University of Texas Southwestern Medical Center Postdoc募集

Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer

A postdoctoral position supported by the Howard Hughes Medical Institute and the National Cancer Institute is available in the laboratory of Dr. Nima Sharifi at UT Southwestern Medical Center.

Our laboratory is focused on molecular mechanisms of androgen receptor (AR) gain-of-function that lead to resistance to androgen deprivation therapy and the translational relevance thereof. Areas of interest in this laboratory include:

1) Metabolic and genetic changes required for androgen synthesis
2) Clinical validation in patients and clinical trials utilizing innovative approaches
3) Animal models of advanced prostate cancer for translational and therapeutic studies
4) Identifying targets for the development of new pharmacologic therapies

We have recently discovered that prostate cancer becomes resistant to hormonal therapy by the synthesis of dihydrotestosterone through a pathway that circumvents testosterone, instead requiring 5α-androstanedione, a previously underappreciated intermediate metabolite. This metabolic pathway occurs commonly in all models and patient tumors tested (Chang, et al. Proc Natl Acad Sci USA. 2011 Aug 16;108(33):13728-33). Our unprecedented approach to the identification of metabolic pathways in tumors from patients redefines the fundamental mechanism that drives the progression of resistant tumors.

This work was featured as a Research Highlight in Nature Reviews Urology (Nat Rev Urol. 2011 Sep 8;8(9):470) and given a “must read” review by the Faculty of 1000 (http://f1000.com/13200029). We have also shown that blocking the enzyme 3β-hydroxysteroid dehydrogenase stops the androgen-response from adrenal precursors, validating this as a potential pharmacologic target for the treatment of advanced prostate cancer (Evaul, et al. Endocrinology. 2010. 151(8):3514-20). Furthermore, our most recent studies have demonstrated that alternative activities of drugs currently utilized in patients with advanced prostate cancer may be harnessed to reverse initial or acquired therapy resistance (Li, et al. Clin Cancer Res. 2012 July 1;18(13):3571-9).

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials. This research program is supported by the Howard Hughes Medical Institute, the American Cancer Society, the Prostate Cancer Foundation, the Department of Defense Prostate Cancer Research Program and the National Institutes of Health. Further details are available at the following link: http://www4.utsouthwestern.edu/sharifilab/index.html

UT Southwestern Medical Center is the home of five Nobel Laureates, 19 members of the National Academy of Sciences and 18 Members of the Institute of Medicine.

The candidate should hold a doctoral degree with a background in molecular biology, metabolism or cancer biology. Candidates with an interest in the position should send their cv and contact information for 3 references to:

Nima Sharifi, M.D.
Division of Hematology/Oncology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8852

c/o Hem/Onc Research HemOncResearch@utsouthwestern.edu

UT Southwestern Medical Center is an Equal Opportunity, Affirmative Action Employer

Posted by Nima Sharifi(nima.sharifi@utsouthwestern.edu)


David Geffen School of Medicine at UCLA Postdoc募集


“Why are some self proteins able to induce significant immune responses when they are abruptly expressed in tumors?” Your work may be able to provide an answer to the above question and translate into immunotherapies against human cancers.

We are currently seeking a self-motivated postdoctoral fellow to work in the laboratory of Gang Zeng, Ph.D. The incumbent will investigate molecular interactions between cancer and the innate immune system in order to define signatures in human cancers that may function as molecular patterns to trigger significant innate immune pathways.

The incumbent should have a doctoral degree within the last 2 years and a strong background in biochemistry and immunology. Knowledge in dendritic cell biology and mouse models is a plus.

Interested candidates should forward their c.v. to
Gang Zeng, Ph.D.
Associate Professor
Department of Urology
Member, Jonsson Comprehensive Cancer Center
Member, UCLA Clinical Translational Science Institute
Office Phone: (310) 794-7635

Posted by Gang Zeng, Ph.D.(gzeng@mednet.ucla.edu)


CPP2012 Boston 開催のお知らせ

CPP2012 Boston 開催のお知らせ (http://cppweb.org)

【場所】The Inn at longwood Medical(米国ボストン)
【 U R L 】http://cppweb.org




Children's National Medical Center Postdoc募集

Postdoctoral Fellow in Developmental Neuroscience

A postdoctoral position is available in the Torii laboratory at the Center for Neuroscience Research, Children’s National Medical Center located in Washington, DC. The goal of our research is to understand the molecular and cellular mechanisms underlying the development of fundamental neural circuits responsible for various brain functions and dysfunctions. We are currently investigating how neurons in the cerebral cortex – a part of the brain contributing to higher cognitive functions – are assembled into functional cortical columns, and how cortical neurons establish specific neuronal connections with other parts of the brain during development.

