The Scripps Research Institute - Posdoc Positions

Postdoctoral positions are available working in the laboratory of Dr. Shuji Kishi at Florida campus of The Scripps Research Institute. The successful candidate will be involved in basic and translational research focused on elucidating underlying molecular mechanisms of metabolic and neurodegenerative diseases, cancer and aging in terms of canonical and non-canonical functions of newly identified gene products and chemical compounds in our zebrafish model system. The researchers may also have a very unique opportunity to develop a cross- and interdisciplinary approach using methods and logic of biochemistry and molecular cell biology merging with genetics, x-ray crystallography, evolutionary analysis, and high-throughput screening assays for disease targets and learn critical aspects of the drug discovery and development process through utilizing zebrafish as the key model organism.

Ph.D. or M.D./Ph.D. in a related scientific discipline such as developmental biology and genetics as well as comprehensive molecular biology background, including genotyping, Q-PCR, molecular cloning, vector design and construction, in situ hybridization, western blotting and immunohistochemistry is required. Must be highly self-motivated and possess a strong ambition to become an independent investigator. Experience in zebrafish physiology, genetics, developmental biology, histopathology and imaging technology would be appreciated but not required.

To be considered, please send a cover letter describing your research backgrounds and interests, your CV, copies of at least two representative publications, and a list of three individuals that can serve as references to:

Shuji Kishi , Department of Metabolism and Aging, The Scripps Research Institute Florida, 130 Scripps Way #3B3, Jupiter FL 33458, USA

Posted by Shuji Kishi(kishi@scripps.edu)


イリノイ大学医学部薬理学科 研究補助員募集

[研究内容] 当研究室では、キネシンによるシグナル物質の細胞内輸送調節と血管新生におけるその役割を、血管内皮細胞を用いて研究しております。タンパク質の活性の制御、構造、局在の変化を生化学、分子生物学、細胞生物学の手法で解析するところから、ノックダウンによる疾患の治療への応用まで発展させていく予定です。これらの研究分野に興味のある研究補助員を募集いたします。研究内容や環境の詳細についてはお気軽にお問い合わせください。

[応募資格] 生物系専門学校、短大、大学卒業以上またはそれと同程度の知識や経験を有していること。クローニング、タンパク質の精製と活性測定、動物実験(マウス、ラット)、組織染色、細胞培養 (初代培養も含む) のいずれかの手法に精通している人は優遇します。

[勤務地] University of Illinois at Chicago, College of Medicine, Illinois, USA.

[待遇] University of Illinoisの規定に準じます。福利厚生あります。

1. 履歴書と研究業績目録(推薦者2-3名の氏名, 連絡先を含む)
2. これまでの研究の概要並びに将来の研究の展望

[就任時期] 採用決定後、出来るだけ早い時期, 開始時期は相談に応じます。2013年1月から1年ごとの契約となります。本事業終了予定の2016年12月まで更新可能(ただし事業の中間審査により継続ができない場合もあります。)


[PI] 山田かおり (Kaori Yamada, Ph.D.)
Research Assistant Professor,
E403 (M/C868), MSB, 835 South Wolcott Ave.,
Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612

E-mail: horiguch@uic.edu
URL: http://www.uic.edu/depts/mcph/resfac_kaori.htm



University of Nevada School of Medicineポスドク募集

Department of Physiology and Cell Biology
Center for Molecular Medicine
University of Nevada School of Medicine

2)Visiting Research Scholar


  現在当ラボには、Research Assistant Professor1名(ベルギー人)、postdoc2名(日本人と中国人)、Lab tech1名(日本人)、PhD student1名(サウジアラビア人)、学生3名(日本人、アメリカ人およびイギリス人)の計8人が所属しております。 当DepartmentのFacultyも半分以上がアメリカ以外の出身で、非常に国際色豊かなDepartmentおよびLabです。


