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2010.03.05

Louisiana State University School of Medicine ポスドク募集

A postdoctoral fellow position is available in the Neuroscience Center of Louisiana State University School of Medicine to study the molecular mechanisms that regulate regeneration of the visual pigments and survival or degeneration of photoreceptors in the normal and diseased retinas. The ongoing research projects in the lab include : (1) characterization of two newly identified regulators of the visual cycle--a biochemical pathway that regenerates the visual chromophore acting as a molecular switch for the phototransduction; (2) identification and characterization of new regulator(s) of the visual cycle by expression cloning and/or yeast two-hybrid screening; (3) analysis of the molecular pathway of IRBP action in retinal photoreceptor survival; and (4) rescuing vision loss and retinal degeneration in the mouse models for human blinding diseases, such as Leber congenital amaurosis and retinitis pigmentosa, through genetic and pharmacological approaches. Background informat!
ion for the projects can be found in the following references: Cell (2005) 122:449-59; J. Biol Chem (2007) 282:20915-24; Hum Mutat (2009) 30:1183-9; J. Neurosci (2009) 29:1486-96.

Candidates should have a doctoral degree in biomedical science. Interested candidates with demonstrated skills in molecular biology, retinoid/lipid biochemistry, protein biochemistry, signal transduction, retinal cell biology and/or ophthalmology should send a CV, a letter of application stating research interests and accomplishments, and contact information of three references to Dr. Minghao Jin at mjin@lsuhsc.edu.

Key words: neuroscience, retina, retinal pigment epithelium (RPE), vision, cell death, photoreceptor degeneration, visual pigments (rhodopsin and iodopsins), retinoid cycle, enzymology.

投稿者:Dr. Jin(mjin@lsuhsc.edu)

2010.03.04

The Ohio State University ポスドク募集

私の同僚のPIである、Dr. David Pitt (The Ohio State University, Department of Neurology) がポスドクを募集しています。Davidはほぼ1年半から2年前ほどにOhio State Universityへリクルートされ、PIとしてラボを立ち上げました。

Seeking motivated postdoctoral fellow (PhD, MD or DVM) with interest in neurosciene and neuroimmunology to join a dynamic multiple sclerosis group. The ongoing projects concern studies of neurodegenerative mechanisms in multiple sclerosis. In particular, we are interested in the pathophysiology of cortical lesions and of iron accumulation in basal ganglia. This is explored in various mouse and tissue culture models as well as in human post mortem MS tissue.
The candidate would use gene expression knockdown in cell culture and stereotactically injected mice. Expertise in cell culture techniques, stereotactic mouse surgery and histopathological and basic molecular biological techniques is a plus.
Please send curriculum vitae, cover letter, and names of three references to:
Dr. David Pitt, Department of Neurology, The Ohio State University, Columbus, OH.
E-mail: david.pitt@osumc.edu.
PMID: 14581674, 11506399, 11205156, 10695733, 10613826, 10980132, 12507897

多発性硬化症(multiple sclerosis)は、発症初期は主な病巣は白質ですが、進行するにつれ、後期になると灰白質に神経変性を来すことが知られております。Pitt研では特に脳皮質における病変および脳基底核への鉄分の蓄積についての研究を主にやっています。
様々なマウスおよび培養細胞系のモデル、さらにはヒトの剖検脳組織(生前にMSの診断が確定していた患者さん)を用いて、多発性硬化症における神経変性の病態の解析を行っています。
実験手技としては、培養細胞系においてknockdownの手法、およびマウスにおいては脳定位手術を用いた実験、また組織病理学的実験、分子生物学の素養を持っておられる方を希望しております。

留学希望の先生(MD, PhD, またはDVM)は、CV, 簡潔なご自身のキャリアゴールについての記述、および3人の推薦者の名前と連絡先を以下にお知らせください。
Dr. David Pitt, Department of Neurology, The Ohio State University, Columbus, OH, 43210.
E-mail: david.pitt@osumc.edu
また、最近の論文は以下のPubMedIDをご参照ください。
PMID: 14581674, 11506399, 11205156, 10695733, 10613826, 10980132, 12507897
Davidは日本語は全く分かりませんので、彼への連絡は全て英語にてお願いいたします。

ColumbusはOhioの州都で、人口の割には物価が安く、住みやすい町だと思います。近郊にはHondaのプラントがあるおかげで、日本人向けのスーパーマーケットやお店もそこそこあります。

投稿者:Yasushi Kisanuki(kisanuki.1@osu.edu)

2010.02.28

ウィスコンシン-マジソン大学 ポスドク募集

 Wei Xuラボでは、ポスドクを募集しています。研究内容は、エストロゲンレセプターのコアクチベーターであるヒストンH3R17のメチルトランスフェラーゼCARM1に焦点をあて、その転写制御における役割を調べています。現在、Wei Xuラボ所属のポスドクが乳癌におけるCARM1の機能を解明し、Cancer Researchに投稿中です。今回の募集は、そのポスドクが帰国する為、その後を続けて研究して頂ける方を募集しています。
 もし、このラボに興味を持たれた方は、Weiに直接連絡を取って下さい。現地やラボの雰囲気などに関して、不安がある方は、私にまでメールでご連絡下さい。宜しくお願い致します。

Postdoctoral Position
Department of Oncology
McArdle Laboratory for Cancer Research
University of Wisconsin, Madison
U.S.A

A postdoctoral position is available immediately to study transcriptional regulation of estrogen receptor (ER) signaling pathways by nuclear receptor co-factors. At the cellular level, we are interested in understanding the molecular underpinnings of co-regulators’ action and biology in ER-involved processes, including cell proliferation, differentiation and cell cycle control. At the molecular level, we are exploring the molecular mechanisms whereby histone arginine methylation takes part in the epigenetic control of cancer cells (Recent publications: Kuhn, P. et al. Protein Science, (2009)18: 1272-1280; Powell E. and Xu, W. PNAS (2008), 105: 19012-19017; Higashimoto, K. et al., PNAS (2007) 104: 12318-12323). For additional information, see http://mcardle.oncology.wisc.edu/faculty/bio/xu_w.html. We recently found that CARM1, a histone arginine methyltransferase, could up-regulate ERα-mediated differentiation, suggesting that CARM1 is a unique activator for ER α and its enzymatic activity maybe therapeutic target in breast cancer (Mariam Al-Dhaheri et al., submitted to Cancer Research). Therefore, we will further study CARM1-mediated epigenetic changes using chromatin-immunoprecipitation coupled with sequencing (ChIP-seq) in cultured cancer cells and mice models. Candidate should have a Ph.D. or equivalent with a solid background in biochemistry and molecular biology. Familiarity with techniques in molecular biology, chromatin immunoprecipitation assay, and breast cancer mouse model is desirable. Candidate with his/her own funding is preferable but not mandatory. Highly motivated individuals should send curriculum vitae, a brief statement of research and career interests, and the names and contact information of three references by email to: Dr. Wei Xu (wxu@oncology.wisc.edu) or by Mail to: Department of Oncology, 1400 University Avenue, Madison, WI 53706-1599, U.S.A. Applications will be reviewed on an ongoing basis unti!
l position is filled.

Wei Xu (wxu@oncology.wisc.edu)
東元 健 (higashim@cc.saga-u.ac.jp)

投稿者:東元 健 (higashim@cc.saga-u.ac.jp)

2010.02.27

カロリンスカ研究所(スウェーデン)ポスドク募集

カロリンスカ研究所Yihai Cao研究室では血管新生に興味のあるポスドクを募集しています。癌と血管新生、脂肪組織と血管新生および各種病態と血管新生との関連・治療応に興味がある方、マウス・ゼブラフィッシュを用いたモデルをスタンダードとしており、in vivo およびin vitroの双方からのアプローチを得意としています。興味のある方は、Dr. Yihai Cao (Yihai.Cao@ki.se) まで、英語にてメールを送ってください。(詳細は下記を参考にして下さい。)


Karolinska Institutet
invites applications for a Postdoc in Vascular Biology


Department
Department of Microbiology, Tumor and Cell Biology

Area of responsibilities/description of the work
Applications are invited for 2-3 postdoctoral positions at the Laboratory of Angiogenesis Research, MTC, Karolinska Institutet. The angiogenesis research group is one of the leading research team at the international front to do cutting-edge angiogenesis research work in the area of cancer, obesity/diabetes, ocular disease and cardiovascular disease. The team is focused on translational research work with emphasis of clinical relevance. MTC is one of the biggest departments at the Karolinska Institutet and it provides the state-of-the-art core facility for biological research at various levels ranging from molecular to in vivo disease models.

2-3 postdoc positions are now open for highly motivated scientists with background in molecular biology, cell biology, animal disease models and metabolic disorders. Candidates with backgrounds in vascular biology, immunohistochemical analysis and mouse genetics have advantages. The projects will be focused in studying molecular mechanisms of angiogenesis in cancer and obesity. Successful candidates will apply animal genetic and disease models to study pathological angiogenesis in these tissues. These studies will most likely lead to identification of novel therapeutic targets for drug development and define new biomarkers for clinical selection of responsive patients and monitoring therapeutic efficacy of existing drugs. Our laboratory has broad international collaborations.

Qualifications
To qualify, the applicant must hold a doctor’s degree. Ph.D. degree is required and M.D. Ph.D. are preferred. Applicants who have completed their degree no more than three years before the last date for applications should be given priority. Candidates who have completed their degree earlier than this should receive equal priority if special grounds exist.

Candidates who have yet to graduate may apply for this position. In this case, exceptional accomplishments at the early career development and promising young scientists should be considered. Additionally, their public defence is scheduled to take place within three months after the application deadline, in which case verification from the Dissertation Committee must be submitted with the application.

Fluent English is required.

The positions available for 2 years (1 year contract at the time) and has the possibility to be extended. Positions should be fulfilled as soon as possible although there are no formal deadlines.

Form of employment:
Fixed term employment with possibility to extension

Contact persons
Professor Yihai Cao
+46-8-524 87596 +46-8-524 87596
Yihai.Cao@ki.se

投稿者:保坂佳代子

2010.02.26

シンガポール国立研究機関 Postdoctoral Fellow, Research Associate募集

Singapore Institute for Clinical Sciences, Infection and Immunity Programmeにて新しい研究チームのメンバーを募集します。研究テーマは、主としてウイルス感染症に対するヒト免疫応答の多様性です。高次元フローサイトメトリー、マイクロビームマイクロダイセクション等、最新の病理学的手法を用い未開拓のヒトの免疫個体差についての研究を展開していきます。研究チームの立ち上げに参加し、新規プロジェクトを立案・展開していく意欲的な若手スタッフを求めます。膜タンパク精製、共焦点顕微鏡による免疫的解析などの経験がある方を歓迎します。研究室の公用語は英語です。

Singapore Institute for Clinical Sciencesは、米国の主要研究機関に比肩する設備と予算を有し国際色豊かな研究環境の下で米国式の運営が行われています。欧州各国、米国やアジア諸国から多くのPrincipal Investigatorやポスドクが集まり、活発にハイレベルのbiomedical researchを行っています。シンガポールはアジア有数の安全で豊かな生活環境を誇る国です。


[応募資格等]
PhD取得者、または取得見込みの方。First authorの英語論文を一報以上持っていること、英語で30分程度のプレゼンテーションと質疑応答が出来ることが必要です。研究チームの一員としてプロジェクトを展開していく協調性と主体性を持つことが求められます。待遇は本instituteの規定に従い経験に応じて決定されます。4月1日以降早期に勤務を開始できることが望ましい。書類による1次選考の後、面接及びプレゼンテーションによる2次選考を行います。2次選考に進んだ方にのみご連絡します。


[応募方法]
応募者は、次のdocumentをpdf形式で下記に送付下さい。
(1) 2ページ以内の英文のletter of intent (self-introduction, brief summary of accomplishments and technology acquired, reason for applyingを含む)。
(2) Curriculum vita with picture(英文)。
(3) Publication list及び代表的な英文publicationを一報 電子ファイルで添付。
(4) 2名のrefereeの連絡先(うち1名は直接のメンター)。
E-mail address for applications:  
Recruit.InfectionImmunity.SICS@gmail.com

Subject title:
“Application for SICS research fellow”


[研究室責任者]
八幡 真人 (医学博士)
Principal Investigator (Assistant Professor)
Singapore Institute for Clinical Sciences
Infection and Immunity Programme
Brenner Centre for Molecular Medicine
30 Medical Drive, Singapore 117609

投稿者:八幡 真人

2010.02.25

シンガポール国立研究機関 実験病理検査技師募集

シンガポールの国立研究機関Singapore Institute for Clinical Sciences (SICS)の新しい研究室において実験病理室の技師を募集します。手術材料及び実験材料の標本作成と管理を担当して頂きます。また、病理的手法を用いた組織の新しい解析方法を開発するプロジェクトにも参加して頂きます。本研究室は日本人研究者が主宰しますが公用語は英語です。

本研究室は、ヒト免疫応答の多様性をテーマとします。高次元フローサイトメトリーやマイクロビームマイクロダイセクション等の先進的な手法を駆使し、ヒト組織の免疫学的・病理学的な解析を展開します。Singapore Institute for Clinical Sciencesは、米国の主要研究機関に比肩する設備と予算を有し、米・欧・亜出身のスタッフがいる国際色豊かな研究環境の下で米国式の運営が行われています。

本研究室の立ち上げと新規プロジェクトの立案・展開に参加したい意欲的な方を求めています。病理検査室の業務を1年以上経験し、組織の固定、包埋、薄切、各種染色法に習熟していること、一人で研究室の病理業務を担当できる能力が必要です。また、英語による日常会話がある程度可能なことが必要です。臨床検査技師(病理)の資格を有することが望ましい。給与は、シンガポール国立研究機関の規定に従い経験に応じて決定されます。4月1日以降早期に勤務を開始できることが望ましい。

書類による1次選考の後、面接による2次選考を行います。応募者は、応募の動機(400字程度)、高校卒業以降の経歴及び病理検査業務の経験を記載した写真付履歴書を下記メールアドレスまで電子ファイルで送付下さい。

メールアドレス :  Recruit.InfectionImmunity.SICS@gmail.com
メールタイトル : 「SICS 病理応募」


研究室責任者

医学博士  八幡 真人 (ヤワタ マコト)
Principal Investigator (Assistant Professor)
Infection and Immunity Programme
Singapore Institute for Clinical Sciences
Brenner Centre for Molecular Medicine
30 Medical Drive, Singapore 117609

投稿者:八幡 真人

2010.02.24

英国インペリアル・カレッジ・ロンドン医学部 ポスドク募集

英国インペリアル・カレッジ・ロンドン医学部生殖発生生物学研究所(IRDB)、染色体接着部門(グループリーダー・工藤 信明 Nobuaki Kudo, PhD)では、博士研究員(ポスドク)を募集しています。

研究内容
当研究室は、哺乳動物生殖細胞の減数分裂(卵形成・成熟、精子形成)における染色体の接着、分離機構、特にコヒーシン分子を中心に研究を進めています。 詳細は、研究室のHP http://www1.imperial.ac.uk/medicine/about/institutes/irdb/stemcell/nobu_kudo/
をご覧ください。

応募資格
博士号取得者、あるいは着任までに取得見込みの方。クロマチン免疫沈降法(ChIP)、生化学、マイクロアレイなどの研究経験を持つ方を希望します。インターナショナルな環境の中、海外で研究に挑戦したい意欲の高い方の応募をお待ちしています。

勤務地
Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK

待遇
当大学規定により、年俸 26,720 から 38,930 ポンド(経験等考慮の上決定)。まずは18か月の雇用契約からですが延長の可能性有り。

着任時期
採用決定後,できるだけ早い時期(応談可)

選考方法
書類審査と面接審査

応募方法
募集の詳細は、http://www3.imperial.ac.uk/employment/research をご覧ください(求人番号 SM030-10)。

締切
2010年 3月 17日

問い合わせ先
工藤 信明(日本語可)

投稿者:工藤 信明(n.kudo@imperial.ac.uk)

2010.02.23

ハーバード大医学部、マサチューセッツ総合病院 ポスドク募集

ハーバード大医学部、マサチューセッツ総合病院の当ラボでは、ポスドク1名を募集しています。ご興味のある方は、ご連絡下さい。やる気のある方であり、在籍中の教室の理解が得られる方であれば、学生であっても検討いたします。ボストンの学術的な素晴らしい雰囲気の中、充実した有意義な留学生活を送ってみたい方にもってこいの環境です。

研究内容は、
1.筋ジストロフィの病態生理学。in vivo microscopy(生体顕微鏡)という技術を用いて、微小循環、カルシウム・シグナル、細胞死、オートファジーなどの関連分野でのユニークな実験系によるアプローチで、筋ジストロフィの新しいメカニズムや包括的な理論を探索しています。世界初、世界でオンリーワンの実験系を多数もっています。

2.やけど、denervation、ischemia-reperfusionなどの急性疾患における、筋萎縮のメカニズムの研究を、オートファジーを中心に、同様に、探索しています。

上記の研究は、幸いなことに、筋ジストロフィの新しい治療方法の発見に結びつき、我々の研究を皮切りに、世界各地で追試に成功し、直接的には日本の大手新聞、間接的にはCNNやBCCなど、多くのメディアにも大きく取り上げられています。

当ラボでの技術面的なアドバンテージは、生理学、分子生物学、生化学、顕微鏡学、組織形態学、オルガネラや小胞の細胞生物学、再構成系、工学的手法など、多岐にわたる方法論で、テーマにアプローチしています。どの手法も、高いレベルの技術を運用しています。今回は、Western Blotting、免疫染色などの経験のあるかた、熱意あふれる方を求めています。動物実験が必須です。具体的なプロジェクトや技術の指導は懇切丁寧に行うことが出来ます。

志向としては基礎研究の視点に立ち、それでいながら、常に病気で苦しんでいる方たちのことも念頭に置き、真の病気の全体像を正しく理解しようとする研究姿勢というのが、当ラボの方向性であり、利点です。また、そのために必要な、斬新な研究手法に裏打ちされている実績と、当ラボの学生・ポスドクの方たちの努力の蓄積があります。是非ご一緒に、難病の研究に一石を投じ、基礎研究の分野にインパクトを与え、苦しんでいる方たちのために、役に立つ研究を、ともに目指して参りたいと思っています。

CVと、reference personの情報、今までの研究経験のまとめ、などをお送り下さい。

安原進吾(研究室長)
Shingo Yasuhara, MD&PhD
Department of Anesthesiology
Shriners Burns Institute
Shriners Hospital for Children
Massachusetts General Hospital
Harvard Medical School
51 Blossom Street
Boston, MA 02114
shingo_yasuhara@yahoo.com

参考文献
Asai A. et al., "Primary role of functional ischemia, quantative evidence for two-hit mechanism, and phosphodiesterase-5 inhibitor therapy of mouse muscular dystrophy", 2007 PLoS One, 2 (8), e806, 1-16
Asai A. et al., "In vivo Micro-circulation Measurement in Skeletal Muscle by Intra-vital Microscopy", 2007 Journal of Visualized Experiments
Yasuhara, S. et al, “Mitochondria, Endoplasmic Reticulum, and Alternative Pathways of Cell Death in Critical Illness (2008) Critical Care Med., 35 (9), 488-495
Martyn, J.A.J. et al., “Obesity-Induced Insulin Resistance and Hyperglycemia: Etiological Factors and Molecular Mechanisms” (2008, Anesthesiology, 109, 1, 137-148)
その他、投稿中論文多数。

投稿者:安原進吾(shingo_yasuhara@yahoo.com)

2010.02.22

International Max Planck Research School PhD Fellowship募集

16 PhD Fellowships in Life Sciences


The International Max Planck Research School – Molecular Biomedicine (IMPRS-MBM) and the Graduate Program Cell Dynamics and Disease (CEDAD) offer 16 PhD Fellowships in Life Sciences.

CEDAD and IMPRS-MBM - jointly run by the University of Muenster and the Max Planck Institute for Molecular Biomedicine - offer integrative approaches to biomedical research with a strong emphasis on imaging.

Research areas:
Cell and Molecular Biology
Stem Cell Biology
Developmental Biology
Neurobiology
Vascular Biology
Immunology
Microbiology
and more.

Applications for the 3-year PhD program can be submitted from 7 March – 20 May 2010. Projects start in October 2010. Applications can only be submitted via our online system.


For online application and further information go to http://www.cedad.uni-muenster.de.

The program offers excellent scientific and transferable skills training. The program language is English. There are no tuition fees. Successful candidates will receive a competitive tax-free fellowship as well as support with administrative matters, accomodation, visas etc. We invite applications from highly qualified and motivated students of any nationality. We are looking forward to your application for a PhD fellowship in Muenster, "the world’s most liveable city" (LivCom Award 2004).

Posted by Martin Wild (cedad@uni-muenster.de)

2010.02.21

University of Illinois at Chicagoポスドク募集

[研究内容]
Chishti研究室では、細胞膜タンパク質や細胞骨格と結合するタンパク質ファミリーの機能を研究しております。
細胞の極性や細胞内小胞輸送、細胞移動を制御することを解明しましたがまだまだ同タンパク質ファミリーの他のファミリーメンバーの機能の解明や、神経や好中球、上皮細胞など様々な細胞における機能など興味深いテーマを研究中です。
タンパク質の活性の制御、構造、局在の変化を生化学、分子生物学の手法で解析するところから、ノックアウトマウスを用いた疾患の治療への応用まで発展させていく予定です。これらの研究分野に興味のあるポスドク研究者を募集いたします。

[応募資格] 生物学分野での博士号取得または取得予定者。
分子生物学、構造解析、タンパク質の精製と活性測定、動物実験(マウス)、組織染色、細胞培養 (初代培養も含む) の手法のいずれかに精通している人は優遇します。

[勤務地] University of Illinois at Chicago Illinois USA. 大学のあるIllinois州Chicago市は、アメリカ中西部に位置し、ミシガン湖畔の美しい都市です。大学はシカゴのダウンタウンに近く、キャンパスから高層ビル群が一望できます。シカゴ郊外は緑も多く住居環境もよいところです。

ポスドクとして採用されましたら、Chishti教授の研究室に所属し、山田の研究グループで研究していただくことになります。
研究メンバーは様々な国から来ており、英語でコミュニケーションしますが、最初は英語が話せなくても大丈夫です。

[待遇] University of Illinoisの規定による

[応募書類]
1. 履歴書と研究業績目録
2. これまでの研究の概要並びに将来の研究の展望

[就任時期] 採用決定後、出来るだけ早い時期
開始時期は相談に応じます

[連絡先] 山田かおり (Kaori Yamada Ph.D.)

Research Assistant Professor
Department of Pharmacology
College of Medicine
University of Illinois
5100 COMRB 909 S. Wolcott Ave. Chicago IL 60612 USA.

Tel: +1-312-355-1296
Fax: +1-312-355-1297

E-mail: ykaori07@gmail.com (日本語可)
horiguch@uic.edu (English only)

URL: http://www.uic.edu/depts/mcph/lab_chishti.htm

投稿者:山田かおり(ykaori07@gmail.com)

2010.02.20

フロリダ州立大学医学部 ポスドク募集

フロリダ州立大学医学部のStefanovic研究室ではポスドクを募集しています。彼の研究室では肝線維症におけるコラーゲンの発現を調節する分子について興味深い研究が行われています。(詳細は下記を参考にしてください。)彼の研究室のポジションに興味をお持ちの方はCVと研究業績リストをDr. Stefanovicまでお送りください。

Postdoctoral fellow position to study collagen expression in liver fibrosis.
Institution: College of Medicine, Florida State University, Tallahassee, FL
I am looking for a postdoctoral associate to join my lab in studying molecular mechanism of type I collagen expression in liver fibrosis. Excessive synthesis of type I collagen is responsible for clinical manifestations of fibrosis. We have cloned a novel RNA binding protein, LARP6, which regulates translation of mRNAs encoding type I collagen and is critical for high level of collagen expression. The LARP6 dependent collagen synthesis requires filaments composed of nonmuscle myosin, these filaments develop in abundance upon activation of hepatic stellate cells. Please refer for the publications bellow for the details:
Cai L, Fritz D, Stefanovic L, Stefanovic B. Binding of LARP6 to the Conserved 5' Stem-Loop Regulates Translation of mRNAs Encoding Type I Collagen. J Mol Biol. 2009 Nov 13. PMID: 19917293
Cai L, Fritz D, Stefanovic L, Stefanovic B. Coming together: liver fibrosis, collagen mRNAs and the RNA binding protein. Expert Rev Gastroenterol Hepatol. 2009 Feb;3(1):1-3.
The future work will focus on the molecular details of the mechanism by which nonmuscle myosin filaments assist in translation of collagen mRNAs. The candidates should have a Ph.D. in molecular biology, cell biology or biochemistry and are expected to have experience in protein analysis, mRNA analysis, immunoprecipitations, immunostaining, cell culture and molecular cloning. The work is funded by a NIH R01 grant until 2013 and the position is offered initially for two years. Interested candidates should contact

Branko Stefanovic, Ph.D.
Associate Prof
Dept. of Biomedical Sciences
College of Medicine, Florida State University
1115 W. Call St, Tallahassee, FL 32306
email: branko.stefanovic@med.fsu.edu

フロリダ州立大学 (http://med.fsu.edu/biomed/) またはタラハシーの生活環境についての質問が御座いましたら、加藤までお気軽にお問い合わせください。
加藤洋一 ( yoichi.kato@med.fsu.edu) 日本語可

投稿者:加藤洋一(yoichi.kato@med.fsu.edu)

2010.02.19

ワシントン州立大学 ポスドク募集

ワシントン州立大学Department of Animal Sciencesでのポスドク募集

Dr. PruはHarvard Medical SchoolでInstructor、 Assistant Professorを経てワシントン州立大学で大きな独立ラボを持ちました。同じ研究センターで働いていましたが、面倒見もよいナイスガイです。日本人に好印象を持っており、グラントも得たので日本人ポスドクを希望しているとのことです。ご興味のある方は電子メールにてjpru@wsu.edu までお問い合わせ下さい。

A Postdoctoral Position is available immediately at Washington State University, Center for Reproductive Biology to study non-classical steroid hormone signaling. These studies will employ the use of transgenic mouse models to assess the functional importance of non-classical steroid hormone receptors in female reproduction. The position is located in a laboratory that investigates maternal:embryo interactions and endometrial stem cell biology. The successful applicant will have a doctoral degree (PhD, DVM or MD) in the biological sciences with proven proficiency in cellular/molecular techniques (eg., siRNA knockdown, western blotting, plasmid vector construction, immunohistochemistry, protein biochemistry). Knowledge of female reproductive biology is preferred, but not required. Candidates interested in ovarian and/or uterine physiology are strongly encouraged to apply. Interested candidates should send their curriculum vitae and contact information for three references (name, address, phone and e-mail) to: Dr. James K. Pru (jpru@wsu.edu).

James K. Pru, PhD
Assistant Professor
PO Box 646351
Department of Animal Sciences
Center for Reproductive Biology
Washington State University
Pullman, WA 99164-6351

投稿者:坂本秀生

2010.02.18

ルイジアナ州立大学生物学科 ポスドク募集

ルイジアナ州立大学生物学科 (Department of Biological Sciences, Louisiana State University)の照山研究室で電気生理(Patch-Clamp)の出来るPostDocを募集しています。独立にあたり研究室を立ち上げている状況で正直環境が整っているとは言いがたいですが共に歩んでくれる研究者を探しています。

研究内容
当研究室では視床下部にある内分泌神経細胞(オキシトシン、バソプレシン)の環境に対する可塑性を電気生理で解明しようとしています。

応募資格
博士号取得または取得予定者。専門分野不問ですが電気生理(patch clamp)の実験を独立で出来る事が条件。

勤務地
Department of Biological Sciences, Louisiana State University (LSU), Baton Rouge, Louisiana, USA

待遇
LSUの規定による

応募書類 (PDFで直接メールして頂いて結構です)
1.履歴書(研究業績目録含む)
2.これまでの研究概要
3.できれば推薦者数名の氏名と連絡先

就任時期
出来るだけ早い時期

連絡先
照山亮一
Ryoichi Teruyama, Assistant Professor
Department of Biological Sciences,
Louisiana State University
202 Life Science Building,
Baton Rouge, LA70803
rteruyama@lsu.edu
225-578-4263

投稿者:照山亮一(rteruyama@lsu.edu)

2010.02.17

Medical University of South Carolina ポスドク募集

当研究室では心筋細胞におけるカルシウムシグナリング、興奮収縮連関に興味のある博士号取得者(または取得見込みの方)を1名募集します。心筋カルシウムチャネルをはじめとするイオンチャネルの制御メカニズムを生化学、分子生物学、細胞生物学、マウスモデルを用いて解析し、これら制御機構の欠損が心疾患とどのように関わっているかを調べます。生化学、分子生物学、細胞培養、電気生理学、動物実験のいずれかに経験のある方が好ましいですが、やる気のある方を最優先に考えております。
2009年12月にスタートしたばかりの新しい研究室で、大学では再生医学、細胞生物学部門(Dr. Roger Markwald, Chair)に所属し、心筋の組織化学、細胞生物学での共同研究が可能です。また、サウスカロライナ州心臓シグナルセンター(Dr. Martin Morad, Director)のメンバーも併任しており、こちらでは電気生理などでの共同研究を行うことができます。
大学のあるサウスカロライナ州チャールストンは米国では人気の高い観光地です。気候も穏やかで非常に住みやすい町です。上記のとおり、大学、州が積極的に心臓研究に取り組んでおり、様々な手法で心筋のカルシウム、電気信号の解析を行うことが可能です。
応募は履歴書、業績リスト、これまでの研究内容と今後の抱負(1-2ページ)、応募者について意見を伺える方(2名)の連絡先をメール(英語)で受け付けます。興味のある方は気軽にお問い合わせ下さい(日本語、英語のどちらでも構いません)。

Naohiro Yamaguchi, PhD
Assistant Professor
Cardiac Signaling Center
Department of Regenerative Medicine and Cell Biology
Medical University of South Carolina
173 Ashley Avenue, PO Box 250508
Charleston, SC 29425
USA
(Phone) +1-843-792-6731
(FAX) +1-843-792-0664
(email) yamaguch@musc.edu
(Department Web Site) http://cba.musc.edu/

投稿者:山口直宏(yamaguch@musc.edu)

2010.02.16

英国マンチェスター大学ポスドク募集

[研究内容] 当研究室では、主に脊索動物を対象に、進化、発生、ゲノムの相互作用について研究をしております。このたび、脊椎動物血液細胞の多様性の進化メカニズムに関するプロジェクトを開始するにあたり、これら研究分野に興味のあるポスドク研究者を募集いたします。

[応募資格] 発生学、動物学、血液学、関連生物学分野等での博士号取得または取得予定者。特にゼブラフィッシュ、ホヤ、ナメクジウオなどの発生学的手法にご経験がある方を優遇いたします。また、進化発生学に限らず他分野からの方でも、基礎的な分子生物学の知識と意欲をお持ちであればかまいません。

[待遇] University of Manchesterの規定による (GBP 28,983 - £35,646 p.a.)

[応募方法]  募集締め切り 3月 3日
応募方法、プロジェクトの詳細は(http://www.manchester.ac.uk/aboutus/jobs/research/vacancy/index.htm?ref=169371) をご参照ください。

[就任時期] 採用決定後、出来るだけ早い時期、開始時期は相談に応じます。

[ 連絡先 ]  高橋 宗春
Tokiharu Takahashi, MD, PhD
Lecturer in Anatomy
The University of Manchester
Faculty of Life Sciences
Michael Smith Building
Oxford Road
Manchester M13 9PT
UK
Tel: +44 (0)161 2755538
E-mail: Tokiharu.Takahashi@manchester.ac.uk (日本語可)

投稿者:高橋 宗春(Tokiharu.Takahashi@manchester.ac.uk)

2010.02.15

Medical College of Georgia ポスドク募集

[classifiedの内容]
Medical College of Georgia・Robert K. Yu研究室 ポスドク募集 (若干名)

 ジョージア州オーガスタにありますMedical College of Georgia・Institute of Molecular Medicine and GeneticsのRobert K. Yu研究室では、1. 神経幹細胞における複合糖質(特に糖脂質)の発現制御機構・機能的役割の解析、2. 神経幹細胞および複合糖質を用いたアルツハイマー病の発症抑制法の確立、ないし3. グリコシダーゼを用いたリソソーム病の発症抑制法の確立に従事していただける方を若干名募集しております。
 生化学、分子生物学および細胞生物学の基本的知識・手技をお持ちの方が対象ですが、当該分野での経験は問いません。給与、健康保険、休暇や退職年金など待遇はMedical College of Georgiaの規定に準じます。任期は一年となっておりますが、延長可能です。できるだけ早く着任していただける方を優先いたします。当地における研究や生活のセットアップは、日本語のわかるスタッフが責任をもってお手伝いさせていただきます。
 ご興味をお持ちの方は CVと研究業績リスト(どちらも英文)をDr. Robert K. Yu(ryu@mcg.edu)までお送りいただけますようよろしくお願いいたします。ご質問等ございましたら、柳澤(myanagisawa@mcg.edu)までお気軽にお問い合わせください(日本語可)。

参考文献
• Yanagisawa, M., Yu, R.K., 2007. The expression and functions of glycoconjugates in neural stem cells. Glycobiology. 17, 57R-74R.
• Ariga, T., McDonald, M.P., Yu, R.K., 2008. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review. J Lipid Res. 49, 1157-75.
• Yu, R.K., Suzuki, Y., Yanagisawa, M., 2010. Membrane glycolipids in stem cells. FEBS Lett. in press.

Website: http://www.mcg.edu/institutes/immag/yu.htm

投稿者:柳澤 亮(myanagisawa@mcg.edu)

2010.02.14

Cedars-Sinai Medical Center, Los Angels ポスドク、テクニシャン募集

米国ロサンジェルスのCedars-Sinai Medical Centerでポスドクならびにテクニシャンを数名募集しております。私どもの研究室 (Tone Lab)ならびにGreene Labでは、制御性T細胞の分化、転写因子Foxp3、TNFR SuperfamilyのGITR/GITR ligandの構造ならびに発現調節機構の研究を米国のペンシルバニア大学にて行ってきました。今回、ペンシルバニア大学から、 Cedars-Sinai Medical Centerへの移動に伴い、さらに 研究領域を抗体等を含むタンパク工学を利用した癌療法の開発にまで拡張いたします。それに伴い、やる気のあるポスドクならびにテクニシャンを数名募集しています。当研究室は、分子免疫の研究室ですので、分子生物、生化学、免疫、マウスの実験の経験者は歓迎されますが、これらの技術をこちらで学んで一流の研究をしたいという意気込みのある方は、これらの経験が無くとも歓迎いたします。ポスドクに関しては、こちらでJ1ビザの取得が可能ですが、テクニシャンに関しましては、米国での就業が可能な方(例えばJ2ビザ、永住権、米国民)に限らせていただきます。参考文献: Y. Tone!
et al. Nature Immunol. (2008) 9, 194, Z. Zhou et al., (2008) PNAS 105, 641, Tone et al., (2003) PNAS 100, 15059, Ruan et al., (2009) Immunity 31, 932
興味のある方は、履歴書(英文)を添付ファイルとしてtoney@cshs.org までe-mailでお送りください。

投稿者:Yukiko Tone(toney@cshs.org)

2010.02.10

University of Minnesota Postdoc募集

The Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota is inviting applications for a postdoctoral position to investigate mechanisms of genomic instability and cancer susceptibility.

Our laboratory is part of the Masonic Comprehensive Cancer Center and focuses on elucidating functions of the Fanconi Anemia (FA) and Breast Cancer Associated (BRCA) Proteins in the context of cellular caretaker protein networks. We utilize biochemical assays in Xenopus cell-free egg extracts and human cell systems to identify novel FA/BRCA pathway players and to functionally and structurally characterize these evolutionarily young proteins. We seek enthusiastic candidates that have a solid background in molecular biology/biochemistry and enjoy being part of a highly motivated research team. A specific interest and expertise in DNA repair and replication would be ideal.
Our research team works in an open lab structure that nurtures interactions with neighboring laboratories studying fundamental questions in cancer research and the DNA damage response.
The start date is negotiable but ideal start will be Spring 2010.
Please send a short statement of your research interests, a complete curriculum vitae, and three reference letters by e-mail to asobeck@umn.edu with "Postdoc Position Sobeck Lab" as subject line.

Posted by Alexandra Sobeck (asobeck@umn.edu)

2010.02.06

University of Southern California-Keck School of Medicine Postdoc募集

Postdoctoral Position
Transcription, Signaling, Genomics

University of Southern California
Keck School of Medicine
Institute for Genetic Medicine and Norris Cancer Center
Los Angeles, California

A Postdoctoral position is available immediately for a highly motivated individual to study mammalian transcriptional control and signaling in both normal and cancer cells using genome-wide high throughput approaches. Requirements include a Ph.D., M.D., or M.D./Ph.D. degree and experience in molecular biology. With Dr. Frenkel’s and Coetzee’s guidance, and collaboration with members of their and other laboratories, the successful applicant will spearhead NIH-funded research project(s) and develop the ability to work independently. To learn more about the Frenkel and Coetzee labs, visit:

http://www.usc.edu/programs/pibbs/site/faculty/frenkel_b.htm

http://www.usc.edu/programs/pibbs/site/faculty/coetzee_g.htm

Candidates should submit a description of their research interests, curriculum vitae, and the names and contact information of three references. Applications should be e-mailed as Microsoft or PDF attachments to igmpdoc@usc.edu with “2010 postdoctoral position” in the subject line.

