Postdoc Position Available in Weill Cornell Medical College, New York City

A Postdoctoral Associate position is available immediately in Ching-Hwa Sung’s Laboratory at the Weill Cornell Medical College, New York City. The Sung lab uses state-of-the-art mouse genetics, molecular cell biological, and ultrastructural techniques to address the molecular basis of retinal degenerative diseases including retinitis pigmentosa (RP), aged-macular degeneration (AMD) and ciliopathy (Cell 130:535; J Clin Invest 114:131; Nat Cell Biol. 13:402; J Cell Biol 190:953; Dev Cell 32:731). The postdoc will work on a new project related to the cell biology/signaling pathway/metabolism of cone photoreceptors and the exploration of therapeutic treatments to prevent cone cell death. PhD candidates are required to have a publication record in one of the following fields (biochemistry, cell biology, neuroscience, biomedicine) and strong communication skills. Experience in stem cell cultures and/or animal handling is preferred. Review of applicants will start immediately until the position is filled. The stipend levels follow the current NIH scale. Interested individuals should submit a single PDF file containing the following information to Ching-Hwa Sung (chsung@med.cornell.edu). (i) CV including 2-3 referees’ contacts. (ii) A 1-page cover letter summarizing your current research, general research interest, and personal goals. Weill Cornell Medical College is an equal opportunity/affirmative action employer.

投稿者:Ching-Hwa Sung(chsung@med.cornell.edu)



PIのBalasubramanian教授は20年以上アクトミオシン研究に従事してきた実績があり、その多くは高い評価を受けてきました。最近までは主に分裂酵母Schizosaccharomyces pombeを用いた遺伝学を中心にアクトミオシン収縮管研究を展開してきましたが、2014年にシンガポールからイギリスにラボを移してからはラボの規模と研究資金の拡大に伴い、合成生物学や生物物理化学的な手法も取り入れ、ゼブラフィッシュや線虫、ヒトの培養細胞、古細菌なども用いた更にエキサイティングでハイレベルな研究を行なっております。
従事していただく研究内容は比較的自由度がありますが、主に細胞生物学(共焦点、超解像度を用いたイメージング)、アクチン及びモータータンパク質の生物物理学(一分子イメージング、脂質膜-タンパク質相互作用の解析、細胞骨格が発する力学の測定)、化学および合成生物学(コドン拡張やchemical genetics)および遺伝学および分子生物学(主に分裂酵母およびゼ​​ブラフィッシュ)を用いた研究を展開していただくことになります。
研究環境も優れており、二台の最新鋭のconfocal spinning disc顕微鏡とTIRFMなどをラボで所有しており、超解像顕微鏡やライトシート顕微鏡なども研究科に導入されておりアクセス可能です。



