Institute de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Strasbourg, France ポスドク募集

Team JM Egly/ F Coin
Institute de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Strasbourg, France

当教室では、主にDNA修復/基本転写因子であるTFIIHの機能解析を通じて、色素性乾皮症、コケンイン症候群ならびにTrichothiodystrophyといった遺伝性疾患の病態を研究しています。(Mol Cell. 2012 Epub ahead of print, Nat Rev Mol Cell Biol. 2012 13(6):343-54.) また逆に遺伝子発現調節異常を来す様々な疾患の病態解析を行うことにより、生命の基本現象のひとつである転写の理解を深めています。(Science. 2011 333(6046):1161-3.) 詳細はホームページご覧ください。http://www.igbmc.fr/research/2/team/20/


応募者はCV(業績目録付)と2-3名の推薦者の氏名連絡先を添付して、チームリーダーであるJean-Marc EGLY egly@igbmc.fr宛てにメールしてください。

投稿者:橋本 悟(hashimo@igbmc.fr)










St Jude Children's Research Hospitalポスドク募集

Open post-doctoral positions at St Jude Children's Research Hospital.

I currently have two open post-doctoral positions due in part to post-doctoral fellows who had to relocate. Positions are competitive. Please send a CV and three letters of recommendation to my address email: martine.roussel@stjude.org

My research program focuses on identifying the genes and microRNAs within signaling pathways that govern the normal development of the cerebellum and formation of medulloblastoma, a malignant cerebellar tumor of childhood. Our long range goal is to define novel molecular targets that are “druggable”. Using molecular profiling of human medulloblastoma, we are creating mouse models that faithfully recapitulate the human disease and that can be used preclinically to screen for small molecule inhibitors as potential novel therapies for medulloblastoma. An overriding theme of our research is that cell cycle regulators, cyclin-dependent kinases and CDK inhibitory proteins control the timed exit of neuronal progenitors from the cell division cycle, while specific transcription factors, including Gli1 and Atoh1 drive proliferation and prevent differentiation, respectively. Altering the balance between pro- and anti-proliferative genes or between genes inducing or pr!
eventing migration and differentiation, might affect neuronal progenitors’ state of proliferation, migration and differentiation and predispose them to induce brain tumors.

Using state-of-the-art technologies, including molecular profiling, mouse models, orthotopic transplantation of marked granule neuron progenitors into the brain, small animal imaging, and targeted molecular library screens, the laboratory focuses on several aspects of cerebellar development and medulloblastoma formation:
1. To characterize the signaling pathways that regulate the differentiation and cell cycle exit of granule neuron progenitors in the cerebellum and identify small molecule agonists of these pathways.
2. To characterize microRNAs that contribute to medulloblastoma formation and tumor maintenance, to assess their relevance in vivo using loss of function in the mouse and antigomiRs and microRNA mimics in tumors, and to define their mRNA targets.
3. To develop novel mouse models of medulloblastoma, including Large Cell Anaplastic (LCA), the most aggressive form of the disease and to screen for small molecule as potential therapeutics.

Recent relevant publications:

Ayrault O, Zhao H, Zindy F, Chunxu Qu, Charles J. Sherr, Roussel MF. Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells. Cancer Res.
70:5618-5627, 2010. PMID: 20516124; PMCID: PMC2896438.

Gibson P, Tong Y, Robinson G, Thompson M, Currle D.S., Eden C, Hogg T, Poppleton H, Martin J,
Finkelstein D, Pounds S, Patay Z, Scoggins M, Ogg R, Pei Y, Brun S, Zindy F, Lindsey JC, Gutmann DH,
Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Taketo MM, Ellison DW,
Wechsler-Reya R, Gilbertson RJ. Subtypes of medulloblastoma have distinct developmental origins.
Nature. 468:1095-1099, 2010. PMID: 21150899; PMICD: PMC3059767.

