Postdoc Position in Nutrigenetics lab:

The Seo lab at the University of Michigan seeks a postdoctoral research fellow to study the mechanisms by which mutations in metal ion transporter genes result in metabolic and neurological disorders in patients. We characterize disease-associated genes to understand the pathological basis of disease, and try to improve the management of patients affected by these conditions. We are working on the cell and mouse models of patients mutations in order to probe disease mechanisms and test therapies.

Seo lab: https://www.seoresearchlab.com/

This position will be supported by the NBIA foundation (https://www.nbiadisorders.org/). The Salary range: $48,000 ~ $55,000 per year, plus a competitive benefits package and the opportunity to appoint and supervise one or more paid undergraduate to work on projects of your choice. The appointment of this position is at least 2 years. The University of Michigan is a largest biomedical research enterprise located in one of the safest and most educated cities of the United States (http://www.annarborusa.org/live-here/facts-rankings).

We are looking for a highly-motivated individual who meets the qualification below.
• PhD in molecular and cell biology/biochemistry/neurobiology or related discipline.
• Experience with CRISPR/Cas9, knockout, and transgenic mice.
• Publications demonstrating research experience and productivity.
How to apply
Qualified candidates send the following materials to youngseo@umich.edu.
• Curriculum vitae
• Brief description about current and future endeavors
• Contact information for references

Posted by Young Ah Seo(youngseo@umich.edu)


Saint Louis University Postdoctral Position

セントルイス大学(ミズーリ州)のDr. Rayラボでは現在ポスドクを募集しております。テーマは肝疾患および頭頚部腫瘍です。セントルイスは米国中西部に位置しており、気候は比較的穏やかで人々も温和です。大学周辺および日本人が多く居住している地域は安全です。都会的な生活を希望している方には物足りないかもしれませんが、自然も多くお子さんが小さいご家庭などにはとてもよい環境だと思います。市内にはセントルイス大学の他にワシントン大学があり、日本からの研究留学者は常に数十人滞在しております。Dr. Rayラボへの研究留学にご興味がおありの方はお気軽に直接Dr. Rayへ連絡をとってみてください。私はDr. Rayラボの所属ではありませんが、同じフロアで顔見知りというご縁から代理で紹介文を書かせて頂きました。もし内々にもう少しセントルイスもしくはDr. Rayラボについての情報を知りたいという方は私にご連絡いただいても結構です。但し私はDr. Rayラボとは別なのでラボの詳細については分かりかねる場合がありますので、その点はご容赦ください。
則武秀尚 noritake@outlook.com

we are looking for a person (preferably with fellowship) to study the underlying mechanism and potential therapy for end stage liver disease.
Ratna Ray--rayrb@slu.edu/ratna.ray@health.slu.edu
We also work on prostate and head & neck cancer

Posted by Ratna Ray, PhD(rayrb@slu.edu)


University of Toronto / Lunenfeld-Tanenbaum Research Institute ポスドク募集

University of Toronto / Lunenfeld-Tanenbaum Research Institute のDurocher labで、ヒト細胞のDNA損傷に対する応答、およびゲノム安定性の原理の研究に従事するポスドク研究員を若干2名ほど募集いたします。

Durocher labでは、CRISPR/Cas9ゲノム編集スクリーニング、構造生物学や、マウスモデルを使った実験など、多彩な手技を用いて、DNA損傷・ゲノム安定性の分野における重要な問題に取り組んでおります。

1- The shieldin complex mediates 53BP1-dependent DNA repair.

Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Álvarez-Quilón A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S, Durocher D.
Nature. 2018 Jul 18. doi: 10.1038/s41586-018-0340-7

2- CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.

Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaitė Ž, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D.
Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z

3- The structural basis of modified nucleosome recognition by 53BP1.

Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D.
Nature. 2016 Aug 4;536(7614):100-3. Epub 2016 Jul 27.