Posted by Dr. Baruch Frenkel (igmpdoc@usc.edu)

2010.02.04

Baylor College of Medicine Postdoc募集

Postdoctoral position - Normal and neoplastic epithelial stem cells

A postdoctoral position is available in a newly established, NIH-funded laboratory in Baylor College of Medicine. The primary project involves the purification of human normal and neoplastic stem cells and the characterization of cell intrinsic program governing the balance between self-renewal and differentiation. Experience in primary epithelial cell culture and cell-based assays strongly preferred. Prior experience in molecular biology techniques and handling mouse models preferred.

http://www.bcm.edu/urology/?pmid=12624

Please include your CV, published papers and name of three references (including current supervisor)

Posted by Dr Keith Syson Chan (kc1@bcm.edu)

2010.02.02

University of Kansas Medical Center Postdoc募集

Post-doctoral fellow position is available to study liver cancer and liver pathphysiology (alcohol, fatty liver, and liver regeneration). A strong background in molecular biology and biochemistry is required. Excellent English writing and communication skill is essential. Please visit http://www.kumc.edu/pharmacology/wan.html and the Liver Center of KUMC http://www.kumc.edu/livercenter/research.html. Please contact Dr. Yu-Jui Yvonne Wan, Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas, e-mail: ywan@kumc.edu An Equal Opportunity/Affirmative Action Employer.

Posted by Yu-Jui Yvonne Wan (ywan@kumc.edu)

2010.01.27

Johns Hopkins University School of Medicine ポスドク募集

The Johns Hopkins University School of Medicine消化器科のDr.Florin M. Selaruが2010年4-5月より働けるポスドクを募集しています。研究対象は消化管炎症性疾患と癌のgenetics/epigeneticsで、microRNA異常に関する仕事も行っております。選考には、細胞培養、molecular biology、マウス等に関する実地経験を重視します。Dr. Selaruは過去の日本人ポスドク達との研究経験から日本人に対し大変良い印象を持っておりますので、現在日本在住の方でも適当な時期に渡米できる方であれば結構です。詳細はメール(英語)にて直接Dr. Selaruに問い合わせてください。

Position: Postdoctoral Fellow
Institution: The Johns Hopkins University School of Medicine; Baltimore, Maryland, USA.
Expected starting date: April or May, 2010

Principal Investigator: Florin M. Selaru, M.D. (Assistant Professor, Division of Gastroenterology)

Research focus: The focus of the laboratory is the study of inflammation leading to cancer in the gastrointestinal tract including microRNA abnormalities associated with gastrointestinal inflammation and cancer. Applicants must demonstrate a strong work ethic and meticulous laboratory technique. The applicants who have been well-trained in cell culture and molecular biological techniques are preferred.

投稿者:Florin M. Selaru(fselaru@jhmi.edu)

2010.01.26

National Institutes of Health Postdoc募集

Postdoctoral Fellow Positions in Aging and Stem Cell Biology

Postdoctoral research fellow positions are available in Dr. Hongjun Liu’s lab in the Department of Microbiology and Molecular Genetics at The University of Pittsburgh, starting April 2010. We are interested in the molecular mechanisms of mammalian aging from the perspectives of adult stem cells and their regulated tissue regeneration and organ homeostasis (Liu et al. 2007. Science. 317: 803-806; Liu et al. 2009. Nature. 459: 387-392). Using mouse genetics, molecular biology, cell biology and genomics approaches, we are currently investigating the effects of energy metabolism on adult stem cell self-renewal and their regenerative potentials and how dysregulation of adult stem cell self-renewal and differentiation in tissues and organs contributes to animal aging and the pathogenesis of age related diseases.

Candidates must possess a Ph.D. or M.D. degree (or equivalent) and have considerable experience in molecular biology, cell biology and signaling techniques. Previous experience with mouse genetics, flow cytometry, and microscopy is a plus.

Interested candidates are invited to apply. To apply, please send by email a single PDF copy of their applications including curriculum vitae, contact information for at least three references, and a cover letter describing their past research experience and career goals to:

Hongjun Liu, Ph.D.
Translational Medicine Branch
NHLBI, National Institutes of Health
10 Center Drive, Building 10-CRC, Room 5-3288
Bethesda, MD 20892
Tel: 301-435-7632
Email: liuh4@nhlbi.nih.gov

Posted by Hongjun Liu (liuh4@nhlbi.nih.gov)

2010.01.23

Washington University School of Medicine Postdoc募集

We are currently looking for a post-doctoral researcher who is interested in studying transcription factor networks and gene regulation in T lymphocyte cell fate decision. We will use genetically manipulated mouse models to understand how developing cells adopt a specific lineage and how lineage specific gene expression/silencing is established. The successful candidate will be expected to perform gene expression analysis, flow cytometric analysis and chromatin immunoprecipitation assays.

For further information, please refer to publication below.
1) Egawa and Littman, Nat. Immunol., 9, 1131-1139 (2008).
2) Egawa et al., Plos One, 3, e1512 (2008).
3) Egawa et al., J.Exp.Med. 204, 1945-1957 (2007).

Candidates should have an MD, PhD, MD/PhD, or equivalent degree(s) with research training in the field of immunology, developmental biology, molecular biology and/or biochemistry. We are particularly looking for candidates with experience in working with animal models. The starting date will be Apr-July 2010. The appointment term will initially be for one year, and will be renewed based on evaluation of achievement. The salary will follow the NIH guideline and be adjusted by achievement.

Please send your CV and a list of three references to the e-mail address below:

Takeshi Egawa, M.D., Ph.D.
Assistant Professor
Department of Pathology & Immunology
Washington University School of Medicine
660 S. Euclid Ave., BOX 8118
Saint Louis, MO 63110
Email: tegawa@pathology.wustl.edu

Posted by Takeshi Egawa (tegawa@pathology.wustl.edu)

2010.01.19

米Cleveland Clinic, Lerner Research Institute ポスドク募集

米Cleveland Clinic, Lerner Research Institute, 酒井lab ではResearch Fellowを公募しています

米オハイオ州クリーブランド、Cleveland Clinic, Lerner Research Institute, 酒井lab では、意欲のあるポスドクを募集します。今回募集するプロジェクトのテーマは、in vitroで間葉系幹細胞の特異細胞への分化を規定する微小環境因子の同定、また既に樹立したトランスジェニックマウスを用いた腱損傷治癒モデルにより、腱•靭帯損傷治癒における分子機構の解明、更には臨床応用に向けた再建法の開発とバイオメデイカルエンジニアリングにおける新技術の創出、を目指しております。従って、マウスin vivoでの実験の為の繊細な手術手技のお持ちの方([整形]外科の経験等)、また分子生物学的検索法を修得されている方、を優先致します。また、当ラボでは新たなるノックアウトマウスの作製も積極的に推進しています。最近の業績は、(Carcinogenesis 28:2074-2081,2007; EMBO J 23:2166-2174,2004; Genes Dev 17:926-940,2003; Nature Med 7:324-330,2001; PNAS 98:3808-3813,2001)を参照して下さい。米Cleveland Clinic, Lerner Research Instituteに関しては、(http://www.lerner.ccf.org/)を参照して下さい。また、詳細については下記のメールアドレスにご連絡下さい。

[ 応募資格 ] 医学系、理学系、農学系博士号保持、または見込みの方。
[ 待遇 ] Cleveland Clinic, Lerner Research Instituteの規格による(社会保険完備)
[ 応募書類 ] 1) 履歴書と研究業績目録
       2) これまでの研究の概要並びに将来の研究の展望
       3) 推薦者3名の連絡先(TEL, Email address)
[ 就任時期 ] 御相談に応じます。

Takao SAKAI, M.D., Ph.D.,
Assistant Professor,
Department of Biomedical Engineering/ND2-22,
Lerner Research Institute,
Cleveland Clinic Foundation,
9500 Euclid Avenue, Cleveland OH 44195, U.S.A.
Email:sakait@ccf.org (Japanese available)

投稿者:酒井尚雄(sakait@ccf.org)

2010.01.15

Cancer Science Institute of Singapore Postdoc募集

Call for Post-Doctoral Applicants
H. Phillip Koeffler, Professor of Medicine and Deputy Director of National Cancer Institution of Singapore has an opening for a postdoctoral research associate focusing on translational cellular and molecular biological cancer research. Laboratory is situated within the Cancer Science Institute and directly adjacent to National University Hospital, and near the Biopolis (contains large group of scientists focusing on a variety of biological questions). Postdoc should be experienced in both cellular and molecular biology, have a burning desire to be successful in academic science, able to think creatively and be facile in the English language.

For consideration, please send CV, a brief statement of scientific/research interests, and contact information for three references to:
Prof H. Phillip Koeffler at mdchpk@nus.edu.sg

posted by H. Phillip Koeffler (mdchpk@nus.edu.sg)

2010.01.14

University of Wisconsin-Madisonポスドク募集

University of Wisconsin-Madisonポスドク募集

[研究内容] 当研究室では、さまざまな種類のヒト幹細胞を対象に、神経変性疾患または神経筋変性疾患、神経発生の基礎研究や治療応用についての研究を行っております。このたび、human embryonic stem (ES) cells and induced pluripotent stem (iPS) cellsを用いたskeletal muscle progenitor/stem cellの分化誘導、単離法の確立についての研究プロジェクトを新たに始めることになりました。将来的には、筋ジストロフィーや筋萎縮性側索硬化症(ルーゲーリック病またはALS)のin vitroモデルの作成および疾患モデル動物を用いた治療応用などの研究に発展させていく予定です。これら研究分野に興味のあるポスドク研究者を募集いたします。

[応募資格] 神経科学、生物学分野での博士号取得または取得予定者。分子生物学、動物実験(マウスまたはラット)、細胞培養 (特にFACS) の手法に精通している人は優遇します。幹細胞や神経科学に精通している方だけでなく、他分野からの方でも基礎的な知識と意欲をお持ちであればかまいません。

[勤務地] University of Wisconsin-Madison, Madison, Wisconsin, USA. 大学のあるWisconsin州Madison市は、アメリカ中西部に位置し、アメリカ国内の住みやすい都市ランキングでも1位になったこともあるくらい、非常に治安や住居環境もよいところです。

[待遇] University of Wisconsin-Madisonの規定による

[応募書類]
1. 履歴書と研究業績目録(できれば推薦者2-3名の氏名, 連絡先を含む)
2. これまでの研究の概要並びに将来の研究の展望

[就任時期] 採用決定後、出来るだけ早い時期, 開始時期は相談に応じます

[ 連絡先 ] 鈴木 正寿 (Masatoshi Suzuki, Ph.D., D.V.M.)
Assistant Professor, Department of Comparative Biosciences, University of Wisconsin-Madison, 4124 Veterinary Medicine Building, 2015 Linden Drive, Madison, WI 53706, USA.
Tel: +1-608-262-4264, Fax: +1-608-263-3926
E-mail: msuzuki@svm.vetmed.wisc.edu (日本語可)
URL: http://www.stemcells.wisc.edu/faculty/suzuki.html
または http://www.vetmed.wisc.edu/people/msuzuki

投稿者:鈴木 正寿(msuzuki@svm.vetmed.wisc.edu)

2010.01.13

State University of New York, Upstate Medical University Postdoc募集

Postdoctoral Position

A NIH funded postdoctoral position is available immediately to study the molecular mechanism of leukemia and myeloproliferative neoplasms. The successful candidate will perform in vivo studies using knock-out and knock-in mice in addition to cell culture, flow cytometric and biochemical studies. The lab is also currently interested in identification and characterization of cancer stem cells in certain hematologic malignancy. The lab has recently generated a novel knock-in mouse model of myeloproliferative neoplasm. Several projects involving this novel mouse model are currently available.

The successful candidate should have a Ph.D. within last 3 years in Immunology, Molecular Biology or Cell Biology with keen interest in science and strong research background. Most recent PhDs are preferred. Experience with flow cytometry and animal studies would be very helpful. Interested individuals should send a cover letter, curriculum vitae, and the names and addresses of three references to:

M. Golam Mohi, Ph.D.
Department of Pharmacology
State University of New York
Upstate Medical University
750 East Adams St. WHA #3319
Syracuse, NY 13210
E-mail: mohim@upstate.edu

posted by M. Golam Mohi, Ph.D. (mohim@upstate.edu)

2010.01.09

インディアナ大学医学部生化学科ポスドク募集

[研究内容] 当研究室では, 真核生物の転写調節機構において重要な役割を果たしている超分子複合体, Mediator の研究を
行っております。 このたび, 癌細胞における Mediatorの役割を調べるため ChIP-Seq 法を用いた Genome-wide の解
析を行います。本プロジェクトを遂行するにあたり, 意欲あるポスドク研究者を募集いたします。 本プロジェクトはIU Cancer Center and Center for Medical Genomicsとの共同研究で行われます。

[応募資格] 博士号取得または取得予定者で分子生物学, ヒト動物細胞の手法に精通している人。
[勤務地] Indiana University School of Medicine, Indianapolis, Indiana, USA
[待遇] インディアナ大学医学部の規定による (社会保険完備)
[応募書類] 1 履歴書と研究業績目録, 2 これまでの研究の概要並びに将来の研究の展望, 3 推薦者2−3名の氏名, 連絡先.
[就任時期] 採用決定後、出来るだけ早い時期, 開始時期は相談に応じます.
[選考方法] 書類審査と面接審査
[ 連絡先 ] 高木 雄一郎 (Yuichiro Takagi, Ph.D. Assistant Professor), Department of Biochemistry and Molecular Biology Indiana University School of Medicine 635 Barnhill Drive, Medical Science Building 4003, Indianapolis, IN 46202, USA TEL : (317) 274-2719, FAX: (317) 274-4686, E-mail : ytakagi@iupui.edu (日本語可)
URL : http://www.biochemistry.iu.edu/body.cfm?id=2993&oTopID=3097

[ 参考文献 ]
1. Cai, G., Imasaki, T., Cardelli, F., Yamada, K., Takagi, Y. Asturias, J.F., (2010). Mediator Head module Structure and Functional Interactions. Nature Structure and Molecular Biology, in press
2. Cai, G., Imasaki, T., Takagi, Y., and Asturias, J.F. (2009). Mediator Structural Conservation and Implication for the Regulation Mechanism. Structure 17, 559-567
3. Toth-Petroczy, A., Oldfield, C., Cheng, Y., Simon, I., Takagi, Y., Dunker, K., Uversky, V;, and Fuxreiter, M., Malleable machines: The roles of intrinsic disorder in the Mediator complex of transcription regulation. PLoS computational Biology 4, e1000243.
4. Takagi,Y, Calero, G., Komori, H., Brown, J. D., Ehrenberger, A.H., Hudmon, A., Asturias, F.J., and Kornberg, R.D., (2006) Head Module Control of Mediator Interactions. Mol. Cell. 23, 355-364

投稿者:高木雄一郎(ytakagi@iupui.edu)

2010.01.07

Baylor College of Medicine Postdoc募集

A postdoctoral position is available at a NIH funded, newly established laboratory in the Baylor College of Medicine.
(http://www.bcm.edu/mcb/?PMID=7566)
(http://www.bcm.edu/urology/?pmid=12624)

MicroRNAs have been implicated in modulating the tumorigenic properties of cancer cells. Preliminary results in our laboratory demonstrated that two MicroRNAs transcribed in a cluster were overexpressed in human cancer stem cells. Forced expression of one MicroRNA in this cluster in a cancer cell line led to an enhancement of its tumorigenic property in vivo. The predicted targets for these MicroRNAs are two tumor suppressors, when inactivated, will lead to the activation of an oncoprotein that is also implicated in the self-renewal of stem cells.

The primary goal of this postdoctoral project is to elucidate the functional role of this MicroRNA cluster, to identify their targets and to examine their abilities in modulating self-renewal and tumorigenicity. Ideal candidate will be a self-motivated individual, with prior experiences in molecular biology and MicroRNA biology. Please send your cover letter stating your research goal, CV and contacts of three references (must include Ph.D. advisor and/or current advisor) to Dr Keith Syson Chan at kc1@bcm.edu.

Posted by Keith Syson Chan (kc1@bcm.edu)

2010.01.05

Mayo Clinic College of Medicine ポスドク募集

ポスドク募集: Mayo Clinic College of Medicine

メイヨークリニックのPaganoラボで、脂質研究に興味のあるポスドク(Ph.D.もしくはM.D.の保持・取得予定者)の方を募集しています。(詳細は以下の英文を参考にしてください。)

メイヨークリニックはミネソタのロチェスター市にあり、治安もよく、日本人コミュニティー(http://sites.google.com/site/mayojapan/)も充実しています。長年脂質研究の最前線を走っているPaganoラボには、過去に多くの日本人研究者が在籍しており、Pagano教授も日本人の性格を熟知しています。興味がありましたら、下記のメールアドレスまで直接メールをするか、もしくは、私宛てまで日本語でメールください。

よろしくお願いします。

--------------------------------
Postdoctoral Position

Cell Biology of Sphingolipids, Pagano Lab, Mayo Clinic

An NIH-funded position is available immediately in the Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota to study the role of sphingolipids in regulating cellular microdomains. Studies will involve the use of molecular and biochemical approaches to manipulate cellular sphingolipid levels and to determine the effects of these changes on such processes as endocytosis, signaling, adhesion and migration. The candidate should have a M.D. or a PhD. and less than five years of postdoctoral experience. Previous research experience in fluorescence microscopy, protein/protein interactions and/or molecular biology is preferred. Some recent publications include:

Singh et al. Caveolar endocytosis and microdomain association of a glycosphingolipid analog is dependent on its sphingosine stereochemistry. J. Biol. Chem. 281 (2006) 30660-30668.

Singh et al., Inhibition of caveolar uptake, SV40 infection, and 1-integrin signaling by a nonnatural glycosphingolipid stereoisomer. J. Cell Biol. 176 (2007) 895-901

Mayor, S. and Pagano, R.E. Pathways of clathrin-independent endocytosis. Nature Reviews Molecular Cell Biology 8 (2007) 603-612.

Marks et al. Use of Bodipy-labeled sphingolipid and cholesterol analogs to examine membrane microdomains in cells. Histochem. Cell Biol. 130 (2008) 819-832

Kim et al. Proteomic Identification of proteins translocated to membrane microdomains upon treatment of fibroblasts with the glycosphingolipid, C8--D-lactosylceramide, Proteomics 9 (2009) 4321-4328.

Singh et al. Gangliosides and 1-integrin are required for caveolae and membrane domains. Traffic, in press.

Additional information can be found at: : http://mayoresearch.mayo.edu/mayo/research/pagano_lab/

Send curriculum vitae and names of three references to Richard E. Pagano, Ph.D.,
E-mail: pagano.richard@mayo.edu

投稿者:池田やすひろ(ikedayasuhiro@gmail.com)

2010.01.02

Indiana University School of Medicine Postdoc募集

Postdoctoral position available:

A postdoctoral position is available to study the mechanisms of Parkinson disease.

Genetic studies in the past decade have identified a number of genes as causal factors of Parkinson disease. Our research focuses on understanding the biochemical functions of the disease associated proteins and the biological pathways in which they function. Our core research technique is structural biology (protein X-ray crystallography) and structure-based drug design, but we use a wide range of techniques including, computational chemistry, biophysical techniques, enzymology, molecular biology and cell biology.

Our laboratory is affiliated with the Department of Biochemistry and Molecular Biology as well as the Stark Neurosciences Research Institute at IUPUI (http://www.iupui.edu/) in Indianapolis Indiana (http://en.wikipedia.org/wiki/Indianapolis).

We are looking for an enthusiastic person who holds a PhD in biochemistry or related field, has a strong background in molecular biology and protein biochemistry. Experience in computational and biophysical techniques are pluses. An ideal candidate should have genuine interest in science and desire to learn new techniques to tackle challenging and important questions.

Please email a cover letter, CV, and three reference letters to:
qqhoang@iupui.edu

Posted by Quyen Hoang (qqhoang@iupui.edu)

2010.01.01

Indiana University School of Medicine Postdoc募集

Postdoctoral position

A postdoctoral position is available in a multidisciplinary team focused on “chemical biology and drug discovery”.
We aim to develop novel molecular entities that modulate cellular signaling pathways with an emphasis on protein-protein interactions (PPIs). PPIs play essential roles in virtually every biological process and thus are emerging as promising therapeutic targets for various diseases including cancer. However, it is very challenging to disrupt PPIs with small organic molecules because protein interaction interfaces are relatively large and shallow. To overcome this, we focus on the design and construction of various “peptidomimetic” (peptide-like molecules) libraries including peptoids. They are expected to be ideally suited molecules to target PPIs due to their relatively large size and biological stability against protease degradation. With these libraries in hand, we will perform high-throughput screens (either affinity based on-bead screens or multi-well plate based screens) to identify novel inhibitors of PPIs involved in cancer (Please see the papers below f!
or more details).
The position will work in a highly interactive and collaborative research environment to identify synthetic molecules through high-throughput screening and to study their biological and therapeutic potentials. We are seeking for a highly motivated candidate who has recent Ph.D. in biochemistry, molecular biology or a related discipline. An individual with experience in protein biochemistry, molecular biology and cell biology is preferred.
Please send your cover letter and CV with names of three references to Dr. Hyun-Suk Lim at limhyun@iupui.edu.

Web: http://www.medicine.iu.edu/body.cfm?id=8341&oTopID
References:
Lim et al. “Identification of a Peptoid Inhibitor of the Proteasome 19S Regulatory Particle” (2007) J. Am. Chem. Soc. 129, 7750 (http://pubs.acs.org/doi/abs/10.1021/ja072027p).
Lim et al. “Periodate-Triggered Cross-Linking Reveals Sug2/Rpt4 as the Molecular Target of a Peptoid Inhibitor of the 19S Proteasome Regulatory Particle” (2007) J. Am. Chem. Soc. 129, 12936 (http://pubs.acs.org/doi/abs/10.1021/ja075469%2B).

Posted by Hynn-Suk Lim (limhyun@iupui.edu)

2009.12.31

The Scripps Research Institute Postdoc募集

Postdoctoral Position at The Scripps Research Institute

Postdoctoral training opportunities are available in the Asturias group at The Scripps Research Institute in La Jolla, CA. Our research is focused on the use of macromolecular electron microscopy (EM) to characterize the structure and conformational dynamics of macromolecular assemblies involved in transcription and chromatin structure regulation.
http://www.scripps.edu/cb/asturias/index.php?page=home. Our aim is to understand the molecular mechanisms that underlie these critical cellular processes by combining structural, biochemical, and functional analyses. Recent examples of our work can be found in the following publications:

1. Cai, G., Imasaki, T., Yamada, K., Cardelli, F., Takagi, Y. and Asturias, F.J. 2010. Mediator Head module Structure and Functional Interactions. Nat Struct Mol Biol In press.
2. Cai, G., Imasaki, T., Takagi, Y. and Asturias, F.J. 2009. Mediator structural conservation and implications for the regulation mechanism. Structure 17:559-567.
3. Brignole, E.J., Smith, S., and Asturias, F.J. 2009. Conformational Flexibility of Metazoan Fatty Acid Synthase Enables Catalysis. Nat Struct Mol Biol 16:190-197.
4. Chaban, Y.L., Ezeokonkwo, C., Chung, W.H., Zhang, F., Kornberg, R.D., Maier-Davis, B., Lorch, Y., and Asturias, F.J. 2008. Structure of a RSC-Nucleosome Complex and Insights into Chromatin Remodeling. Nat Struct Mol Biol 15:1272-1277.

Working with us would provide state-of-the-art training in macromolecular EM and an opportunity for in-depth examination of the molecular mechanisms responsible for the regulation of gene expression. Candidates interested in our research and with previous experience in structural, molecular, or chemical biology are encouraged to apply.

Posted by Francisco Asturias (asturias@scripps.edu)

2009.12.30

Beckman Research Institute of the City of Hope ポスドク募集

ポスドク募集: Beckman Research Institute of the City of Hope

私の研究室では、新規治療薬の開発を念頭に、正常造血機構および血液悪性腫瘍発症機序の解明を目標にしております。Ph.D. もしくは M.D., Ph.D. 保持者(もしくは取得予定者)の方で、腫瘍学、血液学、免疫学に興味のある方を募集致します。

COHは、研究所と病院が隣接しているユニークな研究環境にあり、動物実験施設、次世代シークエンス、FACS sorting等、付属のFacilityも大変充実しています。キャンパスは、ロサンゼルス郊外のパサデナ近郊にあり、気候もよく過ごしやすいところです。
興味のある方は、(1) 過去の研究歴と今後の研究目標(半ページ程度)(2) 英文のCV (3) 推薦者3人の連絡先、を一つのPDF文書にして、下記のe-mailアドレスに送付してください。

前田高宏 (tmaeda@coh.org)
Takahiro Maeda, M.D., Ph.D.
Assistant Professor
Division of Hematopoietic Stem Cell and Leukemia Research
Beckman Research Institute of the City of Hope
1500E Duarte Rd, Duarte, CA 91010
http://www.cityofhope.org/directory/people/maeda-takahiro/Pages/default.aspx

参考文献
1. LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis. Dev Cell, 17: 527-540, 2009.
2. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science, 316: 860-866, 2007.
3. Role of the proto-oncogene POKEMON in cellular transformation and ARF repression. Nature, 433: 278-285, 2005.

投稿者:前田高宏(tmaeda@coh.org)

2009.12.29

コルツ財団(歴史書物翻訳プロジェクトマネージャー)

コルツ財団(歴史書物翻訳プロジェクトマネージャー)


コルツ財団では、オランダLeidenで勤務が可能な博士及びPh.D Candidateを対象とした、プロジェクトマネージャーの採用を予定しております。主な目的は、戦時中の和文資料の検証、英訳を目的としたプロジェクトの推進を担う役割となります。

Corts Foundation
http://www.cortsstichtingen.nl/
The objectives of the Philippus Corts Foundation are:
 The translation of publications in Dutch about the Second World War, for instance the Engelandspiel, into English;
 The translation into English of documents which are related to the history of the Netherlands or the Netherlands Indies; for instance, official Japanese historical documents concerning the Japanese occupation of the Netherlands Indies, and documents written in other languages which are inaccessible to Dutch people such as Japanese or Indonesian
 The preservation on microfilms or the digitalization of VOC (Dutch East India Company) or WIC (Dutch West India Company) archives which are held abroad. In doing so the goal of the foundation is to increase the accessibility of these archives to the public, thereby making a contribution of the long-term conservation of these archives.

The board of directors of the Philippus Corts Foundation is composed of:
 Dr. P.C. Boer (chairman)
 Dr. M.A.G. de Jong (secretary)
 Mr J.C. Snellen van Vollenhoven (treasurer)
 Dr. H.E. Niemeijer
 Rosendahl Huber MA
 Advisor: Dr E.M. Jacobs

Activities for the current year:
 Preparation of: “The publication in English and Japanese of five (maximum of six) volumes of studies about the Second World War (Shensi Sosho) published in Tokio by the Ministry of Defence, which are relevant to the study of the Japanese attack on and subsequent occupation of Indonesia in the period 1941-1945.”
 Contributions to an English language catalogue of Japanese archive material about the Second World War.
 Contributions to the publication of a guide to the archives of the Dutch East India Company (VOC) and its local institutions in Batavia. A joint publication of the Nationaal Archief in the Netherlands and the Arsip Nasional of the Republic of Indonesia.
 The publication of the book The Loss of Java.
 The filming of the Dutch East India Company archives in a joint project with the Arsip Nasionaal of the Republic of Indonesia, Jakarta, and the Nationaal Archief in The Hague. In 2007 the trial project of the filming of the archive of the College van Heemraden (District Council) of Batavia) will be commenced.


Project Manager Job Description

Job Description:
 Define project scope and design by drafting a Project Initiation Document (P.I.D.) through communicating relevant personnel
 Obtain initial approval of the Project Initiation Document (P.I.D.), phase 1 Senshi Sosho Project.
 Set up project infrastructure and base of operations within the Netherlands (International Institute for Asian Studies(IIAS) in Leiden).
 Select translators (Translation Company / companies)
 Obtain final approval to commence the project by the Corts Foundation, the Supervisory Board and the copyright owner: Japanese State through National Institute for Defense Studies (NIDS) in Tokyo

Requirements:
 A young promising Japanese academic;
 Ph.D. candidate or Ph.D.;
 Japanese National;
 Historian;
 Professional interest in military history;
 Capability, aptitude and sensibility to act as a team leader for a long-term international sceientific project in close cooperation with professionals from several countries;
 Competence as a professional translator of Japanese military history;
 Fluent in English writing and English speech;
 Prepared to work abroad in Leiden in the Netherlands for a period of three years.

Employment Condition
Salary Proposal Project manager Senshi Sosho Series:
The designated project manager will be paid by the Corts Foundation through the University of Leiden/ International Institute For Asian Studies.We offer a starting salary for your employment with the Corts Foundation as a project manager based on the pay scale pf the University of Leiden ( January 2009).

The following is based on assumptions about university education and experience as a scientist.

The package we offer is:
Initial contract for one year (an initial 32 hours/week contract is standard, but this can be extended to full time=38 hours/week as soon as the workload warrants this)
(Salary per 1-1-2009 according to scale 11 step 10 CAO-NU (based on 38 hours/week): gross month: E 4.315,-; gross year: E 60.219,-; net montly equivalent (=1/12th of net year): approx. E: 2760,-)

B. Follow on contracts for two to four years, to be extended to cover the complete Senshi Sosho project period (full time=38 hours/week; follow on contracts will be granted on the condition that the project does not collapse and the project manager shows an acceptable performance)
(Salary per 1-1-2010 according to scale 11 step 11 CAO-NU: gross month: E 4.374; gross year: E 61.044,-; net monthly equivalent: approx. E 2.798,-)

Promotion to scale 12 step 5 CAO-NU per 1-1-2011 ( promotion is, of course, dependent on good performance and good progress of the project according to the project plan)
( Salary per 1-1-2011: gross month: E 4.428,-; gross year: E 61.796,-; net monthly equivalent: approx. E. 2.832,- )

The salary will then see yearly increases until the scale max. is reached per 1-1-2016
( Salary per 1-1-2016: gross month: 4.970,-; gross year: E 69.361,-; monthly equivalent: appr. E 3.179,- )

The contract will be fully comparable in all aspects to a regular "wetenschappelijk onderzoeker", payed according to academic staff scales with yearly increases in salary until the maximum of scale 12 is reached. Note: Everyday life in the Netherlands is much cheaper than in Japan..


Application Procedure

上記ポジションに応募を希望される方は、コルツ財団のHP、財団概要、職務要件をご確認いただき、
以下の応募書類を、下記連絡先まで送付ください(メール・郵送いずれも可)。受付後、次選考に進まれる方には、担当者より連絡いたします。

i) 和文・英文履歴書
ii) 和文・英文経歴書(過去の研究プロジェクト、執筆論文等明記)
iii) 推薦レター(2-3名程度、英文のみ)
iv) 自己推薦文(A4用紙1枚程度、英文のみ)

尚、選考結果に関わらず、応募書類の返還はいたしかねます。ご了承願います。

本ポストの応募手続きは、コルツ財団の採用パートナーであるランスタッド株式会社が、国内での採用受付窓口として対応をしております。お問い合わせは、下記担当窓口までいただけますよう、よろしくお願いいたします。

ランスタッド株式会社
東京都千代田区紀尾井町4-1ニューオータニガーデンコート21階
担当:前川

TEL+81-(03)-5275-1883 / FAX+81-(03)-5275-1880
Email: ikumi.maekawa@randstad.co.jp
Website: http://www.randstad.co.jp/

投稿者:ランスタッド株式会社

2009.12.24

テンプル大学医学部心臓血管研究センター ポスドクおよびResearch Scientist (MD, MD/PhD, PhD) 募集

ポスドクおよびResearch Scientist (MD, MD/PhD, PhD) 募集
テンプル大学医学部心臓血管研究センター (Philadelphia, PA)
江口研究室
当研究室は細胞生物学、分子生物学、タンパク工学(プロテオミックス)および遺伝子改変動物を主体とした手法を用いて心血管系の情報伝達と機能解析を中心に現在、以下のテーマで研究を行っています(Current Grants funded include NIH-RO1 and AHA Established Investigator Award)。

1. アンジオテンシン受容体の新しい情報伝達とその機能解析
2. NOと活性酸素を介した 血管系細胞内情報伝達
3. Gタンパクの新しい機能解析
4.
ニュヨーク、ワシントンは車で2-3時間のフィラデルフィアは日本人の生活に適し、郊外の住環境は最高です。当研究室は新築の研究棟に移転し、実験環境もさらに充実しました。留学にあたっては私と日本人のポスドク(現在5名の日本人スタッフ)が生活面、研究面すべてについて懇切丁寧に面倒を見ます。ご興味を持った方は履歴書(学歴と研究歴/業績、日本語可)を以下にe―mailしてください。(分野は問いませんが分子生物学的手法か組織染色に習熟した方を優先します。)

給与および条件
$39000―41000/year、経験により優遇、定期昇給制度あり、家族を含む医療保険(Medical & Dental)完備、休祭日は大学の規定に準じる(+夏休み1週、冬休み1週)。

Satoru Eguchi, MD. PhD. FAHA
Associate Professor of Physiology and Cardiovascular Research Center
Temple University School of Medicine
e-mail: seguchi@temple.edu(日本語可)

最近の当研究室の文献 (Selected from 102 English Publications)
Arterioscler Thromb Vasc Biol 29:217, 2009/Hypertension 53:182, 2009/Hypertension 51:232, 2008, Arterioscler Thromb Vasc Biol 26:e133. 2006, J Biol Chem 280:26592. 2005/Arterioscler Thromb Vasc Biol 25:1831. 2005/Mol Cell Biol 23: 1581. 2003/Hypertension 41:775. 2003/J Biol Chem 277:44695. 2002/Mol Endocrinol 16: 367. 2002/Circulation 106:909-912, 2002/J Biol Chem, 276: 7957. 2001.

当ラボホームページhttp://www.temple.edu/medicine/departments_centers/research/cardiovascular_faculty.htm

投稿者:江口 暁(seguchi@temple.edu)

2009.12.23

Washington University ポスドク募集

アメリカはセントルイスにあるWashington University医学部のDr. Emily Chengが日本人ポスドク(数名)を募集しています。

Postdoctoral positions are available for highly motivated individuals interested in apoptosis and BCL-2 family. Our laboratory focuses on uncovering the critical steps in survival/death decisions and defining the molecular processes that regulate death molecules (see Molecular Cell 36: 487-499; Nature Cell Biology 8:1348-1358; Science Signaling 2: ra48; Science 301:513-517). The successful candidates will apply biochemical, proteomics, and genetic approaches to study the fundamental mechanisms of programmed cell death.
A Ph.D. with a strong background in molecular/cellular biology, biochemistry, or mouse genetics, and a good publication record is required.
Applicants should send cover letters, CV, and contact info of 2-3 references to:

Emily Cheng, M.D., Ph.D.
Molecular Oncology, Department of Medicine
Washington University School of Medicine
660 South Euclid Avenue, Campus Box 8069
St. Louis, MO 63110
Email: echeng@dom.wustl.edu
Website: http://cheng-hsiehlab.im.wustl.edu/

アポトーシス、ネクローシスの分子メカニズムを分子レベルからマウス個体まで様々なアプローチで研究している研究室です。Dr. Stanley Korsmeyer研究室から独立して、ここ数年は特に順調に研究が進んでおり、論文もグループからNature Cell Biology、PNAS、Molecular Cell、Science Signalingなどのトップジャーナルに、共同研究でNature等に掲載されています。Dr. ChengはDistinguished Investigator Award in 2010(Washington University)に選ばれているほかThe American Sciety for Clinical Investigationのメンバーにも選出されており、研究費も複数の大型グラントを順調に獲得、更新しています。共同研究者のDr. James Hsiehと合同研究室を運営しており(2人で1.5研究室を運営)、研究テーマは別扱いですが実験室(機器、試薬、スペース)、セミナー、Journal Clubは共有しているため、共同研究として論文数を増やすチャンスも大きいです。この研究室出身として、留学に関する出来る限りのサポートをします。海外学振の応募先として考慮される方もどうぞ。その場��合には書類作成のお手伝いもします。Cheng-Hsieh研究室には現在、日本人が一人在籍しているのでスムーズに環境に馴染めると思います。

研究内容の詳細やメンバー、これまでに発表された論文リストは研究室のHPを参照して下さい。研究室の内情やセントルイスの生活、直接は聞きにくい給料のことなど、応募前に聞いてみたいという場合には笹川までお気軽にお問い合わせ下さい。

笹川覚
京都府立医大
sasaqawa@gmail.com(コピペ推奨)

投稿者:笹川覚(sasaqawa@gmail.com)

2009.12.21

オンタリオ癌研究所 ポスドク募集

募集内容:ポスドク研究員を1名募集します。
研究内容:癌化におけるエピジェネティクスの役割について。
応募資格:博士過程を終了、あるいは終了見込みで、分子生物学,生化学的手法を十分に習得されている方。独立して研究テーマを推進できる、意欲あふれる方を期待しています。採用時期は2010年4月頃を予定していますが、相談に応じます。
待遇:研究所の規定に従います。2-3年程度。
応募書類:1. 履歴書と発表業績リスト(英語), 2. 推薦者2-3名の連絡先, 3. これまでの研究内容、取得した実験手技と、志望動機(日本語可)をe-mailでお送りください。
ホームページ:http://medbio.utoronto.ca/faculty/okada.html
参考:トロントはカナダの東部に位置した自然豊かな環境で、Sick Kids Childrens Hospital、Toronto General Hospital、University of Toronto、Mount Sinai Hospital 等の研究施設が集まっており、研究交流も盛んです。

連絡先:Hitoshi Okada
Scientist, The Campbell Family Cancer Research Institute,
Division of Signaling Biology, Ontario Cancer Institute
Assistant Professor, Department of Medical Biophysics, University of Toronto
E-mail: hokada@uhnres.utoronto.ca (日本語可)

投稿者:岡田 斉(hokada@uhnres.utoronto.ca)

2009.12.18

カリフォルニア大学ロサンゼルス校  AIDS Institute ポスドク募集

ポスドク募集(カリフォルニア大学ロサンゼルス校  AIDS Institute )

カリフォルニア大学ロサンゼルス校(UCLA) AIDS Institute Dr. An Lab は エイズウイルス感染症に対する遺伝子治療を開発のため、ポストドックを2名募集します。California Institute for Regenerative Medicineから研究費が今後4年間支給されるため、憂慮なく実験に専念できます。 分子生物学、 細胞培養、ウイルス感染実験、マウス実験の経験のある方は優先して採用します。 好奇心が強く、固い意志で実験を遂行できる研究者を募集します。

研究内容:
1)Anti-HIV遺伝子の同定。
2)血液幹細胞に遺伝子導入するレンチウイルスベクターの開発。
3)NOD SCID BLT humanized mouseを用いたHIV-1抑制効果、免疫反応と安全性の判定。
4)HIV-1感染患者の遺伝子治療clinical trialの実施。

最近の論文:Shimizu, S., Hong, P., Arumugan, B., Pokomo, L., Boyer, J., Koizumi, N., Kittipongdaja, P., Chen, A., Bristol, G., Galic, Z., Zack, J., Yang, O., Chen, I., Lee, B. and An,DS. (2009) A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood, 2009.