・ MDあるいはPhD(取得見込みも含む)。
・ 電気生理学的実験手法(パッチクランプまたは細胞内カルシウム測定)の経験者。
・ 基本的なMolecular biology、Cell cultureまたはMouse handling/physiology/surgeryの技術を習得している。

[待遇] 給与額は大学の規定を基本に研究歴や意欲により考慮します(例;ポスドク1年目は年4万ドル)。

[期間] 1年毎の更新で、基本的には2~3年以上研究できる見込みの方が望ましいです(Visiting Scholarは短期でも構いません)。


Hiroto Miura, MD, PhD, FAHA
Associate Professor
Email: hmiura@medicine.nevada.edu



Washington University School of Medicine ポスドク募集

Job description:
A postdoctoral position is available in the laboratory of Hiroko Yano, PhD at Washington University School of Medicine to study molecular mechanisms of neurodegenerative diseases, starting in the spring 2013. Transcriptional dysregulation and mitochondrial dysfunction are thought to contribute to the pathogenesis of neurodegenerative diseases including Huntington’s disease (HD). We are trying to understand how these key cellular changes lead to neuronal death and dysfunction as well as to identify the upstream pathways that regulate these changes. We use molecular biological, cell biological, biochemical, and genetic approaches and take advantage of primary neuron culture as well as cell and animal models of HD. A current major focus is the identification of novel epigenetic pathways that alter histone modifications and lead to aberrant gene expression in HD.

Washington University School of Medicine consistently ranks in the top 5 medical schools in the USA and is home to many of the United States' top scientists and physicians. The Department of Neurological Surgery in particular has a rich tradition of clinical and scientific excellence and is highly collaborative with other Departments in the medical center.

Link to Websites:

Candidates should hold PhD or MD with expertise in molecular and cell biology and biochemistry with a preference for new graduates or postdoctoral fellows with 3 or fewer years of experience. We seek highly motivated individuals who ideally have experience in the field of gene regulation and epigenetics.

Materials needed to send:
Interested candidates should send a short personal statement including their research interests and background, CV, and contact information for three references to: yanoh@wudosis.wustl.edu

Hiroko Yano, PhD
Assistant Professor of Neurosurgery and Neurology
Washington University School of Medicine
660 S Euclid Ave, Box 8057
St. Louis, MO 63110
yanoh@wudosis.wustl.edu (日本語可)

投稿者:Hiroko Yano(yanoh@wudosis.wustl.edu)


Indiana University School of Medicineポスドク募集

Institution Name Indiana University School of Medicine
Department Name Medical & Molecular Genetics
Position Title Postdoctoral Fellow
PI Dr. Hiromi Tanaka
URL http://genetics.medicine.iu.edu/faculty/hiromi-tanaka-ph-d/

A postdoctoral position is available at Indiana University School of Medicine. The qualified applicants holding an MD or PhD will investigate the role of telomere maintenance and telomerase regulation in cancer and aging.

Candidates must be a highly motivated postdoctoral fellow interested in human telomere and telomerase biology. Candidates have less than 3 years of research experience beyond their terminal degree are encouraged to apply. Preference will be given to those who have experiences in molecular and cellular biology, medical genetics, and biochemistry. Their creativity, productivity, and the ability to interact within a team will be required. Candidates who are enthusiastic, critical thinking, inquisitive and desire to make a contribution are ideal.

Application Instructions:
Applications should be sent by email to: Hiromi Tanaka (hirtanak@iupui.edu), and include a curriculum vitae, a letter describing the candidate's research background, and the names of 3 references.

Selected publication:
Hiromi Tanaka*, Satoshi Abe, Nazmul Huda, LiRen Tu, Matthew J. Beam, Brenda Grimes, and David Gilley*: Telomere fusions in early human breast carcinoma. Proc. Natl. Acad. Sci. USA 109:14098-14103, 2012 [*shared corresponding author]

投稿者:Hiromi Tanaka


University of Minnesota, Twin Citiesポスドク募集


DNA Replication & Repair/Basic Cancer Research
at the University of Minnesota, Twin Cities

Replication origins exist in a large excess over the number that will actually fire during S phase. While it is thought that these excess origins usually remain dormant, our recent work shows that these excess origins (often called dormant or backup origins) play a major role in the recovery of stalled forks, contributing to tumor suppression. Currently, we are investigating the functional interactions between dormant origins and DNA repair pathways in stalled fork recovery and tumor suppression using mouse models. For more information, please see our papers listed below.