 博士号を取得していること
 分子生物学、細胞生物学、生化学、構造生物学、マウスを用いた遺伝子の研究、がん生物学などの分野において専門知識を有すること
 優れた研究業績(Publication)を有すること

応募書類として短い志望動機、履歴書(CV)、そして三名の推薦者の連絡先を durocher@lunenfeld.ca にProfessor Daniel Durocher, Senior Investigator, Lunenfeld-Tanenbaum Research Institute, Toronto, ON, CANADA 宛てで送ってください。

研究内容などの詳しい情報はDurocher lab のホームページ(http://durocherlab.org)を参照してください。

Daniel Durocher, Ph.D. FRSC
Senior Investigator
Lunenfeld-Tanenbaum Research Institute

Department of Molecular Genetics
University of Toronto

Posted by Daniel Durocher(durocher@lunenfeld.ca)


University of North Carolina at Chapel Hill (UNC) School of Medicine, Postdoctral Positions

Multiple Postdoctoral Positions of Gene Regulation, Bioinformatics and/or Cancer Biology

Job Description: Lineberger Comprehensive Cancer Center & the Department of Biochemistry, University of North Carolina at Chapel Hill (UNC) School of Medicine

Multiple postdoctoral associate research positions available for the highly motivated candidates with a fresh PHD training in molecular biology, biochemistry and cell biology to join the Lineberger Comprehensive Cancer Center and Department of Biochemistry, University of North Carolina at Chapel Hill (UNC) School of Medicine, USA. Our lab (webpage: http://www.gregwanglab.com) emphasizes on mechanistic understandings of gene regulation, chromatin, stem cells, and human disease notably cancer. We have recently published our findings on various gene regulatory mechanisms, including those related to DNA methyltransferase and histone modifying enzymes, at Molecular Cell 2013, Blood 2015, Cell Reports 2015; Cancer Cell 2016; Nature (2018); Stem Cell Reports (2018) and Molecular Cell (2018 in press).

With recent acquisition of funds from NIH and NCI, we have multiple positions available for
1) Postdoctoral associates focused on experimental biology
2) Bioinformatics associate focused on computation analysis of genomics dataset
These positions will be relatively long-term and supported by our recently secured 5-year funds from NIH/NCI, American Cancer Society and Leukemia & Lymphoma Society.

The on-going projects include (1) biochemical characterization of epigenetic factors/complexes that regulate gene expression in stem cells or cancer cells; (2) CRISPR/dCas9-based editing and screening of pathways crucial for cancer development; (3) knockout and knock-in mouse models with deficiency in histone /DNA methylation regulation in context of development and tumorigenesis, with a special focus on hematopoietic disease; (4) epigenomic and transcriptome analyses (ChIP-Seq and RNA-Seq) of normal versus cancer cells to understand 3D chromatin structure and to delineate pathways essential for tumor growth.

Applicants should be self-motivated with a track record of publication in the above area, have laboratory and analytical skills, and be a critical thinker. Application shall include CV, a cover letter (with summary of research experiences and future interests, and expected availability date), reprints of publications, and contact information of three references. These should be sent to gregwang.unc@gmail.com

The starting annual salary for this postdoc position is around $48,000 in addition to covered medical insurance.

Posted by greg wang(greg_wang@med.unc.edu)


Memorial Sloan-Kettering Cancer Centerポスドク募集

Memorial Sloan-Kettering Cancer CenterのEmily Cheng 研究室では、現在Postdoctoral Fellow 及びResearch Associateを募集しております。当研究室では、BCL-2ファミリーによるアポトーシス制御機構の解明、及びBCL-2ファミリーを標的とした新規癌治療法の確立を目指して研究をおこなっています。応募される方は、以下の英文広告をご参照の上、Dr. ChengまでCV及び推薦者3名の連絡リストをお送りください。なお、日本語でのご質問等ございましたら、当研究室出身の山内茜(ainoyama24@gmail.com)までお気軽にお問合せ下さい。

Postdoctoral fellow and research associate positions are available for highly motivated individuals interested in studying the BCL-2 family and the fundamental mechanisms of cell death, developing novel therapeutics targeting the BCL-2 family, and investigating the molecular control of mitochondrial metabolism by the BCL-2 family (Science 330: 1390-1393; Molecular Cell 36: 487-499; Nature Cell Biology 8: 1348-1358; Nature Cell Biology 17: 1270-1281; Nature Communications 7: 13131; Cell Reports 21, 2926–2939). We are particularly interested in the pathogenesis and targeted therapy of lung and kidney cancers.