Balasubramanian laboratory
Warwick Medical School
University of Warwick

1. Palani S, Srinivasan R, Zambon P, Kamnev A, Gayathri P, Balasubramanian MK. (2017). Steric hindrance in the upper 50 kDa domain of the motor Myo2p leads to cytokinesis defects in fission yeast. J Cell Science. (doi: 10.1242/jcs.205625.
2. Chew, TG, Huang J, Palani, S., Kamnev, A, Hatano, T., Somesse, R., Gu, Y., Oliferenko, S., Sivaramakrishnan, S., and Balasubramanian, M.K. (2017) Actin turnover ensures actin filament homeostasis during cytokinetic ring contraction. J Cell Biology (doi: 10.1083/jcb.201701104).
3. Palani, S., Chew, TG, Srinivasan, R., Kamnev, A., Mishra, M., Sevugan, M., Chapa-y-Lazo, B., Gayathri, P., and Balasubramanian, M.K. (2017) Motor activity dependent and independent functions for Myosin II in Cytokinesis. Current Biology 12:751-757.
4. Zambon, P., Palani, S., Kamnev, A., Balasubramanian, M.K. (2017). Myo2p is the major motor involved in Actomyosin Ring Contraction in S.pombe. Current Biology 27:R99-100.
5. Huang, J., Chew, TG, Gu, Y., Palani, S., Kamnev, A., Carter, N., Martin, D, Cross, RA., Oliferenko, S., Balasubramanian,M.K. (2016). Curvature induced expulsion of actomyosin bundles during cytokinesis in fission yeast. eLife. (http://dx.doi.org/10.7554/eLife.21383).
6. Tao, E.Y., Calvert M.E., and Balasubramanian M.K. (2014). Rewiring Mid1p independent Medial Division in Fission Yeast. Current Biology 18: 2181-2188.
7. Mishra, M.*, Kashiwazaki, J., Tagagi, T., Huang, Y.*, Srinivasan, R.*, Balasubramanian, M.K., and Mabuchi, I. (2013)."In Vitro Contraction of Cytokinetic Ring Depends on Myosin II but not on Actin Dynamics." Nature Cell Biology . 15: 853-859. * MKB is a corresponding author.
8. Huang, J., Huang, Y., Yu, H., Padmanabhan, A., Subramanian, D., Tao, Y., Thadani, R., Tang, X., Wedlich-Soldner, R., and Balasubramanian, M.K. (2012) Non-medially assembled F-actin cables incorporate into the actomyosin ring in fission yeast. J Cell Biology 199: 831-847.
9. N. Sadananda Singh, Nan Shao, Liping Ren, Mayalagu Sevugan, Janel McLean, Ting Gang, Andrea Bimbo, Reetu Sharma, Xie Tang, Kathy Gould, and Mohan K. Balasubramanian. (2011).The SIN inhibitory phosphatase complex (SIP) promotes Cdc11p dephosphorylation and propagates SIN-asymmetry in fission yeast. Current Biology. 21:1968-1979.
10. Calvert, M., Wright, G. D., Leong F.Y., Chiam, K.H., Chen, Y., Jedd, G., and Balasubramanian, M.K. (2011). Myosin II confers cell-size dependent scalability to the rate of actomyosin ring constriction. J Cell Biology. 195:799-813.



横浜市立大学 視覚再生外科 常勤教員(助教)募集

常勤教員(助教)募集 視覚再生外科


1 概要



2 応募資格


3 就任予定年月日

平成30年4月1日 応相談

4 応募方法


ア 履歴書 正本1部〔日本語および英語〕

イ 研究業績書 正本1部〔日本語および英語〕

ウ 主たる研究書・研究論文の要約(日本語2000字程度および英語800ワード程度。教育研究業績書リストの主な業績と対応させること)1部〔日本語および英語〕

エ 学位を証明する文書 正本1部(学位記の写しなど)

オ 応募者の経歴等照会先(2名程度)


2.「視覚再生外科学常勤教員 応募書類在中」と朱書きしてください。


公立大学法人横浜市立大学附属市民総合医療センター 眼科



5 選考方法

平成 30年 3月上旬~中旬に書類審査通過者に対して面接を行います。

6 待遇

常勤教員・助教 (週35時間勤務)
(加入保険等: 労災保険、雇用保険、健康保険料等を賃金から控除)

7 勤務地


8 備考


横浜市立大学 視覚再生外科
E-mail: maicoo@urahp.yokohama-cu.ac.jp


INMED/INSERM Marseille, France Postdoctral Position

Postdoctoral position in Neuroscience/Developmental Neurobiology at INMED/INSERM Marseille, France

We are inviting applications from post-doctoral candidates to investigate the pathomechanisms of epilepsy in brain malformations, and evaluate novel treatment strategies.

Project: Malformations of cortical development (MCDs) are common causes of intellectual disability and epilepsy, yet there is a crucial lack of relevant preclinical models. The project aims (1) to characterize novel preclinical models of epileptogenic MCDs recapitulating pediatric epilepsy syndromes, and (2) to evaluate the potential anti-seizure or disease-modifying effects of novel therapeutic strategies. This will combine several complementary and integrated approaches, from molecular biology and embryonic brain delivery of transgenes, histopathological analyses of resulting phenotypes, to in vivo recordings in freely behaving or head-restrained rodents with single/multi-electrodes.