勤務地 : カリフォルニア大学ロサンゼルス校(UCLA)
応募資格: 医学系、理学系、農学系、または、薬学系博士号保持の方、
または取得見込みの方。
待遇 : University of California Los Angeles (UCLA)の規定による 。
応募書類: 1)履歴書、論文リスト
      2)推薦状3通と推薦者の連絡先

就任時期 : 2010年2月。
以上の書類をemailにてDong Sung An (an@ucla.edu) まで送付してください。英語、日本語どちらでもかまいません。

UCLAは、ロサンゼルスの中でもサンタモニカとビバリーヒルズの間の治安の良い場所に位置し、気候は最高に良く、日本食レストラン、スーパーも沢山あり、安心して生活できる場所です。同Department内には日本人のポスドクが在籍しておりますので,渡米後の生活のセットアップなどのお手伝いが出来るかと思います。

連絡先:Dong Sung An. M.D., Ph.D.
188 (06) BIOMEDICAL RESEARCH BUILDING UCLA
615 Charles E. Young Drive South
Los Angeles, California, 90095
+1(310)206-2063 lab phone number
+1(310)983-1070 office phone number
+1(310)983-1067 fax

投稿者:安 東星(an@ucla.edu)

2009.12.15

Emory University Postdoc募集

Postdoc Positions in Atlanta
ONE POSTDOCTORAL POSTION is available to investigate the regulation of ubiquitin and its involvement in neurodegenerative diseases by proteomics approaches. Research involves state-of-art technologies for profiling thousands of proteins and posttranslational modifications by quantitative mass spectrometry. Examples of our work can be found in the references (J. Neurosci. 2007, 27:9503; Anal. Chem. 2008, 80:4161; Cell 2009, 137:133). Extensive experience in biochemistry, ubiquitin biology or neuroscience is essential. Candidates must have good publication records. Please submit CV, three references and a statement describing doctoral work and future research interests to Dr. Junmin Peng, Dept. of Human Genetics & the Center for Neurodegenerative Diseases, Emory University, Atlanta, GA 30322, e-mail: jpeng@emory.edu

Posted by Junmin Peng (jpeng@emory.edu)

2009.12.13

University of California, Los Angeles Postdoc募集

POSTDOCTORAL FELLOWS TO STUDY EPITHELIAL NORMAL STEM CELLS, EPITHELIAL CANCER STEM CELLS AND STROMAL AND EPITHELIAL INTERACTIONS IN GYNECOLOGIC ORGANS

Funded positions are available immediately in the laboratory of Sanaz Memarzadeh M.D., Ph.D., UCLA School of Medicine, and Assistant Professor in Gynecologic Oncology. This laboratory is located in Department of Obstetrics and Gynecology, Center for Health Sciences, at the David Geffen School of Medicine at UCLA.

The research programs in this laboratory focus on:

1. Identification of normal epithelial stem cells in gynecologic organs (ovarian surface epithelium and glandular endometrium)
2. Identification of cancer initiating/cancer stem cells in epithelial ovarian and endometrial cancer.
3. Role of epithelial and stromal interactions in cancer initiation and progression in gynecologic cancers (epithelial ovarian and endometrial cancer)

Highly motivated, hard working recent Ph.D. /M.D. graduates are welcome to apply for this Post-doctoral fellowship positions. Candidates with strong background and past achievements in molecular biology, microscopy/immuno-histochemistry, cellular biology, FACS analysis, experience working with epithelial cells (primary and cell lines), ability to perform small surgical procedures are particularly encouraged and desired for this position. Outstanding oral and written communication skills are needed in order to communicate with PI and other science and clinical collaborators.

This laboratory is located within the UCLA Medical Center, a block away from Westwood Village. Westwood is a beautiful area with multiple attractions including a variety of dining options, theaters, coffee shops and diverse shopping options. The weather is fantastic, generally in the 70’s and 80’s. Reasonable housing is also available in the Westwood area.

If you are interested in this position please send your personal statement and CV to smemarzadeh@mednet.ucla.edu, PI for this laboratory.

Posted by Sanaz Memarzadeh (smemarzadeh@mednet.ucla.edu)

2009.12.11

UT Southwestern postdoc募集

A postdoctoral position is available in the Zhang' lab to study the relationship between cancer and stem cells. The ideal candidate should have a Ph.D. or M.D. degree, be highly motivated and have a strong background in stem cell or cancer research. Interested individuals please send curriculum vitae, publication list and contact information for three references to:

Dr. Chengcheng (Alec) Zhang
Email: Alec.Zhang@UTSouthwestern.edu

Posted by Alec Zhang (Alec.Zhang@UTSouthwestern.edu)

2009.12.10

University of Pittsburgh School of Medicine ポスドク募集

ピッツバーグはペンシルバニア州西部にある州内第2の都市で、ピッツバーグ大学 、カーネギーメロン大学、そしてピッツバーグ大学医療センターを中心に栄える学園都市です。日本人人口は西海岸やNYほどではありませんが、日本人留学生、研究者、 日系企業関係者、医師など数千人の日本人が住んでいます。 私の所属するDepartment of Microbiology and Molecular Genetics (http://www.mmg.pitt.edu) は、今年12月に市内を流れる川沿いの新しいビルディングに移動したばかりで、ウォーターフロントの美しい環境のもとで研究ができます。

[研究内容]
私の研究室では、アデノ随伴ウィルス(AAV)の基礎生物学と、その遺伝子治療、細胞治療、および基礎生物学研究への応用について研究をしています。外来ウィルスDNAと宿主細胞との相互作用、特に、ウィルスゲノムがトリガーとなるDNA損傷シグナルの伝達とDNA組換えやDNA損傷修復機構の解明といった分子生物学的研究に加え、最近ではインビボイメージング等による AAVウィルス粒子の血管内皮細胞透過のメカニズムの解明といった細胞生物学的研究も開始しています。究極的な目標は、 AAVベクターによる遺伝子導入メカニズムの完全解明ですが、AAVの研究を通して、これまであまり知られていなかった生命現象の発見や、十分に理解されていなかった生命現象の解明もあり得るのではないかと考えています。応用部門では、AAVベクターを用いた血友病、筋ジストロフィー、虚血性心疾患、心筋症、嚢胞性線維症、糖尿病の遺伝子治療の研究、細胞治療への利用を目的とした幹細胞の心筋への分化誘導の研究を、共同研究として行っています。

[ 採用人数]ポスドク1名
[採用期間]2010年1-2月から1-3年。 給与等はピッツバーグ大学の規定に従います。
[ 資格 ]分子生物学、細胞生物学実験の経験を十分にもち、上記研究に興味のある博士号取得(見込)者で、高い意欲のある人材を求めます。
[応募締切]該当者が決まり次第締め切ります。
[応募方法]下記E-mailアドレスまで以下の書類を添付してお送りください。
(1) 履歴書
(2) 研究業績サマリー(A4 1枚程度)
(3) 指導教官など、推薦者2-3人の氏名と連絡方法

質問がごさいましたら、 nakaih@pitt.eduまでお問い合わせください(日本語可)。

[応募先] 
ピッツバーグ大学医学部 微生物学・分子遺伝学
中井浩之
Hiroyuki Nakai, M.D., Ph.D.
Department of Microbiology and Molecular Genetics
University of Pittsburgh School of Medicine
Email: nakaih@pitt.edu
Lab information: http://www.mmg.pitt.edu/personnel/view.asp?uid=nakaih

投稿者:中井浩之(nakaih@pitt.edu)

2009.11.30

Burnham Institute for Medical Research Postdoc募集

Postdoctoral Associate position is available to study epigenetic gene regulation of non-coding RNA (ncRNA) in normal skin and skin cancer melanoma. We have previously shown that malignant melanoma, caused by abnormal cell division of melanocytes in human skin, is associated with irregular patterns of microRNA (miRNA) gene expression in the constituent cells. Several putative tumor suppressors of miRNA origin have been identified in our laboratory and we will characterize these through in-vitro and in-vivo functional genomics studies. The prospective candidate will continue this study at the new facility of The Burnham Institute in Orlando, Florida.

Burnham Institute for Medical Research at Lake Nona (Orlando) is an independent, not-for-profit biomedical research institution dedicated to advancing the frontiers of scientific knowledge in life sciences and medicine, and providing the foundation for tomorrow’s innovative therapies. Burnham is building 175,000 sq. ft. state-of-the-art laboratory facilities for over 300 faculty and staff. The Lake Nona/Orlando site will feature several outstanding technology cores, and faculty will undertake discovery research in several fields, including launching a new center devoted to diabetes & obesity research.

Ph.D. and/or M.D. Candidate must have a strong background in at least one of the following areas: cell biology, molecular biology, and/or transcriptional/post-transcriptional gene regulation/bioinformatics.
Visit Burnham Institute at
http://www.burnham.org/default.asp?contentID=742

Contact:
Ranjan J.Perera, Ph.D.
Associate Professor
Director Genomics
Burnham Institute for Medical Research
6400 Sanger Road
Orlando FL- USA
Phone: 407 7452084
e-mail: rperera@burnham.org

Posted by Ranjan J.Perera (rperera@burnham.org)

2009.11.19

Emory University School of Medicine ポスドク募集

TWO POSTDOCTORAL POSITIONS IN CANCER RESEARCH are available immediately for highly motivated scientists to investigate the role of protein kinase signaling in human tumorigenesis, tumor metastasis and cancer cell metabolism. Our research focuses on translational and preclinical studies on human leukemias and tumors with ultimate goals to develop molecularly-targeted therapeutic strategies to treat human cancers. For related works of our laboratory please see Science Signaling 2009 Nov. 17, Volume 2 Issue 97 ra73; Cancer Cell 2007, 12(3):201-14; Mol. Cell. Biol. 2009 Apr, 29(8):2105-17; and Blood 2007, 110(1):360-369. Successful candidates must hold a doctoral-level degree with solid background of biochemistry, genetics and molecular and cellular biology. Experience with animal models of human diseases such as xenograft tumor models is desirable. Applicants should send a CV, a brief research statement and the names and contact information of three references to:

Su Min Kang, Ph.D., Assistant Professor
or
Jing Chen, Ph.D., Assistant Professor
Hematology/Medical Oncology
Winship Cancer Institute, Emory University
1365-C Clifton Rd. NE, C-3002
Atlanta, GA 30322
404-778-5562 (Dr. Kang)
404-778-5274 (Dr. Chen)
E-mail: smkang@emory.edu or jchen@emory.edu

私が所属しているエモリー大学チェン研究室ではポスドクを募集しています。興味のある方は上記のアドレスに直接メールしていただいても結構ですし、私(thitosu@emory.edu) に連絡していただいても結構です。

投稿者:Taro Hitosugi(thitosu@emory.edu)

2009.11.18

Fred Hutchinson Cancer Research Center ポスドク、大学院生募集

私の所属するラボのボスがポスドク、大学院生を募集しています。詳細は以下をご覧下さい。私自身大学院生として在籍していますが、ボスは非常に優秀で、シアトルは日本人にとってとても生活しやすく、非常にいい環境です。

今年12月に横浜で開催される分子生物学会にボスが参加しますので、興味のある方はそこで面談可能です。質問等ありましたら、日本語でも英語でも構いませんので、秋吉文悟(akiyoshi@u.washington.edu)までお気軽に連絡下さい。

----------------------------------------------------

Lab studying chromosome segregation in the Division of Basic Sciences, Fred Hutchinson Cancer Research Center (Seattle, WA, USA) has potential post-doctoral or pre-doctoral opportunities that can be discussed at the MBSJ2009 Meeting in Yokohama, Dec 9-12, 2009. Potential future projects include:
1. Structural and EM studies on purified kinetochores in collaboration with Tamir Gonen
2. Biophysical TIRF and optical trapping studies on pure kinetochores in collaboration with Chip Asbury
3. Spindle checkpoint studies
4. Studies of centromeric chromatin and contribution of chromatin modifications
5. Kinetochore regulation, biorientation and assembly studies in yeast or mammalian cells

Please contact Sue Biggins at sbiggins@fhcrc.org if you would like to meet at the meeting to discuss possible future positions and projects.

Website: http://labs.fhcrc.org/biggins/index.html

投稿者:秋吉文悟(akiyoshi@u.washington.edu)

2009.11.17

Northwestern大学 ポスドク募集

私が米国留学時のボス Dr. Debu Chakravarti(Northwestern大学)がポスドクを募集しています。

彼はThe Salk InstituteのDr. Ronald M. Evans研出身で、ホルモンレセプターの遺伝子発現制御、Histone Code解読の研究を行っています。日本人研究者の友人をたくさん持ち親日家です。性格は紳士的で温厚です。詳細はHP(http://www.feinberg.northwestern.edu/igp/facindex/ChakravartiD.html)を参照ください。

研究所はシカゴのダウンタウンにあり、大学病院や研究施設の一画にあります。

The Chakravarti laboratory is interested in understanding the roles of nuclear hormone signaling and chromatin modifications in regulating normal cell and organ physiology and how altered transcriptional signaling contributes to reproductive pathology including leiomyoma, cancer development and metastasis. Our work is currently funded by multiple grants RO1s, and PO1 from the NIH (NCI, NICHD and NIDDK).

Applicants with strong molecular and cellular background are encouraged to contact Dr.Chakravarti via email. Applicants should have a Ph.D, MD, MD/Ph.D at the time of appointment. These positions will be filled immediately.

興味がある方は直接Dr. Chakravariti(debu@northwestern.edu)に連絡をとって頂くか、私に照会下さい。

投稿者:直江吉則(naoepenn@gmail.com)

2009.11.16

南カリフォルニア大学 ジルカ神経遺伝学研究所 ポスドク募集

私が留学時に同じフロアーでお世話になった、Dr. Le Ma がポスドクを募集しています。

研究の詳細は、下記のHPを参照頂ければと思います。主にマウスの後根神経節を用いて、軸索の伸張や分岐の分子機構を解析しています。Dr. Ma も自ら手を動かして日々アクティブに実験を行っていますが、性格は大変温厚で、様々な面で協力的です。

研究所は、ロスのダウンタウンにあるメインキャンパスではなく、大学の病院や研究施設が集まった Health Science Campus にあり、アメリカ各地の有名ラボで業績をあげた若手のPIを中心に、活発な研究を展開しています。また、数年前からは幹細胞研究にも多額の投資が行われ、研究の幅が益々広がっています。

Health Science Campus は、ドジャースタジアムや、ダウンタウンのコンサートホール、オペラハウスにも近く、研究以外の面でも、南カリフォルニアの生活を堪能するのに大変魅力的な環境だと思います。

興味のある方は、直接 Dr. Ma に連絡をとって頂くか、私に照会下さい。

----------------------------------------

Postdoctoral Fellow in Developmental Neurobiology,
Los Angeles


We are seeking a highly motivated postdoctoral fellow to join our research
group at the Zilkha Neurogenetic Institute of University of Southern
California, Los Angeles. The institute provides excellent research facilities
and a rich training environment in modern neuroscience. The successful
candidate will employ a combination of molecular, genetic, and cell
biological tools to address fundamental questions concerning axon growth,
guidance and branching in the developing nervous system. Areas of
interests include but are not limited to extracellular cues, intracellular
signaling, cytoskeleton regulation and remodeling, growth cone cell biology,
circuit development and function, and nerve injury and regeneration.
Applicants must have a recent Ph.D. with relevant publications in any of the
following fields: neurobiology, molecular, cell, and/or developmental
biology. Past experience with primary neuronal culture, tissue dissection,
live cell imaging, image analysis, neuroanatomy, expression screening,
and/or mouse genetics is a plus. For more information, please visit our web
site at http://branching.usc.edu.

If interested, please send curriculum vitae, a brief statement of past research
accomplishments and career goals, as well as names of three references to:

Dr. Le Ma
Zilkha Neurogenetic Institute
Keck School of Medicine
University of Southern California
1501 San Pablo Street
Los Angeles, CA 90033
E-mail: le.ma@usc.edu

One-on-one interview can be arranged at the ASCB meeting in San Diego.

投稿者:Shiraishi H.(hshirais@gmail.com)

2009.11.14

The Ohio State University ポスドク募集

今年の1月より、PIとしてラボを立ち上げました。
距離の長いaxonから進行性に変性を来す、遺伝性系痙性麻痺(Hereditary spastic paraplegia)のモデル動物を用いた、疾患の病態解析、およびその治療を主な研究テーマとしております。
ポスドクの先生(PhD, MD, あるいはDVM)を募集中です。
ラット/マウスの神経系の病理組織学的な解析の経験をお持ちの方(具体的には脳や脊髄などの組織切片作成、免疫染色などの実験)を特に希望しております。
Ohio State Universityのある、Columbus(オハイオ州の州都です)は比較的物価が安く住みやすい町で、研究に集中できると思います。
応募希望の先生は、大学のHuman Resourceに応募者の情報を登録する必要があります
ので、CV(referenceの連絡先を2人以上記入してください)および連絡先などの情報
をOhio State University Medical Centerの求人サイトに、登録、uploadしてくださ
い。
以下のURLにアクセスしてください。
http://medicalcenter.osu.edu/careers/Pages/index.aspx
このweb siteの左側にある、Find and Apply for Jobsをクリックしてください。
すると、別のweb siteが開き、求人広告を検索するページが開きます。
ここのBasic Job searchのKeywordsに求人番号(Job ID) 348080を記入して、検索をか
けてください。すると私が現在募集しているポスドクの求人広告のページが開きます。
あとはApply Nowのボタンを押して、登録を行い、その後CVなどをuploadしてください。
もしご不明の点がございましたら、ぜひkisanuki.1@osu.eduまでご連絡ください。
ちなみに現在日本在住で、応募ご希望の先生の面接は私が日本に出張/一時帰国中に行うことも可能です。
木佐貫 泰
Yasushi Kisanuki, M.D.
Assistant Professor
Department of Neurology
Division of Neurogenetics
The Ohio State University
782 Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210
kisanuki.1@osu.edu

投稿者:木佐貫 泰(kisanuki.1@osu.edu)

2009.11.09

ペンシルベニア大学医学部神経科学部門 ポスドク募集

私が非常に仲良くしているペンシルベニア大学医学部神経科学部門のアソシエイトプロフェッサーのDr. Minghong Maが日本人ポスドクを募集しています。

彼女の研究室は嗅覚について研究しており、マウスの鼻の粘膜から直接、細胞のパッチクランプをするという、世界でここのラボしかできない技術をもっています。それ以外にも分子生物学的、生化学的手法を使って様々な角度から嗅覚について研究しており、非常に魅力的なラボです。

ペンシルベニア大学はアメリカ東部のフィラデルフィアにあり、ハーバード大学、イェール大学と並ぶアイビーリーグの一つで、街の中心部に美しいキャンパスを持つすばらしい大学です。ポスドクの雇用システムも整っており、初めてアメリカで研究する人にとって非常に安心できる環境です。

興味のある方は、Dr. Minghong Ma(minghong@mail.med.upenn.edu)にCVを添付の上、メールして下さい。

A postdoctoral position in the Department of Neuroscience, University of Pennsylvania is available to study neurobiology of olfaction. The main interest of the lab (http://www.med.upenn.edu/apps/faculty/index.php/g20001304/p42685) is to study olfactory coding and processing mechanisms in the mammalian olfactory system by combining physiological, cellular, and molecular approaches. Experience in electrophysiology (patch clamp) is desired. Please send application (CV and references) to Dr. Minghong Ma at minghong@mail.med.upenn.edu.

投稿者:Philly76

2009.11.04

University of Kansas Medical Center ポスドク募集

私の所属するラボのボスがポスドクを募集しています。詳細は以下に記します。

Multiple Postdoctoral Positions

Positions are available immediately in the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center (Kansas City, KS, USA) to conduct independent research work in the broad areas related to cancer chemoprevention, mechanism of autophagy and apoptosis, lipid metabolism/homeostasis, and neurobiology. Hard-working, self-motivated applicants with experience in molecular biology, cellular imaging and animal experimentation are encouraged to provide a CV and contact information for three references to Professor Bao-Ting Zhu (email address: BTZhu@kumc.edu). The University of Kansas Medical Center is an Equal Opportunity/Affirmative Action Employer.

直接、Professor Bao-Ting ZhuへCVをメールに添付して送っていただいてもよろしいですが。もし、質問等ございましたら、私のほうにメールを送っていただいても結構です(日本語可)。

投稿者:福井雅之(mfukui@kumc.edu)

2009.11.03

University of Pennsylvania ポスドク募集

ポスドク募集
University of Pennsylvania

ボスの代理で投稿します。
当研究室では、補体を中心に補体/Toll-like receptor/自然-獲得免疫の研究を行なっています。ポスドク、テクニシャンを数名募集しています。
同じラボに日本人が2人働いています。
研究環境は非常にいいです。
応募される方は、Wenchao Song (songwe@upenn.edu)までCVと推薦者2-3名の連絡先を送ってください。質問などありましたら、日本語、英語どちらでも構いませんので、私(三輪隆史 miwataka@mail.med.upenn.edu)までお願いします。

関心のある方はぜひapplyしてみてください。

Postdoctoral researcher positions available at the Institute for Translational Medicine and Therapeutics of the University of Pennsylvania School of Medicine. Research projects are concerned with the following topics: regulation of complement and toll-like receptors, crosstalk between innate and adaptive immunity, complement protein knockout and transgenic mice, pathogenesis and experimental therapeutics of complement-mediated diseases. Candidates with the following training and experience are encouraged to apply: immunology, molecular biology, recombinant protein expression, antibody production and engineering, knockout and transgenic mice, mouse models of inflammatory and autoimmune diseases. Please contact Dr Wenchao Song, Professor of Pharmacology, Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Email: songwe@upenn.edu

投稿者:三輪隆史(miwataka@mail.med.upenn.edu)

2009.10.31

Weill Medical College of Cornell University ポスドク募集

私の友人のラボでポスドクを募集しています。Cancer Stem Cell関連の研究のようですが、詳しくは下をご覧ください。


Research Postdoctoral Associate position available in the research laboratory of Chung Che (Jeff) Chang, M.D., Ph.D. at The Methodist Hospital Research Institute, Weill Medical College of Cornell University, Department of Pathology.

This position is needed to carry out basic/translational research duties, i.e. develop research methods independently, write up research results for publication, assist in maintaining the function and operation of laboratory, and perform other duties assigned by PI.

M.D. and/or Ph.D. with at least two years experience in biomedical research laboratory required to focus on cancer stem cell research. The Institution offers very competitive compensation with exceedingly supportive research environment for outstanding condidates.

Experience in some of following areas will be preferred: animal experiments, miRNA/cDAN microarray, next generation sequencing, epigenetic regulation, real-time PCR, flow cytometry analysis, primary cell culture, western blotting analysis, protein kinase assay, plasmid DNA construction, and cell transfection.

Send CV and three references to:
Chung-Che (Jeff) Chang, MD, PhD
Chief, Hematopathology Service, The Methodist Hospital
Professor, Department of Pathology, Weill Medical College of Cornell University
jeffchang@tmhs.org

投稿者:荻野周史(sogi43@gmail.com)

2009.10.28

ロンドン大学癌研究所 ポスドク募集

ロンドン大学癌研究所(ICR: Institute of Cancer Research)、幹細胞クロマチンチームにてポスドクを募集しております。私達のチームはロンドンから30分南に位置するサットン(サリー州)キャンパスの新しいビルに配属されております。サットン近傍は住居環境もロンドン中心部よりも良く、車で10-20分ほどのところに大きなアジア系食料品店がいくつかあるなど、日本人には住みやすい場所です。

プロジェクト、連絡先、雇用条件などは以下をご覧ください。エピジェネティクス、幹細胞を扱ったことのある研究者を探しております。募集締め切りは11/16です。
http://www.icr.ac.uk/jobs/current_vacancies/12944.shtml

投稿者:澤渡朋之

2009.10.27

City of Hope Beckman Research Institute postdoc募集

The collegial atmosphere at City of Hope provides unique opportunities for translational and basic research, continuing education and professional achievement. We are a National Cancer Institute-designated Comprehensive Cancer Center and a leader in biomedicine. If you share our passion for discovery, consider the following opportunity within City of Hope's Beckman Research Institute, one of the nation's premier biomedical research centers. A postdoctoral fellowship is available in the Laboratory of Dr. Ya-Huei Kuo in the Department of Hematopoietic Stem Cell and Leukemia Research at the Beckman Research Institute. Research projects involve mouse models of acute myeloid leukemias, investigation of molecular mechanisms underlying leukemogenesis, and regulatory mechanisms of hematopoietic stem cells and leukemia stem cells. To qualify: the candidate must have a Ph.D. and a strong background in hematopoietic and leukemia stem cell research. Also, the prospective candidate shoul d be highly motivated and have skills in molecular biology, tissue culture, flow cytometry, mouse handling along with a solid background in molecular and cell biology. To Apply: Please send a cover letter stating research interests, curriculum vitae and names and contact information of three references to Ya-Huei Kuo, Ph.D. at: YKuo@coh.org At City of Hope, discovery and compassion work together - for life. To learn more about our organization and our opportunities, please visit www.cityofhope.org

Posted by Ya-Huei Kuo (YKuo@coh.org)

2009.10.24

University of Cincinnati ポスドク募集

ポスドク募集 University of Cincinnati

私の元同僚で、最近オハイオ州University of Cincinnatiにて独立したDr. Samuel Godar (Samo)がポスドクを募集しているので、代わりに広告を投稿させていただきます。Samoはホワイトヘッド研究所、Weinberg Labにてポスドクをしていた際に、細胞表面分子CD44(乳がんにおける幹細胞マーカー)が転写因子p53により転写制御を受けることを見出し (Godar et al., Cell, 2008)、最近ではp53/p63経路による(がん)幹細胞性の制御、といった内容に研究を進展させています。

彼は人当たりもよく、大変親しみやすい人柄です。また、日本人の話す英語を長年聞きなれているので、コミュニケーションもとりやすいと思います。関心のある方はぜひapplyしてみてください。

/////////////////

Postdoc

Postdoctoral positions are currently available to work on breast cancer, epithelial integrity and process of metastasizing to distant organs. The project focuses on novel tumor suppressor functions of p53 that operate in the absence of external stress (Godar et al., Cell [2008]. 134 62-73).

The successful candidate will get full attention and support from his supervisor and will have the opportunity to work and professionally grow in a cross-disciplinary environment at the Department of Cancer and Cell Biology, College of Medicine at the University of Cincinnati (http://cancerbiology.uc.edu/index.php). Starting date: Immediate. Strong motivation to do science and experience with techniques in the areas of either molecular biology, proteomics or animal biology will be important criteria in considering the suitable candidates.

Cincinnati offers critical mass of science concentrated at the University of Cincinnati and neighboring hospitals, collaborative spirit, low costs of living and relatively high living standard. It offers excellent health care and cultural activities, e.g. Children’s Hospital and College/Conservatory of Music rank among the best nationally.

Applicants should send a letter describing his/her research interests, CV, PDF files of one or two representative publications and the names and contact information (email addresses) of 3 references to godarsl@uc.edu.

投稿者:渋江 司(shibue@wi.mit.edu)

2009.10.22

Washington University in St. Louis ポスドク募集

ポスドク募集
Washington University in St. Louis

ボスの代理で投稿します。
当研究室では、BCL-2ファミリーを中心にアポトーシスの分子機構の研究を行なっています。
以下の通り、ポスドクを1名募集しています。
応募される方は、Emily Cheng(echeng@dom.wustl.edu)までCVと推薦者2-3名の連絡先を送ってください。
日本語での質問などありましたら、私(武田修学 stakeda@artsci.wustl.edu)までお願いします。


Postdoctoral positions are available for highly motivated individuals interested in apoptosis and BCL-2 family. Our laboratory focuses on uncovering the critical steps in survival/death decisions and defining the molecular processes that regulate death molecules (see Nat Cell Biol. 8:1348-1358; Science Signaling 2: ra48; Science 301:513-517; Molecular Cell 8: 705-711). The successful candidates will apply biochemical, proteomics, and genetic approaches to study the fundamental mechanisms of programmed cell death.

A Ph.D. with a strong background in molecular/cellular biology, biochemistry, or mouse genetics, and a good publication record is required.

Applicants should send CV and contact information of 2-3 references to:

Emily Cheng, M.D., Ph.D.
Molecular Oncology/Department of Medicine
Washington University School of Medicine
660 South Euclid Avenue, Campus Box 8069
St. Louis, MO 63110
Email: echeng@dom.wustl.edu
Website: http://cheng-hsiehlab.im.wustl.edu/

投稿者:武田修学(stakeda@artsci.wustl.edu)

2009.10.21

Mayo Clinic – Rochester, MN ポスドク募集

ポスドク研究員募集
Division of Oncology Research
Mayo Clinic – Rochester, MN

当研究室では、ガン細胞における細胞周期や細胞増殖シグナルの異常、染色体の不安定化機構の研究に興味のあるポスドク研究員を募集しています。

[研究内容]
(1)細胞増殖制御に関わるユビキチン関連因子の解析-現在、ガン抑制因子として機能する脱ユビキチン化酵素を中心に研究を行っています。これまでの研究により、この因子が遺伝子の発現調節に関わっていることがわかってきました。その分子機構の解析と制御遺伝子の同定をすすめ、この因子の欠損によって細胞がガン化に向かうメカニズムを明らかにしたいと考えています。
(2)ガン関連経路のプロファイリング-Genome-wide RNAiを用いた網羅的な解析により、細胞のガン化メカニズムの多様性や、抗ガン剤応答性の違いを研究しています。

[最近の論文]
Mol Cell 2006 Aug; 23(4):589-96.
Mol Biol Cell 2006 Nov; 17(11):4837-45.
Genes Dev 2007 Jan 15; 21(2):184-94.
J Biol Chem 2009 Oct 08. [Epub ahead of print] PMID:19815555

Mayo Clinicは全米の病院で2位にランクされ(http://health.usnews.com/health/best-hospitals)、基礎から臨床応用まで多様な研究が行われています。Fortune誌では働きたい会社Best100にも選ばれました(http://money.cnn.com/magazines/fortune/bestcompanies/2009/snapshots/63.html)。Rochesterは、暮らしやすく安全な町です。自然に囲まれアウトドアが楽しめる一方、MinneapolisやSt. Paulといった都市にも簡単に行くことができます。興味のある方は町田雄一 (machida.yuichi@mayo.edu)までご連絡ください(日本語可)。

Yuichi Machida, Ph.D.
Assistant Professor
Division of Oncology Research
Mayo Clinic
200 First Street SW
Rochester, MN 55905
http://www.mayoclinic.org/virtual-tours/minnesota.html

投稿者:町田雄一(machida.yuichi@mayo.edu)

2009.10.20

ダンディー大学 生命科学部 ウェルカムトラストセンター ポスドク募集

ポスドク募集
出芽酵母における染色体分配の研究
Wellcome Trust Centre for Gene Regulation and Expression
College of Life Sciences, University of Dundee
Dundee, UK
英国 ダンディー大学、生命科学部、ウェルカムトラストセンター

研究内容
細胞分裂がくりかえされる際、常に細胞が同じ染色体セットを維持するためには、細胞分裂に先立って、姉妹染色分体を娘細胞に正確に分配するメカニズムが必要です。このメカニズムの破たんは、癌や先天性疾患など、様々な病気の原因になると考えられています。本研究室では、モデル生物として出芽酵母を用い、酵母からヒトにいたるまで保存された、染色分体分配を制御する基本的なメカニズムを研究しています。特に、高解像度蛍光顕微鏡による染色体動態のリアルタイム解析、質量分析器によるタンパク質リン酸化の解析に力を入れています。酵母を扱った経験の有無は問いません。この分野に興味のある、意欲あるポスドク研究者を募集します。

研究室ウェブサイト:http://www.lifesci.dundee.ac.uk/people/tomo_tanaka/

最近の主な業績と総説
Tanaka TU & Desai A. Kinetochore-microtubule interactions: the means to the end. Curr Opin Cell Biol, 20, 53-63. (2008)
Maure J-F et al. Mps1 kinase promotes sister kinetochore bi-orientation by a tension-dependent mechanism. Curr Biol, 17, 2175-82. (2007).
Kitamura E et al. Kinetochore-microtubule interaction during S phase in Saccharomyces cerevisiae. Genes Dev, 21, 3319-30. (2007).
Tanaka K et al. Molecular mechanisms of microtubule-dependent kinetochore transport towards spindle poles. J Cell Biol, 178, 269-81. (2007).
Kitamura E et al. Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories. Cell, 125, 1297-308. (2006)
Tanaka K et al. Molecular mechanisms of kinetochore capture by spindle microtubules. Nature 434, 987-94. (2005).

応募資格:PhD(もしくはMD)取得者および取得見込みで、Molecular cloning (plasmidの構築など)ができる研究者

提出していただく書類
CV、研究業績、志望動機、推薦者2-3名の氏名と連絡先(E-mailアドレスを含む)

問い合わせ先、書類送付先
田中智之(ダンディー大学、生命科学部教授)
Professor Tomoyuki Tanaka
College of Life Sciences
University of Dundee
Wellcome Trust Biocentre, Dow Street
Dundee DD1 5EH, UK
E-mail: t.tanaka@lifesci.dundee.ac.uk(日本語可)

投稿者:田中智之(t.tanaka@lifesci.dundee.ac.uk)

2009.10.19

University of Illinois at Chicago ポスドク募集

ポスドク (PhD, MD, MD/PhD)

University of Illinois at Chicago
Department of Pharmacology, Center for Lung and Vascular Biology and Center for Cadiovascular Research

我々の研究室では、現在日本人のポスドクを募集しています。シカゴは、ミシガン湖に面したアメリカ大陸の中心部に位置し、日本からの直行便もあり、大変交通に便利な大都市です。イリノイ大学は、シカゴダウンタウンから車で10分ほどの所にありますので、生活面でも問題ありません。現在日本人のスタッフが5人います。

[研究テーマ] 遺伝子タ─ゲティングマウスを用いた、活性酸素による心血管病態(高血圧、糖尿病)および血管新生制御機構に関する研究、活性酸素関連遺伝子発現調節に関する研究、酸化ストレスを介した細胞内シグナル伝達機構の解明

[資格] 分子生物学技術、あるいは動物実験、あるいは細胞生物学の経験を有する博士号取得 (見込)者で、研究に興味を持っている意欲的な方を募集します。
[給与] $38,000-43,000/year、家族を含む医療保険完備、休祭日は大学の規定に準じる。
[採用」2009年12月―2010年3月より2―3年

[提出書類] 履歴書、研究業績リストおよび主要論文の別刷(発表論文のない場合は、これまでの研究の概略)、推薦者の連絡先(e-mail address)

「連絡先」
Masuko Ushio-Fukai, PhD, FAHA (深井真寿子)
Tohru Fukai, MD, PhD, FAHA (深井透)

University of Illinois at Chicago
Department of Pharmacology
835 S. Wolcott. M/C868
E403 MSB
Chicago IL 60612
TEL:312-996-7665
FAX:312-996-1225
E-mail:mfukai@uic.edu; masuko.fukai@gmail.com
http://www.uic.edu/depts/mcph/index.htm

投稿者:Masuko Ushio-Fukai(masuko.fukai@gmail.com)

2009.10.17

テンプル大学医学部心臓血管研究センター (Philadelphia, PA) ポスドク募集

ポスドク (PhD, MD, MD/PhD)

テンプル大学医学部心臓血管研究センター (Philadelphia, PA)

私の同僚で共同研究者の Dr. Rosario Scaliaが以下の英文のように日本人のポスドクを募集しています。 Dr. Rosario Scaliaは優しく勝つ丁寧に研究を指導してもらえ、ボスとしても信頼できる先生であると認識しています。

また、ニュヨーク、ワシントンは車で2-3時間のフィラデルフィアは日本人には生活しやすいところでしょう。留学にあたっては私と日本人のポスドク(現在5名の日本人スタッフ)が生活面では全般的にサポートさせていただきます。ご興味を持った方は履歴書(学歴と研究歴/業績)を以下にe―mailしてください。詳細は日本語で私に質問していただいてもかまいません。

給与 $40000/year、家族を含む医療保険完備、休祭日は大学の規定に準じる。

連絡先

Postdoctoral positions available immediately to study roles of endothelial nitric oxide synthase (eNOS) and adhesion molecules in diabetic vascular complications. A PhD in Biomedical Sciences or MD is required. Previous training in cardiovascular physiology preferred. Skills in general microscopy also preferred. Experiences in mouse/rat models of diabetes desired. Please send CV and contact information of three references to Dr. Rosario Scalia at rscalia@temple.edu

投稿者
Satoru Eguchi, MD. PhD. FAHA
Associate Professor of Physiology and Cardiovascular Research Center
Temple University School of Medicine
e-mail: seguchi@temple.edu(日本語可)
Tel/FAX 215-707-8378

最近の Scalia Lab の文献
Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain. Diabetes. 56(7):1842-9, 2007

Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest 117(6):1718-26, 2007

The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. Diabetes. 54(4):1132-40, 2005

投稿者:江口 暁(seguchi@temple.edu)

2009.10.16

the Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Trondheim, Norway ポスドク募集

A postdoc position in the Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Trondheim, Norway

We invite applications for a postdoctoral position in the Tashiro group in the Kavli Institute for Systems Neuroscience and the Centre for the Biology of Memory (www.ntnu.no/cbm) at Norwegian University of Science and Technology, located in Trondheim, Norway.

