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Rush University Alzheimer's Disease Center ポスドク募集


Rush University Alzheimer's Disease Center (RADC)では患者由来のiPS細胞コレクションを使ったアルツハイマー病の治療法に一緒に取り組んで頂けるポスドク研究者を募集しています。



RADCは30名のFacultyと100名のスタッフからなる組織です。こちらのポジションはPIであるYanling Wangのリードもと研究を進める事になりますが、バリアーのない組織ですので、異なる専門性をもつFacultyと協力し、学際的な研究を実施することが可能です。


The Rush University Alzheimer's Disease Center (RADC) is leading experimental and epidemiological center for the study of Alzheimer’s disease, which has no preventative drugs and is expected to soon triple in incidence. Over the past decade, the RADC has carried out numerous community-based cohort studies to better understand Alzheimer’s disease and aging, generating many omic datasets from human samples. Now we invite you to capitalize on this research to explore candidate genes and proteins have been identified to be relevant to Alzheimer’s disease molecular pathology, by developing human cell-based validation systems.

Position Highlights:

As part of a major expansion into experimental models of Alzheimer’s disease, Rush University is seeking highly motivated candidates for Postdoctoral positions in Stem Cell Biology. The successful applicant will lead research generating 2D and 3D Alzheimer’s disease models in a dish. The range of experiments are expected to include reprogramming human somatic cells into induced pluripotent stem cells (iPSCs), stem cell line banking and validation, stem cell differentiation into disease-relevant cell types, generating 2D and 3D culture models, and phenotyping diseased cells with cellular, molecular and functional assays.

Our group has published in Science, Nature, and Cell, and we expect that your research will be of similar high impact. To facilitate these results, you will be assisted in utilizing the most clinically detailed and extensive collection of Alzheimer’s brain resources in the world. You will be supported by a faculty team of 30 statisticians, neuropathologists, systems and experimental biologists, as well as staff of 100+ who are gathering clinical and experimental detail on Alzheimer’s cohorts. Examples of the rich data can be seen here and in many 1000+ citation papers. Additionally, this position offers:

• Priority on quickly producing high-impact publications, taking advantage of unique Alzheimer’s datasets at Rush University.

• Thousands of post-mortem tissues available for person-specific AD models

• Deeply phenotyped sample origins, with multiple omics, cognitive testing, and neuroimaging

• Sole access to the latest sequencing and cellular phenotyping equipment

• Pursue highly novel targets and follow effects wherever they lead

• Scientific focus in a flat organizational structure, with stable funding

• Career development and grant-writing opportunities alongside highly successful scientists

Position Responsibilities:

• Lead and perform a range of lab-based experiments including reprogramming human somatic cells into induced pluripotent stem cells, stem cell banking and validations, stem cell differentiation into disease-relevant cell types, generating 2D and 3D culture models, phenotyping diseased cells with cellular, molecular and functional assays.

• Oversee the day to day organization of different components of the projects.

• Work collaboratively with other RADC teams who are working on related research questions.

Position Qualifications Include:

• Ph.D. or MD or equivalent degree in the field of Neuroscience, Cell Biology, Developmental biology, Stem cell biology or Molecular biology or a related Field

• Excellent skills and experience in human iPSC derivation, stem cell culture and differentiation, 2D and organoid 3D culture

• Excellent skills and experience in cellular and molecular biology and fluorescence imaging

• Experience in calcium imaging, multielectrode array are highly desirable

• Experience in genome editing and next gene sequencing is a plus

• Excellent analytic and problem-solving skills

• Excellent project planning and organization skills

• Excellent written and oral communication skills

• Proven ability to work independently and in collaborative team environments

Company Highlights:

• Ranked among the top academic medical centers in the country, Rush University Medical Center is an outstanding place to enhance your career. Everything we do centers on one goal: improving patient care.

• Rush offers a competitive salary, valuable healthy living benefits to include: health, dental and vision to help you maintain and improve your health. Rush also offers several ways to invest in your future. Whether you’re saving for retirement or a child’s education, Rush offers benefits to help you make the most of your money…now and in the future.

Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.

投稿者:Shinya Tasaki

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