Roussel, MF, Robinson, G. Medulloblastoma: advances and challenges. F1000 Biol Reports 3: 5, 2011.
PMID:21655335; PMICD: PMC3100785

Hatten ME, Roussel, MF. Development and Cancer of the Cerebellum. Trends in Neurosciences,
34: 134-142, 2011. PMID: 21315459. PMCID: n/a. book chapter.

Kawauchi D, Robinson G, Uziel T, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson
RJ, Roussel MF. A mouse model of the most aggressive subtype of human medulloblastoma. Cancer Cell, 21, 168-180, 2012. PMID: 22340591. Journal cover. PMICD: PMC3285412.

Gibson P, Tong Y, Robinson G, Thompson M, Currle D.S., Eden C, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Patay Z, Scoggins M, Ogg R, Pei Y, Brun S, Zindy F, Lindsey JC, Gutmann DH, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Taketo MM, Ellison DW, Wechsler-Reya R, Gilbertson RJ. Subtypes of medulloblastoma have distinct developmental origins. Nature, 468, 1095-2010. PMID: 21150899; PMICD: PMC3059767.

Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Lei W, Zhu X, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong H, Beckford J, Gupta P, Ma J, Easton J, Pounds S, Zhao D, Gajjar A, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Ching C. Lau CC, Bouffet E, Hassal T, Gururangun S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ for the St Jude Children’s Research Hospital - Washington University Pediatric Cancer Genome Project. Novel mutations target distinct subgroups of medulloblastoma. Nature. June 20, 2012. Ahead of print.

Martine F. Roussel, Ph.D.
Department of Tumor Cell Biology, Mail Stop #350
Danny Thomas Research Center, DTRC 5006C
St. Jude Children’s Research Hospital
262, Danny Thomas Place
Memphis, Tennessee, 38105
Tel: 901-595-3481
FAX: 901-595-2381
Cell: 901-335-9511
Email: martine.roussel@stjude.org
Web: http//www.stjude.org/roussel




Cincinnati Children's Hospital Medical Centerポスドク募集

Cincinnati Children's Hospital Medical Center (CCHMC)、Division of Reproductive Sciences、小川研究室において、博士研究員(ポスドク)を募集いたします。当研究室では、 long noncoding RNAを介したエピジェネティックな遺伝子発現制御に興味を持ち、主にマウスES細胞を用いて哺乳類遺伝子量補正機構であるX染色体不活性化の詳細な分子機構の解明を目指しています。

任期:2-3 年 (実績および状況に応じて更新の可能性あり)
募集人数:1-2 名
応募資格:上記の研究に興味のある博士号取得者、あるいは着任までに取得見込みの方。 細胞生物学、マウス遺伝学、生化学、バイオインフォマティクス、エピジェネティクス分野での経験のある方を歓迎しますが、それ以外の分野の方でも検討します。
応募書類: 1) CV(履歴書)、2) 研究業績等、3) これまでの研究の概要と本研究への興味・意欲、4) 所見を求め得る方2名の氏名・連絡先

We are seeking a highly motivated and enthusiastic individual with excellent interpersonal skills to join our research team in the Division of Reproductive Sciences at Cincinnati Children’s Hospital Medical Center. Our research focuses on elucidating the molecular mechanism of long noncoding RNA-mediated epigenetic gene regulation using mouse X-chromosome inactivation as a model system. (http://www.cincinnatichildrens.org/bio/o/yuya-ogawa/):
(1) How is chromosome-wide silencing induced by long noncoding RNAs?
(2) How is long-range silencing maintained and organized?

Applicants must have a Ph.D. or M.D., and should be experienced with standard methods of molecular biology. Candidates with a strong background in any of the following areas are encouraged to apply: epigenetics, mammalian cell biology, mouse genetics, bioinformatics or biochemistry. Interested individuals should send 1) CV, 2) publication list, 3) brief statement of past and future research interests, and 4) names and contact information of two references by e-mail to Yuya Ogawa (yuya.ogawa@cchmc.org).