A major goal of research in the Tashiro group is to understand the cognitive functions of the dentate gyrus and its adult neurogenesis. Candidates are expected to have strong background in Neuroscience, particularly in Molecular/Cellular neuroscience or electrophysiology, and be capable of independently performing research activities. A successful candidate will be involved in either of the following two broadly-defined projects:
1) Experience-dependent functional integration of new neurons (Ref. Tashiro et al. Nature 442:929-33, 2006.; Tashiro et al., J Neurosci, 27:3252-9, 2007).
2) Recording neural activity in the dentate gyrus during memory-related behavior (Ref. Leutgeb et al. Science, 315:961-6, 2007)

To apply, please send C.V. and a description of your research interest by email to ayumu.tashiro@ntnu.no

投稿者:田代歩(ayumu.tashiro@ntnu.no)

2009.10.13

University of Texas Health Science Center at Houston ポスドク募集

Full-time postdoctoral positions are immediately available in the Department of Biochemistry and Molecular Biology at the University of Texas Health Science Center at Houston. Our research currently focuses on the regulation and function of biological clocks. Biological clocks orchestrate a wide variety of essential cellular and physiological processes to ensure the well-being of the host organisms. Of particular interest in the lab is a group of highly-validated, drug-like small chemicals that were identified in a high throughput screen (HTS) to potently reset the mammalian circadian clock (unpublished). We will integrate biochemical, genetic and genomic approaches to interrogate the cellular targets and modes of action for select compounds. Success in the studies of these compounds may reveal novel regulatory functions of the clock, provide drug leads for clock-associated diseases, and establish the technological know-how for future chemical genetic studies. For more information, please go to: http://www.uth.tmc.edu/bmb/faculty/zheng-chen.html .

Highly motivated candidates with a Ph.D. or an equivalent degree are encouraged to apply. The candidate should have a demonstrated publication record and strong background in one or more of the following areas: molecular biology and biochemistry, drosophila genetics, and chemical biology. The successful applicant will be working in an active research department within the renowned Texas Medical Center (TMC) and gaining exposure to cutting-edge technologies. The city of Houston also offers comfortable lifestyle and ample career opportunities. To apply, please email a cover letter, CV, and names and contact information for three referees to Dr. Jake Chen at zheng.chen.1@uth.tmc.edu .

テキサス大学ヒューストンにおいてDr. Jakeがポスドクを募集しています。最近、Scienceに論文がアクセプトされたのを機に、私の隣の研究室に引越して来まして、ラボを立ち上げるに際してポスドクを募集したいとのことで、代理で投稿させていただいています。Dr. Jakeは人当たりが良く、日本人とも働いた経験があります。興味のある方はDr. Jakeまで直接カバーレターとCVをお送り下さい。

投稿者:みき

2009.10.06

Massachusetts General Hospital, Gastrointestinal Unit ポスドク募集

Massachusetts General Hospital, Gastrointestinal Unit

We are currently searching for a research fellow who is interested in studying the area of cellular and molecular mechanisms during the development of inflammatory bowel disease. The successful candidate will be involved in studies on physiological functions of key molecules in colonic epithelial cells/microbial interactions. Candidates are required to have an MD, PhD, MD/PhD, or equivalent degree with research training in the field of immunology and/or cellular/molecular biology. Actual starting date will be March or April 2010. Interested candidates are encouraged to send their CV to the address below:

Terry D. Lott
Administrative Assistant, GI Unit
Massachusetts General Hospital
55 Fruit Street, Boston, MA 02114

投稿者:Terry Lott

2009.10.05

University of Wisconsin - Madison ポスドク募集

直接会ったことはないのですが、何度かやり取りしたことがある先生からポスドク募集のメールが送られてきましたので関心があればapplyしてみて下さい。
Wisconsin大学のVemuganti先生で、テーマはtraumatic brain injuryです。
NIHのグラントを獲得されたようで、なるべく早く仕事を始めたいようです。

ワープロで送られてきましたものを貼っておりまして、読みづらく申し訳ありません。

【Detailed Job Description】
Job Title: Postdoctoral Fellow in Neuronal death and protection
Department: Neurological Surgery
Institution or Company: University of Wisconsin - Madison
Application Deadline: Till filled
Position Start Date: October 2009
Job Categories: Post-doctoral Research Associate
Academic Field(s): Neuroscience, TBI, Stroke, Molecular mechanisms
Job Description: A postdoctoral position is available to study the role of transcription factors and microRNAs in modulating inflammation and brain damage following TBI. Experience with TBI/Stroke rodent models, immunohistochemistry, behavioral testing, Western blotting, real-time PCR, cloning and neural cell culture are desirable. Writing and communication skills are expected.
Salary: NIH Post-doc Salary Scale
Requirements: A Ph.D. in Neuroscience or related field is required.
EEO/AA Policy: The University of Wisconsin-Madison is an equal opportunity employer, and specifically encourages applications from women and minorities.

Contact Information
Contact person: Raghu Vemuganti, Ph.D.
Address: University of Wisconsin-Madison
Dept of Neurological Surgery
600 Highland Ave
City, State & Zip Code Madison, WI 53792
Country USA
Phone: (608) 263-4055
Email: vemugant@neurosurg.wisc.edu
Lab home page: http://www.neurosurg.wisc.edu/labs/vemuganti

投稿者:にも

2009.10.04

Cornell University Postdoc募集

Two post-doctoral associate positions are immediately available for an NIH Pioneer Award-funded project to study hybrid organic-inorganic devices designed to produce energy by means of scaffolded metabolic pathways. Based on a biomimetic strategy, studies will incorporate cell and molecular biology, biochemistry, nanofabrication, and bioengineering to produce energy-generating platforms for implantable medical devices. Effective written and verbal communication skills are essential for participating in our multi-disciplinary team.

Qualifications: Ph.D. in a related field. Experience with molecular biology, recombinant protein generation, enzyme biochemistry, surface attachment chemistry, and/or protein patterning are desired. Salary will be commensurate with experience. Strong work ethic, creativity, and enthusiasm required.

Please provide curriculum vitae, letter of application, and contact information for 3 references to Dr. Alexander Travis (ajt32@cornell.edu).

Cornell University is an Affirmative Action, Equal Opportunity Employer and Educator.

Posted by Alex Travis (ajt32@cornell.edu)

2009.10.03

The Scripps Research Institute ポスドク募集

スクリプス研究所(The Scripps Research Institute)、代謝加齢研究部門(Department of Metabolism and Aging)の貴志研究室(Kishi Lab)ではポスドク研究員、技官、学生の募集をしています。

我々の研究室ではゼブラフィシュを用いて発生過程と老化の関連制御機構に関する研究を進めています。もともとカリフォルニアのラホヤにあるスクリプス研究所はフロリダに新しい研究施設をスクリプスフロリダとして今年完成し、我々の研究部門はパームビーチのリゾート地ジュピター(Jupiter)にあります。 私の研究室は今夏にボストンのハーバードからこちらへ移動しました。ドイツのマックスプランク研究所も米国初の研究施設を隣接して建設中で、スクリプスとマックスプランクの共同による米国の新しい研究拠点と成りつつあります。ゼブラフィシュを用いた研究に経験もしくは強い関心があり、新しい環境での研究展開に挑戦する意欲のある方は気軽にご連絡下さい。

連絡先
貴志周司
Shuji Kishi
Department of Metabolism and Aging,
The Scripps Research Institute,
Scripps Florida,
130 Scripps Way #3B3, Jupiter, FL 33458
Tel: 561-228-2959
Fax: 561-228-3059
E-mail: kishi@scripps.edu

投稿者:貴志周司(kishi@scripps.edu)

2009.10.02

Cedars-Sinai Medical Center, Los Angels ポスドク募集

米国ロサンジェルスのCedars-Sinai Medical Centerでポスドクを募集しています。私どもの研究室では、制御性T細胞の分化を研究する目的で、転写因子Foxp3の発現調節機構、TNFR SuperfamilyのOX40ならびにGITRシグナルの研究をイギリスのオックスフォード大学、ならびに米国のペンシルバニア大学にて行ってきました。今回、ペンシルバニア大学から、 Cedars-Sinai Medical Centerへの移動に伴い、さらに 研究領域を癌の免疫治療法の開発にまで拡張いたします。それに伴い、やる気のあるポスドクを募集しています。当研究室は、分子免疫の研究室ですので、分子生物、免疫、マウスの実験の経験者は歓迎されますが、これらの技術をこちらで学んで一流の研究をしたいという意気込みのある方は、これらの経験が無くとも歓迎いたします。
参考文献: Y. Tone et al. Nature Immunol. (2008) 9, 194, Y Tone et al., J. Immunol. (2007) 179, 1760, M. Tone et al., (2003) PNAS 100, 15059
興味のある方は、履歴書(英文)を添付ファイルとしてtoney@cshs.org までe-mailでお送りください。

投稿者:刀禰 有紀子(toney@cshs.org)

2009.10.01

アラバマ大学バーミンハム校・医学部・神経学科 ポスドク募集

アラバマ大学バーミンハム校・医学部・神経学科 アメリカ合衆国

当研究室では、一緒に研究してくれる意欲あふれるポスドクを1名募集します。
[ 募集人数 ] 1名
[ 応募資格 ] 医学、薬学、理学、工学、あるいは農学系博士号保持の方、または取得見込みの方
[ 待遇 ] NIHの規格による(社会保険完備)
[ 応募書類 ] 1) 履歴書と研究業績目録
       2) 推薦者3名(指導教官を含む)の連絡先(TEL, Email address)
[ 就任時期 ] できるだけ早い時期

以上の書類をemailにてYuqing Li (yli@uab.edu) まで送付してください。
候補者が決定次第締め切りとさせていただきます。
日本語でのお問い合わせは横井史章(yokoi@uab.edu)までお気軽にどうぞ。

当大学は、アメリカ中南部アラバマ州バーミンハムにあり、全米Top25に入る優秀な医学部です。バーミングハム市周辺は物価も安く、家族がおられる方にも安心してお勧めできます。
大学ランキング:
http://en.wikipedia.org/wiki/University_of_Alabama_School_of_Medicine#Rankings
アラバマ州バーミンハム市:
http://www.hia.jp/jp_sc_birmingham.html

Postdoctoral Positions in Molecular and Translational Neuroscience

A postdoctoral position in molecular and translational neuroscience is available immediately to study pathophysiology of dystonia or restless legs syndrome using gene targeted mouse models. The candidates will join a dynamic lab focusing on the function and dysfunction of basal ganglia and mouse models of movement disorders. Depending on the funding, the candidates are also expect to develop siRNA-based therapeutic treatment for DYT1 dystonia using genetically modified mouse models (Dang et al., Experimental Neurology, 196:452-463, 2005; Dang et al., Neuroscience Research, 56:470-4, 2006; Dang et al., PNAS USA, 103:15254-9, 2006; Hewett et al., PNAS USA, 104:7271-7276, 2007; Yokoi et al., J. Biochem. 143:39-47, 2008). Dystonia is defined clinically as involuntary, often sustained co-contraction of agonist and antagonist muscles causing abnormal and often painful postures or movements. It is generally believed to be mediated by the central nervous system and represents the th!
ird most common movement disorder after Parkinson's disease and tremor (Breakefield et al., Nature Review Neuroscience, 9, 222-234, 2008). Highly motivated candidates with solid publication record in international journals in the area of neuroscience, molecular biology, biochemistry, or cell biology are encouraged to apply. Experience in molecular or cell biology is desirable and knowledge in neuroscience or neurology is a plus.

To apply, please email a CV, and names and contact addresses of references to:

Dr. Yuqing Li,
Department of Neurology, School of Medicine,
University of Alabama at Birmingham,
Birmingham, AL 35294-0021.
Email: yli@uab.edu,
Tel. +1-205-996-6299, Fax. +1-205-996-7200.

The Department of Neurology and the University of Alabama at Birmingham have established a Center for Neurodegeneration and Experimental Therapeutics, a state-of-art facility to accelerate discovery and to bring treatment to patients. Furthermore, a new Comprehensive Neuroscience Center was established last year and funded by NIH Blueprint Neuroscience Core Grant. It provides advanced research core services and extensive inter-disciplinary interactions. Further information about Dr. Li, the UAB Department of Neurology, the Center for Neurodegeneration and Experimental Therapeutics, the Comprehensive Neuroscience Center, postdoctoral training environment at UAB, and Birmingham area information may be found at the following Web sites:

http://main.uab.edu/neurology/Templates/Inner.aspx?pid=99179
http://138.26.61.118/depts/MEB/SOMResearchFaculty/currentfacultydata.asp?ID=yli
http://medicine.uab.edu/neurology/DivsPgmsCtrs/CNET/
http://medicine.uab.edu/neurology/DivsPgmsCtrs/CNET/labs/Li/
http://www.cnc.uab.edu
http://www.postdocs.uab.edu/

University of Alabama at Birmingham is an Affirmative Action/Equal Opportunity Employer

投稿者:Yuqing Li(yli@uab.edu)

2009.09.25

Beth Israel Deaconess Medical Center, Harvard Medical School research assistant募集

The research assistant's job is an entry level position, working on the pathogenesis of Helicobacter pylori at the Beth Israel Medical Center in Boston. The work would involve cell culture, microbiology, protein analysis, molecular biology and possibly animal work. It would be preferable that the applicant have some previous experience working in a lab, be organised and detail oriented, and have a positive attitude. I am ready to hire someone immediately, and have funding until the end of July 2011. Anyone interested should contact Dr. Sarah Keates at email skeates@bidmc.harvard.edu.

Posted by Sarah Keates (skeates@bidmc.harvard.edu)

2009.09.22

University of California Los Angeles Postdoc募集

POSTDOCTORAL FELLOWS TO STUDY EPITHELIAL NORMAL STEM CELLS, EPITHELIAL CANCER STEM CELLS AND STROMAL AND EPITHELIAL INTERACTIONS IN GYNECOLOGIC ORGANS

Funded positions are available immediately in the laboratory of Sanaz Memarzadeh M.D., Ph.D., UCLA School of Medicine, and Assistant Professor in Gynecologic Oncology. This laboratory is located in Department of Obstetrics and Gynecology, Center for Health Sciences, at the David Geffen School of Medicine at UCLA.

The research programs in this laboratory focus on:

1. Identification of normal epithelial stem cells in gynecologic organs (ovarian surface epithelium and glandular endometrium)
2. Identification of cancer initiating/cancer stem cells in epithelial ovarian and endometrial cancer.
3. Role of epithelial and stromal interactions in cancer initiation and progression in gynecologic cancers (epithelial ovarian and endometrial cancer)

Highly motivated, hard working recent Ph.D. /M.D. graduates are welcome to apply for this Post-doctoral fellowship positions. Candidates with strong background and past achievements in molecular biology, microscopy/immuno-histochemistry, cellular biology, FACS analysis, experience working with epithelial cells (primary and cell lines), ability to perform small surgical procedures are particularly encouraged and desired for this position. Outstanding oral and written communication skills are needed in order to communicate with PI and other science and clinical collaborators.

This laboratory is located within the UCLA Medical Center, a block away from Westwood Village. Westwood is a beautiful area with multiple attractions including a variety of dining options, theaters, coffee shops and diverse shopping options. The weather is fantastic, generally in the 70’s and 80’s. Reasonable housing is also available in the Westwood area.

If you are interested in this position please send your personal statement and CV to smemarzadeh@mednet.ucla.edu, PI for this laboratory.

Posted by Sanaz Memarzadeh (smemarzadeh@mednet.ucla.edu)

2009.09.18

Université Libre de Bruxelles Postdoc募集

POSITION IN BASIC DIABETES RESEARCH

We utilize cell biological, genomic, and systems biology approaches to identify and characterize the mechanisms leading to immune-mediated death of pancreatic beta cells in type 1 diabetes mellitus. We have unveiled a large part of beta cell responses (at mRNA and protein levels) to pro-inflammatory cytokines and have identified key transcription factors involved in beta cell apoptosis (Eizirik DL et al. Nat Rev Endocrinol. 2009). We are now delineating the molecular pathways involved in beta cell dysfunction and death, focusing on endoplasmic reticulum stress and mitochondria death pathways (Cardozo et al. Diabetes 2005, Eizirik DL et al Endocr Rev 2008, Gurzov E et al. Cell Death Diff 2009).

We are seeking a talented, innovative and enthusiastic researcher with a PhD awarded within the last 3 years. Broad knowledge and adequate laboratory experience in cellular, molecular biology and animal studies, good command of spoken and written English and excellent communication and team skills are required. Knowledge on methods of intracellular Ca2+ measurements is a plus.

Our laboratory (Laboratory of Experimental Medicine) is located at the Faculty of Medicine at the Université Libre de Bruxelles – Brussels – Belgium. It has a highly dynamic research environment with teams dealing with the pathogenesis of type 1 and type 2 diabetes. We are one of the few laboratories in the world able to FACS purify and keep in culture rat beta cells which allow us to perform detailed mechanistic studies on pure beta cell preparations.

Applications, including CV, list of publications, names of two references and statement of future interests should be sent to akupperc@ulb.ac.be.
Funding is available for an initial period of 18 months, starting middle 2010.

Posted by Alessandra Kupper Cardozo (akupperc@ulb.ac.be)

2009.09.17

Washington State University Postdoc募集

Plant Hormone Signaling Postdoctoral Position
Steber Laboratory
Washington State University
Pullman Washington USA

Research Environment: The Steber Laboratory conducts research on the hormonal control of seed germination in Arabidopsis and in wheat, and has an opening for the position of postdoctoral research associate. The Steber Laboratory is housed in the recently constructed Orville A. Vogel Plant Biosciences Building. Besides the usual equipment required for molecular biology, the laboratory has extensive and well-maintained greenhouse and growth chamber facilities. There are more than 70 independent laboratories at Washington State University investigating various aspects of plant science. In plant science, Washington State University consistently ranks in the top three universities in the United States.

Position Description. As part of an NSF-funded project, the successful candidate will conduct research on the control of seed dormancy and germination by gibberellin (GA) signaling in Arabidopsis. Research will examine the pattern of GID1 and DELLA protein expression and interactions in dormant and after-ripened seeds, as well as examine the global pattern of gene expression in sly1 mutant seeds. For background see:

Proteolysis-independent down-regulation of DELLA repression by the gibberellin receptor GID1. Ariizumi, T., Murase, K., Sun, T.P., Steber, C.M. (2008) Plant Cell 20: 2447-59.

Seed germination of GA-insensitive sleepy1 mutants does not require RGL2 protein disappearance in Arabidopsis. Ariizumi, T., Steber, C.M. (2007) Plant Cell 19: 791-804.

Molecular aspects of seed dormancy. Finkelstein, R., Reeves, W., Ariizumi, T., Steber, C.M. (2008) Annual Reviews Plant Biology 59: 387-415.

Qualifications. A PhD degree in Molecular Genetics, Biochemistry, or a related field is required. The candidate must have experience in molecular biology research. Experience in studying protein-protein interactions, protein expression, or microarray analysis are desired. The successful candidate will be able to conduct research independently, guide graduate students, keep accurate and detailed lab notebooks, and communicate research results in both oral and written formats.

To Apply. The position will remain open until filled. Position is full-time for two years. To apply for the position, send a cover letter, curriculum vitae detailing previous research experience, and telephone numbers and e-mail addresses of three (3) references by email to csteber@wsu.edu or by mail to:

Dr. Camille M. Steber
USDA-ARS, Washington State University
209 Johnson Hall
Pullman WA 99164-6420
USA
Tel: 509-335-2887

WASHINGTON STATE UNIVERSITY IS AN EQUAL OPPORTUNITY/AFFIRMATIVE ACTION EDUCATOR AND EMPLOYER.

Posted by Camille M. Steber (csteber@wsu.edu)

2009.09.12

オンタリオ癌研究所 ポスドク募集

募集内容:ポスドク研究員を1-2名募集します。
研究内容:主としてDNA損傷応答、ヒストンのメチル化および脱メチル化による転写制御の研究を通じて、癌化や形態形成の諸問題に取り組みます。
応募資格:博士過程を終了、あるいは終了見込みで、分子生物学,生化学的手法を十分に習得されている方。必要に応じてマウスの系を用いますので、ノックアウトマウス作成等、マウスの実験経験がある方が望ましいと思いますが、必須ではありません。自由な雰囲気の中で、独立して研究テーマを推進できる、意欲あふれる方を期待しています。2010年4月頃を予定していますが、採用時期は相談に応じます。
待遇:研究所の規定に従います。2-3年程度。
応募書類:1. 履歴書と発表業績リスト(英語), 2. 推薦者2-3名の連絡先, 3. これまでの研究内容、取得した実験手技と、志望動機(日本語可)をE-mailでお送りください。
参考文献:J Cell Biol. 182(3):449-58 (2008); Genes Dev 21: 848-61 (2007); J. Cell Biol.170 (4):559-570(2005); Nat. Ca. Rev. 4(8):592-603. (2004).
研究所ホームページ:http://www.uhnresearch.ca/researchers/
参考:トロントはカナダの東部に位置しオンタリオ湖に面した自然豊かな環境で、Sick Kids Childrens Hospital、Toronto General Hospital、University of Toronto、Mount Sinai Hospital等の研究施設が集まっており、研究交流も盛んです。

連絡先:Hitoshi Okada

The Campbell Family Cancer Research Institute,
Division of Signaling Biology, Ontario Cancer Institute

Department of Medical Biophysics, University of Toronto

E-mail: hokada@uhnres.utoronto.ca (日本語可)

投稿者:岡田 斉(hokada@uhnres.utoronto.ca)

2009.09.11

University of Texas Southwestern ポスドク募集

元同僚の友人が日本人ポスドクを探しています。彼は、エリック・オルソンとロン・エバンスという2人の一流サイエンティストのところでトレーニングを受け、テキサス大に移りました。人柄もよく、研究者としても優秀な人物です。興味のある方は、直接Chun-Liまで問い合わせてください。

----------
Genetic and Epigenetic Regulation of Adult Neural Stem Cells and Their Role in Regeneration, Aging, and Cancer

A postdoctoral position is available in the laboratory of Dr. Chun-Li Zhang at UT Southwestern. The major interest of this laboratory is to elucidate the molecular and cellular mechanism regulating brain function with a focus on adult neural stem cells and epigenetics. Combinations of techniques in molecular and cell biology, biochemistry, mouse genetics and behavior will be employed. Detailed research interests and related publications can be found at:

http://www.utsouthwestern.edu/findfac/research/0,2357,29691,00.html

Self-motivated individuals with a Ph.D. and/or a M.D. degree are encouraged to apply. Candidates with demonstrated records in molecular or developmental biology, biochemistry or neuroscience are preferred. The candidate is expected to work in a collaborative environment. Salary will be competitive and commensurate with experience.

Please send curriculum vitae, description of research background and interests and contact information of three references to:

Chun-Li Zhang, Ph.D.
Department of Molecular Biology
UT Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, TX 75390-9148.
Email: Chun-Li.Zhang@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

投稿者:杉井 重紀

2009.09.10

Brigham and Women's Hospital, Harvard Medical Schoolポスドク募集

Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School ポスドク募集

私どもと一緒に研究を進めていくポスドクを募集しております。動物実験、細胞培養、ウェスタンブロッティング、免疫染色、FACS、RT-PCR等の技術を使用しています。分子生物学、動物実験の経験がある方を優遇しますが、研究に意欲的な方で、新しい技術を意欲的に習得される方なら、経験は問いません。日本から、給料あるいはフェローシップを得られる方を希望しております。採用された方は、複数のPI (Principle Investigator) と一緒に働くことになり、複数のプロジェクトを進めることになります。興味のある方は英文で書かれた履歴書を添付ファイルとして電子メールで送信して下さい。

連絡先:
高倉あゆみ
Ayumi Takakura, PhD, FASN
Instructor in Medicine
Harvard Medical School
Renal Division, Department of Medicine
Brigham and Women's Hospital
Harvard Institutes of Medicine, Room 520
4 Blackfan Circle
Boston, MA 02115
Work phone: 616-525-5867
E-mail: atakakura@rics.bwh.harvard.edu

投稿者:高倉あゆみ(atakakura@rics.bwh.harvard.edu)

2009.09.09

Boston College Postdoc募集

Postdoctoral Fellow: Epigenetics/Genomics
Employer: Boston College
Location: Boston Massachusetts, USA

Job description: A postdoctoral position is available starting in October 2009 at Boston College in the laboratory of Dr. Hugh P. Cam of the Biology Department. The lab employs a broad range of approaches, from genetics and biochemistry to genomics and bioinformatics to uncover novel epigenetic pathways in the fission yeast S. pombe and mammals that might have relevance to cancer and nuclear reprogramming. Boston College is a small thriving private university located a few miles west of downtown Boston and just across the Charles river from MIT and Harvard University. We are looking for highly motivated individuals with a recent Ph.D. or M.D. degree. Interested candidates are welcome to email or mail CV that includes contact information of three reference sources to the address below.

Selected publications:
Cam et al., Cell 136: 610–614 (2009).
Cam et al., Nature 451: 431–436 (2008).
Cam et al., Nature Genetics 37: 809–819 (2005).
Cam et al., Molecular Cell 16: 399–411 (2004).

Hugh P. Cam Ph.D.
Assistant Professor of Biology
Higgins Hall Room 501A
140 Commonwealth Ave
Chestnut Hill, MA 02467
camh@bc.edu

Posted by Hugh P. Cam (camh@bc.edu)

2009.09.07

Brown University Postdoc募集

I have just been awarded an administrative supplement to my R01 grant that will fund a research associate/post-doc/tech for 2 years, effective immediately. The work will examine how H. pylori modulates expression of the tumor suppressor protein p27 in gastric epithelial cells, helping our effort to improved understanding of H. pylori-related gastric carcinogenesis. Experience in cell culture, transfection and other basic molecular biology methods is essential. An interest in cancer biology is helpful.

Steven Moss, MD
Prof Medicine, Brown University

Rhode Island Hospital
593 Eddy St, APC 414
Providence, RI 02903
E-mail: steven_moss@brown.edu

Posted by Steven Moss (steven_moss@brown.edu)

2009.09.06

Yale University School of Medicine ポスドク募集

Postdoctoral Associate-Cardiovascular/Vascular Biology

Employer: Yale University School of Medicine
Location: New Haven, CT, USA

Job description:
Postdoctoral position is available in the Yale Cardiovascular Research Center in the Yale University School of Medicine. The project is in the area of vascular biology, in studying signaling mechanisms that regulate endothelial cells and vascular smooth muscle cells. Our lab is involved in the study of disease processes involving both the systemic and the pulmonary vasculature.
Candidates must hold a recent MD or PhD. A strong background in cardiovascular/vascular biology is preferred. Preference will be given for prior experience with genetically engineered mice, cDNA subcloning, isolation and culture of primary endothelial cells and vascular smooth muscle cells, confocal microscopy, invasive and noninvasive assessments of mouse cardiovascular function. Competitive salary and excellent work environment are offered. Please send CV and names of three references to:

Hyung Chun, M.D.
Yale University School of Medicine
Section of Cardiovascular Medicine
300 George St., Room 759F
New Haven, CT 06511
or email to: hyung.chun@yale.edu

投稿者:村上 昌弘(Masahiro.Murakami@Yale.edu)

2009.09.05

Fox Chase Cancer Center in Philadelphia Postdoc募集

One postdoctoral position is available in the laboratory of Dr. K. Hayakawa at Fox Chase Cancer Center in Philadelphia. The laboratory specializes in natural autoreactive B cell development, growth regulation, and transformation (leukemia). Applicants must have Ph.D./M.D. with substantial research experience, preferably in immunology and molecular biology. The role of self-antigen in generation of chronic B cell leukemia, potential cancer stem cells, and mechanism(s) of growth dysregulation will be explored. Candidate must be hard-working and highly motivated. Send curriculum vitae, summary of research experience, and names of at least three references to: K_Hayakawa@fccc.edu

Posted by Kyoko Hayakawa, MD. PhD. (K_hayakawa@fccc.edu)

2009.09.04

Unviersity of Maryland School of Medicine Postdoc募集

Two NIH-funded postdoctoral positions are available immediately to study signaling pathways that regulate the translational machinery. Current lab focus is on the abnormal regulation of protein synthesis in lymphoma cells and how this can be exploited for cancer therapy. Interested candidates must possess a recent Ph.D. with relevant experience in molecular biology. Priority will be given to candidates with experience/interest in RNA technology. The laboratory is located in the Bressler Research Building with state-of-the-art facilities including core facilities for confocal microscopy, mass spectrometry, flow cytometry, bioinformatics, animal husbandry, etc. The University of Maryland Marlene and Stewart Greenebaum Cancer Center is an NCI-Designated Cancer Center. Interested candidates should email curriculum vitae, statement of research interests and contact information for three references to: Ronald B. Gartenhaus, M.D., Associate Professor of Medicine, The University of Maryland School of Medicine, Email: rgartenhaus@som.umaryland.edu

Posted by Koji Tamada (ktamada@som.umaryland.edu)

2009.08.31

Signal Transduction Laboratory, Massachusetts General Hospital, Harvard Medical School ポスドク、テクニシャン募集

私たちの研究室では、一緒に研究を進めて行くポスドク、テクニシャンを募集しています。具体的な実験の内容は、動物実験、細胞培養、ウェスタンブロッティング、組織培養などです。経験のある方、新しい技術の習得に意欲的な方を期待しています。研究の内容は以下の通りです。気軽に連絡して下さい。

[研究内容] 私たちの研究室では、Nitric Oxide (NO)の多様な作用の中で、とくに、誘導型 NO合成酵素(iNOS)の作用や、糖尿病の成因におけるNOの働きにおいて、S-nitrosylation(S−ニトロシル化、 NOがシステイン残基のSH基に共有結合する反応)が重要な役割を果していることを見い出しました。そこで、現在、 S−ニトロシル化したグルタチオン(GSNO)からNOを取り除く還元酵素であるS-nitrosoglutathione reductase (GSNOR)を主たる分子標的として、様々なヒトの病気の分子機序を理解し、新たな治療法を開発しようと研究を進めています。また、酵母の長寿遺伝子Sir2の哺乳類ホモログSirt1の制御メカニズム、スタチンによるファルネシル化の抑制の意義なども細胞内情報伝達の観点から研究を進めています。糖尿病、敗血症、熱傷など、急性ならびに慢性炎症による多様なヒトの病気を、NOを介したストレスシグナルの観点からできるだけ一元的に理解しようと、 GSNORの欠損マウス、トランスジェニックマウス、細胞培養系等を用いて、分子生物学的、生化学的、プロテオミックアプローチからの解析を行っています。現在の主な研究分野は(1) 糖尿病(1型および2型)の成因、 (2) インスリン分泌におけるNOとS−ニトロシル化の生理的役割、(4) ラ氏島移植、(3) 敗血症におけるスタチンの効果 、(5)ストレス(熱傷)によるイン スリン抵抗性-等です。

金木正夫

連絡先:
Masao Kaneki M.D., Ph.D.
Associate Professor
Harvard Medical School
Director, Signal Transduction Laboratory
Department of Anesthesia and Critical Care
Massachusetts General Hospital
149 Thirteenth Street, Rm. 6604
Charlestown, MA 02129, USA
Tel: 617-726-8122 & 4179
Fax: 617-726-8134
E-mail: mkaneki@helix.mgh.harvard.edu
http://www.diabetes.org/diabetes-research/researcherinfo.jsp?researcher=939
http://www.massgeneral.org/anesthesia/index.aspx?page=faculty&subpage=kaneki
http://www.dfhcc.harvard.edu/membership/member-profile/member/9729/0/

投稿者:金木正夫(mkaneki@helix.mgh.harvard.edu)

2009.08.29

University of California, Davis Postdoc募集

Laboratory of Prof. Alexander Revzin in the Department of Biomedical Engineering at the University of California, Davis is looking to recruit a Postdoctoral Fellow to work on a large project funded by the National Science Foundation (USA) to develop electrochemical biosensors for single cell analysis. This position will offer an opportunity to conduct research on an interdisciplinary project aimed at interfacing single living cells with immuno- or enzyme-based biosensors for real-time detection of cell function. A postdoctoral fellow will interact with other team members including immunologists and biomedical engineers, and will have an excellent opportunity to apply biosensors to the interrogation of living cells. A strong candidate will have expertise in multiple aspects of bioanalytical chemistry including surface modification, surface analysis, biosensors and aspects of electrochemical techniqeus (e.g. amperometry, impedance spectroscopy). Familiarity with microfabri!
cation techniques such as photolithography, soft lithography and microfluidics is a plus but not essential.

To apply for this research opportunity, please send your CV to Prof. Alexander Revzin via e-mail: arevzin@ucdavis.edu

Posted by Alexander Revzin (arevzin@ucdavis.edu)

2009.08.23

Childrens Hospital Los Angeles Postdoc募集

Postdoctoral Position for in Vivo studies of Lung Inflammation

We are looking for a postdoctoral fellow with a doctorate degree in Cellular/Molecular Biology, Immunology or Pathology to join a project on inflammation in the lung. Experience in working with mice is essential and with primary cells such as alveolar macrophages in tissue culture an advantage. Studies focus on mechanisms of inflammation that are mediated through the innate immune system using in vitro and in vivo techniques.

Inflammation of the lung is common and can lead to life-threatening complications. Our project focuses on cellular mechanisms in neutrophils, macrophages and endothelial cells that are responsible for the negative regulation of pro-inflammatory functions of these cells. Through gene targeting, we have generated mice that lack functional bcr and abr genes, which are negative regulators of the small GTPase Rac. These mice have a hyper-responsive innate immune system. We hope that ultimately this research will lead to the development of novel therapies to treat acute lung inflammation, chronic lung disease and sepsis.

Salary range for this position is from $40,000 depending upon experience, including fringe benefits. To apply, please send a resume including cover letter and two letters of reference to jgroffen@chla.usc.edu. We will only contact the most competitive candidates who provide all the necessary information.

For more information about CHLA go to the employer website. Also visit http://www.usc.edu/programs/pibbs/site/faculty/groffen_j.htm and http://www.usc.edu/programs/pibbs/site/faculty/heisterkamp_n.htm


Key words: Postdoctoral, knockout mice, innate immunity, lung, inflammation, macrophages, rac GTPases

Employer: Childrens Hospital Los Angeles (CHLA)

Company URL: http://www.childrenshospitalla.org

Location: 4650 Sunset Boulevard, Los Angeles CA 90027, USA

Posted by Nora Heisterkamp (jgroffen@chla.usc.edu)

2009.08.22

Texas Tech University Health Sciences Center, Lubbock ポスドク急募

NIH-funded postdoctoral position is available immediately in a membrane protein transport and structural biology laboratory in the Department of Cell Physiology and Molecular Biophysics at Texas Tech University Health Sciences Center, Lubbock.

The laboratory is well equipped with the state-of–the-art equipment for robotic high throughput membrane protein crystallization. Our current focus is on structure and mechanism of bacterial and human sugar transporters. Highly motivated candidates with a strong background in protein biochemistry or biophysics are encouraged to apply. Experiences in molecular biology and/or protein X-ray crystallography are desirable. Competitive applicants should have demonstrated scientific productivity and innovation.

More information is available at http://www.ttuhsc.edu/SOM/physiology/faculty/Guan/guan.aspx or http://www.webpages.ttu.edu/myousef/Guan.htm.
Salary is competitive based on experience. Please submit your CV through TTUHSC’s website (http://jobs.texastech.edu), requisition #79710, and the contact information for three references to Dr. Lan Guan (lan.guan@ttuhsc.edu).

投稿者:Lan Guan (代理:永森收志)

2009.08.20

Columbia University Postdoc募集

A NIH supported postdoctoral fellow position is available at the Department of Biological Sciences, Columbia University to study the mechanism of epigenetic regulation. Our lab is focused on studying chromatin organization by histone lysine methylation that includes histone methyltransferase, histone demethylases and methyl-lysine binding proteins. We employ diverse biochemical and genetic approaches to study higher order chromatin organization and the DNA damage response. Detailed information can be found at our website: http://www.columbia.edu/cu/biology/faculty-data/songtao-jia/faculty.html and our publications:
Molecular Cell (2009) 33: 428-437;
Nature Cell Biology (2005) 7:1007-1013;
Cell (2004) 119:469-480;
Science (2004) 304:1971-1976;
Science (2004) 303: 672-676.

Successful candidates will be eligible for Columbia University housing, which are priced significantly below market rate. Experience in molecular biology, biochemistry or yeast genetics is desired. Interested candidates please email CV, brief description of research experience and interest, names and contact information of 3 references to Dr. Songtao Jia by email to jia@biology.columbia.edu.
or by mail to:
Dr. Songtao Jia
Department of Biological Sciences, MC2458
Columbia Unviersity
New York, NY 10027

Posted by Songtao Jia (jia@biology.columbia.edu)

2009.08.19

University of Pittsburgh Postdoc募集

Postdoctoral positions at University of Pittsburgh School of Medicine are open immediately to study the role of cell death in adult stem cells, cancer biology and therapy (PNAS 104: 4054, 2007; Cell Stem Cell 2:576, 2008; Cancer Research 69: 4999; and Oncogene 28:2348, 2009). The laboratory is co-directed by Dr. Lin Zhang (http://myprofile.cos.com/zhangli) and Dr. Jian Yu (http://path.upmc.edu/personnel/Faculty/YuJ.htm). Highly motivated recent graduates with strong background in molecular biology are encouraged to apply. Experience working with mice is a plus but not required. Please direct inquires, CVs and contacts of three references via email to:

Dr. Lin Zhang
Hillman Cancer Center Research Pavilion, Office 2.42D
5117 Centre Ave.
Pittsburgh, PA 15213
Phone: (412) 623-1009
Email: zhanglx@upmc.edu

Posted by Lin Zhang (zhanglx@upmc.edu)

2009.08.18

州立ニュージャージー医科歯科大学 ポスドク募集

DNA損傷に対する応答機構(checkpoint)、テロメア制御の関係を研究するポスドクを募集します。

州立ニュージャージー医科歯科大学(New Jersey Medical School)のDepartment of Cell Biology and Molecular Medicine の研究室で, DNA損傷に対する応答機構(checkpoint)、テロメア制御の関係を研究するポスドクを募集します。主に酵母を使っていますが、過去の経験は問いません。生化学と分子生物学的実験に精通していることが重要です。

Department の研究活動は、非常に活発です。(http://njms.umdnj.edu/departments/cell_biology_and_molecular_medicine/index.cfm)。たとえば、NIHからの研究費の獲得額は、2005年度、医学部学科別 (Cell Biology/Anatomy)、全米で、16位にランクされています。(http://grants1.nih.gov/grants/award/trends/medschc.htm; ちなみにハーバード 3位、エール 14位、スタンフォード 22位) 

ニュージャージー州は、ニューヨーク州のとなり、大西洋に面しています。米国の誇る文化施設、アウトドアスポーツへのアクセス、また日本食材の入手は、非常に簡単です。New Jersey Medical Schoolは、公共交通機関を利用して、ニューヨークマンハッタンから、30分です。


2)参考文献 (最近のおもな発表論文)
Science (2001) 294:867-870; Genes & Dev (2003) 17: 1957-1962; Nature (2003) 424:1078-1083; MCB (2004) 24: 10016-10025; MBC (2005) 16:5227-5235; Current Biology (2006) 16:586-590; MBC (2007) 18:2026-2036; Molecular Cell (2009) 33:312-322.


