genetics and Complex Diseases
Division of Biological Sciences
Harvard University School of Public Health
clee@hsph.harvard.edu

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