The environment at the Center for Neuroscience Research is highly interactive and fosters collaboration across groups with focusing on developmental neuroscience. Our laboratory is also affiliated with George Washington University with full access to their core facilities.

Highly motivated MD/PhD or PhD scientists trained in Neuroscience, Developmental Biology, or related fields are welcome to apply. The position will be starting in fall 2012 – spring 2013. To apply, please e-mail your CV, research interests and future research plans, and contact information of two to three references.

If you plan to attend 2012 SfN annual meeting held in New Orleans, please mention about it in your application. We could meet there if you like.

Masaaki Torii, Ph.D.
Assistant Professor
Center for Neuroscience Research
Children’s National Medical Center
111 Michigan Avenue, NW
Washington DC, 20010



Harvard School of Public Health Postdoc募集

Dr. Tiffany Horng in the Department of Genetics and Complex Diseases in Harvard School of Public Health is looking for an outstanding postdoctoral fellow to pursue ongoing studies of the inflammasome pathway and other innate immune signaling pathways (PNAS. 109(28):11282-7, 2012; Nat Med. 17(2):164-5, 2011).

Candidates should have a solid background in molecular biology and cell biology and experience working with mice and mouse husbandry, as demonstrated in their publication record. A Ph.D. or M.D. degree is required. It is preferable for candidates to work together with Dr. Horng to apply for postdoctoral fellowships before starting in the lab.

Please submit application, including a cover letter, CV, and names and contact information of at least 3 references to:

Tiffany Horng, Ph.D.
Assistant Professor
Department of Genetics and Complex Diseases
Harvard School of Public Health
655 Huntington Ave, II-115
Boston, MA 02115

村上(日本語可: tmurakam@hsph.harvard.edu)

Posted by Tiffany Horng(thorng@hsph.harvard.edu)


University of Illinois at Chicago ポスドク募集


University of Illinois at Chicago
Department of Pharmacology and Center for Cardiovascular Research

[Research projects]
1. Oxidative stress in cardiovascular diseases (atherosclerosis, inflammation, hypertension, myocardial infarction), diabetes, and angiogenesis using gene targeting and knockout mice.

2. Redox Signaling and cell metabolism in vascular biology, angiogenesis, stem/progenitor cell function and bone marrow niche.

3. Role of copper metabolism and copper transport systems in cardiovascular diseases, diabetes, and angiogenesis.

PhD and/or MD degree (or equivalent) Experience with molecular biology or cell biology or cell signaling or animal study with immunohistochemistry (One of them is acceptable for consideration).

[Research environment] Our research and training programs on vascular biology in the Department of Pharmacology at UIC consistently ranks among the top ten nationally (http://www.uic.edu/depts/mcph/). State of the art facilities (ESR to measure free radicals, imaging, proteomics, etc) are accessible. Chicago is a beautiful international and cosmopolitan city located on the shores of Lake Michigan (http://www.uic.edu/depts/mcph/chic.htm).

Please send by e-mail 1) CV, 2) lists of publications, 3) names and e-mail addresses for three references to:

Tohru Fukai MD, Ph.D and Masuko Ushio-Fukai, PhD(e-mail: tfukai@uic.edu; tohrufukai@gmail.com),
Department of Pharmacology (MC 868), University of Illinois at Chicago, College of Medicine, 835 S. Wolcott Ave., Room E403, Chicago, IL 60612.

投稿者:Tohru Fukai, MD, PhD(tohrufukai@gmail.com)


名古屋大学大学院医学系研究科 機能組織学分野 ポスドク募集

名古屋大学大学院医学系研究科 機能組織学分野(教授:木山博資)では、ポスドク研究員を1名募集致します。


【勤務地】名古屋大学大学院医学系研究科 機能組織学分野(解剖学第二教室)
 ①履歴書 ②これまでの研究内容・業績 ③照会できる方(1名以上)の連絡先
 〒466-8550 名古屋市昭和区鶴舞町65
 名古屋大学大学院医学系研究科 機能組織学分野

 名古屋大学大学院医学系研究科 機能組織学分野



Samuel Lunenfeld Research Institute Postdoc募集

Post-doctoral Research in Super-Resolution imaging of Mitotic Processes.