3)応募書類
(a) 履歴書 (英文)、論文発表リスト(英文)、簡単な志望動機または研究計画
(b) 応募者について照会できる方(本人の能力を責任もって紹介できる人)の氏名と連絡先 、または、推薦状

4)応募、問い合わせ先
Katsunori Sugimoto
E-mail: sugimoka@umdnj.edu

投稿者:Katsunori Sugimoto(sugimoka@umdnj.edu)

2009.08.11

カリフォルニア大学デービス校 ポスドク募集

UC Davis, Department of DermatologyのIsseroff研究室で若干名のポスドク(MD and/or PhD) を募集しております。
Isseroff先生は私のPIの同僚で,患者さんからの信頼の厚い臨床医でありながら,損傷治癒に関する基礎研究も精力的に行っている研究者です。彼女の現在の研究内容の概要は以下に示しておりますが,遺伝子から蛋白質まで幅広く標的にしており包括的な治癒機転を解明することにより,新たな治療戦略の開発を目指しております。
NIH R01を含む研究費を継続して獲得することにより研究室の運営も安定しておりますので充実した研究生活を送る事が可能かと思います。Davisの他学部や,学外との共同研究も積極的に行われており,やる気次第で多くの事を吸収出来る環境にあると言えます。

同Department内には日本人のポスドク,教職員も在籍しておりますので,渡米後の生活のセットアップや,実験の相談などもお手伝いが出来るかと思います。(http://www.ucdavis.edu/index.html)
 
興味を持たれました方は以下の書類を添付しProf.Isserof宛に,問い合わせをお願い致します。またDavisやDepartmentについて日本語でお返事が出来る事もありますので,気軽にメールでの問い合わせをお待ちしております。

Postdoc Position - University of California, Davis
TB 192, One Shields Avenue
Davis, CA, 95616

Candidates are invited to apply for a Postdoctoral Research position for two to three years at the University of California, Davis, to work on molecular mechanisms and novel therapeutic approaches to combined radiation and burn wound injury. In vitro culture based, ex vivo and in vivo models of healing are used and tools used to probe these models include DNA microarays and microbead array assays for kinase reactants. The role of the adrenergic signaling system in modifying the healing response will be examined. The candidate would join a multidisciplinary group of investigators in a stimulating academic environment with strong potential for translational research. Collaborative laboratories in this project share an interest in wound repair, microarray analysis of gene expression, and stem cell contribution to tissue regeneration. The candidate should have proficiency in basic cell biological techniques, and familiarity with microscopic image analysis and immunohistochemistry. Background in keratinocyte biology, wound healing and/or adrenergic receptor signaling areas would be an asset. Strong verbal and written English skills required.

The position is funded by a five-year grant from the NIH. Salary is dependent on level of training, and is competitive. Generous University benefits package. Applicants should submit a curriculum vitae, including list of publications, a description of their present research activity and contact information for three referees, to:

Rivkah Isseroff, M.D.
University of California, Davis
TB 192, One Shields Avenue
Davis, CA, 95616
fax: 530-752-9766, phone: 530-752-9767
email:rrisseroff@ucdavis.edu

投稿者:小野 葉子(yknono@ucdavis.edu)

2009.07.30

University of California, Irvine ポスドク募集

米国カルフォルニア大学アーバイン校,薬理学, 星lab。 当研究室では、タンパク複合体による電位依存性カリウムチャンネル(KCNQ2/3 channel)の制御機構を電気生理、生化学、live cell imagingを組み合わせて解析しています。新たに心房ペースメーカーチャンネルのタンパク複合体解析も立ち上げているところです。

ホームページ) http://www.faculty.uci.edu/profile.cfm?faculty_id=5556

参考文献)1. Hoshi, N., et al. (2003). AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat. Neurosci. 6, 564-571.
2. Hoshi, N., Langeberg, L. K., and Scott, J. D. (2005). Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat. Cell Biol. 7, 1066-1073.

当研究室では、やる気のあるポスドクを若干名募集しています。脳スライスのパッチクランプに精通している方で、基本的な分子生物学, 細胞生物学的実験手法をマスター、もしくはマスターしたい方を探しています。
応募資格:MDまたは、医学、理学、農学系博士号保持者、取得見込みの方。
待遇:University of California, Irvineの規定による。
応募書類:
1)履歴書(CV)と研究業績目録。
2)これまでの研究概要要約とそれの当該分野での位置付けと将来展望 
3)本人について評価できる研究者・推薦者3名の氏名と連絡先(Tel. e-mail address)。
就任時期:2009年12月頃、応談。

アーバインはロサンザルス南部郊外にあり、 全米の安全な町ランキングで常に上位に選ばれている街です。一年を通じて温暖で晴天日の多いカルフォルニアらしいところで、日系企業も多く所在し、日本食材、書籍も容易に入手でき住みやすい町です。

興味をもたれた方、質問のある方は気兼ねなくe-mailで連絡ください。

Naoto Hoshi M.D., Ph.D.
Assistant Professor,
Department of Pharmacology,
University of California, Irvine
e-mail: naotohos@gmail.com (日本語可)

投稿者:星 直人(naotohos@gmail.com)

2009.07.29

University of Minnesota Postdoc募集

POSTDOCTORAL FELLOW - CANCER PREDISPOSITION AND DNA REPAIR PATHWAYS

The Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota is inviting applications for a postdoctoral position to investigate mechanisms of genomic instability and cancer susceptibility.

Our laboratory is part of the Masonic Comprehensive Cancer Center and focuses on elucidating functions of the Fanconi Anemia (FA) and Breast Cancer Associated (BRCA) Proteins in the context of cellular caretaker protein networks. We utilize biochemical assays in Xenopus cell-free egg extracts and human cell systems to identify novel FA/BRCA pathway players and to functionally and structurally characterize these evolutionarily young proteins. We seek enthusiastic candidates that have a solid background in molecular biology/ biochemistry and enjoy being part of a highly motivated research team. A specific interest and expertise in DNA repair and replication would be ideal.
Our research team works in an open lab structure that nurtures interactions with neighboring laboratories studying fundamental questions in cancer research and the DNA damage response.

The start date is negotiable but ideal start will be Fall 2009.

Please send a short statement of your research interests, a complete curriculum vitae, and the names and contact information of at least two references by e-mail to
asobeck@umn.edu with "Postdoc Position Sobeck Lab" as subject line.

Posted by Alexandra Sobeck (asobeck@umn.edu)

2009.07.28

Saint Louis University ポスドク募集

私が昨年まで留学してましたSaint Louis University, MO, USAのProf. Rayがポスドクを探しています。
Hepatitis C virus (HCV)のグラントがとれたとのことです。
HCVに関する研究をされてみたい方、話を聞いてみたい方は連絡をお待ちしております。

(PS)私は約3年こちらのLabにいました。その時の仕事は以下のWebを参照してください。
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=kanda+t+ray+r

投稿者:神田達郎(kandat-cib@umin.ac.jp)

2009.07.23

UMDNJ-New Jersey Medical School, New Jersey ポスドク募集

Postdoctoral Position
Department of Cell Biology and Molecular Medicine
UMDNJ-New Jersey Medical School, New Jersey

One position is open to study the link between DNA damage checkpoint response and telomere control using yeast and mammalian cells. Candidates must have excellent communication skills, ability to conduct research independently and as a team, and strong backgrounds in molecular biology and biochemistry.

References; Science (2001) 294:867-870; Genes & Dev (2003) 17: 1957-1962; Nature (2003) 424:1078-1083; MCB (2004) 24: 10016-10025; MBC (2005) 16:5227-5235; Current Biology (2006) 16:586-590; MBC (2007) 18:2026-2036; Molecular Cell (2009) 33:312-322.

Department web site (http://njms.umdnj.edu/departments/cell_biology_and_molecular_medicine/index.cfm).


Interested candidates should send a cover letter and curriculum vitae with contact information for three references (name, address, phone and e-mail) by email to: Dr. K. Sugimoto (sugimoka@umdnj.edu).

投稿者:K Sugimoto (sugimoka@umdnj.edu)

2009.07.22

The Duke University Center for Human Genetics postdoc募集

Post-doctoral Research Fellowship position

The Duke University Center for Human Genetics (CHG) is establishing a research project to investigate the effects of a recently identified sequence variant on cytokine T-cell signaling in multiple sclerosis patients. The project also aims to discover proteins associated with alternative splicing of the cytokine receptor and to identify genetic association of these proteins in a 2400 patients MS case/control population.

Individuals who satisfy the selection criteria should be recent PhD graduates, have a strong background in molecular biology, genomics and immunology. Additional requirements include an ability to think independently and work well within a group setting. Candidates will be expected to help establish and supervise the research project, interact with research groups and clinical departments within Duke University Medical Center (DUMC), and prepare manuscripts. The position is supported by 5 years of NIH funding and the salary will be commensurate with experience.

The CHG (http://wwwchg.duhs.duke.edu/) offers a highly collaborative and interdisciplinary environment located in a 40,000 square-foot facility on the DUMC / Duke University campus. To apply send a CV, bibliography & names of 3 references to;


Simon G. Gregory, Ph.D.
Assistant Professor
DUMC Box 3445
Phone: 919-684-0726
Fax: 919-684-0924
Email: simon.gregory@duke.edu

Posted by Simon G. Gregory (simon.gregory@duke.edu)

2009.07.21

Dana-Farber Cancer Institute ポスドクと研究技師(ボランティア)の募集

Dana-Farber Cancer Institute, Harvard Medical School

私の研究室のポスドクの方が実績を積まれて急に栄転されることになったのに伴いまして、欠員ができますので募集させていただきます。

ポスドクと研究技師(ボランティア)の募集

ボストンの Dana-Farber Cancer Institute にある私の病理学・腫瘍学・疫学の研究室でやる気のあるポスドクと研究技師(ボランティア)を募集しています。データが長年にわたってすでに蓄積されていますので、ポスドクの方にはやる気しだいで1年以内に論文を書いていただけますし、Contributionにより複数の論文の共著者になることも可能です。研究技師の方でも、Contributionにより複数の論文の共著者になることが可能です。

同じラボに日本人が5人働いていますので、英語の苦手な人でもコミュニケーションの問題がありません。英語にもすぐに慣れます。ポスドクのcandidateでしたら、病理学や腫瘍学あるいは消化器科学の研究(あるいは病理診断)の経験があると強みです。研究技師のcandidateでしたら、いろいろな学歴や職場経験がありえますが、それらをすべて考慮いたします。

主な仕事はパラフィン癌組織サンプルの管理とプロセシング、データーベースの管理、免疫組織染色、DNA解析、統計解析、プログラミングです。統計解析とプログラミングについては、経験のない方にはきちんと指導いたします。ラボの仕事をしながら、統計学とプログラミングを勉強できるのは私の研究室のユニークさです。

プロジェクトは大腸癌、線腫、膵臓癌、消化器内分泌腫瘍の分子病理疫学です。私のラボでは大規模な前向き疫学コホートを使って大腸癌と膵臓癌の様々な分子異常の疫学的病因を研究しています。ハーバード大学公衆衛生大学院とBrigham and Women’s Hospitalではこれまで当初は健康な12万人の女性を30年(Nurses' Health Study、http://www.channing.harvard.edu/nhs/)、5万人の男性を20年(Health Professionals Follow-up Study、http://www.hsph.harvard.edu/hpfs/)追跡して、病気の発生を疫学的に研究してきました。私のラボではこの2つの大規模コホートにおいて追跡中に発生した大腸癌と膵臓癌の癌細胞内の遺伝子の異常、Epigenetic changes (DNAメチル化)、酵素やその他のたんぱく質発現の変化を解析しています。追跡に先立ち、あるいは20年、30年という追跡中に、食べ物、ライフスタイル(運動・肥満度・たばこ・アルコールなど)、薬、家族歴、癌や他の病気の発生、生存状況を記録しています。こうした病因に関するデータは癌の発生に先立って集められているためにバイアスのリスクがより少ないのが、前向きコホート研究の長所です。こうして蓄積された貴重な病因データと癌組織の分子異常、あるいはさま ざまな遺伝子の多形(SNPs)とを合わせて分析するというのが私の研究の内容です。一例としてアスピリンがCOX-2高発現の大腸癌の発生の防ぐのに加えてCOX-2高発現の大腸癌による死亡率を下げる、という病理疫学データを発表しています(New Engl J Med 2007、JAMA-J Am Med Assoc 2009 in press)。これまでこれらのコホート研究はUS National Institute of Health(NIH)より研究費をとり続けています。その他、Multicenter Collaborative ProjectであるCancer and Leukemia Group B (CALGB http://www.calgb.org/)のメンバーとして、大腸癌のBiomarkerを調べています。

論文のリストがUpdateされていないのですが、プロジェクトの様子などは下のリンクでごらんください。2009年以降の論文のリストはいちばん下にペーストしておきます。2008年までの論文については、Pubmedで検索してください。

http://bwhpathology.partners.org/CV.aspx?pathologistName=SO26
http://www.dfhcc.harvard.edu/membership/profile/member/1099/0/
http://www.dfci.harvard.edu/abo/danafarber/detail.asp?PersonID=660&RD=True

興味のある方は(sogi43@gmail.com)宛てに直接連絡をお願いします。興味のありそうな人をご存知の方は、この情報をパスして頂きますと幸いです。お問い合わせや応募が多い場合は返答しきれないこともあるかとございますが、どうかご容赦ください。

荻野周史
Shuji Ogino, M.D., Ph.D.
Associate Professor of Pathology, Harvard Medical School
Department of Pathology, Brigham and Women's Hospital
Department of Medical Oncology, Dana-Farber Cancer Institute


Recent original publications (2009以降)

Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Meyerhardt JA, Loda M, Giovannucci EL, Fuchs CS. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 2009;58:90-96.

Nosho K, Shima K, Kure S, Irahara N, Baba Y, Chen L, Kirkner GJ, Fuchs CS, Ogino S. JC virus T-antigen in colorectal cancer Is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. Neoplasia 2009;11:87-95.

Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol 2009;27:1477-1484.

Ogino S, Shima K, Baba Y, Nosho K, Irahara N, Kure S, Chen L, Toyoda S, Kirkner GJ, Wang YL, Giovannucci EL, Fuchs CS. Colorectal cancer expression of peroxisome proliferator-activated receptor- (PPARG, PPARgamma) is associated with good prognosisis. Gastroenterology 2009;136:1242-1250.

Baba Y, Nosho K, Shima K, Irahara N, Kure S, Toyoda S, Kirkner GJ, Goel A, Fuchs CS, Ogino S. Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. Neoplasia 2009;11:418-425.

Ogino S, Nosho K, Irahara N, Shima K, Baba Y, Kirkner GJ, Meyerhardt JA, Fuchs CS. A cohort study of p27 localization in colon cancer, body mass index and patient survival. Cancer Epidemiol Biomarkers Prev 2009;18:1849-1858.

Nosho K, Shima K, Irahara N, Kure S, Baba Y, Kirkner GJ, Chen L, Gokhale S, Hazra A, Spiegelman D, Giovannucci EL, Jaenisch R, Fuchs CS, Ogino S. DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. Clin Cancer Res 2009;15:3663-3671.

Ogino S, Nosho K, Irahara N, Kure S, Shima K, Baba Y, Toyoda S, Chen L, Giovannucci EL, Meyerhardt JA, Fuchs CS. A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases. Clin Cancer Res 2009;15:4431-4438.

Nosho K, Shima K, Irahara N, Kure S, Firestein R, Baba Y, Toyoda S, Chen L, Hazra A, Giovannucci EL, Fuchs CS, Ogino S. SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol 2009;22:922-932.

Ogino S, Nosho K, Baba Y, Kure S, Shima K, Irahara N, Toyoda S, Chen L, Kirkner GJ, Wolpin BM, Chan AT, Giovannucci EL, Fuchs CS. A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis. Am J Gastroenterol 2009: in press.

Ogino S, Nosho K, Irahara N, Shima K, Baba Y, Kirkner GJ, Meyerhardt JA, Fuchs CS. Prognostic significance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers. J Clin Oncol 2009: in press.

Baba Y, Nosho K, Shima K, Freed E, Irahara N, Philips J, Meyerhardt JA, Hornick JL, Shivdasani RA, Fuchs CS, Ogino S. Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. Clin Cancer Res 2009;15:4665-4673.

Souglakos J, Philips J, Wang R, Marwah S, Silver M, Tzardi M, Silver J, Ogino S, Hooshmand S, Kwak E, Freed E, Meyerhardt JA, Saridaki Z, Georgoulias V, Finkelstein D, Fuchs CS, Kulke MH, Shivdasani RA. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Brit J Cancer 2009: in press.

Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA 2009: in press.

Meyerhardt JA, Ogino S, Kirkner GJ, Chan AT, Wolpin B, Ng K, Nosho K, Shima K, Giovannucci EL, Loda M, Fuchs CS. Interaction of molecular markers and physical activity on mortality in patients with colon cancer. Clin Cancer Res 2009: in press.

Worthley DL, Le Leu RK, Whitehall V, Conlon M, Christophersen C, Belobrajdic D, Mallitt K, Hu Y, Irahara N, Ogino S, Leggett BA, Young GP. A human, double-blind, placebo-controlled, cross-over trial of prebiotic, probiotic and synbiotic supplementation: effects on luminal, inflammatory, epigenetic and epithelial biomarkers of colorectal cancer. Am J Clin Nutr 2009: In press.

Ogino S, Nosho K, Irahara N, Meyerhardt JA, Baba Y, Shima K, Glickman JN, Ferrone CR, Mino-Kenudson M, Tanaka N, Dranoff G, Giovannucci EL, Fuchs CS. Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, MSI and CpG island methylator phenotype. Clin Cancer Res 2009: in press.

Ogino S, Nosho K, Shima K, Baba Y, Irahara N, Kirkner GJ, Hazra A, De Vivo I, Giovannucci EL, Meyerhardt JA, Fuchs CS. p21 expression in colon cancer and modifying effects of patient age and body mass index on prognosis. Cancer Epidemiol Biomarkers Prev 2009: in press.

投稿者:荻野周史(sogi43@gmail.com)

2009.07.14

University of Illinois at Chicago ポスドク募集

ポスドク募集
University of Illinois at Chicago
Department of Pharmacology
Center for Lung and Vascular Biology
Center for Cardiovascular Research

米国イリノイ大学医学部薬理学研究室では、活性酸素を介したシグナル伝達機構、血管新生、再生と幹細胞の分化作用、酸化ストレスの循環器疾患における役割に興味のある意欲溢れるポスドク研究員を募集します。

[研究テーマ] 1) 酸化ストレスと心血管病態 (高血圧、動脈硬化、糖尿病) に関する研究、2) 活性酸素関連遺伝子発現調節と蛋白質結合相互作用に関する研究、3) 活性酸素を介した細胞内増殖シグナル伝達機構の解明、4) 活性酸素を介した血管新生と再生に関する研究

「資格」分子生物学、細胞生物学、あるいは動物実験の経験を有する博士号取得(見込)者で研究に興味を持っている意欲的な方。Histologyが出来る方も歓迎します。

「給与」博士号取得後年数に依存
「提出書類」履歴書、研究業績リストおよび主要論文の別刷(発表論文のない場合は、これまでの研究の概略)

日本人のポスドクが常に3−4名いますので、初めての海外生活をサポートいたします。安心してアメリカにいらしてください。

「問い合わせ先」
Masuko Ushio-Fukai, PhD (深井真寿子)
University of Illinois at Chicago,
Department of Pharmacology
Center for Lung and Vascular Biology
Center for Cardiovascular Research,
835 S. Wolcott. M/C868
E403 MSB
Chicago, IL 60612
Tel: 312-996-7631 (TF office) 312-996-7665 (MUF office)
312-996-7622 (lab)
Fax: 312-996-1225

E-mail: masuko.fukai@gmail.com (日本語可); mfukai@uic.edu
Lab URL: http://www.uic.edu/depts/mcph/ushio.htm

投稿者:深井真寿子(masuko.fukai@gmail.com)

2009.07.12

New England Primate Research Center of Harvard Medical School Postdc募集

Postdoctoral Research Fellow

Postdoctoral positions are available in a newly established lab at the New England Primate Research Center of Harvard Medical School, to study how botulinum neurotoxins target and affect neuronal cells at the molecular and cellular levels. We are seeking to elucidate the molecular basis for the action of botulinum neurotoxins and also use these toxins as probes to study fundamental cellular functions in neurons. Specific topics include: 1) identification of toxin receptors; 2) mechanisms of substrate recognition and toxin degradation; 3) neuronal degeneration triggered by botulinum neurotoxins. Please visit: http://donglab.hms.harvard.edu for a description of research directions. Experience in protein biochemistry and/or neuronal cell culture, and a background in biochemistry, biophysics, cell biology, microbiology or neuroscience is beneficial, but not required. Relevant papers include: Mol. Bio. Cell, 19:5226, Nature, 444:1096, Science, 312:592, PNAS, 101: 14701. Interested candidates please forward your curriculum vitae and names of three referees to Dr. Min Dong, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA, 01772, or by email: (donglab@hms.harvard.edu).

New England Primate Research Center is located at the Southborough campus of Harvard Medical School. It is about 25 miles west of the Harvard Medical School main campus in Boston and about 14 miles east of UMass Medical School in Worcester. The location offers reasonable living expenses and an easy commute (free parking, driving to work is necessary). The lab is newly established in 2009. Successful applicants will enjoy close working relationship with the Principal Investigator and will play significant roles in formulating the research projects as well as the lab culture.

Harvard Medical School and the New England Primate Research Center are equal opportunity employers, committed to diversity in the workplace.

Posted by Min Dong (donglab@hms.harvard.edu)

2009.07.10

City of Hope National Medical Center Postdoc募集

Postdoctoral research fellow position is available in the Department of Cancer Biology for working on a NIH funded project in the field of early cancer detection using serologic tumor biomarkers. Candidate should have a Ph.D. degree in Molecular Biology and a strong background in Tumor Biology and Immunology. Experience with ELISA, microarray techniques, cDNA library construction and statistical data analysis is helpful. Good English communication and writing skills are needed. Please send a cover letter, CV and the contacts of three references (including name, address, telephone and email) to Dr. Li Zhong: lzhong@coh.org Beckman Research Institute of the City of Hope, Flower Bldg Rm132, 1500 E. Duarte Road, Duarte, California 91010-3000, USA

Posted by Li Zhong (lzhong@coh.org)

2009.07.09

EMBL in Biochemistry and Structural Biology Postdoc募集

Post-Doc Position at EMBL
in Biochemistry and Structural Biology

The position is available from January 2010 in the team of Christiane Schaffitzel, EMBL Grenoble (www.embl.fr).

The project is part of the interdisciplinary effort of the teams of Christiane Schaffitzel and Stephen Cusack (Structural Biology Unit Grenoble) and Andreas Kulozik and Matthias Hentze (Molecular Medicine Partnership Unit, EMBL Heidelberg). We want to address the exciting question how nonsense-mediated mRNA decay (NMD) is triggered by a ribosome that encounters a premature stop codon on the mRNA.

The activities will include: Recombinant expression with baculovirus in insect cells, protein isolation, cell-free translation, ribosome purification, in vitro and in vivo biochemical characterization, cryo-electron microscopy and X-ray crystallography.

We seek a highly-motivated biochemist and/or structural biologist who is keen to apply state-of-the-art technologies for producing and characterizing human multiprotein-ribosomal complexes involved in NMD. By this interdisciplinary approach, involving structural and biochemical methods, we expect new revealing insights into the molecular mechanism of NMD and shed light on important medical implications.

Please send your application, including a CV and a list of referees to:
Christiane Schaffitzel, Email: schaffitzel@embl.fr

Our Publications:
Mitra, K., Schaffitzel, C., et al., Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature 2005: 318-324.

Schaffitzel, C. et al., Structure of the E. coli signal recognition particle bound to a translating ribosome. Nature 2006: 503-506.

Bingel-Erlenmeyer, R. et al. A peptide-deformylase complex reveals mechanism of nascent chain processing. Nature 2008: 108-111

Kohler et al., YidC and Oxa1 form dimeric insertion pores on the translating ribosome. Mol. Cell 2009: 344-353.

Posted by Christiane Schaffitzel (Schaffitzel@embl.fr)

2009.07.08

Duke University Medical Center Postdoctoral Fellow募集

The laboratory of Motonari Kondo, M.D., Ph.D., Associate Professor of Immunology
Duke University Medical Center, Durham, NC 27710, USA
研究内容: サイトカインなどの液性因子のリンパ球分化における機能解析を主として研究を行っています。解析はシグナル伝達などの分子レベルからマウスモデルまでをカバーします。 研究内容の詳細はhttp://immunology.mc.duke.eduを参照してください。
応募資格: 博士号取得者あるいは取得見込みの方。かつ、分子生物学, 細胞生物学の経験があり、 研究に熱意を持っている方を望みます。免疫学研究経験の有無は問いません。
着任時期:2009年秋から2010年春を期待しています。もちろん相談に応じます。このポジションはオバマ大統領による経済刺激策、ARRA fundによるものです。
提出書類:次の書類をEメールでお送り下さい。(1)履歴書、(2)研究業績一覧、(3)推薦者2名以上の氏名と連絡先。
応募締切:適任者が決まり次第、募集を終了します。
書類送付先、問合せ先:近藤元就 (motonari.kondo@duke.edu) 日本語で構いません。ただし、提出書類は英語でお願いします。

A postdoctoral position is available in the laboratory of Dr. Motonari Kondo in the Department of Immunology at Duke University Medical Center. This position will be a part of a team investigating either the regulation of the lymphoid and myeloid lineage commitment from hematopoietic stem cells, or the role of cytokine receptor signaling in lymphocyte development. We are looking for someone who can work independently and is highly motivated. Applicants should have M.D., Ph.D., M.D./Ph.D. or equivalent degrees and experience in the cellular and molecular biology.

Appointments are for one year, with renewal based upon satisfactory performance and funding availability. Applications, which include a cover letter, curriculum vitae (including a list of publications), and contact information for three (at least two) references, should be sent to Motonari Kondo, M.D., Ph.D., Associate Professor in Immunology at motonari.kondo@duke.edu.

Duke University Medical Center is an equal opportunity/affirmative action employer.

投稿者:近藤 元就(motonari.kondo@duke.edu)

2009.07.01

Yale University School of Medicine ポスドク募集

私の同僚のYale大学Dr. Daniela TirziuよりPostdoc募集の依頼がありましたので代わりに投稿します。彼女は内科心臓病学のyoung facultyです。

興味のある方は直接彼女に連絡してください。

-------------------

Postdoctoral position available in the Department of Internal Medicine, Yale University School of Medicine. The project is in the area of cardiovascular biology, angiogenesis and cardiac hypertrophy.
Candidates must hold a recent MD or PhD, must have a strong background in cardiovascular biology. Preference will be given for prior experience with genetically engineered mice, cDNA subcloning, isolation and culture of primary endothelial cells and cardiac myocytes, confocal microscopy, invasive and noninvasive assessment of mouse cardiovascular function.

To apply please contact Daniela Tirziu at

Daniela.Tirziu@yale.edu

投稿者:村上昌弘

2009.06.28

ニューヨーク州立大学 Stony Brook 校 薬学部 ポスドク募集

                海外ポスドク募集のお知らせ

    ニューヨーク州立大学 Stony Brook 校 薬学部 (http://www.pharm.sunysb.edu/)


当研究室では、主に Wnt/beta-catenin シグナル伝達経路の脊椎動物の発生や人の
疾病における役割に関する研究を、マウスや培養細胞を用いて行っています。現在は、特に、
Wnt/beta-catenin シグナリングの繊毛形成や機能における役割の解明を中心とした研究を行っています。
ニューヨーク州立大学 Stony Brook 校では、多くの研究室が、マウス、ゼブラフィ
ッシュ、アフリカツメガエル、ショウジョウバエなどを用いた研究を盛んに行っており、共同研究の機会にも恵まれた環境にあります(http://www.osa.sunysb.edu/)。


応募資格:上記の研究に興味のある博士号取得者または取得見込み者(過去の研究分野は特に問いませんが、意欲的に研究を行う方)。

興味のある方は、以下までメールで気軽にお問い合わせ下さい。


問い合わせ先及び応募先:
竹丸 憲一
State University of New York at Stony Brook
Dept. of Pharmacological Sciences
Stony Brook, NY 11794
E-mail: takemaru@pharm.stonybrook.edu(日本語可)


参考文献
Voronina et al., J. Cell Biol., 185:225-233, 2009
Mofunanya et al., BMC Mol. Biol., 10:41, 2009
Li et al., J. Cell Biol., 181:1141-1154, 2008
Cohen et al., BMC Dev. Biol., 8:70, 2008
Takemaru et al., Nature, 422:905-909, 2003

投稿者:竹丸憲一(takemaru@pharm.stonybrook.edu)

2009.06.27

University of Southern California ポスドク募集

Postdoctoral Fellowship at the University of Southern California

There are multiple R01 funded postdoctoral positions available immediately in the laboratory of Don B. Arnold (http://college.usc.edu/labs/arnold) to follow up on our recent discoveries, both published (Nature Neurosci. 12(5) 568-76) and unpublished, in the area of neuronal protein trafficking. The goal of this project is to uncover fundamental mechanisms underlying targeting of axonal and dendritic proteins and to apply the findings to create molecular tools for studying function at the cellular and circuit level. Candidates should have experience in Cell and Molecular Biology, Biochemistry or Electrophysiology.
Please send CVs (including a list of publications) and the names and contact information for three references to darnold@usc.edu and put Postdoc Applicant as the subject.


日本語での問い合わせは御園生まで(E-mail: hmisono@umaryland.edu)

投稿者:御園生裕明(hmisono@umaryland.edu)

2009.06.26

テンプル大学医学部心臓血管研究センター ポスドクおよびResearch Scientist (MD, MD/PhD, PhD) 募集

ポスドクおよびResearch Scientist (MD, MD/PhD, PhD) 募集
テンプル大学医学部心臓血管研究センター (Philadelphia, PA)
江口研究室
当研究室は細胞生物学、分子生物学、タンパク工学(プロテオミックス)および遺伝子改変動物を主体とした手法を用いて心血管系の情報伝達と機能解析を中心に現在、以下のテーマで研究を行っています(Current Grants funded include NIH-RO1 and AHA Established Investigator Award)。
1. アンジオテンシン受容体の新しい情報伝達とその機能解析
2. NOと活性酸素を介した 血管系細胞内情報伝達
3. Gタンパクの新しい機能解析
ニュヨーク、ワシントンは車で2−3時間のフィラデルフィアは日本人には生活しやすいところでしょう。当研究室は年内に新築の研究棟に移転予定です。留学/就職にあたっては私と日本人のポスドク(現在5名の日本人スタッフ)が生活面、研究面共に懇切丁寧に面倒を見ます。ご興味を持った方は履歴書(学歴と研究歴/業績、日本語可)を以下にe—mailしてください。(分野は問いませんが今回の募集は分子生物学的手法に習熟した方を特に優先します。)
給与および条件

ポスドク$38000/year、 J1 Visa: 博士課程修了見込みもしくは最終博士学位取得後3年未満の方

Research Scientist $41000/year、H1B Visa: 最終学位取得後3年以上の研究経験を有する方 (Green Card 申請可能、グラントも申請可能 、ただし既に業績のある方)

経験によりさらに優遇、定期昇給制度あり、家族を含む医療保険完備、休祭日は大学の規定に準じる(+夏休み1週、冬休み1週)。

Satoru Eguchi, MD. PhD. FAHA
Associate Professor of Physiology and Cardiovascular Research Center
Temple University School of Medicine
e-mail: seguchi@temple.edu(日本語可)
Tel/FAX 215-707-8378

最近の当研究室の文献 (Selected from 102 English Publications)
Arterioscler Thromb Vasc Biol 29:217, 2009, Hypertension 53:182, 2009, Hypertension 51:232, 2008, Arterioscler Thromb Vasc Biol 26:e133. 2006, J Biol Chem 280:26592. 2005, Arterioscler Thromb Vasc Biol 25:1831. 2005, Mol Cell Biol 23: 1581. 2003, Hypertension 41:775. 2003, J Biol Chem 277:44695. 2002, Mol Endocrinol 16: 367. 2002, Circulation 106:909-912, 2002, J. Biol. Chem., 276: 7957. 2001.

投稿者:江口 暁(seguchi@temple.edu)

2009.06.25

Yale University School of Medicine Postdoc募集

Positions in the laboratory of Dr. Yibing Qyang

Postdoctoral positions are available in the area of cardiovascular (CV) stem cell biology. We are striving to ameliorate heart disease utilizing a novel population of CV stem cells, coupled with embryonic stem (ES) cells, high-throughput chemical screening and tissue engineering. Current ongoing projects cover the following areas:

1. Characterize novel signaling pathways implicated in the regulation of this novel population of CV stem cells during heart development with murine models (Laugwitz et al., Nature 433, 647-53; Qyang et al., Cell Stem Cell 1, 165-79, 2007).

2. Derive CV stem cells from human embryonic stem cells, induced pluripotent stem cells (iPS) and patient specific stem cells, utilize bio-degradable scaffold to establish engineered heart tissues (EHT) with these cells, and examine their contribution to heart repair and regeneration in animal models.

3. Establish assays for high-throughput small molecule screens to directly reprogram heart fibroblast (scar-forming cells) and quiescent adult epicardial cells into CV stem cells, respectively.

Essential Qualifications: The successful candidate must have a doctoral degree in related areas. Experience in studying embryonic development is required. Expertise in studying heart development with murine models is a plus.

Interested candidates should submit their CV including names and contact information for three references and a short description of their doctoral training and future research goals.

Dr. Yibing Qyang
Yale Cardiovascular Research Institute and
Section of Cardiology, Dept. of Internal Medicine
Yale Stem Cell Center
TAC S-310, Yale University School of Medicine
300 Cedar Street
New Haven, CT 06519

yibing.qyang@yale.edu
yqyang02@gmail.com

Please feel free to visit our laboratory website:
http://users6.nofeehost.com/yaleqyang/Qyanglabresearch.htm

Posted by Yibing Qyang (yibing.qyang@yale.edu)

2009.06.16

Yale Cardiovascular Research Institute Postdoc募集

Positions in the laboratory of Dr. Yibing Qyang

Postdoctoral positions are available in the area of cardiovascular (CV) stem cell biology. We are striving to ameliorate heart disease utilizing a novel population of CV stem cells, coupled with embryonic stem (ES) cells, high-throughput chemical screening and tissue engineering. Current ongoing projects cover the following areas:

1. Characterize novel signaling pathways implicated in the regulation of this novel population of CV stem cells during heart development with murine models (Laugwitz et al., Nature 433, 647-53; Qyang et al., Cell Stem Cell 1, 165-79, 2007).

2. Derive CV stem cells from human embryonic stem cells, induced pluripotent stem cells (iPS) and patient specific stem cells, utilize bio-degradable scaffold to establish engineered heart tissues (EHT) with these cells, and examine their contribution to heart repair and regeneration in animal models.

3. Establish assays for high-throughput small molecule screens to directly reprogram heart fibroblast (scar-forming cells) and quiescent adult epicardial cells into CV stem cells, respectively.

Essential Qualifications: The successful candidate must have a doctoral degree in related areas. Experience in studying embryonic development is required. Expertise in studying heart development with murine models is highly preferred.

Interested candidates should submit their CV including names and contact information for three references and a short description of their doctoral training and future research goals.

Dr. Yibing Qyang
Yale Cardiovascular Research Institute and
Section of Cardiology, Dept. of Internal Medicine
Yale Stem Cell Center
TAC S-310, Yale University School of Medicine
300 Cedar Street
New Haven, CT 06519

yibing.qyang@yale.edu
yqyang02@gmail.com

Please feel free to visit our laboratory website:
http://users6.nofeehost.com/yaleqyang/Qyanglabresearch.htm

投稿者:Yibing Qyang (yibing.qyang@yale.edu)

2009.06.14

NIH ポスドク募集

NIHのDr. Shih-Chieh Linより、postdocの募集がありましたので、代理投稿いたします。Dr. Shih-Chieh LinはDuke大学のMiguel Nicolelisラボ出身で、多点電極を用いたbasal forbrainの解析を行っています。温厚で親しみやすい人柄です。興味のある方はShih-Chiehへ直接ご連絡下さい。
Shih-Chieh Lin

河崎洋志
http://square.umin.ac.jp/top

---------------------
The National Institute on Aging (NIA), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (HHS), is recruiting postdoctoral fellows in the Laboratory of Experimental Gerontology (LEG), located on the Bayview Campus in Baltimore, Maryland.   