Environment: INMED (www.inmed.fr/en) is a mixed entity of INSERM (www.inserm.fr/en/home), a French governmental research agency, and Aix-Marseille University (www.univ-amu.fr/en). At INMED, 11 multidisciplinary research groups join their efforts to gain a better understanding of brain development and plasticity, and brain disorders such as epilepsy. Located at the heart of the Parc National des Calanques in Marseille, France (www.calanques-parcnational.fr/fr), INMED offers an outstanding scientific and scenic environment for a successful postdoctoral career.

Candidates: We are seeking a highly motivated person holding a PhD in Neuroscience (or equivalent), with a good track record in electrophysiology including patch-clamp and/or field recordings from brain slices and/or EEG recordings in vivo. Experiences in data analysis and programming are a plus. Excellent candidates with expertise in other areas may also be considered. The successful candidate will have the ability to develop projects with a high level of autonomy and work in a team environment.

Please send a cover letter describing your motivations and research experience, a CV and 2 references to Dr Jean-Bernard Manent (jean-bernard.manent@inserm.fr)

Posted by Jean-Bernard Manent(jean-bernard.manent@inserm.fr)


Lunenfeld-Tanenbaum Research Institute and University of Toronto Postdoctral Position

The Ramalho-Santos lab at UCSF will move to the Lunenfeld-Tanenbaum Research Institute (LTRI) at the University of Toronto in 2018, and is recruiting postdoctoral fellows effective immediately.
• Dr. Ramalho-Santos will be the Canada 150 Research Chair in Developmental Epigenetics and lead an exciting new initiative in this area in Toronto.
• The LTRI is the top biomedical research institute in Canada: http://www.lunenfeld.ca/
• The LTRI has major strengths in Systems Biology and Developmental and Stem Cell Biology.
• The lab will be supported by stellar core facilities for sequencing, proteomics, imaging, flow cytometry, metabolomics: http://research.lunenfeld.ca/invivo/?page=Technology%20Platforms
• The LTRI has one of the best academic mouse facility in North America http://www.phenogenomics.ca/
• The University of Toronto is one of the top 20 universities in the world. In one single campus in downtown Toronto there is arguably the highest concentration of top biomedical research in North America.
• Very interactive/collaborative community.

Toronto is a vibrant, cosmopolitan, diverse, liberal and safe city: https://en.wikipedia.org/wiki/Toronto
• Excellent quality of life: https://www.economist.com/blogs/graphicdetail/2017/08/daily-chart-10
• Great cultural offer, professional sports, restaurants, parks, schools and public transit. Low crime.
• Nearby: good hiking, camping, biking, water sports, cross-country skiing, etc.
• Very easy to travel to/from with 2 modern airports with connections all over the world.
• Direct flights to all major cities in US, Europe, Asia.
• Rents in Toronto are much more affordable than San Francisco or Boston: https://www.rentjungle.com
• Ontario lake effect and big city heat island make Toronto weather milder than most other places in Canada. Weather is very similar to Boston, but Toronto has later sunsets and much less rain/snow than Boston. Unlike San Francisco, Toronto has a proper, warm Summer: https://weatherspark.com
• Large city with many opportunities for spouses/partners in academic labs, hospitals, biotech, pharma, etc.

Scientific Areas of Interest
• Preference will be giving to candidates with a strong published record in several of these areas:
Developmental Biology, Fertilization, Pre-Implantation Development, Pluripotency, Germline Development, Embryonic and Adult Stem Cell Biology, DNA Methylation, Chromatin Biology, Non-Coding RNAs, Epigenomics, Transgenerational Epigenetic Inheritance, Functional Genomics, Genome Editing, Transposon Biology, Nuclear Dynamics, Bioinformatics
• Qualified candidates should send a CV, cover letter detailing research experience and how their interests fit with the broad field of Developmental Epigenetics, and the names of 3 references to: mrsantos@ucsf.edu

Posted by Miguel Ramalho-Santos(mrsantos@ucsf.edu)