1. Kawabata et al., (2011) Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Mol Cell 41:543-553.
• Previewed by Klotz-Noack, K and Blow, JJ (Mol Cell 41:495-496, 2011).
• See an invited auto-commentary in Japanese at First-Authors’ http://first.lifesciencedb.jp/archives/2446
• Cited by the Faculty of 1000
2. Shima N et al. (2007) A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice, Nature Genetics 39: 93-98.
• Previewed by Dutta, A (Nature Genetics 39:10-11, 2007).
• Cited by the Faculty of 1000

We are looking for a highly motivated individual with a recent Ph.D. or MD. A successful candidate must have a strong background in molecular biology and genetics and is expected to work at the bench independently. Experience with mouse genetics is a plus, but not necessary. To apply, please send your curriculum vitae, a brief description of your career goal, and the names and addresses of 3 references to shima023@umn.edu.


Naoko Shima, Ph.D.
Associate Professor
Department of Genetics, Cell Biology and Development
Masonic Cancer Center, University of Minnesota
Minneapolis, MN 55455 USA
Phone: 612-626-7830
FAX: 612-626-6140
E-mail: shima023@umn.edu (日本語可)



名古屋大学大学院医学系研究科 環境労働衛生学 ポスドク募集

名古屋大学大学院医学系研究科 環境労働衛生学 ポスドク若干名募集
【概要】 神経学、腫瘍学、疫学または環境分析化学のどれかの領域の御経験がある方で、環境労働衛生学研究を積極的に推進していただける方を博士取得後研究員(ポスドク)として若干名募集致します。興味のある方は、1)履歴書(生年月日、性別、配偶者や子供、emailアドレス等の情報も含むもの)、2)志望動機、3)研究業績(論文・特許・科学研究費等外部資金取得状況)、4)主要論文とその概要(5編以内、各400字以内)、5)現在迄の研究概要と抱負(A4で1枚以内)、6)現在の指導者および学位論文指導者のemailアドレス、についてPDFの添付文書にて、電子メールにてお送りください(送信用メールアドレス:katomasa@isc.chubu.ac.jp)。応募書類を拝見させていただきました後、「現在の指導者から1通」と「学位論文指導者から1通」の合計2通の推薦書(電子メールで可)をご依頼させていただく場合がございます。推薦書を拝見させていただきました後、面接のご依頼をさせていただき、面接後に最終的な採否に関してのご連絡をさせていただく予定です。



【雇用期間等】 契約は単年の更新で、原則として平成26年3月末日迄の雇用を考えています。非雇用者と雇用者の両方が承諾すれば、期間の延長も考慮致します。賃金や保険等は、名古屋大学の規定に従います。

【研究室】 現時点での研究室は、中部大学にありますが、2013年1月1日より、本件の責任者および研究室が名古屋大学大学院 医学系研究科 環境労働衛生学に移動します。ゆえに、ポスドクの方は、名古屋大学大学院医学系研究科 環境労働衛生学の所属として、名古屋大学を主として、研究を遂行していただきます。