The candidates will work with Dr. Shih-Chieh Lin, principal investigator of the newly established Neural Circuits and Cognition Unit in LEG. The mission of the Neural Circuits and Cognition Unit is to understand how cognitive functions are mediated by interactions of cortical and subcortical circuits. The primary focus of the laboratory is to elucidate how specific basal forebrain neuronal populations modulate cortical activity to serve as mechanisms for top-down attention. The laboratory combines multiple experimental approaches, including neuronal ensemble recording in behaving rats and mice, as well as behavioral, genetic, pharmacological and computational techniques. Individuals with interests and background in attention, reward or basal forebrain circuitry are especially encouraged to apply. Additional information of Dr. Lin’s research is available at 
http://sites.google.com/site/shihchiehlin

Candidates must have a Ph.D. or M.D. with less than five years of postdoctoral research experience, as well as a strong research background in systems neuroscience-related disciplines. Salary is commensurate with experience and accomplishments
(http://www.training.nih.gov/stipends.asp).
Initial appointment is one to two years, with extension up to five years. Positions are open until filled.

Send curriculum vitae, statement of research interests, relevant publications, and contact information of three references to Kristine Rozankowski at
RozankowskiK@grc.nia.nih.gov
OR LEG-NIA-NIH, 251 Bayview Blvd, Baltimore MD 21224.  Additional information regarding the NIA IRP and the LEG are available at the following websites: 
http://www.grc.nia.nih.gov
AND 
http://www.grc.nia.nih.gov/branches/leg/leg.htm

投稿者:河崎 洋志(kawasaki@m.u-tokyo.ac.jp)

2009.06.12

University of California, San Diego(UCSD) ポスドク募集

University of California, San Diego(UCSD), Division of Cardiology, ポスドク募集
当研究室では心疾患、特に拡張型心筋症の発症メカニズム、診断、予防、治療の研究に意欲的なポスドクを1名募集します。

<研究内容>
心筋細胞はほとんど再生されることがないと考えられていますが、50年以上の長きにわたりどのように恒常性を維持しているかはほとんどわかっていません。ご存知のように心臓は休むことなく働き続けており、様々な血行動態の変化に常にさらされています。我々は、ウイルス性心筋炎の研究を通じて、自然免疫に関わるメカニズムが心筋内で非常に重要な役割をはたしていることを発見しました(参考文献)。さらに、こうしたメカニズムがウイルス感染のみならず心筋が酸化的ストレスにさらされた時などにも働いている可能性を見つけました(未発表)。生態内でこうしたメカニズムがいかに働くかを詳細に検討するため、これまでにノックアウトマウスとトランスジェニックマウスの作成を終了しました。こうした未発表のマウスモデルを用いて心筋内の自然免疫システムが心筋防御機構にどのように関与し、心筋の恒常性維持や心筋症の発症にいかに影響を与えているかを徐々に明らかにしていこうと考えています。
(参考文献)
1. Yasukawa H & Yajima T et al. J Clin Invest. 2003;111(4):469-78.
2. Yajima T. et al. Circulation. 2006;114(22):2364-73.
3. Yajima T. & Knowlton KU Circulation. 2009;119(19):2615-24.

<研究環境>
大学のあるLa JollaはUCSD以外にも, Salk Institute, Scripps Research Institute, Burnham research institute, La Jolla Institute for Allergy & Immunologyなど世界的に有名な研究施設がひしめきあい、全米でも有数の研究環境を形成しています。研究者間の交流も盛んで世界中から優秀な若手研究者が集まっています。UCSDのDivision of Cardiologyには多くの研究グループがあります。我々はDr. Kirk U. Knowlton (Division Chief), Dr. Ju Chen, Dr. Robert Ross, Dr. Kirk L. Peterson, Dr. Sylvia Evans, Dr. Gianluigi Condorelliのラボと研究スペースを共有しており、お互いに情報交換、研究協力などを頻繁に行っています。特にKnowlton, Chen, Ross, Condorelliラボとは週一回共同のラボミーティングを開いています。グループ全体としては、20名以上のポスドクをはじめ、大学院生、大学生、アシスタントなどが常に出入りしていて大変にぎやかです。全米で活躍している研究者を招待した講演も毎週のように開かれおり非常に刺激的な環境となっています。

<募集要件>
資格:医学・理学・薬学・農学系PhD(見込み可)または、MD
基本的な分子生物学、細胞生物学的実験の手法をマスターしていることが望ましい。ノックアウトマウスの表現系解析、プロテオミクス、細胞電気生理などに経験のある方は優先的に考慮致します。
<募集人数> 1名
<募集期間>適任者が決まり次第締め切り
<期間>本年9月から。仕事振りに応じて3年まで延長可。
<給与>
PhD (大学院卒業者、または見込み): UCSDの規定に準ずる(医療保険は給料とは別にカバーされます)
MD: これまでの臨床経験や研究業績に応じて判断。PhD相当の研究技術があると判断された方は上記PhDの規定に準ずる。
<提出書類>
(1)履歴書(これまでの研究業績、学会発表なども含む)
(2)Self Assessment 1通 (重要)
Applicantがこれまでの研究や臨床の現場でどのような目標をたて、どのように工夫し、どのような成果を得たのか、将来的にどんなVisionを持っているかなどを自分なりにアピールして下さい。(Applicantがいかに素晴らしいかを形式にとらわれず自由に表現して下さい。自己批判的なことは一切必要ありません。)
(3) 推薦状 1通
Applicantの人柄、仕事振りなどをよく知る方からのものが望ましい。
全て、日本語、英語、どちらでも可。

<その他>
企業の研究員などで1-2年の短期留学を考えている方、留学Grantのある方、自費留学を考えている方なども遠慮なくご応募下さい。上記募集枠とは別に随時考慮致します。臨床の経験しかないが、ぜひ循環器の基礎研究をやってみたいと真剣に考えている方もご連絡下さい。
<San Diego生活>
南カリフォルニアの温暖な気候で一年を通じてとても暮らしやすいところです。治安も良く、家族で暮らすには最高の条件がそろっています。日本食のレストラン、スーパーマーケットもあり食事にも不自由しません。美しい海、ゴルフ場などにも恵まれており、サーフィンやゴルフ好きには最高の息抜きとなります。他にもキャンプやハイキング、サイクリングなどアウトドアでの楽しみには事欠きません。

<連絡先>
矢島利高(下記)までメールにてお願いします。(日本語可)
応募につきご不明な点などあれば遠慮なくお問い合わせ下さい。

Toshitaka Yajima, M.D., Ph.D.
Assistant Professor
Division of Cardiology, Department of Medicine
University of California, San Diego
9500 Gilman Drive, 0613K
La Jolla, CA 92093
Phone: (858)822-0334
Fax:(858)822-3027
e-mail: tyajima@ucsd.edu

投稿者:矢島利高(tyajima@ucsd.edu)

2009.06.11

Cleveland Clinic, Lerner Research Institute ポスドク募集

[classifiedの内容]
米オハイオ州クリーブランド、Cleveland Clinic, Lerner Research Institute, 酒井lab では、意欲のあるポスドクを募集します。今回募集する新プロジェクトのテーマは、in vitroで間葉系幹細胞の特異細胞への分化を規定する微小環境因子の同定、また既に樹立したトランスジェニックマウスを用いた腱損傷治癒モデルにより、腱•靭帯損傷治癒機構、更には臨床応用に向けた再建法の開発とバイオメデイカルエンジニアリングにおける新技術の創出、を目指しております。従って、70%はマウスを用いたin vivoでの実験が主体となる為、繊細な手術手技のお持ちの方([整形]外科の経験等)を優先致します。また、当ラボでは新たなるノックアウトマウスの作製も積極的に推進しています。最近の業績は、(Carcinogenesis 28:2074-2081,2007; EMBO J 23:2166-2174,2004; Genes Dev 17:926-940,2003; Nature Med 7:324-330,2001; PNAS 98:3808-3813,2001)を参照して下さい。米Cleveland Clinic, Lerner Research Instituteに関しては、(http://www.lerner.ccf.org/)を参照して下さい。また、詳細については下記のメールアドレスに御連絡ください。

[ 応募資格 ] 医学系、理学系、農学系博士号保持、または見込みの方。
[ 待遇 ] Cleveland Clinic, Lerner Research Instituteの規格による(社会保険完備)
[ 応募書類 ] 1) 履歴書と研究業績目録
       2) これまでの研究の概要並びに将来の研究の展望
       3) 推薦者3名の連絡先(TEL, Email address)
[ 就任時期 ] 2009年9月頃からを期待しております。

Takao SAKAI, M.D., Ph.D.,
Assistant Professor,
Department of Biomedical Engineering/ND2-22,
Lerner Research Institute,
Cleveland Clinic Foundation,
9500 Euclid Avenue, Cleveland OH 44195, U.S.A.
Email:sakait@ccf.org (Japanese available)

投稿者:酒井尚雄(sakait@ccf.org)

2009.06.10

Samuel Lunenfeld Institute in the Mount Sinai Hospital in Toronto Postdoc募集

Post-doctoral Research in Functional Genomics and Super-Resolution imaging of Mitotic Processes.

A Postdoctoral position is available in Dr. Laurence Pelletier’s laboratory at the Samuel Lunenfeld Institute in the Mount Sinai Hospital in Toronto. Dr. Pelletier’s laboratory is keenly interested in the molecular mechanisms that govern various aspects of mitotic cell division including centrosome duplication, microtubule dynamics, mitotic spindle assembly and kinetochore function. Studies in the Pelletier lab revolve around cutting-edge microscopy techniques including FRAP/FLIM, 4-D multiplex time-lapse imaging and structured illumination (SI), functional genomics and high-content screening approaches in mammalian cells. In this position, the successful applicant will be part of a fast-paced dynamic and multi-disciplinary environment and play an integral role in novel and ongoing projects within the laboratory as well cementing collaborations with other labs.

The applicant should have experience in advanced light microscopy imaging systems, image analysis and statistical approaches to quantitative microscopy. Training in molecular and cell biology will be considered an asset.

Salary: 45,000 CAN$.

Selected Publications:

Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, Pinchev D, Buchholz F, Peters JM, Hyman AA, Gingras AC, Pelletier L. HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity. Curr Biol (2009).

Zhu, F., Lawo, S., Bird, A., Pinchev, D., Ralph, A., Richter, C., Müller-Reicher, T., Kittler, R., Hyman, A., Pelletier, L. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Curr Biol. (2008).

Kittler, R., Pelletier, L., Heninger, AK., Slabicki, M., Theis, M., Miroslaw, L., Poser, I., Lawo, S., Grabner, H., Kozak, K., Wagner, J., Surendranath, V., Richter, C., Bowen, W., Jackson, AL., Habermann, B., Hyman, AA., Buchholz, F. Genome-scale RNAi profiling of cell division in human tissue culture cells. Nat Cell Biol (2007).

Pelletier, L., O'Toole, E.T., Schwager, A., Hyman, A.A. and Müller-Reichert, T. Centriole assembly in Caenorhabditis elegans. Nature (2006).

Pelletier, L., Özlü, N., Hannak, E., Cowan, C., Habermann, B., Ruer, M., Muller-Reichert, T. and Hyman, A.A. The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication. Curr Biol (2004).

For more information visit:

http://www.mshri.on.ca/pelletier/

Posted by Laurence Pelletier (pelletier@lunenfeld.ca)

2009.06.05

Purdue University Postdoc募集

A postdoctoral position in the area of protein bioinformatics is available immediately in Professor Kihara's group at Department of Biological Sciences, Computer Science in Purdue University.

Qualified candidates should hold a PhD in Physics, Computer Science, Biology, Chemistry, Doctor of Engineering, or in a related field.
The areas sought include, but are not limited to: protein global/local shape comparison and search, protein docking, and protein tertiary structure modeling or prediction. Previous experience in 3D shape retrieval in Engineering, computational geometry is a large plus. Fluent programming skill and good communication skills are essential. Highly motivated and creative candidates with a strong record of publication are encouraged to apply.
Send curriculum vitae and contact information of three references to: dkihara@purdue.edu . Postal mail should be sent to: Dr. Daisuke Kihara, Department of Biological Sciences, Purdue University, Lilly Hall, 915 West State St. West Lafayette, IN 47907.

http://dragon.bio.purdue.edu
http://www.bio.purdue.edu/people/faculty/index.php?refID=166
http://www.cs.purdue.edu/people/faculty/dkihara/

Posted by Daisuke Kihara (dkihara@purdue.edu)

2009.05.29

Indiana University School of Medicine Postdoc募集

POSTDOCTORAL FELLOW

A postdoctoral position is available within the Stark Neuroscience Research Institute (WEBSITE: http://snri.iusm.iu.edu/) to study the role that calcium signaling plays in regulating ion channel function in neurons and myocytes. The postdoctoral candidate will explore how localization and protein-protein interactions influence ion channel regulation by the multifunctional calcium-calmodulin-dependent protein kinase II (CaMKII); (http://snri.iusm.iu.edu/body.cfm?id=67). Recent PhDs with a strong background in biochemistry/protein chemistry are encouraged to apply. Applicant will be expected to have some experience with standard molecular biology and biochemical techniques, including subcloning and mutagenesis, recombinant protein expression, and protein purification. Techniques the post-doc can expect to learn through this research include fluorescent imaging (confocal and epifluorescent) of living cells, high throughput peptide design and synthesis, inhibitor screens, as well as assays to measure excitotoxic cell death in neurons. Only highly motivated candidates with good communication skills will be considered. Dr. Hudmon’s laboratory is located at the Stark Neuroscience Research Institute at the University of Indiana Medical School. This university is located in Indianapolis (http://visitindy.com/indianapolis/web/jsp/index.jsp?p=1); a charming mid-western city that has a wonderful blend of restaurants, performing arts/museums and world-class spectator events (hosting Super Bowl XLVI in 2012, with over 10 world-class sports venues, including the Indianapolis 500, and the Colts NFL team and Pacers NBA team); all in a city that extremely affordable to live in, yet only a few hours drive to a number of other major cities, including Chicago, Louisville, and Cincinnati. Send cover letter and curriculum vitae to Dr. Andy Hudmon PhD, Assistant Professor, Department of Biochemistry and Molecular biology, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 via FAX-317-278-5849 or EMAIL:ahudmon@iupui.edu. Posted May 28, 2009

Posted by Andy Hudmon (ahudmon@iupui.edu)

2009.05.26

University of Minnesota ポスドク募集

University of Minnesota (Minneapolis, MN, USA) にて、ポスドク研究員として一緒に研究をして下さる方を募集しております。昨年からスタートした私たちの研究室では、DNA組み換え、修復、などにかかわるタンパク質の構造と機能を、主としてX線結晶解析を用いて研究しています。生化学、生物物理学、分子生物学、などの分野での研究経験(と博士号)をもち、やる気のある方であれば、X線構造解析の経験、知識は、必ずしも問いません。研究内容の詳細、参考文献などについては、
http://www.cbs.umn.edu/BMBB/faculty/Aihara.H.shtml)をご覧ください。

ミネソタ州は、アメリカ合州国中西部の北端、カナダとの国境付近に位置します(簡単に言うと、真ん中の上のほうです)。一年を通じて比較的乾燥していて過ごしやすく、特に春から秋口にかけては、避暑地のような気候で、日も長く、とても快適です(“Land of 10,000 lakes”といわれるように、湖が非常に多く、アウトドア派の方には特にお勧めです)。冬にはかなり寒くなるのですが、日本に暮らしていては経験のできないような寒さなので、中途半端に寒いよりもむしろ、貴重な体験、会話の種、になるなどして良いのではないかと思います。ミネアポリス・セントポール地域は、アメリカ国内での暮らしやすい都市のランキングで、上位にランクされることも多いように、生活環境という面では大変良いところです。また、日本からノースウエスト航空の直行便があり、日本人にとっては便利です(最寄りの大都市は、シカゴです)。
興味のある方は、相原秀樹(aihar001@umn.edu)までご連絡ください。日本語でも英語でも結構です。

Postdoctoral position(s) is available in Hideki Aihara’s laboratory at the University of Minnesota (Minneapolis, MN, USA). Our laboratory, which started about a year ago, studies structure and function of various DNA-processing enzymes primarily using X-ray crystallography. We seek highly motivated individuals with research experience (and Ph.D.) in biochemistry, biophysics, molecular biology, or similar disciplines. Prior experience on x-ray crystallography or other structural biology techniques is preferred but not essential. For more about our research interests and references, please visit http://www.cbs.umn.edu/BMBB/faculty/Aihara.H.shtml.
Interested individuals are encouraged to contact Hideki Aihara by e-mail (aihar001@umn.edu) in either English or Japanese.

投稿者:相原秀樹(aihar001@umn.edu)

2009.05.24

Temple University Postdoc募集

ポスドクおよびResearch Scientist (MD, MD/PhD, PhD) 募集
テンプル大学医学部心臓血管研究センター (Philadelphia, PA)
江口研究室

当研究室は細胞生物学、分子生物学、タンパク工学(プロテオミックス)および遺伝子改変動物を主体とした手法を用いて心血管系の情報伝達と機能解析を中心に現在、以下のテーマで研究を行っています(Current Grants funded include NIH-RO1 and AHA Established Investigator Award)。
1. アンジオテンシン受容体の新しい情報伝達とその機能解析
2. NOと活性酸素を介した血管系細胞内情報伝達
3. Gタンパクの新しい機能解析

ニュヨーク、ワシントンは車で2−3時間のフィラデルフィアは日本人には生活しやすいところでしょう。当研究室は年内に新築の研究棟に移転予定です。留学/就職にあたっては私と日本人のポスドク(現在5名の日本人スタッフ)が生活面、研究面共に懇切丁寧に面倒を見ます。ご興味を持った方は履歴書(学歴と研究歴/業績、日本語可)を以下にe—mailしてください。(分野は問いませんが分子生物学的手法を習熟した方や組織染色、動物実験等に習熟した方を優先します。)

給与および条件

ポスドク$38000/year、 J1 Visa 博士課程修了見込みもしくは最終博士学位取得後3年未満の方

Res Scientist $41000/year、H1B Visa 最終学位取得後3年以上の研究経験を有する方 (Green Card 申請可能、グラントも申請可能 、ただし既に業績のある方を優先)

経験によりさらに優遇、昇給も可能、家族を含む医療保険完備、休祭日は大学の規定に準じる(+夏休み1週、冬休み1週)。

なお、大学院生も継続して募集しています。

Satoru Eguchi, MD. PhD. FAHA
Associate Professor
Department of Physiology and Cardiovascular Research Center
Temple University School of Medicine
e-mail: seguchi@temple.edu(日本語可)
Tel/FAX 215-707-8378

最近の当研究室の文献 (Selected from 102 English Publications)
Arterioscler Thromb Vasc Biol 29:217, 2009, Hypertension 53:182, 2009, Hypertension 51:232, 2008, Arterioscler Thromb Vasc Biol 26:e133. 2006, J Biol Chem 280:26592. 2005, Arterioscler Thromb Vasc Biol 25:1831. 2005, Mol Cell Biol 23: 1581. 2003, Hypertension 41:775. 2003, J Biol Chem 277:44695. 2002, Mol Endocrinol 16: 367. 2002, Circulation 106:909-912, 2002, J. Biol. Chem., 276: 7957. 2001.

投稿者:江口 暁(seguchi@temple.edu)

2009.05.21

University Of Minnesota Postdoc募集

I am interested in a postdoc who has proficiency in routine cell and molecular biology, mouse breeding, and rodent surgical techniques. Position will be for minimum of two years following an initial evaluation period of 3-6 months.

Posted by Sandeep Gupta (gupta024@umn.edu)

2009.05.20

Miller School of Medicine University of Miami Postdoc募集

A full-time postdoctoral research position in the Department of Microbiology and Immunology at the Miller School of Medicine of the University of Miami, to study immune regulation, autoimmunity and antitumor immunity, using transgenic and knockout mouse models, with cellular and molecular approaches. http://chroma.med.miami.edu/micro/faculty_chen.html;
http://www.diabetesresearch.org/AbouttheDRI/DRIFaculty/ZhibinChen.htm
Minimum qualifications include a new PhD graduate in immunology and/or molecular biology, solid research experience with mouse models and excellent written/oral communication skills. Expertise and skills in immunofluorescence imaging and microsurgery are highly desired.
Cool city. Hot science. Miami is one of the most dynamic and fascinating metropolitans on this planet. If interested, please send CV to Dr. Zhibin Chen, zchen@med.miami.edu.

Posted by Zhibin Chen (zchen@med.miami.edu)

2009.05.19

Weill Medical College of Cornell University ポスドク募集

私の研究室では、一緒に研究をしてくれるポスドクを1名募集しています。場所は、New Yorkのマンハッタンの中で、Department of Cell and Developmental Biology, Weill Medical College of Cornell Universityです。Rockefeller UniversityやSloan-Kettering Instituteに隣接しており、scientificな環境に優れています。

研究テーマ:コレプレッサーによるcis-regulatory moduleの調節と癌抑制。

生命体の根本的構成要素である多量な遺伝情報の出力は、主に転写調節領域であるcis-regulatory module(CRM)が入力装置となり調節されます。通常、1つの遺伝子に複数のCRMが近傍にあります(Berman, 2002)。典型的なCRMは、長さが500bp程度のDNAで、DNA結合性転写抑制因子とDNA結合性転写活性化因子の結合配列がそれぞれ複数存在します。出力を上げる機構(転写の活性化)の理解は、多数の研究者の長年の成果により、飛躍的に進展しました。一方、出力を下げる機構(転写の抑制)は、多細胞生物の形づくりに関わる遺伝子ネットワークの時間的空間的制御に必須ですが、未だ謎が多いです。DNA結合性転写抑制因子とそのコレプレッサー複合体が抑制可能な距離という点から、100bp以内に限定される「Short-range repression」と1 kb以上でも抑制できる「Long-range repression」があります(Mannervik, 1999)。Short-range repressionは、その抑制因子が結合したCRMだけを阻害しますが近傍のCRMを阻害しないので、柔軟な出力調節を可能にします。一方、Long-range repressionは、その遺伝子を制御する複数のCRMかプロモーターを阻害するので、オンかオフだけの単純な出力調節をします。これらの転写抑制は、進化的に保存されているコレプレッサーたち(CtBP, Drap1, Ebi/SMRTER/HDAC3, Mi2/NuRD, Groucho/HDAC1, Atrophin/HDAC1/2)が行います。これらの中には、クロマチンの構造変化を引き起こすコレプレッサー複合体も含まれています。しかし、そのコレプレッサーたちがどのように抑制できる距離を決めているのかは、全く分かっていません。我々は、CRM依存的な転写調節の解析に適したショウジョウバエをモデルにして、分子機構を解明します。
また、ある転写抑制が解除された結果、癌が形成するハエのモデルを、我々の研究室で最近確立しました。この癌形成は、進化的に保存されていると考えられるので、優れたモデル系となりえます。

テーマは、主に以下の4つです。
1、Long-range repressionを仲介するコレプレッサーの分子機構の解明。
2、Short-range repressionを仲介するコレプレッサーの分子機構の解明。
3、新しいShort-range repressorの同定、機能解析。
4、癌形成モデルの機能解析。

ChIP-qPCRや ChIP-on-chip (or ChIP-seq)といった技術を取り入れています。ショウジョウバエの経験は問いませんが、転写の研究や分子生物学的手法(プラスミド構築やPCR)に精通している人を歓迎します。着任時期は、できるだけ早く。給料と健康保険などの待遇は、大学で決められた規定によります。我々の大学は、ポスドク用のアパートを用意しています。

問い合わせは、電子メールでお願いし ます。また、応募に際しては、履歴書(業績リストとこれまでの簡単な研究内容も含 めます)と推薦者3名の氏名・所属・連絡先を電子メールで送って下さい。

Yutaka Nibu, Ph.D.
----------------------------------------
Assistant Professor,
Department of Cell and Developmental Biology,
Weill Medical College of Cornell University,
1300 York Avenue - Box 60, A308,
New York, NY 10065, USA
Tel: +1-212-746-6202
Lab Tel: +1-212-746-6184
Fax(Department): +1-212-746-8175
E-mail: yun2001@med.cornell.edu
lab's home page: http://cornellcelldevbiology.org/nibu/
http://www.med.cornell.edu/research/ynibu/index.html
-----------------------------------------

投稿者:Yutaka Nibu(yun2001@med.cornell.edu)

2009.05.16

University of California in Los Angeles, UCLA AIDS Institute ポスドク募集

University of California in Los Angeles, UCLA AIDS Institute, An研究室は、さらにNIHグラントを獲得できる予定があるため、エイズ遺伝子治療研究に興味のあるポストドクトラルフェローを追加募集します。

An研究室は2007年に発足した新しいラボです。ラボの研究目的は、エイズ感染症の遺伝子治療を確立することです。現在日本から留学しているポストドックは、今年論文を2報投稿しました。

研究課題は、1、抗エイズウイルス遺伝子の同定 (特にRNAi)。2、血液幹細胞に遺伝子導入するベクターの開発。3、動物モデルを用いウイルス抑制効果と安全性を判定する。 4、HIV感染患者の遺伝子治療clinical trialを実施する。

論文 (2003-2009, 抜粋)
1. Qin X-F*, An DS*, Chen IS and Baltimore D. Inhibiting HIV-1 infection in human T-cells by lentiviral-mediated delivery of siRNA against CCR5. Proceedings of National Academy of Sciences of the United States of America. 2003 Jan 7;100(1):183-8.
2. An DS, Qin X-F, Auyeung VC, Mao SH, Kung SP, Baltimore D, Chen IS. Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors. Mol Ther. 2006 Oct;14(4):494-504.
3. An DS, Poon B, Fang RH, Weijer K, Blom B, Spits H, Chen IS, Uittenbogaart CH. The Human immune system (HIS) RAG-/-{gamma}c-/- mouse, a novel chimeric mouse model for HIV-1 infection. Clin Vaccine Immunol. 2007 Feb 21.
4. An DS, Donahue RE, Kamata M, Poon B, Metzger M, Mao SH, Bonifacino A, Krouse AE, Darlix JL, Baltimore D, Qin FX, Chen IS. Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13110-5.
5. Shimizu S, Kamata M, Kittipongdaja P, Chen KN, Kim S, Pang S, Boyer J, F. Qin XF, An DS, Chen IS. Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5. Manuscript accepted in The Genetic Vaccines and Therapy.
6. Shimizu S, Hong P, Pokomo L, Boyer J, Koizumi N, Kittipongdaja P, Chen A, Bristol G, Galic Z, Zack JA, Chen IS, Lee B, An DS. RNA interference induces CCR5 down-regulation in systemic lymphoid organs including in the gut of the NOD/SCID-hu BLT mouse model. Manuscript submitted.

[ 募集人数 ] 1名

[ 応募資格 ] 医学系、理学系、農学系、または、薬学系博士号保持の方、
または取得見込みの方。

[ 待遇 ] University of California Los Angeles (UCLA) の規定による。
[ 応募書類 ]1)履歴書、論文リスト2)これまでの研究概要(1000字程度)3)An研究室に応募した理由(500字程度 )。4)推薦状3通と推薦者の連絡先
[ 就任時期 ] 採用決定後、速やかに就任してもらいます。

好奇心が強く、固い意志で実験を遂行できる研究者を募集します。当研究室はやる気のある研究者に最適の研究環境を提供します。分子生物学、 細胞培養、ウイルス感染実験マウス実験の経験のある方は優先して採用します。
UCLAは、ロサンゼルスの中でも治安の良い場所に位置し、気候は最高に良く、日本食レストラン、スーパーも沢山あり、安心して生活できると思います。

以上の書類をemailにてDong Sung An (an@ucla.edu) まで送付してください。英語、日本語どちらでもかまいません。

「問い合わせ先」
Dong Sung An. M.D., Ph.D.
Adjunct Assistant Professor
Dong Sung An office 183-AN
Dong Sung An lab 188(06)
UCLA AIDS Institue
BIOMEDICAL RESEARCH BUILDING
UCLA
615 Charles E. Young Drive South
Los Angeles, California 90095
+1(310)206-2063 lab phone number
+1(310)983-1070 office phone number
+1(310)983-1067 fax

投稿者:Dong Sung An(an@ucla.edu)

2009.05.15

ペンシルヴァニア大学病理学部 ポスドク募集

Tone Lab (ペンシルヴァニア大学病理学部) にてポスドクを募集しています。

高等生物の免疫系は、T細胞、B細胞、樹状細胞(dendritic cells, DC)等の免疫細胞により、抗原の提示、細胞表層リセプターを介した細胞間のコミュニケーション等により巧妙に制御されています。
 PIのTone_M (刀禰)は、長年 英国オックスフォード大学にて制御性T細胞(Treg)、 DCの活性を制御するサイトカイン、TNF並びにTNF Receptor superfamily(GITR, GITR ligand, CD40等)の研究をおこなっておりました。現在、 ペン大の研究室では、Treg細胞の分化、T細胞内での遺伝子発現機構の解明、更にはT細胞並びに抗原提示細胞(DC)を介した免疫系の活性化機構への解明、癌治療への応用を主眼に据え研究を行っております。
 今回こちらの研究者の移動/帰国ならびに当研究室の移動に伴い、新たにポスドクを募集する事となりました。当研究には マウスを使用する事もございますので、マウスを用いた研究の経験者は歓迎いたしますが、やる気の有る方であればこちらで技術を取得する事も可能です。PhD またはMD取得者で、出来れば、 免疫、分子生物学等の基礎知識の有る方を希望いたします。奨学金や大学などからの留学資金のサポートのある希望者は、経験の有無に関わらず採用を検討いたします。 研究室の移動に伴い職務先はフィラデルフィアとは限りませんのでご了承ください。
興味の有る方は、ytone@mail.med.upenn.eduまでご連絡ください。
期間:3年程度。NIH指導要綱のポスドクの一年目の給料相当額が基準になります。

Reference:
1.Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Tone Y., et.al. Nat Immunol. 2008 Feb;9(2):194-202.
2.Structural basis for ligand-mediated mouse GITR activation. Zhou Z., et.al. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):641-5.
3.OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites. Tone Y., et.al. J Immunol. 2007 Aug 1;179(3):1760-7.
4.Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Tone M., et.al. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15059-64.

投稿者:Yukiko TONE (刀禰 有紀子)(ytone@mail.med.upenn.edu)

2009.05.14

National University of Singapore ポスドク募集

Postdoctoral position available in protein degradation, stem cell, and cancer

Cancer Science Institute (CSI)-Singapore
National University of Singapore (NUS)

Regulated protein degradation plays crucial roles in many biological processes. De-regulation of protein degradation is frequently observed in human diseases including cancer.

The APC (anaphase promoting complex), an E3 ubiquitin ligase essential in regulating cell cycle, was first identified as a factor mediating mitotic Cyclin degradation. Recent studies have shown that the APC also mediates the degradation of proteins not related in function to mitosis in higher eukaryotes.

My group focuses on studying the molecular mechanism and physiological relevance of "non-canonical" APC-dependent protein degradation in multicellular organisms using both in vitro and in vivo systems (Wu Q, et al. Curr Biol. 17: 213-224, Araki M, et al. Genes Dev. 19: 2458-2465). In addition, we study the protein degradation pathways involved in tumorigenesis and development.

Experience in molecular and cell biology techniques as well as having strong communicative skills is advantageous. Candidates should submit a full CV with the names and contact information of three referees and a brief description of intent of research to Dr. Marito Araki, Cancer Stem Cell Program, Cancer Science Institute (CSI)-Singapore, National University of Singapore, Email: csima@nus.edu.sg

投稿者:荒木 真理人(csima@nus.edu.sg)

2009.05.10

La Jolla Institute for Allergy & Immunology Postdoc募集

One postdoctoral position is available in the laboratory of Dr. Nunzio Bottini at the La Jolla Institute for Allergy & Immunology, La Jolla, California. The laboratory specializes in tyrosine phosphatases and in their role in T cell signaling and in autoimmunity. The research project will focus on the regulation of the tyrosine phosphatase PTPN22, encoded by a major autoimmunity gene (Nat Genet 37:1317, 2005 and Hum Mol Genet 18:569, 2009), using a combination of signal transduction/cell biochemistry and in vivo immunology approaches. The position is available immediately and funded by a new NIH R01 grant. Postdoctoral candidates must have a Ph.D. or M.D./Ph.D. in Cellular or Molecular Biology, Immunology, or a related field, and must have an outstanding record of publications in peer-reviewed journals. Candidates must be hard-working, highly motivated, and able to work independently. Excellent team-working abilities are also required. Interested individuals should send a co!
ver letter and CV with names of at least three references. Please do not include reference letters in the application. Please no phone inquiries. Please email all material to:
Nunzio Bottini, MD, PhD, Associate Member
Division of Cell Biology
La Jolla Institute for Allergy & Immunology
9420 Athena Circle
La Jolla, CA 92037
Phone: (858) 752-6815
Fax: (858) 752-6985
Email: nunzio@liai.org

posted by Nunzio Bottini, MD, PhD (nunzio@liai.org)

2009.05.09

University of Nebraska Medical Center Postdoc募集

Position is available immediately on NIH-funded project at the level of Postdoctoral fellow. Successful candidate will use gene-targeting technology, microarray and Chip assay analysis to address important questions in regulation of cell survival facing various environmental stresses. Projects include analysis of gene regulation and identification of factors that regulate cell survival. Candidate must have Ph.D. or equivalent degree and have a background in molecular and cellular biology. Additional experience in one or more of the following areas is preferred: protein chemistry/ protein-protein interaction(s), cell culture and gene transcription. Interested candidates should send curriculum vitae and name of three references to Dhirendra P. Singh, Ph.D., Associate Professor, Laboratory of Cellular and Molecular Biology, Rm# 4051, 4056 and 4058, University of Nebraska Medical Centre, 985840 Nebraska Medical Centre, Omaha, NE 68198-5840. Tele: 402-559-8805, Fax: 402-559-8808,!
EMAIL; dpsingh@unmc.edu
Affirmative Action / Equal Employment Opportunity

Reference:
Kubo E, Singh DP, Akagi Y. Gene expression profiling of early Diabetic and galactosemic cataractous rat lens by microarray analysis. Diabetologia, 2005;48:790-798
Fatma N, Kubo E, Sharma P, Beier DR, Singh DP. Impaired homeostasis and phenotypic abnormalities in Prdx6-/- mice lens epithelial cells by reactive oxygen species: increased expression and activation of TGFbeta. Cell Death and Differentiation. 2005; 12: 734-750
Takamura Y, Fatma N, Kubo E, Singh DP. Regulation of heavy subunit chain of &gamma-glutamylcysteine synthetase by tumor necrosis factor-alpha; in lens epithelial cells: role of LEDGF/75. Am J Physiol.-Cell Physiol. 2006; 290: C554-566
Singh D.P, Kubo E, Takamura Y, Shinohara T, Chylack LT,Jr., Fatma N. DNA-binding domains of LEDGF; Contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of N-terminal to the transactivation potential of LEDGF. J. Mol. Biol. 2006;355:379- 394

Posted by Dhirendra P. Singh, Ph.D. (dpsingh@unmc.edu)

2009.05.05

International Max Planck Research School - Molecular Biomedicine PhD Fellowship

The International Max Planck Research School – Molecular Biomedicine (IMPRS-MBM) and the Graduate Program Cell Dynamics and Disease (CEDAD) offer 16 PhD Fellowships in Life Sciences. CEDAD and IMPRS-MBM - jointly run by the University of Münster and the Max Planck Institute for Molecular Biomedicine - offer integrative approaches to biomedical research with a strong emphasis on imaging.

Research areas:
Cell and Molecular Biology
Stem Cell Biology
Developmental Biology
Neurobiology
Vascular Biology
Immunology
Microbiology
and more

The application deadline for the 3-year PhD program is June 15, 2009. Projects start in October 2009.

Please apply via WWW.CEDAD.UNI-MUENSTER.DE

The program offers excellent scientific and transferable skills training. The program language is English. There are no tuition fees. Successful candidates will receive a competitive tax-free fellowship as well as support with administrative matters, accomodation, visas etc. We invite applications from highly qualified and motivated students of any nationality. We are looking forward to your application for a PhD fellowship in Münster, "the world’s most liveable city" (LivCom Award 2004).

Posted by Martin Wild (cedad@uni-muenster.de)

2009.05.04

ルイジアナ州立大学医学部微生物学・免疫学講座 ポスドク募集

ルイジアナ州立大学医学部Louisiana State University Health Science Center (LSUHSC)微生物学・免疫学講座Department of Microbiology and Immunologyでは自己免疫・ウイルス感染病態・神経病(特に神経内科)に興味がおありのポスドクを募集いたします。

当研究室では、神経病理学・免疫学・ウイルス学的手法を用いて中枢神経の自己免疫およびウイルス感染症のマウスモデルの研究をユタ大学医学部でしてまいりました。具体的には、多発性硬化症の動物モデルである実験性アレルギー性脳脊髄炎とタイラーウイルス感染症モデルを主に使用しております。7月の研究室のルイジアナへの移転に伴い、人のサンプルの解析やマイクロアレイ解析をもとにしたバイオインフォマテクス研究の予定もあり、この分野の経験のある方も歓迎いたします。

現在までの当研究室の情報はユタ大学の以下のサイトをご覧ください。
http://www.path.utah.edu/research/cbi/ikuo-tsunoda-md-phd

ルイジアナの情報は以下のサイトをご覧ください。
http://www.lsuhscmicro.com/Tsunoda1.htm


資格:PhDまたはMDが好ましい。分子生物学・細胞生物学の実験手技を有する方(RT-PCR, Microarray, siRNAなど)でマウスを用いた動物実験に携われる人(マウスの扱いの経験がなくても可)。ただし、奨学金や大学などからの留学資金のサポートのある希望者は、経験の有無に関わらず採用を検討いたします(研究歴のない臨床医の先生など)。

待遇:1−3年程度。NIH指導要綱のポスドクの一年目の給料相当額$37,000/年(ただし、ルイジアナの規定により保険その他は各自負担となります)が基準になります。学位取得前であれば、ルイジアナの大学院生の給料$22,000/年が参考になります。

着任時期:2009年7月中旬以降、できるだけ早い時期。採用が早ければ9月末締め切りの総説に第一著者として執筆をお願いします(招待された総説ですので採択率は100%)。また、現在、実験が半分まで終了している論文を仕上げていただければ一年以内に第一著者として論文を投稿していただきます。

応募書類:1)履歴書 (日本の一般的な履歴書で結構です) 2)業績リスト 3)推薦者の連絡先(できれば3名ですが1名でも可。現時点では推薦状は不要)。4)これまでの研究内容、取得した実験手技と志望動機 

興味のある方は下記のメールアドレスまで日本語で連絡ください。文字化けすることがありますので、メールの本文と応募書類を添付文書にしてご送付ください。できれば6月中旬に日本で希望者に面接を行います。


itsunoda@hotmail.com またはikuo.tsunoda@hsc.utah.edu

角田 郁生
ユタ大学医学部病理学講座Assistant Professor
ユタ大学医学部神経内科学講座Adjunct Assistant Professor


現住所
Ikuo Tsunoda, MD, PhD
Assistant Professor
Department of Pathology, Division of Cell Biology and Immunology
University of Utah School of Medicine
Salt Lake City, Utah 84103, USA

2009年7月からの住所
Ikuo Tsunoda, MD, PhD
Assistant Professor
Department of Microbiology and Immunology
Louisiana State University Health Science Center
Shreveport, Louisiana

投稿者:Ikuo Tsunoda(itsunoda@hotmail.com)

2009.05.01

Southern Illinois University School of Medicine ポスドク募集

Postdoctoral Position in Neurophysiology

A postdoctoral position (research associate) is available to study the role of a neuropeptide and its receptor in synaptic transmission and plasticity in slices from the hippocampus and the amygdala. You will use whole cell patch clamp recording under IR microscopy to study how this recently discovered receptor modulates excitatory postsynaptic responses and long-term potentiation (LTP) and what the cellular mechanisms are underlying this modulation. Renewal of this position is available up to 2 years. Minimum qualifications include a doctoral degree. Experience with electrophysiology in brain slices is desirable, but those who have experience with in vivo physiology and want to expand their research expertise to in vitro electrophysiology are highly welcome. The laboratory is equipped with four state-of-the-art electrophysiology setups, including one for multi-electrode array recording from slices, as well as for conducting molecular biological studies, cell culture, micros!
copy, and receptor binding assays. For more information about the laboratory, visit the Arai lab website
(http://www.siumed.edu/pharm/faculty/Arai/AraiLab.htm). Applications for this position will be received through May 29, 2009, or until filled, for an anticipated start date of July 1.