テキサス大学Health Science Center at San Antonio ポスドク募集

テキサス大学Health Science Center at San Antonioの同僚のPIがポスドクを募集しています。以下が募集広告になります。ご不明な点があれば、担当者へ直接お問い合わせください。

Postdoc Positions Focusing on Gene Regulation in Cancer Progression Multiple postdoctoral positions are available in the laboratory of Dr. Jason Liu (http://molecularmedicine.uthscsa.edu/FAC_Research.aspx?facID=206) in the Department of Molecular Medicine at the University of Texas Health Science Center at San Antonio (UTHSCSA). The focus of the lab is studying enhancer function and epigenetic mechanism in gene regulation in cancer progression. Selected candidates will perform highly interdisciplinary and collaborative scientific research in one or more of the following projects, working with human cell lines, mouse models and clinical samples:
(1) Explore the function of signaling-regulated enhancers in breast and prostate cancers, and understand how enhancers are regulated by the crosstalk of different signaling pathways including sex hormones, inflammation signals and metabolic signals;
(2) Decipher the epigenetic and chromatin 3D level changes in enhancers upon developmental/pathological stimuli or during hormone/drug resistance acquisition;
(3) Identify diagnostic/prognostic biomarkers and therapeutic targets for cancer and develop drugs for pre-clinical studies and potential clinical applications.
Our research integrates next-generation sequencing (NGS)-based technologies and bioinformatics tools to investigate the component, epigenetic, and 3D level changes of enhancers in cancers (refer to Cell, 2014 159: 358–373). We are efficiently combining biochemical, cellular, and animal model-related studies with different NGS-based assays. Our research program will help the trainees from both wet and dry lab sides to build up strong expertise and training record in molecular biology and multi-omics (genomics, transcriptomics, proteomics, epigenomics and metabolomics).
Positions require a Ph.D. degree (or equivalent) in biochemistry, cell biology, cancer biology, bioinformatics, or closely related biological sciences. The candidates need to have high motivation
and strong molecular biology background. Any prior experience in patient-derived xenograft (PDX) models, breast/prostate cancer, and computational analyses will be valued.
San Antonio is one of the fastest growing cities. The UTHSCSA is the largest university of health science in South Texas and one of four medical schools in the UT System. The affiliated Cancer Therapy & Research Center (CTRC) is one of the NCI-designated national cancer centers in the state of Texas. A competitive salary and benefits package will be provided.
To apply:
Please send the application package in one single pdf file including a cover letter briefly describing your previous experience and your future research interest/plan, curriculum vitae with list of publications, and contact information of at least three references to the following email. You are also welcome to send any inquiries or questions you might have.
Contact information:
Dr. Jason Liu
Department of Molecular Medicine
The University of Texas Health Science Center at San Antonio
7703 Floyd Curl Drive
San Antonio, TX, 78229-3900
Email: LiuZ7@uthscsa.edu
Institution Web Site: http://molecularmedicine.uthscsa.edu/index.aspx
"All Postdoctoral appointments are designated as security sensitive positions."
"The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer including protected veterans and persons with disabilities."



カルフォルニア州ロサンゼルス、Cedars-Sinai Medical Center研究員募集

カルフォルニア州ロサンゼルス、Cedars-Sinai Medical Center, Yamashita Labでは意欲のある研究員を2名募集しています。

1:糸球体腎炎の発病メカニズム、特にTLRとEGFRの半月体形成性糸球体腎炎における役割について、cell culture, animal model, そしてヒトの腎生検組織を用いて調べています。
また、これに加えて、mitochondrial injury, inflammasomes, trained immunityそしてACEのRAS非依存的な腎炎への影響についても調べています。
Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling. Sci Signal. 2012 Jul 17; 5(233):ra50.
TRIF-independent branch of TLR3 signaling. J Immunol. 2012 Mar 15; 188(6):2825-33.
Antiviral innate immunity disturbs podocyte cell function. J Innate Immun. 2013; 5(3):231-41.
Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy. Am J Physiol Renal Physiol. 2017 Nov 29[Epub ahead of print]
非常にsupportiveな大ボスならびにCollaborator達(Drs. Moshe Arditi, Kenneth Bernstein, David Engman, Ravi Thadhani, and Ananth Karumanchi)に囲まれて、ラボを立ち上げました。非常に面白い数々のTransgenic miceや機材、試薬も揃っており、非常に恵まれた環境です。私達のグループには現在25人が働いており、私も含めて6人の日本人研究者が在籍しています。みなさん非常に協力的で環境の変化にも適応しやすいかと思います。