【選考方法】 1)応募書類→2)推薦文→3)面接、による選考をさせていただきます。



01) Arch Toxicol in press, 2012.
02) J Immunol 188(11):5365-76, 2012
03) Cancer Res 72(11):2757-67, 2012.
04) Neurobiol Aging 33(3):626.e25-34, 2012.
05) Arch Toxicol 86(6):961-73, 2012.
06) Cancer Res 71(22):6997-7009, 2011.
07) Cancer Res 71(16):5393-9, 2011.
08) Proc Natl Acad Sci USA 108(41):17111-6, 2011.
09) J Biol Chem 286(34):29621-6, 2011.
10) Cancer Epidemiol Biomaker Prevent 20(8):1622-8, 2011.
11) PLoS Biol 9(9): e1001162, 2011.
12) Proc Natl Acad Sci USA 107(29):13051-6, 2010.
13) J Clin Invest 120(6):2030-9, 2010.
14) J Exp Med 207(3):491-503, 2010.
15) Cancer Res 70(1):24-9, 2010.
16) J Clin Invest 119(5):1251-63, 2009.
17) Dev Cell 17(2):199-209, 2009.

【担当責任者】加藤昌志(email: katomasa@isc.chubu.ac.jp)
2012年12月31日迄: 中部大学生命健康科学部 教授
2012年1月1日以降(予定):名古屋大学大学院医学系研究科 環境労働衛生学 教授



Memorial Sloan-Kettering Cancer Centerポスドク募集

Memorial Sloan-Kettering Cancer Center (New York, USA) Emily Cheng 研究室では下記のとおりポスドクを募集しております。応募される方は、chengpostdocapps@gmail.comまでCV及び推薦者3名の連絡リストをお送りください。なお、日本語でのご質問等ございましたら、ポスドクの山内茜 (yamaucha@mskcc.org)、小山敏尚 (oyamat@mskcc.org) までお気軽にお問合せ下さい。
Post-doctoral positions are available for highly motivated candidates with a strong background in biochemistry, molecular biology, cell biology, and/or mouse genetics to join a research group studying the BCL-2 family, the fundamental mechanisms of cell death, and the impact of cell death regulators on tumorigenesis and cancer therapy (Science 330: 1390-1393; Molecular Cell 36: 487-499; Nature Cell Biology 8:1348-1358; Science Signaling 2: ra48; Science 301:513-517). Projects will include characterization of cell death mechanisms using biochemistry, proteomics or next-generation high-resolution imaging studies, delineation of cell death pathways in vivo using mouse models, high throughput functional genomics and chemical screens to identify modulators for cancer-specific cell death mechanisms, and development of cell death mechanism-based targeted therapies. Applicants should hold a PhD and/or MD degree and have strong laboratory and analytical skills. Special consideration !
will be given to candidates who have prior experience in biochemistry, mitochondrial physiology, TIRF microscopy, stochastic optical reconstruction microscopy (STORM) or Photo-activated localization microscopy (PALM).
Full applications include curriculum vitae, a description of past research experience and accomplishments, and a list of three references. Please submit the application material through chengpostdocapps@gmail.com to: Emily Cheng, M.D., Ph.D., Associate Member, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.



Dana-Farber Cancer Institute ポスドク募集

ボストンの Dana-Farber Cancer Institute にある私のMolecular Pathological Epidemiology (MPE, 分子病理疫学)の研究室でやる気のある研究室員(Postdoc)を募集しています。Pathology (特にdiagnostic pathology)あるいはEpidemiologyあるいはBiostatisticsあるいはBioinformaticsあるいはComputational BiologyあるいはCancer BiologyのBackgroundが望ましいです。

ラボでの仕事はいろいろありますが、パラフィン癌組織サンプルの管理とプロセシング、データーベースの管理、免疫組織染色、病理組織解析、DNA・RNA解析、Image Analysis、統計解析、あるいはプログラミングです。もちろんすべての手技をできる人はいませんので、得意な分野・経験を生かしていただきます。