Send CV and the name, phone number and e-mail address of three references to: aarai@siumed.edu, or to Amy C. Arai, Ph.D., Department of Pharmacology, Southern Illinois University School of Medicine, P.O. Box 19629, Springfield IL 62794-9629. AA/EOE.

投稿者:Amy C. Arai, Ph.D.(aarai@siumed.edu)

2009.04.26

University of California Davis ポスドク募集

 University of California DavisのDr.Isseroff (Department of Dermatology)が損傷の治癒機構における分子学的解析ならびに,新規の損傷治療法の開発に携わって頂けるPostdocを募集しております。
 Dr.Roslyn Rivkah Isseroff,M.D.は私の上司の同僚で,教室内での信頼が厚く,人柄,仕事の内容など色々な点において安心して仕事が出来る研究者です。
 DavisはCaliforniaの州都Sacramentoの隣に位置し UC Davis(UCD; www.ucdavis.edu/index.html)を中心とする学園都市です。比較的治安も良く,大きな支障が無く日常生活を送られるかと思います。UCDには多くの日本人のPostdocならびに教職員の先生方が在籍されており,様々な基礎研究ならびに臨床研究が行われております。また他教室,他大学との共同研究も積極的に実施されております。
 以下にDr.Isseroffの募集要項を掲示致しますので,関心を持たれました方は
Dr.Isseroff(rrisseroff@ucdavis.edu)宛にメールにて直接ご連絡をお願い致します。またUCD等についての御質問などがありましたら,私宛にメールを頂ければお手伝いが出来るかと思いますのでお気軽にお問い合わせ下さい。

Postdoc Position - University of California, Davis
TB 192, One Shields Avenue
Davis, CA, 95616

Candidates are invited to apply for a Postdoctoral Research position for two to three years at the University of California, Davis, to work on molecular mechanisms and novel therapeutic approaches to combined radiation and burn wound injury.

In vitro culture based, ex vivo and in vivo models of healing are used and tools used to probe these models include DNA microarays and microbead array assays for kinase reactants. The role of the adrenergic signaling system in modifying the healing response will be examined. The candidate would join a multidisciplinary group of investigators in a stimulating academic environment with strong potential for translational research. Collaborative laboratories in this project share an interest in wound repair, microarray analysis of gene expression, and stem cell contribution to tissue regeneration. The candidate should have proficiency in basic cell biological techniques, and familiarity
with microscopic image analysis and immunohistochemistry. Background in keratinocyte biology, wound healing and/or adrenergic receptor signaling areas would be an asset. Strong verbal and written English skills required.

The position is funded by a five-year grant from the NIH. Salary is dependent on
level of training, and is competitive. Generous University benefits package.
Applicants should submit a curriculum vitae, including list of publications, a
description of their present research activity and contact information for three
referees, to:

Rivkah Isseroff
University of California, Davis
TB 192, One Shields Avenue
Davis, CA, 95616
fax: 530-752-9766, phone: 530-752-9767
email:rrisseroff@ucdavis.edu

投稿者:Yoko Ono(yknono@ucdavis.edu)

2009.04.25

国立シンガポール大学メカノバイオロジーポスドクあるいは大学院生募集

国立シンガポール大学メカノバイオロジー(ポスドクあるいは大学院生)

私たちのグループでは、メカニカルストレス(物理的な環境・刺激・因子)が、組織、細胞、さらには分子の機能を制御するメカニズムの解明を目指しています。メカノバイオロジーというと、これまでは骨や血管循環器系に関わる研究が多かったのですが、その定義はまだ確立おらず、「こんなことまでメカノなの?」というくらいに物理/機械的因子は広く細胞の機能や現象に関わっていることを示そうと考えています。そこで、骨や血管に限らず、神経、癌、転写因子、細菌、酵母などをふくめて、バイオロジーのどのような研究分野でも構いません。「こいつもメカノでは?」あるいは「こんなのをメカノという観点でみたら超大物が釣れないだろうか?」といった発想で、新しい流れをつくってみたいという方に、ライフサイエンスの新興国シンガポールで研究に没頭できる環境を用意したいと思います。大学およびラボ内の公用語は英語ですが、日本語、中国語、マレー語(?)が飛び交っているため、英語に自信がない方でもスムーズにラボに溶け込むことができ、すぐに研究を遂行できると思います。なお、メカノバイオロジープログラムはすでに始まっておりますが、今如�11月に大学キャンパス内の新築のビルにラボが移転・拡充いたします。そこで11月からの赴任がベストではないかと思います(それ以降でももちろん結構です)。
 ポスドクでの採用に際しては、英文のpeer-reviewed paperが少なくとも1編、アクセプトになっていることが必要です(アクセプトになりそうになっている、でも可)。また、海外学振(http://www.jsps.go.jp/j-ab/ab_boshu_f.htm)に応募したいという方は、申請期限が迫っておりますので早めにご連絡ください。
 大学院は博士課程(4年間奨学金授与)であり、毎年2回、1月と8月に新入生を受け入れますが、それぞれ約3ヶ月前までに応募する必要があります。今年8月の入学でも今ならまだ間に合いますので、やはり早めにご連絡ください。

参考文献
1. Sawada Y. et al. Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell. 2006
2. Tamada M., M. P. Sheetz, and Y. Sawada. Activation of a signaling cascade by cytoskeleton stretch. Dev Cell. 2004.
3. Sawada Y. and M. P. Sheetz. Force transduction by Triton cytoskeletons. J Cell Biol. 2002.
4. Sawada Y. et al. Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase. J Cell Sci. 2001.
5. 澤田泰宏ほか. Srcファミリーキナーゼの基質p130Casの伸展を介するメカノセンシング. 実験医学. 2007年4月号
6. 澤田泰宏. 細胞骨格に存在する新しいタイプのメカノセンサーの発見. 蛋白質核酸酵素. 2007年9月号

Web-sites
Lab: http://www.dbs.nus.edu.sg/staff/sawada.html
Research Centre for Excellence in Mechanobiology: http://www.dbs.nus.edu.sg/mechano/index.html

Yasuhiro Sawada, M.D., Ph.D.
Associate Professor
Research Centre for Excellence in Mechanobiology
Department of Biological Sciences and Division of Bioengineering
National University of Singapore

投稿者:澤田泰宏(dbssy@nus.edu.sg)

2009.04.18

University of Wisconsin-Madison ポスドク募集

A postdoctoral position is available immediately at the Department of Medical Genetics, University of Wisconsin-Madison.

-Projects-
Our laboratory works on a number of mouse mutants as models to study neurodegeneration, synaptic abnormalities in neurological diseases, aging of the synaptic structure, abnormal cell proliferation and neovascularization. We are trying to identify genes responsible for these phenotypes and their interacting factors, which will allow us to understand genetic disorders as well as normal biological mechanisms at the molecular level.
Potential projects are described below:
(1) Identification of modifier gene(s) that rescues retinal abnormalities
We identified a major modifier locus, which rescues retinoschisis (splitting of the retinal layer) in Rs1 mutant mice. We are currently testing the candidate genes. Upon identification of the modifier gene, functional analysis of the gene will be performed.
(2) Identification of gene(s) involved in vesicle trafficking and neurodegeneration
We recently positionally cloned a novel gene that is responsible for Purkinje cell degeneration. The gene is involved in the vesicle trafficking pathway. Characterization of the gene product for vesicle trafficking, identification of physically and genetically interacting factors will be the potential project.
(3) Positional cloning of the gene associated with aging of the retinal synapse
We have ENU-induced mutant mice in which some aspects of age-associated retinal abnormalities are mimicked and accelerated. We have mapped the responsible gene and are currently in the process of positionally cloning the gene.
(4) Role of actin regulatory molecules in the control of cell proliferation.
We work on mutant mice showing abnormal cell proliferation and neovascularization in the cornea. We identified a key transcription factor that may mediate the status of actin filaments and change the gene expression profile in these mutant mice. We are analyzing the role of this transcription factor in the development of mutant phenotypes using a combination of the Tet-on and Cre-lox systems and in vitro molecular biological approaches.

-Laboratory-
Our laboratory is still young and relatively small (total 6 researchers and students combined are currently working in the lab). However, we have been quite productive and a number of exciting projects are growing in the lab. We are sure that we can offer a great research environment. The lab is well funded by NIH and other agencies, and is located in Madison, Wisconsin, which is a very nice place to live.

-Candidate-
The successful candidate will have a Ph.D. degree in any of the biological areas. Prior experience in our area of study or mouse genetics is not necessary. However, passion for learning hard-core mouse genetics and motivation to be successful are required.

-Terms of employment-
The position is for a period of 2 years initially.

-Application-
Please send a CV (including a research interest, a publication list and the names of 3 potential referees) by mail or e-mail to:

Akihiro Ikeda, D.V.M., Ph.D.
Sakae Ikeda, D.V.M.

Department of Medical Genetics
University of Wisconsin-Madison
425-G Henry Mall
Madison, WI 53706
Office Tel: +1-(608)262-5477
Lab Tel: +1-(608)262-5991
Fax: +1-(608)262-2976
email: ai777@charter.net (English or Japanese)

https://www.genetics.wisc.edu/faculty/profile.php?id=158
http://vision.wisc.edu/leader_ikeda.html
http://vision.wisc.edu/member_ikeda.html

投稿者:Akihiro Ikeda

2009.04.17

Harvard Medical School, Beth Israel Deaconess Medical Center Postdoc募集

A post-doctoral position is available immediately in the Wei lab at Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School. The lab’s focus is on understanding how Ubiquitin E3 ligase APC (Wei et al., Nature 428: 194, 2004; Gao et at Nature Cell Biology 11: 397, 2009) and SCF (Wei et al., Cancer Cell 8: 25, 2005) activities contribute to cell cycle regulation and subsequent tumor formation. Future projects in the lab engage the use of biochemistry, molecular biology and genetic approaches, cell culture techniques and potentially mouse modeling. Therefore, energetic applicants with strong experimental background in biochemistry, molecular and cellular biology and/or genetics are encouraged to apply.

Dr. Wei is looking for self-motivated individuals to become involved in the challenging and rewarding environment of the laboratory. If interested, please send your CV/resume and three references to

Wenyi Wei, Ph.D
Dept. of Pathology, Harvard Medical School
Beth Israel Deaconess Medical Center
CLS-534, 330 Brookline Avenue
Boston, MA 02115
Phone: (617) 735-2495
Email: wwei2@bidmc.harvard.edu

Posted by Wenyi Wei (wwei2@bidmc.harvard.edu)

2009.04.16

University of Texas Medical Branch ポスドク募集

リフトバレーウイルス(ブニヤウイルス)の病原性因子(NSs蛋白) の機能を解析するプロジェクトに興味のある方を募集しています。NSsは感染細胞の転写を抑制し、PKRを分解することによってtype-I IFNによる初期免疫を抑制しウイルスの増殖を助けます(PLos Pathog. 2009, PMID19197350)。当研究室ではReverse geneticsによって作製した変異ウイルスを用いて各機能の意義やメカニズムを解析しています。研究室は2009年の4月に立ち上げたところで、Ph.D (できればウイルス学かその他関連する分野)取得後1年未満の候補者を約3年契約で募集します。実験、アメリカのウイルス学会などでの発表、論文作製などが仕事内容です。大学内もしくは学外の奨学金取得による期間延長も可能です。興味のある方はCVを下記アドレスまでe-mailで送って下さい。採用はVISA手続(2-3ヵ月)後、9月頃を予定しています。良い候補者が見つかり次第、募集を終了します。

Tetsuro Ikegami, D.V.M., Ph.D (e-mail: teikegam@utmb.edu)
Department of Pathology
University of Texas Medical Branch
301 University Blvd. Galveston TX77555

投稿者:Tetsuro Ikegami(teikegam@utmb.edu)

2009.04.14

Ontario Cancer Institute, University of Toronto ポスドク募集

募集内容:ポスドク研究員を1名募集します。
研究内容:主としてDNA損傷応答、ヒストン修飾(メチル化、脱メチル化)の研究を通じて、癌化や形態形成の諸問題に取り組みます。
応募資格:博士過程を終了、あるいは終了見込みで、分子生物学的手法を十分習得し, 細胞生物学、或は遺伝子改変マウスの表現形質解析経験のある方。優れたコミュニケーション能力を有し,自由な雰囲気の中で独立して研究テーマを推進できる、意欲あふれる方を期待しています。採用時期は相談に応じます。興味のある方は気軽にお問い合わせ下さい。

待遇:研究所の規定に従います。2−3年程度。
応募書類:1. 履歴書と発表業績リスト, 2. 推薦者3名の連絡先, 3. これまでの研究内容、取得した実験手技と、志望動機(日本語可)をE-mailでお送りください。
参考文献:J. Cell Biol. 182 (3):449-458 (2008), Genes Dev 21: 848-61 (2007)
参考:トロントはカナダの東部に位置しオンタリオ湖に面した自然豊かな環境で、Sick Kids Childrens Hospital、Toronto Gneral Hospital、University of Toronto、Mount Sinai Hospital等の研究施設が集まっており、研究交流も盛んです。

連絡先:Hitoshi Okada, MD, PhD
Assistant Professor
Signaling Biology Division, Ontario Cancer Institute
Department of Medical Biophysics, University of Toronto
E-mail: hokada@uhnres.utoronto.ca (日本語可)

投稿者:岡田 斉(hokada@uhnres.utoronto.ca)

2009.04.13

ミシガン大学ポスドク募集

わたしの同僚でもあり共同研究者でもある、ミシガン大学歯学部のベサ カーティネン博士の研究室では下記の要領でポスドクを募集しています。カーティネン研究室ではマウスモデルを用いてTGF-bやBMPシグナルの顔面形成や心臓発生での役割を精力的に調べています。昨年秋にこのサイトで顔面形成の解析をするポスドク募集の案内をさせていただきましたが、幸いなことに非常に優秀な人材を得ることができ、ベサ本人も大変喜んでいます。

今回は特に心臓発生を中心に解析を進めるメンバーを募りたいということです。ミシガン大学はデトロイトの郊外のアナーバーという大学町にあり、便利さと安全性をともに備えたところです。こちらの歯学部は医学部や理学部などとの交流もさかんで、研究環境としては大変よいところです。興味のある方は直接ベサあてにご連絡ください。

ミシガン大学歯学部生命材料科学科 三品裕司 mishina@umich.edu

====================


A post-doctoral research specialist position is immediately available at the Department of Biologic and Materials Sciences, University of Michigan, School of Dentistry to work in the area of growth factor signaling in cardiac development and its translational applications. Our investigation and characterization of heart development involves generation of new mouse models, analysis of existing mouse models, mammalian tissue and organ culture, and models of tissue regeneration in normal and diseased animal models For additional information see: http://www.dent.umich.edu/depts/bms/personnel/faculty.php?uname=vesak.
A strong background in cellular biology, biochemistry or developmental biology is essential. We are seeking an outstanding individual who will have the opportunity to investigate both basic biology of cardiac development and its translational applications. Qualified applicants should send their curriculum vitae and the names and email addresses of two references to:

Vesa Kaartinen, PhD
Associate Professor
vesak@umich.edu

投稿者:三 品 裕 司

2009.04.12

オハイオ州立大学脳神経外科腫瘍幹細胞研究室 ポスドク募集

<研究内容>
オハイオ州立大学脳神経外科腫瘍幹細胞研究室(PI: Ichiro Nakano)では、ポスドクを募集します。当研究室はUCLA脳神経外科において2006年に立ち上がり、2009年9月からOSUに移ります。仕事内容は、神経幹細胞及び脳腫瘍の遺伝子解析、脳腫瘍における腫瘍幹細胞(cancer stem cell)の解析、動物モデルを用いた腫瘍増殖のメカニズムの解析(preclinical trial)です。参加されるフェローには、当研究室独自のbrain tumor stem cellに対する新たな治療法を解析するプロジェクトと共に、学内での共同研究に積極的に関わっていただきます。

<生活>
オハイオ州コロンブスは五大湖周辺都市としては珍しく人口増加を続ける、都市圏人口150万人の州都です。自動車会社ホンダの北米生産拠点を有し、日本の食料品や日用品も多くは手に入ります。この地は知的財産を扱う業種が多く、街は清潔感あり安全面も整っており生活しやすい中堅都市です。気候は日本の札幌に近く冬は寒いですがそれ以外はすごしやすいところです。近い都市としては、Washington DCまで車で6時間程度、New Yorkまで車で8時間程度です。物価は私自身が以前住んでいたLAの60%程度で、留学生活を快適に過ごしていただけると感じております。

<募集要件>
(1)有給の研究ポスドク
資格:MDまたはPhD
生化学と分子生物学の実験手技を有する方(PCR, cloning, Western blot, IHC, ICC, cell culture, cDNA microarray, RNA/DNA handling 等)で、特にin vivoの実験(transplantation, ventricular injection, in utero injection, gene targeting等)が出来る方。ただ、技術より情熱と協調性を重要視します。

<期間>
2009年夏以降 2-3年間。1年ごとに契約更新。

<募集人数>
1名

<給与>
NIH grantを有しておりそこからの給与を保障します。各候補者の経験年数、NIH指導要綱をもとに決定します。

(2)脳外科臨床オブザーバーシップ、およびACGME認定クリニカルフェロー
<米国における脳神経外科の臨床>
OSU脳神経外科では、ACGME認定の脳腫瘍外科のクリニカルフェローシップが2009年に立ち上がりました。プログラムディレクターは、北米脳腫瘍外科をリードする一人Chiocca脳外科部長です。このプログラムは北米脳外科レジデンシープログラムの最終学年2年間(PGY6 and 7)のトレーニングと同等の内容を行うもので各年1人のポストで、現在のところFY2010まで埋まっています。主に脳腫瘍の手術(年間300件)と外来診療、オンコール対応と緊急手術対応を学びます。

<研究室所在地>
Department of Neurological Surgery, Ohio State University

<提出書類>
cover letter, CV(English), 3 recommendation letters

<問い合わせ先>
Ichiro Nakano, M.D., Ph.D.
Associate Professor,
Director, Brain Cancer Stem Cell Program,
The Khan Foundation Clinical Investigator,
Departments of Neurological Surgery,
Ohio State University
e-mail: inakano@mednet.ucla.edu

<参考文献>
A) Maternal Embryonic Leucine Zipper Kinase (MELK) Regulates Multipotent Neural Progenitor Proliferation. Nakano, I., Paucar, A.A., Bajpai, R., Dougherty, J,.D., Zewail, A., Kelly, T.K., Kim, K.J., Ou, J., Groszer, M., Imura, T., Freije W.A., Nelson, S.F., Sofroniew, M.V., Wu, H., Liu, X., Terskikh, A.V., Geschwind, D.H., and Kornblum, H.I. J Cell Biol. 2005 Aug 1;170(3):413-27

B) Cancerous stem cells can arise from pediatric brain tumors. Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15178-83.

C) Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Nakano I, Dougherty JD, Kim K, Klement I, Geschwind DH, Kornblum HI. Stem Cells 2007 Aug;25(8):1975-84.

D) Maternal embryonic leucine zipper kinase (MELK) is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. Nakano I, Saigusa K, Masterman-Smith M, Horvath S, Watanabe M, Negro A, Paucar AA, Lelievre V, Waschek JA, Lazareff JA, Freije WA, Liau LM, Gilbertson RJ, Cloughesy T, Geschwind DH, Nelson SF, Mischel PS, Tesrskikh A, Kornblum HI. J Neurosci Res 2007 Aug 24;86(1):48-60

E) 脳腫瘍幹細胞同定がもたらす新たな脳神経外科治療法の可能性(1) (2) 三枝邦康、中野伊知郎 脳神経外科速報 vol.18 no.3 32-332, 2008, vol.18 no.4 402-413, 2008

F) UCLAの脳科学研究とその臨床応用 中野伊知郎 脳神経外科速報 vol.17 no.3 2007.3. 371

G) Neural Stem Cell Research Center at UCLA—神経幹細胞から腫瘍幹細胞まで細胞機能解明に向けた大型プロジェクト— 中野伊知郎 実験医学 (Vol.24No.12) 2006年8月号

H) Special Review 癌幹細胞:現在の知見と医療応用
阿部剛典,稲垣亮仁,中野伊知郎 細胞工学 (Vol. 27 No.10)2008年10月号

投稿者:中野伊知郎(inakano@mednet.ucla.edu)

2009.04.11

St. Jude Children's Research Hospital Postdoc募集

Postdoctoral Fellowships in Immunology/Cellular Signaling
St. Jude Children’s Research Hospital
Department of Immunology
Memphis, TN, USA

Postdoctoral Fellowships are available at St. Jude Children’s Research Hospital to investigate cellular signaling in the immune system. The experimental models include genetically-modified mice and primary immune cells derived from these mice. We are particularly interested in dissecting the role of signaling pathways mediated by MAP kinases and sphingosine 1-phosphate (S1P) receptors in regulating basic immunological and cell biological processes. These include the development, activation, trafficking, cell cycle progression, and death of T cells and dendritic cells. We also aim to define molecular mechanisms of inflammatory, infectious and autoimmune diseases. Please see the following articles (Nature Immunology 8:1236, 2007; PNAS 103: 2274, 2006; Nature Immunology 7: 851, 2006; Journal of Immunology 174:2485, 2005; and EMBO J 23: 1576, 2004) and the website (www.stjude.org/chi) for additional information.

St. Jude Children’s Research Hospital, a private, non-profit research institute, located in Memphis, Tennessee, USA, offers a stimulating, highly collaborative research environment with state-of-the-art research resources, along with competitive salary and excellent benefits to postdoctoral fellows.

Highly motivated individuals with a recent Ph.D. in immunology, biochemistry, or cellular and molecular biology, with evidence of scientific accomplishment, are encouraged to apply. Please send curriculum vitae including a list of three references to: Dr. Hongbo Chi (hongbo.chi@stjude.org).

Hongbo Chi, PhD
Department of Immunology
St. Jude Children's Research Hospital
332 N. Lauderdale
Memphis, TN 38105
USA

St. Jude is an Equal Opportunity Employer and a Drug Free Workplace.

Posted by Hongbo Chi (hongbo.chi@stjude.org)

2009.04.10

University of Illinois at Chicago ポスドク募集

ポスドク募集
University of Illinois at Chicago
Department of Pharmacology
Center for Lung and Vascular Biology
Center for Cardiovascular Research
USA

米国イリノイ大学循環器内科/薬理学研究室では、活性酸素を介したシグナル伝達機構、血管新生、再生と幹細胞の分化作用、酸化ストレスの循環器疾患における役割に興味のある意欲溢れるポスドク研究員を募集します。

[研究テーマ] 1) 酸化ストレスと心血管病態 (高血圧、動脈硬化、糖尿病) に関する研究、2) 活性酸素関連遺伝子発現調節に関する研究、3) 活性酸素を介した細胞内シグナル伝達機構の解明、4) 活性酸素の細胞増殖、血管新生、再生に関する研究

「資格」分子生物学および細胞生物学技術あるいは知識を有する博士号取得(見込)者で研究に興味を持っている意欲的な方。動物実験およびhistologyが出来る方も歓迎します。

「給与」博士号取得後年数に依存
「提出書類」履歴書、研究業績リストおよび主要論文の別刷(発表論文のない場合は、これまでの研究の概略)、推薦者の連絡先

「問い合わせ先」
Masuko Ushio-Fukai, PhD, FAHA
Tohru Fukai MD,PhD, FAHA

University of Illinois at Chicago,
Department of Pharmacology
Center for Lung and Vascular Biology
Center for Cardiovascular Research,
835 S. Wolcott. M/C868
E403 MSB
Chicago, IL 60612
Tel: 312-996-7631 (TF office) 312-996-7665 (MUF office)
312-996-7622 (lab)
Fax: 312-996-1225

E-mail: masuko.fukai@gmail.com (日本語可)
tohrufukai@gmail.com (日本語可)

Lab URL: http://www.uic.edu/depts/mcph/ushio.htm, and http://www.uic.edu/depts/mcph/fukai.htm

投稿者:Masuko Ushio−Fukai (masuko.fukai@gmail.com)

2009.04.09

Columbia University Postdoc募集

A postdoctoral fellow position is available at the Department of Biological Sciences, Columbia University to study the mechanism of epigenetic regulation. Our lab is focused on studying chromatin organization by histone lysine methylation that includes histone methyltransferase, histone demethylases and methyl-lysine binding proteins. We employ diverse biochemical and genetic approaches to study higher order chromatin organization and the DNA damage response. Detailed information can be found at our website: http://www.columbia.edu/cu/biology/faculty-data/songtao-jia/faculty.html and our publications: Molecular Cell (2009) 33: 428-437; Nature Cell Biology (2005) 7:1007-1013; Cell (2004) 119:469-480; Science (2004) 304:1971-1976; Science (2004) 303: 672-676.

Successful candidates will be eligible for Columbia University housing, which are priced significantly below market rate. Experience in molecular biology, biochemistry or yeast genetics is desired. Interested candidates please email CV, brief description of research experience and interest, names and contact information of 3 references to jia@biology.columbia.edu.

Posted by Songtao Jia (jia@biology.edu)

2009.04.08

City of Hope's Beckman Research Institute Postdoc募集

The collegial atmosphere at City of Hope provides unique opportunities for translational and basic research, continuing education and professional achievement. We are a National Cancer Institute-designated Comprehensive Cancer Center and a leader in biomedicine. If you share our passion for discovery, consider the following opportunity within City of Hope's Beckman Research Institute, one of the nation's premier biomedical research centers.

A postdoctoral fellowship is available in the Laboratory of Dr. Ya-Huei Kuo in the Department of Hematopoietic Stem Cell and Leukemia Research at the Beckman Research Institute. Research projects involve mouse models of acute myeloid leukemias, investigation of molecular mechanisms underlying leukemogenesis, and regulatory mechanisms of hematopoietic stem cells and leukemia stem cells.

To qualify: the candidate must have a Ph.D. and a strong background in hematopoietic and leukemia stem cell research. Also, the prospective candidate should be highly motivated and have skills in molecular biology, tissue culture, flow cytometry, mouse handling along with a solid background in molecular and cell biology.

To Apply: Please send a cover letter, curriculum vitae and names and contact information of three references to Ya-Huei Kuo, Ph.D. at: YKuo@coh.org

For more information regarding Dr. Kuo's Laboratory visit: http://www.cityofhope.org/directory/people/kuo-ya-huei/Pages/default.aspx

At City of Hope, discovery and compassion work together - for life. To learn more about our organization and our opportunities, please visit http://www.cityofhope.org

Posted by Ya-Huei Kuo (YKuo@coh.org)

2009.04.07

University of Illinois College of Medicine ポスドク募集

Postdoctoral Position Available

Department of Pharmacology
University of Illinois College of Medicine
909 South Wolcott Avenue
Chicago, IL 60612-3725

Project will involve studies directed at the role of the cytoskeleton in cell signaling pathways important for cell metabolism and diabetes. Experiments will investigate the function of dematin, an actin binding protein, in the regulation of glucose transporters using genetically altered mouse models (see Khanna et al. PNAS 2002; Chen et al., J. Biol. Chem. 2007; Khan et al., J. Biol. Chem. 2008; Mohseni and Chishti, Mol. Cell Biol. 2008). Responsibilities will include phenotype analysis of the gene knockout mice, protein-protein interactions, and fluorescence microscopy to visualize cytoskeletal dynamics in the transfected cell lines.

The University of Illinois College of Medicine, the largest medical school in the United States, is located about a mile west of downtown Chicago, within proximity to many academic institutions. Chicago is a cosmopolitan world class city located on the coast of Lake Michigan. Excellent benefits including health and dental insurance will be offered consistent with the policies of the University.

For further inquiries, please send a cover letter and resume to:

Dr. A.H. Chishti
Professor, Department of Pharmacology
MC-704, COMRB, Room 5100
University of Illinois College of Medicine
909 South Wolcott Avenue
Chicago, IL 60612-3725

Email: chishti@uic.edu
Office: 312-355-1293
Lab: 312-355-1294 or 1296
Fax: 312-355-1297
www.uic.edu/depts/mcph

投稿者:Dr. Athar H. Chishti(chishti@uic.edu)

2009.04.06

Yale University School of Medicine ポスドク募集

Position in the laboratory of Dr. Yibing Qyang

A postdoctoral position is available in the area of cardiovascular (CV) stem cell biology. We are striving to ameliorate heart disease utilizing a novel population of CV stem cells, coupled with embryonic stem (ES) cells, high-throughput chemical screening and tissue engineering. Current ongoing projects cover the following areas:

1. Characterize novel signaling pathways implicated in the regulation of this novel population of CV stem cells during heart development with murine models (Laugwitz et al., Nature 433, 647-53; Qyang et al., Cell Stem Cell 1, 165-79, 2007).

2. Derive CV stem cells from human embryonic stem cells, induced pluripotent stem cells (iPS) and patient specific stem cells, utilize bio-degradable scaffold to establish engineered heart tissues (EHT) with these cells, and examine their contribution to heart repair and regeneration in animal models.

3. Establish assays for high-throughput small molecule screens to directly reprogram heart fibroblast (scar-forming cells) and quiescent adult epicardial cells into CV stem cells, respectively.

Essential Qualifications: The successful candidate must have a doctoral degree in related areas. Experience in studying embryonic development or heart physiology with animal models is required. Expertise in studying heart development with murine models is highly preferred, but not required.

Interested candidates should submit their CV including names and contact information for three references and a short description of their doctoral training and future research goals.

Dr. Yibing Qyang
Yale Cardiovascular Research Institute and
Section of Cardiology, Dept. of Internal Medicine
Yale Stem Cell Center
TAC S-310, Yale University School of Medicine
300 Cedar Street
New Haven, CT 06519

yibing.qyang@yale.edu
yqyang02@gmail.com

Please feel free to visit our laboratory website:
http://users6.nofeehost.com/yaleqyang/QyangLabResearch.htm

投稿者:Yibing Qyang(yibing.qyang@yale.edu)

2009.04.05

University of California Davis, School of Medicine Postdoc募集

Postdoc Positions Available:
Directional cell migration and the molecular genetics
at University of California Davis, School of Medicine

Highly motivated postdoctoral researchers are sought to join projects on directional cell migration (supported by Cell Migration Consortium and UC Davis fund). The postholders will undertake research projects that aim to determine the molecular mechanisms of directional cell migration. He/she can work on one or more of the following projects:
1. Cell migration in 3D cultures and the PI3 K signaling;
2. Electric field-directed cell polarization, organelle polarization and the mechanisms;
3. Genetic analysis of molecular mechanisms of electric field directed cell migration;
4. Electrical signaling in wound healing and regeneration.
Those projects are exciting development following our laboratory moved to UC Davis from University of Aberdeen. Following publications reflect some of our research direction: Nature. 2008;453:475-80. Dev Cell. 2006;11:279-87.Nature 2006; 442: 475-60. J Cell Biol 2002; 157: 921-7. Physiol Rev 2005; 85: 943-78.

Qualifications: You should have a PhD degree or equivalent, be highly motivated and have a strong commitment and interest in laboratory work. The ability to work independently and collaboratively as a member of group is essential. Experience in time-lapse video recording of DIC, Hoffman microscopy and fluorescence imaging with advanced imaging systems is what we are looking for. Experience in the following techniques would be useful: immunohistochemistry, confocal microscopy, mammalian cell transfection, tissue cultures and molecular biological techniques. We are looking for individuals who are able to design and conduct experiments independently, have interest in novel hypotheses testing. The successful candidate is expected to prepare and submit manuscripts to peer-reviewed journals, and participate in seminars and bi-weekly lab meetings.
Term: The posts are for a period of two years initially starting as soon as possible or on August 1st 2009. The successful candidate can expect a competitive salary and benefits that commensurate with the person's qualifications and experience.
To Apply: Enquiries and application should be sent to Dr. Min Zhao (email: minzhao@ucdavis.edu; http://www.ucdmc.ucdavis.edu/dermatology/faculty2/zhao.html) or Dr. Alex Mogilner (mogilner@math.ucdavis.edu; http://www.math.ucdavis.edu/~mogilner/)
(1) a brief cover letter explaining your experience, background, and career interests; (2) CV (including publications), (3) names and contact information for three references. We will evaluate applications as they arrive, until the positions are filled.

Posted by Min Zhao (minzhao@ucdavis.edu)

2009.04.04

University of California, San Diego ポスドク募集

We have an opening for a postdoctoral fellow to elucidate the molecular basis of wound healing and inflammatory skin diseases. Research projects include the investigation of the mobilization and proliferation of resident stem cells in the skin, recruitment and activation of circulating immune cells, and tissue remodeling at the wound site. These studies will take advantage of a mouse model with the conditional deletion of epidermal caspase-8 which we recently demonstrated is capable of recapitulating a complete wound healing response (Nature 2009). Interestingly, elevated expression of this protein may be the cause of impaired wound healing in diabetics and constitutively low levels of caspase-8 elicits a phenotype common to many inflammatory diseases. Thus there is an emphasis on translating our findings in this mouse model to determine how they impact human diseases.
This research program is part of a larger interest in the lab using the skin and hair as a model system to study organogenesis and tissue regeneration/repair. Our work is supported by grants from the National Institutes of Health, the American Cancer Society, the Dermatology Foundation and others. The laboratory is located on the campus of the University of California, San Diego (UCSD) in La Jolla, California and we have fruitful collaborations with colleagues in various departments at UCSD and at neighboring biomedical research institutes such as the Scripps Research Institute. A CV and letter of interest from individuals with a Ph.D. can be sent to Professor Colin Jamora at cjamora@biomail.ucsd.edu. Prior experience working with mice is preferable, but the main criteria for selecting the candidate are outstanding technical and analytical skills, enthusiasm for learning and the dedication to carry a project through to completion resulting in an important publication.

投稿者:Colin Jamora

2009.03.27

Mayo Clinic – Rochester, Minnesota ポスドク募集

ポスドク研究員募集
Division of Oncology Research
Mayo Clinic – Rochester, Minnesota

当研究室では、ガン細胞における細胞周期や細胞増殖シグナルの異常、染色体の不安定化機構の研究に興味のあるポスドク研究員を募集しています。

[研究内容]
(1)細胞増殖制御に関わるユビキチン関連因子の解析−現在、ガン抑制因子として機能する脱ユビキチン化酵素を中心に研究を行っています。これまでの研究により、この因子が遺伝子の発現調節に関わっていることがわかってきました。その分子機構の解析と制御遺伝子の同定をすすめ、この因子の欠損によって細胞がガン化に向かうメカニズムを明らかにしたいと考えています。
(2)ガン関連経路のプロファイリング−Genome-wide RNAiを用いた網羅的な解析により、細胞のガン化メカニズムの多様性や、抗ガン剤応答性の違いを研究しています。

[資格]分子生物学および細胞生物学の技術と知識を有する博士号取得(見込)者。着任時期は相談に応じます。

[提出書類]履歴書、研究業績リスト、推薦者3名の所属とe-mailアドレス。

[問い合わせ先]町田雄一 (machida.yuichi@mayo.edu) (日本語可)

Yuichi Machida, Ph.D.
Assistant Professor
Division of Oncology Research
Mayo Clinic
200 First Street SW
Rochester, MN 55905

投稿者:町田雄一 (machida.yuichi@mayo.edu)

2009.03.26

State University of New York, Upstate Medical University Postdoc募集

Postdoctoral Position

A NIH funded postdoctoral position is available immediately to study the molecular mechanism of leukemia and myeloproliferative disorders. The successful candidate will perform in vivo studies using knock-out and knock-in mice in addition to cell culture studies to identify the critical signaling pathways required for transformation/ leukemogenesis. Additional studies will involve determination of phenotype in mice by flow cytometric and biochemical analyses. [Please see some of our recent publications- Curr Opin Genet Dev (2007) 17:23-30; Cancer Cell (2005) 7:179-191; Proc. Natl. Acad. Sci. USA. (2004) 101:3130-3135; Nat. Med. (2004) 10:849-857; Cancer Cell (2002) 1:479-492]. For more information, please visit http://www.upstate.edu/pharm/faculty.php?ID=mohim

The successful candidate should have a Ph.D. within last 3 years in Molecular Biology, Cell Biology or Immunology with keen interest in science and strong research background. Most recent PhDs are preferred. Experience with flow cytometry and animal studies would be helpful although not essential. Interested individuals should send a cover letter, curriculum vitae, and the names and addresses of three references to:

M. Golam Mohi, Ph.D.
Department of Pharmacology
State University of New York
Upstate Medical University
750 East Adams St. WHA #3319
Syracuse, NY 13210
E-mail: mohim@upstate.edu

Posted by M. Golam Mohi, Ph.D. (mohim@upstate.edu)

2009.03.24

International Max Planck Research School – Molecular Biomedicine PhD fellowship募集

International Max Planck Research School – Molecular Biomedicine (IMPRS-MBM)
and
Graduate Program Cell Dynamics and Disease (CEDAD)

International PhD Program in Life Sciences
Muenster, Germany

16 PhD Fellowships

Muenster’s Graduate Program on Cell Dynamics and Disease (CEDAD) offers cutting edge science together with the newly founded International Max Planck Research School – Molecular Biomedicine (IMPRS-MBM).
CEDAD and IMPRS-MBM - jointly run by the University of Muenster and the Max Planck Institute for Molecular Biomedicine - offer integrative approaches to biomedical research with a strong emphasis on imaging.