A Postdoctoral position is available at the Samuel Lunenfeld Institute in the Mount Sinai Hospital in Toronto. The Pelletier lab is keenly interested in the molecular mechanisms that govern various aspects of mitotic cell division including centrosome duplication, microtubule dynamics, mitotic spindle assembly and kinetochore function. Studies revolve around cutting-edge microscopy techniques including structured-illumination, FRAP/FLIM, 4-D multiplex time-lapse imaging and high-content screening approaches in mammalian cells. Our imaging lab is equipped with DeltaVision Elite systems tweaked for fully automated high-resolution imaging of both live and fixed cells. Critically, our laboratory houses a structured illumination (SI) based OMX microscope with a resolution limit far superior to that of conventional wide-field and confocal microscopes allowing the study of the above mentioned processes with unprecedented detail.

In this position, the successful applicant will be part of a fast-paced dynamic and multi-disciplinary environment and play an integral role in novel and ongoing projects within the laboratory as well cementing collaborations with other labs in the vibrant Toronto research community. Applicants with experience in any of the following disciplines are preferred: advanced light microscopy, functional genomics and statistical approaches to quantitative microscopy and image analysis. Training in molecular and cell biology and at the interface be physics and biology will also be considered an asset.

Posted by Laurence Pelletier(pelletier@lunenfeld.ca)


バージニア工科大学 ポスドク募集


バージニア工科大学に所属する当研究室(Laboratory of Plant Stress Physiology and Molecular Biology)では、下記の要領でポスドク研究員を募集しております。ご興味のある方は、ぜひご応募ください。また、お近くに適任者がいらっしゃいましたらご周知くださいますようお願いします。


【勤務場所】Department of Crop and Soil Environmental Sciences, Virginia Tech, Blacksburg, Virginia.



【雇用条件】給与は、Virginia Techの規定により決定します。福利厚生に関しては、健康保険、生命保険、労災保険、年金があります。年金は、退職時に掛け金+利子を払い戻すこともできます。

1.採用時に博士号を取得されてから3年以内の方(2013年3月に博士課程修了見込みの方の応募も歓迎します)。Virginia Techからの給与を必要とされない方(学術振興会海外特別研究員など)は、博士号取得からの年数に制限はありません。



応募書類は、日本語でも英語でもかまいません。興味のある方は、履歴書 ( 形式自由)と照会可能な方2名の連絡先をMS-WordまたはPDFファイルでfukao@vt.eduに送付してください。


Takeshi Fukao, PhD.
Assistant Professor
Dept of Crop and Soil Environmental Sciences
Virginia Tech
Blacksburg VA 24061

Bailey-Serres, J., Fukao, T., Gibbs, D.J., Holdsworth, M.J., Lee, S.C., Licausi, F., Perata, P., Voesenek, L.A.C.J., and van Dongen, J.T. (2012) Making sense of low oxygen sensing. Trends in Plant Science 17: 129-138.

Gibbs, D.J., Lee, S.C., Md Isa, N., Gramuglia, S., Fukao, T., Bassel, G.W., Correia, C.S., Corbineau, F., Theodoulou, F.L., Bailey-Serres, J., and Holdsworth, M.J. (2011) Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants. Nature 479: 415-419.

Fukao, T., Yeung, E., and Bailey-Serres, J. (2011) The submergence tolerance regulator SUB1A mediates crosstalk between submergence and drought tolerance in rice. Plant Cell 23: 412-427.

Fukao, T. and Bailey-Serres, J. (2008) Submergence tolerance conferred by Sub1A is mediated by SLR1 and SLRL1 restriction of gibberellin responses in rice. PNAS 105: 16814-16819.

Fukao, T., Xu, K., Ronald, P.C., and Bailey-Serres, J. (2006) A variable cluster of ethylene response factor-like genes regulates metabolic and developmental acclimation responses to submergence in rice. Plant Cell 18: 2021-2034.

Xu, K., Xu, X., Fukao, T., Canlas, P., Maghirang-Rodriguez, R., Heuer, S., Ismail, A.M., Bailey-Serres, J., Ronald, P.C., and Mackill, D.J. (2006) Sub1A is an ethylene-response-factor-like gene that confers submergence tolerance to rice. Nature 442: 705-708.

Fukao, T., and Bailey-Serres, J. (2004) Plant responses to hypoxia - is survival a balancing act? Trends in Plant Science 9: 449-456.


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