プロジェクトは大腸癌、線腫、膵臓癌、消化器内分泌腫瘍のMolecular Pathological Epidemiology (MPE)です。MPEは2010年に私が提唱した学問分野で、疫学の中にInherent heterogeneity of disease processesをIntegrateしたという今までにない新しい学問ということがいえます(S Ogino et al. JNCI 2010; Gut 2011; Nat Rev Clin Oncol 2011)。私のラボでは大規模な前向き疫学コホートを使って大腸癌と膵臓癌の様々な分子異常の疫学的病因を研究しています。ハーバード大学公衆衛生大学院とBrigham and Women’s Hospitalではこれまで当初は健康な12万人の女性を34年(Nurses' Health Study、http://www.channing.harvard.edu/nhs/)、5万人の男性を24年(Health Professionals Follow-up Study、http://www.hsph.harvard.edu/hpfs/)追跡して、病気の発生を疫学的に研究してきました。私のラボではこの2つの大規模コホートにおいて追跡中に発生した大腸癌と膵臓癌の癌細胞内の遺伝子の異常、Epigenetic changes (DNAメチル化)、酵素やその他のたんぱく質発現の変化を解析しています。追跡に先立ち、あるいは24年、34年という追跡中に、食べ物、ライフスタイル(運動・肥満度・たばこ・アルコールなど)、薬、家族歴、癌や他の病気の発生、生存状況を記録しています。こうした病因に関するデータは癌やそのほかの疾患の発生に先立って集められているためにバイアスのリスクがより少ないのが、前向きコホート研究の長所です。こうして蓄積された貴重な病因データ、さまざまな遺伝子の多形(SNPs)、癌細胞の分子異常、患者の生存状況とを総合的に分析するというのが私のラボの研究内容です。MPE Researchの強みは最近のさまざまな論文で示されています(X Liao et al. NEJM 2012; E Barry et al. Nature online; R Straussman et al. Nature 2012; S Ogino et al. JNCI 2013; A Kuchiba et al. JNCI 2012; T Morikawa et al. JAMA 2011, etc).

MPE とMPE関連のさまざまな新しい概念についてはこのサイトで説明しました。



2013年1月に日本にてInterviewが可能かも知れませんがまだ未定です。2013年1月にRIKEN (大阪)、癌研、国立癌センター、東大医科研附属病院でMPEについて講演します。


Shuji Ogino, MD, PhD, MS (Epidemiology)
Associate Professor of Pathology, Harvard Medical School
Department of Pathology, Brigham and Women's Hospital
Department of Medical Oncology, Dana-Farber Cancer Institute

Associate Professor (Department of Epidemiology)
Harvard School of Public Health



Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California Postdoc募集

Postdoctoral Fellowship on Stem Cell Biology

A postdoctoral fellow position is available immediately in the Broad Center for Regenerative Medicine and Stem Cell Research at the University of Southern California. Our laboratory studies cell signaling and epigenetic control of stem cells. We focus on:
1. Molecular mechanisms of self-renew and differentiation of neural stem cells (Cell, 119, 97-108; Developmental Cell, 15(5): 773-80, Development, 138(3):409-19).
2. Molecular mechanisms of somatic cell reprogramming to induced pluripotent stem (iPS) cells (Stem Cells, 27(12): 2969-78).

The salary will be $40000 to $45000 depending on research experience. The laboratory is on a newly built building funded by CIRM and Broad foundation. Los Angeles is a metropolitan city with a diverse of culture.

Applicants should have had training in cell biology and molecular biology. Previous experience with neural development is a plus but not required. Applicants with strong motivation and publication record are especially encouraged to apply. Interested candidates please send a CV to wangelu@usc.edu.

Contact: Wange Lu, Ph.D.
USC Keck School of Medicine
Center for Stem Cell and Regenerative Medicine
1425 San Pablo Street, BCC413, MC 2821
Los Angeles, CA 90033
e-mail: wangelu@usc.edu

Posted by Kouichi Hasegawa(khasegawa@icems.kyoto-u.ac.jp)


Friedrich Miescher Laboratory of the Max Planck Society in Tübingen postdoctoral position

Two ERC funded postdoctoral positions are available at the Friedrich Miescher Laboratory of the Max Planck Society in Tübingen in the group of Wolfram Antonin (http://www.fml.tuebingen.mpg.de/antonin-group.html) to study the molecular mechanisms of chromatin decondensation at the end of mitosis.