Yuya Ogawa, Ph.D.
Assistant Professor
Division of Reproductive Sciences
Cincinnati Children's Hospital Medical Center
3333 Burnet Ave., Cincinnati, OH 45229 USA.
E-mail: yuya.ogawa@cchmc.org

投稿者:Yuya Ogawa(yuya.ogawa@cchmc.org)


School of Medicine, Universit of Pittsburgh ポスドク募集

Department of Developmental Biology, School of Medicine, Universit of Pittsburgh (USA)では、マウス胎児を始めとした超音波心臓検査手技が可能な若手の医師または同等の手技を有する(または手技を習得したい方でも可能です)研究者(日本人の有無は問いません)を募集しております。期間は最低2年から3年です。
当科Developmental Biology、主任教授のDr. Cecilia Loの研究室では、N-ethyl-N-nitrosoureaをマウスに投与、ランダムに遺伝子変異を誘導し、胎児およびそのoffspringの先天奇形を超音波検査、micro-CT, micro-MRIおよび3次元組織解析にて診断、その後、遺伝子解析、責任遺伝子の同定を行っております。ご興味ある方は、小生の方まで連絡下さい (Kimimasa Tobita, kit3@pitt.edu)。



National Institute of Allergy and Infectious Diseases, National Institutes of Health Postdoc募集

Postdoctoral Fellow in Structural Biology of Innate Immune Recognition

A postdoctoral fellow position is available at the Structural Immunobiology Unit (SIBU), Laboratory of Immunology, NIAID/NIH for a highly motivated individual to study the molecular mechanisms of innate immune recognition. Our research program is composed of two integrated themes: the mechanisms of nucleic acid recognition by innate immune receptors and the study of large macromolecular signaling platforms known as the “inflammasomes.” We use X-ray crystallography as the primary method to dissect the molecular details of innate receptors and signaling adapters, integrated with chemical tools that target these signaling pathways for potential therapeutic applications.

SIBU is well funded with state-of-the-art equipment for molecular biology, protein chemistry and crystallography, including participation in dedicated synchrotron beam time allocation. There are numerous opportunities for collaboration and acquiring new skills at NIH with one of the leading scientific communities dedicated to structural biology and immunology research.

We are seeking future career scientists capable of independent thinking and interested in learning new techniques. The ideal candidate must have a M.D. or Ph.D. degree with less than five years of postdoctoral experience. Strong skills in protein expression, purification and molecular biology are essential. Knowledge in protein crystallization and X-ray crystallography is highly desirable. The candidate must possess excellent written and oral communication skills, and will be expected to work in a diverse and collaborative environment.

Salary will be competitive and commensurate with experience, supplemented with excellent fringe benefits.

To apply, please e-mail a CV, bibliography, and cover letter with a brief description of research experience and interests, and three reference letters to: T. Sam Xiao, Ph.D., xiaot@niaid.nih.gov

T. Sam Xiao, Ph.D.
Chief, Structural Immunobiology Unit
Laboratory of Immunology
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Building 4, Room 228B
4 Memorial Drive
Bethesda, MD 20892-0430, USA
Phone: 301-402-9782, FAX: 301-480-1291, E-mail: xiaot@niaid.nih.gov

Posted by T. Sam Xiao(xiaot@niaid.nih.gov)


Georgia Health Sciences Universityポスドク募集

Postdoctoral Opportunities in Cancer Signaling Research
at Georgia Health Sciences University, Augusta, Georgia, United States

Postdoctoral positions are immediately available in Cancer Biology in the Department of Biochemistry and Molecular Biology at Georgia Health Sciences University (GHSU), Augusta, Georgia, USA. Highly motivated individuals, who have recently obtained a Ph.D. degree (or will obtain an equivalent degree, shortly) in biochemistry, molecular biology, and/or cancer cell biology, and who are interested in advanced training in cancer signaling research and experimental therapeutics, are encouraged to apply. Our laboratory is interested in oncogenic transcription factors and their counter molecules (i.e., corepressors) in DNA damage responses, tumor dormancy, and epithelial-to-mesenchymal transition (EMT). As potential anticancer drug design targets, we are particularly interested in better understanding the crosstalk between c-MYC oncoprotein and BIN1 tumor suppressor in chemo- and radiation-resistant cancers, cell-cell contact inhibition, and anoikis pathways. As part of collaborati!
on with the members within the department and the Cancer Center at GHSU, we will also be actively involved in translational cancer research. Please send your Curriculum Vitae, a brief statement of your past and current research experience and interest, and contact information (including E-mail address) of three references to: Dr. Daitoku Sakamuro, Associate Professor, at dsakam@lsuhsc.edu and sakamurodaitoku@yahoo.com (in either English or Japanese), or Ms. Bennie Brisco at bbrisco@georgiahealth.edu (only in English). Applications will be reviewed immediately until the positions are filled. GHSU is an equal opportunity/affirmative action employer.