Research areas:
Cell and Molecular Biology
Stem Cell Biology
Developmental Biology
Neurobiology
Vascular Biology
Immunology
Microbiology
and more

The application deadline for the 3-year PhD program is June 15, 2009.
Projects start in October 2009. Application forms, further information about the program and research projects can be found at
www.cedad.uni-muenster.de

The program offers excellent scientific and transferable skills training. The program language is English. There are no tuition fees. Successful candidates will receive a competitive tax-free fellowship as well as support with administrative matters, accomodation, visas etc.

We invite applications from highly qualified and motivated students of any nationality.

We are looking forward to your application for a PhD fellowship in Muenster, "the world’s most liveable city" (LivCom Award 2004).

Contact: Dr. Martin K. Wild, CEDAD / IMPRS-MBM, Schlossplatz 5, 48149 Muenster, Germany, cedad@uni-muenster.de

Posted by Martin K. Wild (cedad@uni-muenster.de)

2009.03.22

Washington State University Postdoc募集

A postdoctoral research position is available immediately to join an enthusiastic research team in the Neuroscience program (http://www.vetmed.wsu.edu/research_vcapp/Appelyard_S.asp). Our group studies how neural pathways regulate appetite. We use patch clamp techniques to determine how specifically identified neurons in the brainstem integrate and relay the effects of both neuronal and hormonal signals about energy homeostasis. A Ph.D. in a related field and peer-reviewed publications are a requirement for this position. A background in electrophysiology or cellular neuroscience is preferred. Salary is commensurate with experience. Please send your cover letter, CV and the names and email addresses of three references to Suzanne Appleyard, Dept. of VCAPP, Washington State University, Pullman, WA 99164, USA or by e mail to appleyas@vetmed.wsu.edu. WSU is EEO/AA

Posted by Suzanne Appleyard (appleyas@vetmed.wsu.edu)

2009.03.21

University of Manchester, UK Postdoc募集

Positions for Postdoctoral Scientists in Tumour microenvironment

CR-UK, Stromal-tumour Interaction, Paterson Institute for Cancer Research, Manchester Cancer Research Centre, University of Manchester, UK (www.paterson.man.ac.uk.).

• Salary ranges from £25,500 – £38,000 dependent upon experience
• Immediate start available for this position

Research areas: tumour microenvironment, metastasis, stem cells, EMT(epithelial-mesencymal transition)

Co-ordination of involvement of stromal myofibroblasts in mammary tumour progression

Paterson/Manchester Cancer Research Centre is an actively growing cancer research institute and Manchester is getting the second biggest city in UK, attracting young people to live. A 3 year Postdoctoral Scientist position is available in the laboratory of Dr Akira Orimo to elucidate molecular mechanisms by which tumour microenvironment promotes carcinoma invasion and metastasis, especially, focusing on myofibroblasts, frequently recruited into invasive human epithelial carcinomas and involved in tumour progression.
We previously demonstrated that a large population of myofibroblasts, designated carcinoma-associated fibroblasts (CAFs), present within invasive human breast carcinomas exhibited an ability to promote carcinoma growth and angiogenesis. Thus, myofibroblast-secreted stromal cell-derived factor-1 (SDF-1)/CXCL12 chemokine mediated, in part, the tumour-promoting ability of these myofibroblasts by recruiting endothelial progenitor cells (EPCs) into tumour, boosting angiogenesis (Orimo A. et al, Cell, 121, 335-348, 2005; Orimo A. and Weinberg R.A., Cell Cycle, 5, 1597-1601, 2006).


Informal enquiries please contact via email on AOrimo@PICR.man.ac.uk

Akira Orimo. M.D., Ph.D.
Group Leader, CR-UK Stromal-Tumour Interaction
The Paterson Institute for Cancer Research,
The University of Manchester, UK
Phone:44-(0)161-446-3030
web: http://www.paterson.man.ac.uk/stromal/

Posted by Akira Orimo (AOrimo@PICR.man.ac.uk)

2009.03.20

Yale University School of Medicine (New Haven, CT) ポスドク募集

Yale Cardiovascular Research InstituteはYale大学内科心臓病学主任Michael Simons 教授が率いる研究所です。今年夏に新しい研究施設に移り大幅に規模が拡大し、アメリカ国内でも有数の基礎から臨床に及ぶ包括的な心臓研究の拠点となる予定です。私のラボはSimons研究室と共同で研究を進めており、多様な研究ができる環境にあります。

エキサイティングな研究をしてみたいというモチベーションの高い研究者を募集しています。

[募集人員] ポスドク1名

[研究内容]
心血管系におけるFGFの役割の解明
血管内皮細胞と心筋細胞の相互作用の解析

[資格]
MDもしくはPhD、または学位取得見込みの方
基本的には分子生物学、細胞生物学、マウス取り扱いの経験を持つ方を募集していますが、経験より研究に対する姿勢や意欲のほうが重要と考えています。

[参考文献]
1. Murakami M, Nguyen LT, Zhuang ZW, Moodie KL, Carmeliet P, Stan RV, Simons M. The FGF system has a key role in regulating vascular integrity. J Clin Invest 2008; 118: 3355-3366
2. Murakami M, Simons M. Fibroblast growth factor regulation of neovascularization. Curr Opin Hematol 2008, 15: 215-220
3. Murakami M, Elfenbein A, Simons M. Non-canonical fibroblast growth factor signalling in angiogenesis. Cardiovasc Res. 2008, 78: 223-231

[応募方法]
Masahiro.Murakami@Yale.edu に以下を送ってください(日本語可)。
CV, cover letter, list of publication, three possible references

Masahiro Murakami, MD, PhD
Instructor of Internal Medicine/Cardiology
Yale University School of Medicine
Masahiro.Murakami@yale.edu

投稿者:村上 昌弘(Masahiro.Murakami@Yale.edu)

2009.03.19

Wistar 研究所 ポスドク募集

研究テ−マ: “RNA 編集 と RNAi 機構 の相互作用解析”

背景: ADARは部位特異的にアデノシンからイノシンに塩基修飾する RNA 編集酵素である。重要な遺伝子 (例えば GluR や 5-HT2CR) の翻訳領域で起きる RNA 編集により、生理機能の多様化に寄与する他、 多数のヒト遺伝子 pre-mRNA 非翻訳領域の repeat elements でも高頻度でRNA 編集が起きている。 ADAR1 遺伝子改変マウスは、全身に広がった細胞死により胎生致死表現型となる。さらに最近我々は microRNA の前駆体でも RNA 編集が起き、 microRNA 発現の調節、またターゲット遺伝子選択に重要な機能を果たしている事、また RNA 編集 と RNAiメカニズムが 相互干渉している事を明らかにした。細胞死機構に関与しているターゲット二重鎖 RNAの同定、またRNA 編集 と RNAi 機構の相互作用の意義の解明等が研究目標です。

応募:
Ph.D. 取得後間もない方で (1−2 年以内希望)、少なくとも3−4年は滞在できる方。分子生物学的手法を習得し、 バイオインフォマティツクス、protein-RNA interaction, 或は遺伝子改変マウスの表現形質解析経験のある方で、miRNA や non-coding RNA 研究に興味のある方を望みます。履歴書、研究業績リスト、推薦状3通を郵送。連絡先:Dr. Kazuko Nishikura (西倉和子)、 The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104-4268 USA. Tel 1-215-898-3828; Fax 1-215-898-3911; E-mail kazuko@wistar.org (日本語可)。

参考文献:
1) Chendrimada et al. 2005. TRBP links the RNase III Dicer to Argonaute 2, the catalytic engine of RNA-induced silencing complex. Nature 436: 740
2) Yang et al. 2006. Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat. Struct. Mol. Biol.13: 13.
3) Nishikura 2006. Editor meets silencer: crosstalk between RNA editing and RNA intereference. Nat. Rev. Mol. Cell. Biol. 7: 919.
4) Kawahara et al. 2007. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 315: 1137.
5) Kawahara et al. 2007. RNA editing of microRNA-151 blocks cleavage by the Dicer-TRBP complex. EMBO Reports 8: 763.
6) Kawahara et al. 2008. Frequency and fate of microRNA editing in human brain. Nucleic Acids Res. 36: 5270.
7) Kawahara et al. 2008. Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J. Neurosci. 28: 12834.
8) Iizasa and Nishikura. 2009. A new function for the RNA-editing enzyme ADAR1. Nat. Immunol. 10: 16.

投稿者:Dr. Kazuko Nishikura(kazuko@wistar.org)

2009.03.18

University of Dundee, Colledge of Medicine Postdoc募集

University of Dundee, Colledge of MedicineでPost-Docを1名募集しております。

The Biomedical Research Institute at the University of Dundee, United Kingdom (www.dundee.ac.uk/biomedres) invites postdoctoral applications in the area of cellular responses to stress and chemoprotective agents. The postdoctoral position is for a new Cancer Research UK-funded project that aims the design of mechanism-based chemoprotective agents for reducing the high risk of skin cancer associated with immunosuppressive therapies and exposure to ultraviolet radiation. The candidates are expected to hold a PhD in Biology or Biochemistry with a strong background in cell signaling, immunology, and skin biology. Experience with animal models and quantitative analytical skills are highly desirable. The salary is ~29,000 GBP per annual.

The position is available to commence at a mutually convenient date after 01.05.2009 and will last for three years with the option of extension depending on performance.

The University of Dundee is internationally recognized as a centre of excellence for life sciences research and, for the past 10 years, has been the most cited University in the UK and Europe in the field of Pharmacology and Toxicology.

Applicants should send a CV with a detailed academic qualifications, a complete list of publications, contact details of at least three professional referees, and a cover letter to Ms. Lisa Thompson (Email: l.m.thompson@dundee.ac.uk).

PIはBiochemical Reserch Instituteに所属するInstructor, Albena Dinkova-Kostovaさんになります。業績はDinkova-Kostova ATを参考にしてください。
なお、研究施設、研究内容については、私まで日本語でも問い合わせてもらって結構です。

投稿者:Tadayuki Tsujita(ttsujita@dundee.ac.uk)

2009.03.17

University of Massachusetts Medical School Postdoc募集

Post-doctoral positions are available immediately in Usha Acharya’s laboratory (Molecular Genetics of Lipid Metabolism and Signaling) in the Program in Gene Function and Expression, University of Massachusetts Medical School, MA, USA. The research involves a combined genetic, molecular, cell biological and biochemical approach to understand the in vivo functions of sphingolipids using Drosophila as a model organism. For details please refer to: Science 299; 1740(2003); PNAS 101; 1922 (2004); Neuron 57; 69 (2008). Candidates interested in applying must have a Ph.D degree and salary will be based on candidates’ experience. Interested candidates could send their CV by email to usha.acharya@umassmed.edu

Posted by Usha Acharya (usha.acharya@umassmed.edu)

2009.03.16

国立シンガポール大学がん科学研究所ゲノム腫瘍医学プログラム ポスドク(または大学院生)募集

国立シンガポール大学がん科学研究所ゲノム腫瘍医学プログラムで、ポスドク(または大学院生)1名を募集しています。

研究内容:難治性がんを治すという目的のもと、発現マイクロアレイなどのハイスループット情報と、実験生物学を組み合わせて、がんの診断学、治療学を研究しています。臨床腫瘍学とがん生物学、生物学とバイオインフォーマティクスの境界領域がフィールドです。

応募資格:発現マイクロアレイ解析を中心としたバイオインフォマティクス、および生物(または医学)統計学の経験と知識があり、自立的に解析ができることが必要です。RまたはMatlabできれば両方使えることが望ましい。また、コンピュータ科学やゲノムのシーケンス解析に精通してる方は優遇します。バイオインフォーマティクスまたは生物統計学をやってこられた方で、医学への応用を目指したい方、ウェットラブを学びたい方などには最適のラボだと思います。

着任時期:2009年9月以降、できるだけ早い時期(応相談)
待遇:国立シンガポール大学規定に準じます(住宅手当など含む)。博士取得後の年数及び経験によりますが、概して日本のポスドク給与と同レベルです。契約は最初の1年のみ単年、その後はプロジェクトの進捗に応じて複数年契約します。

シンガポールは英語の環境ですし、当研究所に限らずシンガポールには欧米の超大物研究者(当研究所の場合はDan Tenen (Harvard Univ), Joe Nevins (Duke Univ), Lorenz Poellinger (Karolinska Inst))がたくさんいらっしゃいますから、欧米への留学を考えている人のトランジションには非常に向いていると思います。2007年に一人当たりのGDPが、日本を抜いてアジアで1位となったシンガポールでは、現在、国を挙げて医学生物学研究に投資を行なっています。当研究所は年間予算20億円の大型プロジェクトです。日本人有力PIとしては伊藤嘉明先生、田矢洋一先生がいらっしゃいます。シンガポール全体の研究のレベルは、多数の優秀な外国人研究者の誘致により、すでに非常に高い位置にあります。また、シンガポールは、治安も良く、物価も安く、日本人を含む外国人が多いことから、外国人として住むのに困る事は、全くと言ってよいほどありません。

提出書類:
1. 履歴書
2. 推薦者2名の氏名および連絡先
3. これまでの研究概要(A4用紙1頁程度)
4. 研究業績リスト

問合せ先:
森 誠一
Seiichi Mori, M.D., PhD
Junior Principal Investigator
Cancer Science Institute Singapore, Genomic Oncology Programme National University of Singapore

Centre for Life Sciences #02-07
28 Medical Drive
Singapore 117456
Tel: (65) 6516 1148
Fax: (65) 6873 9664
Website: http://www.csi.nus.edu.sg/09/PI-Mori.html
email: seiichi.mori@nus.edu.sg

投稿者:森 誠一(seiichi.mori@nus.edu.sg)

2009.03.15

Katholieke Universiteit Leuven, Belgium ポスドク募集

Postdoctoral researcher – Katholieke Universiteit Leuven, Belgium

K.U.Leuven
The University of Leuven is a modern university, located within the vibrant city of Leuven in the centre of Belgium and close to Brussels, the centre of Europe. K.U.Leuven offers an ideal research and learning environment, rooted in a solid and venerable tradition but with its sights set squarely on the future.
K.U.Leuven is a richly varied community of people, with diverse interests, missions, nationalities, and expertise. That is why we invest in collaboration and human relations. We actively encourage the integration of all staff and students. Equal opportunities for all are a cornerstone of our policies. Young talent is given the necessary space to grow, in a stimulating environment. Outstanding student services are central to our vision of a university. The network of Leuven alumni reinforces the ties between the university and its former students. More information is available on:
http://www.kuleuven.be/kuleuven/japanese.html

Job description
The laboratory of Translational Cardiomiology at the University of Leuven, a part of the Stamcelinstituut, Faculty of Medicine, has a postdoctoral position available for research in stem cell biology and muscle differentiation under the direction of Prof. Maurilio Sampaolesi.

The project aims to improve the knowledge on the molecular mechanisms of cardiac and skeletal muscle differentiation and on stem cell biology, genomics and proteomics applied to both normal and pathological muscle generation. Currently we are interested in stem cell therapy for muscular dystrophies and cardiomyopathy related to some of those. Primary cultures and mesoangioblast stem cell lines established from muscle biopsies and dorsal aorta and at different post-natal ages of the animal disease models, including mice, rat and dog are available. Established cell bank of several human mesoangioblast clones are also available. Moreover, we generated recently transgenic mice developing muscle hypertrophy, which could be used for further investigations.

The laboratory of Translational Cardiomiology offers a stimulating international environment as well as state-of-the-art research facilities.

Profile
Highly motivated individuals with a strong background in biology, biochemistry and good level of spoken and written English are encouraged to apply.
The applicant will be assisting in the supervision of PhD students.

Publications
-Cassano M, Biressi S, Finan A, Benedetti L, Omes C, Boratto R, Martin F, Allegretti M, Broccoli V, Cusella De Angelis G, Comoglio P, Michieli P, Cossu G and Sampaolesi M. Magic-F1, a dimerized c-met binding domain, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis. PLOS ONE 2008 16; 3(9): e3223

-Sampaolesi M, Blot S, Bottinelli R, and Cossu G. Brief Communication Arising in Replying to Bretag AH, Nature 2007 Dec; 450: E23-25

-Tonlorenzi R, Dellavalle A, Schnapp E, Cossu G, and Sampaolesi M. Isolation and Characterization of Mesoangioblasts from Mouse, Dog, and Human Tissues. Current Protocols in Stem Cell Biology 2007, 2B.1.1-2B.1.29 Published on line September 2007 in Wiley Interscience DOI:10.1002/9780470151808.sc02b01s2

-Dellavalle A #, Sampaolesi M # , Tonlorenzi R, et al. Pericytes of human post-natal skeletal muscle are committed myogenic progenitors, distinct from satellite cells, and efficiently repair dystrophic muscle. Nat Cell Biol., 2007 9(3): 255-267
# = equal contributors

-Sampaolesi M, Blot S, D'Antona G, Granger N, Tonlorenzi R, Innocenzi A, Mognol P, Thibaud JL, Galvez BG, Barthélémy I, Perani L, Mantero S, Guttinger M, Pansarasa O, Rinaldi C, Cusella De Angelis MG, Torrente Y, Bordignon C, Bottinelli R, Cossu G. Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs. Nature, 2006, 444(7119): 574-9

-Sampaolesi M, Torrente Y, Innocenzi A, Tonlorenzi R, D'Antona G, Pellegrino MA, Barresi R, Bresolin N, De Angelis MG, Campbell KP, Bottinelli R, Cossu G. Cell therapy of alpha sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts. Science, 2003, 301(5632): 487-92.

Contact
Submit application with CV, motivation letter, list of publications and three possible references to:
Christina Vochten – christina.vochten@med.kuleuven.be

Posted by Christina Vochten (christina.vochten@med.kuleuven.be)

2009.03.11

Mayo Clinic ポスドク募集

Mayo Clinic(Rochester, MN)でポスドクを募集しています。

【1】職種:ポスドク
【2】募集人数:若干名
【3】勤務場所:Mayo Clinic, Rochester, MN(Phone: 507 284 4516)
【4】PI:Dr. Viji Shridhar
【5】研究分野:Ovarian/breast cancer
【6】募集資格:博士号取得者もしくは3月取得見込み。分子生物学的手法を持つこと、及びマウスの取り扱いが可能であること。
【7】処遇:研究所の規定に従います(経験により優遇)
【8】採用時期:できるだけ早く
【9】応募方法:下記、問い合わせ先にCV及び論文リストをEmailしてください。
【10】問い合わせ先:Shailendra Giri, PhD, Assistant Professor (Email: giri.shailendra@mayo.edu)
【11】参考論文
1. J Chien, J Staub, S-I Hu, MR Erickson-Johnson, FJ Couch, DI Smith, RM Crowl, SH Kaufmann, and V Shridhar*. A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene 2004; 23:1636-44.
2. J. Chien, J. Staub, R. Avula, H. Zhang, W. Liu, L.C. Hartmann, S.H. Kaufmann, D.I. Smith, and V. Shridhar*. Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer. Oncogene 2005, 24:5089-5100.
3. K Narita, J Staub, J Chien, K Meyer, M Bauer, A Friedl, S Ramakrishnan and V Shridhar*. HSulf-1 inhibits Angiogenesis and Tumorigenesis in vivo. Cancer Res 2006; 66: 6025-32.
4. J Chien, G Aletti, A Baldi, V Catalano, P Muretto, GL Keeney, KR Kalli, J Staub, M Ehrmann, WA Cliby, YK Lee, KC Bible, LC Hartmann, SH Kaufmann, and V Shridhar*. Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. Journal of Clinical Investigations 2006: 116:1994-2004.
5. Z Yang, NJ Camp, H Sun, Z Tong, D Gibbs, DJ Cameron, H Chen, Y Zhao, E Pearson, X Li, J Chien, A DeWan, J Harmon, PS Bernstein, V Shridhar, NA Zabriskie, J Hoh, K Howes, K Zhang. A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration. Science 2006; 314: 992-993.
6. Staub J *, Chien J *, Pan Y, Qian X, Narita K, Aletti G, Scheerer M, Roberts LR, Molina J, Shridhar V. Epigenetic silencing of HSulf-1 in ovarian cancer- Implications in chemoresistance. Oncogene 2007, 26(34):4969-78.
7. Narita K, Chien J, Mullany SA, Staub J, Qian X, Lingle WL, Shridhar V. Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer. J Biol Chem 2007; 282(19):14413-14420.
8. Chien, J., Rattan, R., Narita, K., Giri, S., Shridhar, R., Staub, J., Beleford, D., Lai, J., Molina, J., Kaufmann, SH., Prendergast, GC and Shridhar V. (2008) Candidate tumor suppressor gene TCEAL7 negatively regulates c-Myc. Oncogene, 27, 7223–7234.

問い合わせ先のDr. Giriは私の留学時代の友人で面倒見がよく、渡米後の生活セットアップ等の協力をしてくれます。急募ですので興味のある方は、出来るだけ早く問い合わせてください。

投稿者:宇都 拓洋

2009.03.06

Harvard School of Public Health Posdoc募集

Postdoctoral Fellow Position in Molecular Mechanisms Regulating Inflammatory Gene Expression : Boston, MA

Position available immediately for an outstanding postdoctoral fellow in the Department of Genetics and Complex Diseases in Harvard School of Public Health, Boston, Massachusetts. The candidate will study the molecular mechanisms regulating inflammatory gene expression in macrophages. Areas include the role of chromatin in control of inflammatory gene expression and its modulation by anti-inflammatory signals and other signals; transcriptional regulation of macrophage function; and analysis of chromatin perturbations in chronic inflammatory diseases.
Candidates should have a solid background in molecular biology. Previous training and experience in studying molecular immunology and/or gene regulation, as demonstrated in the publication record, is strongly preferred. Candidates must have a Ph.D. or M.D. degree. Candidates must have some fluency in spoken and written English.
Interested candidates should send a cover letter, CV, and names of 3 references electronically to thorng@hsph.harvard.edu.

Posted by Tiffany Horng (thorng@hsph.harvard.edu)

2009.03.04

フロリダ州立大学医学部 ポスドク募集

フロリダ州立大学医学部加藤研究室ではポスドクを一名募集しております。

フロリダ州立大学医学部はフロリダ州の州都タラハシーに位置し、創立7年の新しい医学部です。加藤研究室では様々な発生過程におけるNotch シグナル伝達経路の役割の研究、およびNotchシグナル経路を制御する新規因子の単離を中心に行っています。実験動物は主にアフリカツメガエルを使用しておりますがマウスなどを使用することも将来的に考えています。特にアフリカツメガエルの使用経験の有無は問いませんが、基本的な分子生物学の知識を習得した探究心旺盛な方を募集しています。

待遇はフロリダ州立大学医学部の規定に沿って決定致します。

興味のある方または質問のある方は下記のメールアドレス(日本語可)へ直接連絡下さい。

Yoichi Kato
Assistant Professor
Department of Biomedical Sciences
Florida State University College of Medicine
yoichi.kato@med.fsu.edu
【研究室のホームページ】
http://med.fsu.edu/biomed/lab/yoichi.kato.asp

投稿者:加藤洋一(yoichi.kato@med.fsu.edu)

2009.03.01

Duke University Medical Center Postdoc募集

My research interest is to delineate regulatory mechanisms that define signal transduction and trafficking of 7 transmembrane receptors. Currently we are dissecting the roles of ubiquitination to see whether it could serve as a molecular mechanism to initiate beta adrenergic receptor signalling both in in vitro and in vivo (mouse) model systems. The project is multidisciplinary and will involve collaborations with top-notch research labs at Duke University.
I am seeking a bright and highly motivated recent graduate (PhD) to join my lab for post doctoral training. Candidates should have a background in disciplines related to signalling/biochemistry/pharmacology. Experience in techniques such as protein biochemistry, basic molecular biology is required; Some basic training with in-vivo murine models is also required.
The candidate should have a good presentation and writing skills. Excellent interpersonal skills is also desired, since this candidate will be involved in collaborative projects and will have to train/assist other members in the group.
Submit CV and names/contact information of three references to Sudha K. Shenoy via email:sudha@receptor-biol.duke.edu

Posted by Sudha K. Shenoy (sudha@receptor-biol.duke.edu)

2009.02.28

University of Nebraska Medical Center ポスドク募集

Instructor or Postdoctoral Research Associate

University of Nebraska Medical Center

Instructor or Postdoctoral Research Associate position is available in the Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, to investigate the therapeutic effect of transplanted stem cells and gene transfer to the animal models of neurodegenerative disorders. Candidates must have PhD or MD/PhD degree with excellent skills in neurobiology and stem cell biology. Strong experience in generation and differentiation of iPS cells is a plus. Successful candidate should have an excellent publication record. Ability to learn new research technologies, work independently and self-motivation are required. The laboratory will be housed in a new state-of-the-art research institute with core facilities at the Center for Neurodegenerative Disorders.

Applicants should submit current CV, a list of reference persons, and a publication list to:

Dr. Tsuneya Ikezu
Department of Pharmacology and Experimental Neuroscience
Center for Neurodegenerative Disorders
University of Nebraska Medical Center
Omaha, NE 68198-5880
Email: tikezu@unmc.edu
Phone: +1 (402) 559-9565

投稿者:Tsuneya Ikezu(tikezu@unmc.edu)

2009.02.27

The University of North Carolina at Chapel Hill ポスドク募集

Postdoctoral Position at UNC-Chapel Hill to study epigenetics and reprogramming:

Several postdoctoral positions are available in Dr. Yi Zhang’s laboratory of the Howard Hughes Medical Institute and The University of North Carolina at Chapel Hill. The positions have been created to conduct research on the following areas of studies:
a) The genetic and epigenetic mechanism of reprogramming, especially as related to iPS generation;
b) The molecular events surrounding paternal genome reprogramming in the zygote;
c) Epigenetic mechanisms underlying obesity and diabetic disease states.

The Zhang lab has been traditionally focused on the identification and characterization of epigenetic modifying enzymes (http://www.med.unc.edu/~zhangyi/lab.htm). Recently, the lab has been using cutting edge technologies, including single cell live imaging, FACS cell sorting, and iPS generation techniques to study the function of various epigenetic factors in specific biological processes. These processes range from cellular differentiation and reprogramming to the generation of disease states. More information about the lab can be found at http://www.med.unc.edu/~zhangyi/lab.htm. Candidates with good track record and previous experience in stem cell manipulation, live cell imaging, microinjector manipulation, metabolism or diabetes are encouraged to apply. Please send your CV, and three letters of reference to:

Dr. Yi Zhang
Investigator, Howard Hughes Medical Institute
Professor, Biochemistry and Biophysics
Lineberger Comprehensive Cancer Center
The University of North Carolina at Chapel Hill
yi_zhang@med.unc.edu

投稿者:Keisuke Tateishi

2009.02.26

Johns Hopkins University School of Medicine ポスドク募集

Johns Hopkins University School of Medicine (Baltimore, MD) で研究員を募集しています

[研究代表者] 飯島美帆 (Assistant Professor, Department of Cell Biology)
http://www.hopkinsmedicine.org/cellbio/website/index.cfm

[募集人員] ポスドク2名
[研究内容] イノシトールリン脂質の合成を介した細胞骨格を調節する情報伝達系に注目し、細胞運動と細胞分裂の分子機構を解析します。分子生物学、光学顕微鏡、生化学等の経験を持つ方を募集します。6-7月から採用可能です。

[参考文献] Cell 109:599 (2002), Dev. Cell 3:469 (2002), Cell 114:559 (2003), JBC 279:16606 (2004), Dev. Cell 8:467 (2005), Dev. Cell 12:603 (2007) .

[応募方法] miijima@jhmi.eduに履歴書をお送りください。

飯島美帆
Miho Iijima, Ph.D.
Assistant Professor
Department of Cell Biology
Johns Hopkins University School of Medicine
Hunterian 107, 725 N. Wolfe Street
Baltimore, MD 21205
Phone: 410-502-6836

投稿者:飯島美帆(miijima@jhmi.edu)

2009.02.19

Max Planck Institute of Molecular Biomedicine Postdoc募集

The Max Planck Institute for Molecular Biomedicine in Muenster (Germany) has several openings for Postdoctoral Research scientists in the Department of Tissue Morphogenesis (Director Prof. Ralf H. Adams) and in the newly founded group ‘Angiogenesis in zebrafish’ (Prof. Wiebke Herzog).

Blood vessels play essential roles in vertebrate organisms and are also directly involved in a range of disease conditions such as cancer. We are studying the signaling processes that control the angiogenic growth of the vasculature, the interactions between the different cell types forming the vessel wall and the communication between blood vessels and the surrounding tissues (more information at: http://www.mpi-muenster.mpg.de/ngm/gme.shtml and at: http://www.mpi-muenster.mpg.de/an/an.shtml)
Technical approaches include genetic studies in mouse or zebrafish, confocal and time laps microscopy, immunohistochemistry, micromanipulation of zebrafish embryos, cell/tissue culture, biochemistry and molecular biology.

The Max Planck Institute for Molecular Biomedicine offers an excellent research environment with strong local links to the Center for Molecular Biology and Inflammation and the University of Muenster.
Core support at the Institute includes service facilities for Fluorescence Activated Cell Sorting, Electron Microscopy, Research Animal Units and the production of genetically modified mice and zebrafish.
The Institute offers a very international environment, so that knowledge of the German language is not essential. Additionally Muenster is a very liveable city (http://www.muenster.de/en/) and extra help with German administration, apartment hunting, etc. will be provided for people without German language skills.

We invite applications by enthusiastic, committed and talented prospective postdoctoral fellows who share our passion for research, are interested in acquiring new skills and wish to be part of an international team. Postdoctoral fellowships are fix-term appointments for initially two to three years with the possibility of extension.

Please send your application and CV including the names of 2-3 referees via e-mail to:

ralf.adams@mpi-muenster.mpg.de
or to:
wiebke.herzog@mpi-muenster.mpg.de

Posted by Ralf H. Adams (ralf.adams@mpi-muenster.mpg.de)

2009.02.18

テンプル大学医学部心臓血管研究センター ポスドク募集

ポスドク (PhD, MD, MD/PhD)

テンプル大学医学部心臓血管研究センター (Philadelphia, PA)
江口研究室、募集期間(2010年4月までに留学可能な方)
当研究室は細胞生物学、分子生物学、タンパク工学(プロテオミックス)および遺伝子改変動物を主体とした手法を用いて心血管系の情報伝達と機能解析を中心に現在、以下のテーマで研究を行っています(Current Grants funded include NIH-RO1 and AHA Established Investigator Award)。

1. アンジオテンシン受容体の新しい情報伝達とその機能解析
2. 血管系でのインスリン抵抗性の意義
3. NOと活性酸素を介した細胞内情報伝達
4. Rho/Rho kinaseの新しい機能解析

ニュヨーク、ワシントンは車で2時間のフィラデルフィアは日本人には生活しやすいところでしょう。当研究室は年内に新築の研究棟に移転予定です。留学にあたっては私と日本人のポスドク(現在5名の日本人スタッフ)が生活面、研究面共に懇切丁寧に面倒を見ます。ご興味を持った方は履歴書(学歴と研究歴/業績、日本語可)を以下にe—mailしてください。(分野は問いませんが分子生物学的手法を習熟した方や組織染色、動物実験等に習熟した方を優先します。)
給与 $37000/year (経験により優遇、さらに昇給も可能)、家族を含む医療保険完備、休祭日は大学の規定に準じる(+夏休み1週、冬休み1週)。

連絡先

Satoru Eguchi, MD. PhD. FAHA
Associate Professor of Physiology and Cardiovascular Research Center
Temple University School of Medicine
e-mail: seguchi@temple.edu(日本語可)
Tel/FAX 215-707-8378

最近の当研究室の文献 (Selected from 102 English Publications)
Arterioscler Thromb Vasc Biol 29:217, 2009, Hypertension 53:182, 2009, Hypertension 51:232, 2008, Arterioscler Thromb Vasc Biol 26:e133. 2006, J Biol Chem 280:26592. 2005, Arterioscler Thromb Vasc Biol 25:1831. 2005, Mol Cell Biol 23: 1581. 2003, Hypertension 41:775. 2003, J Biol Chem 277:44695. 2002, Mol Endocrinol 16: 367. 2002, Circulation 106:909-912, 2002, J. Biol. Chem., 276: 7957. 2001.

教室紹介 http://www.temple.edu/medicine/departments_centers/research/cardiovascular_faculty.htm

投稿者:江口 暁(seguchi@temple.edu)

2009.02.17

Duke University Medical Center Postdoc募集

Postdoctoral Position Available
Postdoctoral position is immediately available to study nutrient sensing by the targets of the immunosuppressant drug rapamycin: the TOR kinase homologs. Previous experience with yeast as a model system and/or signal transduction mechanisms, gene expression analysis by microarray preferable. Proficiency in English required. Submit application with pdf files of CV, professional interest, publication prints or preprints, 3 reference names/Emails, to Dr. Maria E. Cardenas (carde004@mc.duke.edu) Department of Molecular Biology and Microbiology, Duke University Medical Center, Durham, NC.

Recent publications:
Bastidas, R.J., Heitman, J., and Cardenas, M.E. (2009). The protein kinase Tor1 regulates adhesin gene expression in Candida albicans. PLoS Pathog. 5-2, e1000294.

Puria, Rekha, Zurita-Martinez, S.A., and Cardenas, M.E. (2008). Nuclear translocation of Gln3 in response to nutrient signals requires Golgi to endosome trafficking in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 105:7194-7199. "with special commentary at PNAS and Science Signaling"

Puria, R. and Cardenas, M.E. (2008). Rapamycin bypasses vesicle-mediated signaling events to activate Gln3 in Saccharomyces cerevisiae. Commun. & Integrat. Biol. 1, 23-25.

Rohde, J.R., Bastidas, R., Puria, Rekha, and Cardenas, M.E. (2008). Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr. Opin. Microbiol. 11:153-160.

Bastidas, R.J., Reedy, J.L., Morales-Johansson, Heitman, J., and Cardenas, M.E. (2008). Signaling cascades as drug targets in model and pathogenic fungi. Curr. Opin. Invest. Drugs. 9:856-864.

Rutherford, J.C., Chua, G., Hughes, T., Cardenas, M.E., and Heitman J. (2008) A Mep2-dependent transcriptional profile links permease function to gene esxpression during pseudohyphal growth in Saccharomyces cerevisiae. Mol. Biol. Cell. 19:3028-3039.

*Zurita-Martinez, S.A., *Puria, Rekha, Pan, X., Boeke, J.D., and Cardenas, M.E. (2007). Efficient Tor signaling requires a functional Class C Vps protein complex in Saccharomyces cerevisiae. Genetics 107, 2139-2150. *co-first authors

Bahn, Y-S., Xue, C., Idnurm, A., Rutherford, J.C., Heitman, J., and Cardenas, M.E. (2007). Sensing the environment: lessons from fungi. Nat. Rev. Microbiol. 5:57-69.

投稿者:原島 俊明(t0084h@nibb.ac.jp)

2009.02.15

National Cancer Institute ポスドク募集

再掲します。
National Cancer Institute (NCI)-Frederick, Laboratory of Experimental ImmunologyのDennis M. Klinmanラボではポスドクを募集しています。
応募資格はMD取得者もしくは医学、生物学のPhD取得/来春見込みの方です。
雇用はNIHの規定によります。
ワシントンDC近郊のメリーランド州フレデリックにあるNCI/NIHの施設です。現在NCIが最も力を入れているCancer Inflammation Programで、研究環境に関しては非常に整備されておりとても実験がしやすいところだと思います。
ここのラボの特徴は1995年にNatureに発表したCpG DNAの発見に始まり、マウス、ヒト型CpG DNA配列、2つのタイプCpG DNA配列、抑制性のDNA配列の発見、それらのメカニズムの解析、さらにこれらのDNAを使ったワクチン、感染免疫、アレルギー、自己免疫疾患のマウスモデルへの応用といった免疫系を制御するDNAにフォーカスを当てております。
自然免疫、癌免疫、ワクチン等々免疫学に興味がある方、我々と楽しく実験できる方を募集しています。
興味のある方は私宛に日本語でけっこうですのでCVをメールで送ってください。よろしくお願いします。
城田英和
Hidekazu Shirota

投稿者:城田英和 (hideshirota@yahoo.co.jp)

2009.02.13

テンプル大学医学部心臓血管研究センター ポスドク募集

ポスドク (PhD, MD, MD/PhD)

テンプル大学医学部心臓血管研究センター (Philadelphia, PA)

私の同僚で共同研究者の Dr. Rosario Scaliaが以下の英文のように日本人のポスドクを募集しています。 Dr. Rosario Scaliaは優しく丁寧に研究を指導してもらえ、ボスとしても信頼できる先生であると認識しています。

ニュヨーク、ワシントンは車で2時間のフィラデルフィアは日本人には生活しやすいところでしょう。留学にあたっては私と日本人のポスドク(