2. 豊富な腎生検のデータ(2006以降だけでも37,000件)や臨床データを用いて、臨床研究を行っています。全体の内、70%が自己腎(Native Kidney)で30%が移植腎(Transplant Kidney)です。Transplant Centerでは腎移植自体も活発に行われており、年間200例ほど行われています。これだけ大きなデータがあれば、腎生検/腎病理に関係することであれば、臨床上の些細な疑問も含めてすべてプロジェクトになり、比較的簡単に論文化(少なくとも年3-4本)されると思います。

Cedars-Sinai Medical Centerはビバリーヒルズにある、およそ900床の病院でそれに併設している研究所では活発にtranslational researchが行われております。ロサンゼルスは気候もよく、日本の食材も簡単に手に入り、また日本人も多いため、他の州に比べて非常に快適な生活が送れると思います。私が所属するRenal Pathologyは腎生検標本年間3600例を有し、私も含め5人のrenal pathologistsが所属するアメリカ西海岸最大の施設です。うち、移植腎生検も活発に行われており、年間700件以上あります。
また、2017年11月よりMGHのNephrologyのトップであったDr. Ravi ThadhaniとBeth Israel HospitalのDr. Ananth Karumanchi(両者ともHarvardのProfessor)がCedars-Sinaiに移ってきており、共同研究を行っています。腎臓研究はますます活発になっていくと思います。

給与:Cedars-Sinai Medical Centerの内規に沿ったものとなります。


Michifumi Yamashita, MD, PhD, FASN
Assistant Professor
Department of Pathology & Laboratory Medicine
Cedars-Sinai Medical Center
8700 Beverly Blvd. PACT 500
Los Angeles, CA 90048
Email: Michifumi.Yamashita@cshs.org



Boston University School of Medicine Postdoctral Position

A Postdoctoral Associate position is available immediately at Boston University School of Medicine in the laboratory of Dr. Huiping Zhang to study the genetic and epigenetic mechanisms of alcohol use disorders (AUD) and other mental disorders. The candidate will be mainly working on a NIH-funded project to (1) profile microRNA and mRNA transcriptome alterations in postmortem brains of alcoholic subjects using RNA-Seq, (2) construct microRNA-mRNA regulatory networks using bioinformatics programs, (3) validate AUD-associated microRNA and mRNA expression changes using human embryonic stem cell (hESC)-derived neurons as models, and (4) refine microRNA-mRNA regulatory networks using 3' UTR reporter assays. Further information about the research directions may be found at: http://www.bumc.bu.edu/genetics/huiping-zhang-ph-d/.
Experience in one or more of the following areas is desired: RNA-sequencing and bioinformatics, stem cell differentiation, reporter gene assays, and genome editing. Experience in stem cell differentiation and reporter gene assay is preferred. Strong written and oral communication skills are required.
Candidates should have a recent Ph.D. in genetics, cell biology, neuroscience, or a related discipline.
Boston University is located in Boston, Massachusetts. Boston University is an equal opportunity/affirmative action employer. NIH scale salary support is available.
To apply for this position, please email your CV, a cover letter detailing research experience, and contact information for three references to Dr. Huiping Zhang (huipingz@bu.edu).

