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The University of Alabama at Birmingham ポスドク募集

私の留学時代の同僚であるDr. Hengbin Wangがポスドクを募集しております。詳しくは以下の募集内容を参考にしていただき、募集に関する問い合わせはDr. Hengbin Wang(hbwang@uab.edu)にお願いします。彼の人柄などについて質問のある方は、束田裕一(ytsukada@bioreg.kyushu-u.ac.jp)に問い合わせいただいても構いません。

Postdoctoral Position Available to Study Epigenetic Regulation inNormal and Pathological Development
Epigenetics, the mechanism that defines gene expression pattern without changing DNA sequences, provides cells with transcriptional memory to allow the transmission of gene expression patterns during cell division, and with developmental flexibility to permit reprogramming of gene expression patterns during embryogenesis. The far-reaching consequences of epigenetics on normal development and pathological conditions have recently been demonstrated in many model systems and in multiple biological processes. Our laboratory has been focusing on studying posttranslational histone modifications in epigenetic regulation. We have been using biochemical approaches to dissect the molecular mechanisms for epigenetic regulation. We are currently investigating the roles of these enzymes in stem cell function, embryogenesis, and cancer development. We employ a combination of biochemical and genetic approaches to decipher the functions of these histone modifying! enzymes in chromatin and cellular regulation. People with strong interests in chromatin and epigenetic are encouraged to apply. Experiences with mouse model are preferred but not definitely required. Please send CV and the names of three references to:
Hengbin Wang, PhD
Department of Biochemistry and Molecular Genetics
The University of Alabama at Birmingham
Kaul Human Genetics Building, 402A
720 South 20th Street
Birmingham, AL 35294-0024
Tel: 205-934-5286 (O); 205-934-5289 (L)
Fax: 205-934-0758
E-mail: hbwang@uab.edu
Selected References:
1. Hengbin Wang, Zhiqing Huang, Li Xia, Qin Feng, Hediye Erdjument-Bromage, Brain D. Strahl, Scott Briggs, David C. Allis, Jiemin Wong, Paul Tempst, and Yi Zhang (2001). Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science, 293, 853-857.
2. Hengbin Wang, Ru Cao, Li Xia, Hediye Erdjument-Bromage, Christoph Borchers, Paul Tempst, and Yi Zhang (2001). Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Molecular Cell, 8,1207-1217.
3. Hengbin Wang, An Woojin, Ru Cao, Li Xia, Hediye Erdjument-Bromage, Bruno Chatton, Paul Tempst, Robert G. Roeder, and Yi Zhang (2003). mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Molecular Cell, 12 (2), 475-487.
4. Hengbin Wang, Liangjun Wang, Migual Vadel, Hediye Erdjument-Bromage, Paul Tempst, Richard S. Hones, and Yi Zhang (2004). Role of H2A ubiquitination in Polycomb gene silencing. Nature 431:873-878.
5. Hengbin Wang*, Ling Zhai, Jun Xu, Heui-Yoo Joo, Sarah Jackson, Hediye Erdjument-Bromage, Paul Tempst, Yue Xiong, and Yi Zhang*. (2006). Histones H3 and H4 ubiquitylation by the Cul4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Molecular Cell. 22(3):383-394. (*co-correspondence author).
6. Jianhua Wei, Ling Zhai, Jun Xu, and Hengbin Wang. (2006). Role of Bmi1 in H2A Ubiquitylation and Hox Gene Silencing, Journal of Biological Chemistry, Aug 11;281(32):22537-44.
7. Heui-Yoo Joo, Ling Zhai, Chunying Yang, Shui Nie, Hediye Erdjument-Bromage, Paul Tempst, and Chenbei Chang, Hengbin Wang. (2007) Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature, Oct 25;449(7165):1068-72.

Complete publication list of Dr. Hengbin Wang can be found in PubMed.

投稿者:束田 裕一(ytsukada@bioreg.kyushu-u.ac.jp)

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