東京理科大学生命医科学研究所 特任助教またはポスドク募集

東京理科大学 生命医科学研究所 実験動物学研究部門 岩倉研究室では特任助教またはポスドク1名を募集しております。

1. 研究テーマ

2. 採用形態・期間

3. 給与

4. 応募資格
博士号取得者で免疫学の知識を持ち、免疫学研究、遺伝子改変マウスを用いたin vivo実験の経験がある方が望ましい。研究グループの一員として協力して実験を実施できる方。

5. 応募方法

6. 募集期間

7. 応募書類送付先・本募集の照会先
〒278-0022 千葉県野田市山崎2669
東京理科大学 生命医科学研究所 実験動物学研究部門 岩倉洋一郎
e-mail: iwakura@rs.tus.ac.jp



独立行政法人理化学研究所 生命システム研究センター研究員募集

Seeking Research Scientist at Frey Initiative Research Unit, RIKEN
English > http://www.riken.go.jp/engn/r-world/info/recruit/k120622_s_qbic.html

独立行政法人理化学研究所 生命システム研究センター
国際主幹研究ユニット Frey国際主幹研究ユニット (所属長:Urs Frey)
研究員 募集





事業所名:独立行政法人理化学研究所 神戸研究所


(1)Cover letter with research interest
(2)Curriculum vitae
(3)List of publications and other research achievements
(4)At least one letter of recommendation (two preferred) with contact information





ご質問は、Urs Frey (E-mail: ufrey (送信の際には“@riken.jp”をつけてください ))まで、英文でお願いいたします。

独立行政法人理化学研究所 生命システム研究センター
Urs Frey
Email: ufrey (送信の際には“@riken.jp”をつけてください )

〒650-0047 兵庫県神戸市中央区港島南町2-2-3
神戸研究所 研究推進部 総務課 採用担当者宛て
封書に「Frey国際主幹研究ユニット 研究員 応募書類在中」と朱書き願います

投稿者:(独)理化学研究所 神戸研究所 研究推進部総務課



[ 助教またはポスドクの公募]







     応募者について問い合わせ可能な人物(2名)の氏名・メールアドレ  ス・電話番号
     提出先:〒466-8550 名古屋市昭和区鶴舞町65
         名古屋大学大学院医学系研究科 生物化学講座分子生物学
         e-mail: kkadoma@med.nagoya-u.ac.jp


連絡先:〒466-8550 名古屋市昭和区鶴舞町65
    名古屋大学大学院医学系研究科 生物化学講座分子生物学
   e-mail: kkadoma@med.nagoya-u.ac.jp
   tel: 052-744-2059



University of Texas Southwestern Medical Center Postdoc募集

Molecular Mechanisms of Advanced Prostate Cancer

A postdoctoral position supported by the Howard Hughes Medical Institute and the National Cancer Institute is available in the laboratory of Dr. Nima Sharifi in the Division of Hematology/Oncology.