Posted by Huiping Zhang(huipingz@bu.edu)


A Postdoctoral Position Available at Cleveland Clinic Lerner Research Institute in the USA

2018年3月発足予定のMatsuoka Labでは研究推進の主力となる熱意ある研究員を募集しています。臓器形成および再生時(とりわけ神経組織)の脈管形成機序の基本原理の解明を目指し、主にゼブラフィッシュをモデル動物として精力的に研究を進めていける意欲的な研究員の応募をお待ちしております。

A postdoctoral position is available in Ryota Matsuoka's Laboratory at the Lerner Research Institute, Cleveland Clinic. This newly established group starting in March, 2018, aims to define the cellular and molecular basis of vascular and lymphatic assembly in the central nervous system (CNS) using zebrafish and mouse as model organisms. Dr. Matsuoka's past work addressed how the vascularization of tissues surrounding the spinal cord is established in zebrafish (Matsuoka et al. eLife, 2016: PNAS, 2017) and how retinal neural circuits are organized in mouse (Matsuoka et al. Nature, 2011: Neuron, 2011). The future lab projects are directed towards understanding dynamic coordination of neuronal and vessel growth at the cellular and molecular level, which leads to the formation of the mature, functional CNS in vertebrates. The lab uses a combination of advanced 3D imaging, forward and reverse genetics to uncover this coordinated process during development and regeneration, with the goal to reconstitute vascularized functional neuronal tissues following CNS disease/injury.
The successful applicant is expected to apply for external fellowships, present data at scientific conferences, and prepare manuscripts for publication. Candidates with a publication record in developmental biology, genetics, neuroscience, or cell biology are preferred. Previous experiences working with animal models are also preferred.

Review of applicants will start immediately and continue until the position is filled. The stipend levels follow the current NIH scale, and start date is flexible. The contract will be renewed annually and extended for a period of 4 years and possibly longer, dependent upon satisfactory progress and the lab's funding situation. Interested individuals should submit a single PDF file containing the following materials to matsuoka.lab.recruit@gmail.com:
1) CV, including a list of publications and contact information for 2‐3 references
2) Cover letter describing previous research, research interests, and career goals

For more information, please contact at matsuoka.lab.recruit@gmail.com.
Ryota Matsuoka, Ph.D.
Principal Investigator
Lerner Research Institute, Cleveland Clinic
9500 Euclid Avenue
Cleveland, OH 44195, USA

投稿者:Ryota Matsuoka


Temple University School of Medicine ポスドク募集

私の所属するTemple University School of Medicine, Department of Physiology
(Philadelphia)で教授のRosario Scalia PhDがNIH RO1 grant 取得に伴い新たに
Postdoctoral Fellow を 募集致します。このgrantではmicrocirculationにおける血管炎症

Postdoctoral position
Department of Physiology
Temple University School of Medicine, Independence Blue Cross Cardiovascular
Research Center.
Project Title: The role of aging on vascular signal transduction and endothelial
inflammation in micro-circulation.
Position Type: Postdoctoral Position at an Academic Institution
My laboratory is looking for a post-doctoral fellow (commitment for 2 years or more) to
conduct collaborative in vitro and in vivo research experiments focused on the signal
transduction mechanisms of cardiovascular and adipose inflammation and aging.
Cutting-edge cell biological and biochemical approaches, genetic mouse models, large
animal models and human tissue specimens will be employed during the training period.
Applicants must have a Ph.D. or M.D. degree. One position is currently available with
full financial support (NIH standard) up to 4 years.

Preferred Qualifications:
1. Familiarity with at least one of the followings: molecular biology, organelle/cell
biology, biochemistry, mouse models, intravital microscopy, and surgical skills.
2. Publication record in biomedical journals.

Rosario Scalia, PhD
Professor of Medicine
Temple University School of Medicine
Department of Physiology
Independence Blue Cross Cardiovascular Research Center
3500 N. Broad Street
Philadelphia, PA 19140

イタリア系で陽気なScarlia先生のラボは比較的小さなラボですがNIH Grantの更新に伴
応募あるいは興味、質問のある方はCV (PDF)を添付して下記メールアドレスまで 気軽











〒241-8515 横浜市旭区中尾 2-3-2
神奈川県立がんセンター 臨床研究所 

〒241-8515 横浜市旭区中尾 2-3-2
TEL:045-520-2222(代表) 内線2105


笹田 哲朗
電話(045)520-2222(代表) 内線5063
e-mail: tsasada@kcch.jp


投稿者:笹田 哲朗(tsasada@kcch.jp)

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