Applicants should hold a Ph.D. degree and have a strong background in molecular/cellular biology, biochemistry, mouse genetics, or cancer biology, and a good publication record.

Full applications including curriculum vitae and a list of three references should be submitted through chenge1@mskcc.org to: Emily Cheng, M.D., Ph.D., Member, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.



The University of Texas MD Anderson Cancer Centerポスドク募集

The University of Texas MD Anderson Cancer Center の高橋研究室では、癌ゲノミクス、バイオインフォマティクス、分子生物学、分子疫学などにバックグラウンドをもつポスドクの方を一名募集します。
最近の業績としては、治療関連性白血病の前白血病クローン性造血の同定(Lancet Oncology)、染色体コピー数異常としてのクローン性造血(Blood Advance)、レナリドマイド治療群のCLLの遺伝子解析(Blood)、遺伝子異常の微小残存性病変としての臨床的意義(JCO)、混合形質性白血病の網羅的遺伝子解析(Nature Comm)などがあります。
Department ChairのDr.Andrew FutrealのCo-mentor制度となります。


Koichi Takahashi, MD
Assistant Professor
Department of Leukemia
Department of Genomic Medicine
The University of Texas MD Anderson Cancer Center

投稿者:Koichi Takahashi(ktakahashi@mdanderson.org)


Southern Research Institute Postdoctral position

The NIH-funded Nakazawa lab is seeking an independent-thinking, highly motivated postdoctoral fellow to study in the Neuroscience Department at Southern Research (SR), which is focused on the cellular mechanisms underlying the positive, negative, and cognitive symptoms of schizophrenia. We utilize genetically-engineered mice to investigate hypofunction of N-Methyl-D-aspartate (NMDA)-type glutamate receptor (NMDAR), which interacts with the major excitatory neurotransmitter of the CNS, glutamate. This hypofunction model of schizophrenia, in which NMDARs are developmentally-deleted from cortical and hippocampal GABA neurons, enables study of the role of NMDARs in the pathogenesis of schizophrenia. The Nakazawa lab is particularly interested in (1) perinatal abnormalities leading to cortical GABAergic dysfunction, and (2) the circuitry mechanisms of hyper-excitable auditory cortex. The NIH-funded postdoctoral fellowship position suits candidates highly motivated to perform i!
n vivo Ca2+ imaging from awake behaving animals and interested in understanding neuronal circuitry function. A developmental neurobiologist with expertise of handling perinatal mouse brain organs are also welcome. Candidates should be capable of and willing to learn new techniques to perform delicate surgical procedures and must demonstrate abilities to think independently and work collaboratively. Prospective candidates should send the following in a single PDF: a statement of interest describing research experience and future goals, curriculum vitae, and contact information for two references willing to provide a letter of support to: Kazu Nakazawa, M.D., Ph.D., electronically to e-mail: knakazawa@southernresearch.org. Expect to join a growing cadre of supportive, outstanding, and collaborative neuroscientists in an exciting research environment. Southern Research provides a competitive benefits package, including insurance and retirement benefits, and is an Equal Opp!
ortunity/Affirmative Action Employer. Lab web site: https://s!

Posted by Kazu Nakazawa(knakazawa@southernresearch.org)




当研究室では、肥満によって発症リスクが増加する代謝性・炎症性疾患、特に2型糖尿病や肝臓疾患において、その発症機構を1)RNAサイレンス機構、2)細胞外小胞(エキソソームなど)、3)炎症性代謝ストレス、に注目して研究を行っています。新ラボメンバーの方とは、最近の知見 [Nature Comms (accepted), bioRxiv 2018, Cell Reports 2018, Cell Reports 2015, Diabetes 2014, Nature, 2012, Cell 2010]を更に発展させ、主に細胞外小胞の動態・機能変化の解析を通し、代謝性・炎症性疾患の発症機構の解明を目指します。意欲の高い方、そして、代謝、免疫、細胞外小胞などの研究経験を代謝性・炎症性疾患の病態モデルに応用したい方を大歓迎いたします。