Our laboratory is focused on molecular mechanisms of androgen receptor (AR) gain-of-function that lead to resistance to androgen deprivation therapy and the translational relevance thereof. Areas of interest in this laboratory include:

1) Metabolic and genetic changes required for androgen synthesis
2) Animal models of advanced prostate cancer for translational and therapeutic studies
3) Defining targets for the development of new pharmacologic therapies
4) Clinical validation in patients and clinical trials utilizing innovative approaches

We have recently discovered that prostate cancer becomes resistant to hormonal therapy by the synthesis of dihydrotestosterone through a pathway that circumvents testosterone, instead requiring 5α-androstanedione, a previously underappreciated intermediate metabolite. This metabolic pathway occurs commonly in all models and patient tumors tested (Chang, et al. Proc Natl Acad Sci USA. 2011 Aug 16;108(33):13728-33. This work was featured as a Research Highlight in Nature Reviews Urology (Nat Rev Urol. 2011 Sep 8;8(9):470) and given a “must read” review by the Faculty of 1000 (http://f1000.com/13200029). We have also shown that blocking the enzyme 3β-hydroxysteroid dehydrogenase stops the androgen-response from adrenal precursors, validating this as a potential pharmacologic target for the treatment of advanced prostate cancer (Evaul, et al. Endocrinology. 2010. 151(8):3514-20). Furthermore, our most recent studies have demonstrated that alternat!
ive activities of drugs currently utilized in patients with advanced prostate cancer may be harnessed to reverse initial or acquired therapy resistance (Li, et al. Clin Cancer Res. 2012. In press. (July 1 issue).

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials. Further details are available at the following link: http://www4.utsouthwestern.edu/sharifilab/index.html

UT Southwestern Medical Center is the home of five Nobel Laureates, 19 members of the National Academy of Sciences and 18 Members of the Institute of Medicine.

The candidate should hold a doctoral degree with a background in molecular biology, metabolism or cancer biology. Candidates with an interest in the position should send their cv and contact information for 3 references to:

Nima Sharifi, M.D.
Assistant Professor
Division of Hematology/Oncology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8852

c/o Hem/Onc Research HemOncResearch@utsouthwestern.edu

UT Southwestern Medical Center is an Equal Opportunity, Affirmative Action Employer

Posted by Nima Sharifi, M.D.(nima.sharifi@utsouthwestern.edu)


University of Minnesotaポスドク募集

同僚教授がポスドクを求人中なので、代理で投稿させていただきます。興味のある方は、Dr. Sobeckに直接コンタクトをお願いします。論文等の業績については、彼女のウェブサイトをご覧下さい。

Postdoctoral Fellow – Genomic Instability and Fanconi Anemia

A postdoctoral position is immediately available in the laboratory of Dr. Sobeck at the University of Minnesota, Minneapolis. Our laboratory focuses on elucidating the roles of the enigmatic Fanconi Anemia proteins in protecting genome stability throughout the cell cycle. We use a combination of human cell-based assays, cell-free Xenopus laevis egg extracts, and in vitro biochemical assays to decipher how different FA pathway members communicate with other genomic caretaker proteins to prevent chromosomal instability. This position will work on elucidating physical and functional interactions between FA proteins and the ATR/ATM-regulated signaling pathways under normal and perturbed cellular conditions. We are seeking a highly dedicated scientist with a strong background in mechanisms of DNA replication and repair, and a genuine passion for dissecting the complex DNA damage response mechanisms that protect our cells from carcinogenic influences.

A successful candidate holds a PhD and has experience in the following areas:
-human cell culture and basic cell-based techniques including siRNA-mediated gene knockdown, proliferation and survival assays, immunofluorescence analysis of protein localization.
-Basic molecular biology and proteomics techniques including cloning, PCR, subcellular fractionation, immunoprecipitation, and immunoblots
-Previous experience with human gene targeting would be an advantage
Applicants should be within 1-2 years of the time they obtained their PhD and must demonstrate a clear interest in pursuing an independent career in science.

Contact Information:
Alexandra Sobeck, Ph.D.
Assistant Professor
6-112 MCB
420 Washington Ave SE
Minneapolis, MN 55455
phone: 612-624-1343
fax: 612-625-2163
email: asobeck@umn.edu

Sobeck laboratory website: http://openwetware.org/wiki/Sobeck


« 2012年06月 | 最新の10件 | 2012年08月 »


  • 2012年08月
  • 2012年07月
  • 2012年06月
  • 過去ログ一覧