Re-establishment of a functional interphase nucleus that allows for DNA transcription and replication involves a remarkable level of chromatin decondensation and reorganization. Using cell free assays and tissue culture cells we study the molecular details of this ill-defined process and seek to strengthen our research team by two highly motivated postdocs.

Candidates should have a strong background in biochemistry and cell biology, preferentially in the fields of chromatin structure/function and/or cell cycle research. Additional expertise in light and/or electron microscopy is helpful.
Applications including detailed CV, a brief description of previous work, a list of publications as well as the names and contact information of three referees should be sent before the 15th of December 2012 preferably electronically to:

Wolfram Antonin, Dr. rer. nat. Friedrich Miescher Laboratory of the Max Planck Society Spemannstrasse 39 72076 Tübingen Germany

The Max Planck Society is committed to equal opportunities, to addressing the family needs of employees, and to employing individuals with disabilities.

Posted by ジジ(jijilamo@gmail.com)


Samuel Lunenfeld Institute Research Institute in Mount Sinai Hospital in Toronto Postdoctoral Position

Post-doctoral Research in High Resolution Spatiotemporal Imaging of Mitotic Processes.

A Postdoctoral position is available at the Samuel Lunenfeld Institute Research Institute in Mount Sinai Hospital in Toronto. The Pelletier lab is keenly interested in the molecular mechanisms that govern various aspects of mitotic cell division including centrosome duplication, pericentriolar material assembly, microtubule dynamics, mitotic spindle formation and kinetochore function. Our studies revolve around cutting-edge quantitative microscopy approaches including structured-illumination, FRAP/FLIM, 4-D multiplex time-lapse imaging and high-content screening approaches in mammalian cells. Our imaging lab is equipped with 6 DeltaVision Elite deconvolution systems tweaked for fully automated high-resolution imaging of both live and fixed cells. Our laboratory also houses a 3D structured-illumination microscope allowing the study of the above-mentioned processes beyond the diffraction limit.

In this position, the successful applicant will be part of a fast-paced dynamic and multi-disciplinary environment and play an integral role in novel and ongoing projects within the laboratory. Applicants with experience in any of the following disciplines are preferred: advanced light microscopy, functional genomics and statistical approaches to quantitative microscopy and image analysis. Outstanding applicants in the field of molecular and cellular biology will also be considered.

Selected Publications:

Lawo S., Hasegan M., Gupta G.D. and Pelletier, L. Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material. Nature Cell Biology, October 21 (2012). PMID: 23086237

Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, Pinchev D, Buchholz F, Peters JM, Hyman AA, Gingras AC, Pelletier L. HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity. Current Biology, May 26;19(10):816-26 (2009). PMID: 19427217

Zhu, F.*, Lawo, S.*, Bird, A., Pinchev, D., Ralph, A., Richter, C., Müller-Reicher, T., Kittler, R., Hyman, A. and Pelletier, L. Cep192 regulates centrosome biogenesis in mammalian cells. Current Biology, 18(2):136-41) (2008). *Joint-first authors. PMID: 18207742
Kittler, R.*, Pelletier, L*, Heninger, A., Slabicki, M., Theis, M., Miroslaw, L., Poser, I., Lawo, S., Grabner, S., Kozak, K., Wagner, J., Surendranath, V., Richter, C., Bowen, W., Jackson, A.L., Habermann, B., Hyman, A.A. and Frank Buchholz. Genome-wide RNAi profiling of cell cycle progression in human tissue culture cells. Nature Cell Biology, 9(12):1401-1412 (2007). *Joint-first authors. PMID: 17994010

Pelletier, L., O'Toole, E.T., Schwager, A., Hyman, A.A. and Müller-Reichert, Centriole assembly in Caenorhabditis elegans. Nature, 444 (7119):619-23 (2006). PMID: 17136092

For more information visit:


Posted by Laurence Pelletier(pelletier@lunenfeld.ca)

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