応募資格:上記の研究に興味のある PhD, MD, MD-PhD 取得者、あるいは着任までに取得見込みの方。
応募書類:1) 履歴書、2) これまでの研究の概要、3) 信用照会3名以上の連絡先。
送付先:中村能久 (Takahisa Nakamura)

Takahisa Nakamura, Ph.D.
Assistant Professor
Divisions of Endocrinology and Developmental Biology,
Cincinnati Children's Hospital, MLC 7012
3333 Burnet Ave., Cincinnati, OH 45229
Office phone: 513-803-9230
Email: Takahisa.Nakamura@cchmc.org



Weill Cornell Medical College Postdoctral Position

Postdoc Position Available in Weill Cornell Medical College, New York City

A Postdoctoral Associate position is available immediately in Ching-Hwa Sung’s Laboratory at the Weill Cornell Medical College, New York City. The Sung lab uses state-of-the-art mouse genetics, molecular cell biological, and ultrastructural techniques to address the molecular basis of retinal degenerative diseases including retinitis pigmentosa (RP), aged-macular degeneration (AMD) and ciliopathy (Cell 130:535; J Clin Invest 114:131; Nat Cell Biol. 13:402; J Cell Biol 190:953; Dev Cell 32:731). The postdoc will work on a new project related to the cell biology/signaling pathway/metabolism of cone photoreceptors and the exploration of therapeutic treatments to prevent cone cell death. PhD candidates are required to have a publication record in one of the following fields (biochemistry, cell biology, neuroscience, biomedicine) and strong communication skills. Experience in stem cell cultures and/or animal handling is preferred. Review of applicants will start immediatel!
y until the position is filled. The stipend levels follow the current NIH scale. Interested individuals should submit a single PDF file containing the following information to Ching-Hwa Sung (chsung@med.cornell.edu). (i) CV including 2-3 referees’ contacts. (ii) A 1-page cover letter summarizing your current research, general research interest, and personal goals. Weill Cornell Medical College is an equal opportunity/affirmative action employer.

投稿者:Ching-Hwa Sung(chsung@med.cornell.edu)


University of California, Davisポスドク募集

私のCold Spring Harbor Laboratory, Tuveson Labでの同僚であったChang-il HwangがUniversity of California, Davisでの独立に伴い、ポスドクを募集しております。


Position Description:

A postdoctoral fellow position in pancreatic cancer biology is available at the Department of Microbiology and Molecular Genetics, University of California, Davis. Our research interest is to study genetic and epigenetic alterations in pancreatic cancer progression using genetically engineered mouse models and patient-derived organoid models and exploit therapeutic vulnerabilities for pancreatic cancer. The position provides outstanding opportunities for building research career with recently developed organoid models in the interface of basic and translational pancreatic cancer research in close collaboration with UC Davis Comprehensive Cancer Center.

Outstanding individuals skilled in molecular biology, cell biology, mouse genetics, cancer (epi)genetics and/or next generation sequencing (RNA-seq, ChIP-seq, ATAC-seq) with bioinformatic analysis are encouraged to apply for a postdoctoral position in a dynamic interdisciplinary team studying pancreatic cancer.

Basic Qualifications:

The applicant must have a Ph.D. in biochemistry, cell biology, genetics, molecular biology, cancer biology, or related field, and must have proven productivity as a first author. In addition, the applicant should be proficient in tissue culture, mouse genetics and basic molecular biology techniques. It is preferable that the successful applicant has experience with either 1) cancer biology with mouse and tissue culture models , or 2) genomics approach (next generation sequencing and basic analysis). Finally, the applicant should be well versed in Microsoft Office, Excel, PowerPoint, and a graphing program such as Prism or R. The applicant must be attentive and reliable with various modes of communication and must have the motivation to pursue and drive a project independently. Candidates should be willing to apply for independent funding.

Please send an email with a cover letter, curriculum vitae with the names of three references to:

Chang-il Hwang, D.V.M., Ph.D.

Assistant Professor

241B Briggs Hall

Department of Microbiology and Molecular Genetics

College of Biological Sciences

University of California, Davis

One Shields Ave, Davis, CA 95616

Email : cihwang@ucdavis.edu



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