Institute of Hepatology London Postdoc募集

The Institute of Hepatology in London is seeking an enthusiastic, flexible and committed post-doctoral scientist to investigate the roles of Matricellular Proteins (splice variants and altered translation products) in liver inflammation, fibrosis and cancer. The post-holder will be based at the Institute of Hepatology and will be required to work closely with other colleagues at the Institute of Hepatology and collaborators (Overseas and UK-based), to proactively design/run experiments, publish data in high impact peer reviewed journals and participate in educational programs within the Institute.

Applicants must have a MD or MD/PhD in immunology/molecular/cell biology or a closely related discipline and a proven scientific interest in inflammation, fibrogenesis, immunity and/or cell signaling. He/she will require an array of molecular and cellular biology techniques (including RTPCR and Real-time RTPCR, ELISA, immunoprecipitations (including ChiP), protein expression and purification, western blotting, cloning / transfections, lentivirus infections). He / she will be expected to isolate primary liver cells (hepatocytes, hepatic stellate cells, Kupffer cells) from humans and mice for downstream experiments. He / she should have basic working knowledge of Immunohistochemistry and FACS analysis. They must also have demonstrable laboratory based experience in cell / molecular biology and aseptic tissue culture techniques.

Salary would be commensurate with experience (depending on Visa Status). Individuals who are funded by their local governments will also be considered. Candidates should submit a detailed curriculum vitae together with a description of research experience to:

Dr Wing-Kin Syn
Consultant Clinician-Scientist
Head of Regeneration and Repair (Fibrosis) Group
Institute of Hepatology
Harold Samuel House
69-75 Chenies Mews

Honorary Professor
Department of Physiology
University of the Basque Country

Honorary Senior Research Fellow
Centre for Liver Research
University of Birmingham

Posted by Wing-Kin Syn(wsyn@doctors.org.uk)


Duke University Medical Center ポスドク募集

Duke University Medical Center, Department of Biochemistry
Yokoyama lab (http://www.biochem.duke.edu/modules/biochem_yokoyama_lab/index.php?id=1)

研究内容 :
参考文献(総説):Schwarz, G., Cellular and Molecular Life Sciences 2005, 62, 2792-2810; Nordlund, P. and Reichard, R., Annu. Rev. Biochem. 2006, 75, 681-706. 過去の研究はWebサイトをご参照ください。

方法論:前定常状態酵素反応速度論解析、各種分光法(EPR, NMR, UV-vis, 蛍光)、非天然型アミノ酸の部位特異的導入(Schultz法)、タンパク質の蛍光標識、基質やリガンドを模倣した低分子プローブなど。

応募資格: 博士号取得者あるいは取得見込みのある方。
書類送付先、問合せ先:横山健一 (ken.yoko@duke.edu, http://www.biochem.duke.edu/modules/biochem_yokoyama_lab/index.php?id=1) 日本語可。


Mechanistic enzymology, radicals and metals in biology.

Kenichi Yokoyama Lab; Duke University Medical Center (http://www.biochem.duke.edu/modules/biochem_yokoyama_lab/index.php?id=1)

A postdoctoral position (or a research scientist position) is available for either of the following projects in the Yokoyama lab at Duke University Medical Center:
1. Mechanism and regulation of radical enzymes in nucleotide and energy metabolisms in pathogenic bacteria with strong emphasis on ribonucleotide reductases and pyruvate formate lyase.
2. Modes of action of redox sensing antibiotics targeting anaerobic and chronic infections.
3. Mechanism of enzymes in the molybdenum cofactor biosynthetic pathway and their relations to neurologic disease.

The successful candidate will use variety of pre-steady state kinetic methods combined with biophysical detection methods and/or chemical biology tools, which include site-specific unnatural amino acid incorporation, protein labeling and EPR/NMR spectroscopies. The successful candidate will also experience extensive mechanistic thinking and discussions in the interdisciplinary fields of chemistry, enzymology, biophysics, neurology and bacteriology.

Applicants should have profound experience in general protein expression/purifications and enzyme activity assays. Solid background in basic biochemistry or chemistry is required. A candidate must be strong in communication, focused and motivated to succeed, and able to work as a team as well as independently. We are also looking for specialists in human tissue culture, in vivo imaging and metabolomics/proteomics. Synthetic chemical background would also be appreciated.

Salary is commensurate with qualifications and experience based on Duke University or NIH scale. The position will be initially available for one year, with the renewal (up to 4-5 years) based on the performance and funding availability. The successful candidate will be encouraged to apply for independent fellowships to gain independent programs for his/her future career path. Send a cover letter (1-2 pages) outlining your research interest and career goal, current curriculum vitae, and a name and e-mail address of three references to:

Kenichi Yokoyama, Ph.D.
Assistant professor
Department of Biochemistry, Duke University School of Medicine
233 Nanaline H. Duke, Durham, NC, 27710
Tel (Office): (919) 684-8848
Tel (Cell): (919) 317-2783



玉川大学 脳科学研究所(教授:木村 實)博士研究員募集

Yoland Smith, James Surmeier, Peter Redgrave, and Minoru Kimura Thalamic Contributions to Basal Ganglia-Related Behavioral Switching and Reinforcement Journal of Neuroscience (in press)

Enomoto K., Matsumoto N., Nakai S., Satoh T., Sato T.K., Ueda U., Inokawa H., Haruno M. & Kimura M. Dopamine neurons learn to encode the long-term value of multiple future rewards Proceedings of National Academy of Sciences 108 (37) 15462-15467, 2011

Yamada H, Inokawa H, Matsumoto N, Ueda Y, Kimura M. Neuronal basis for evaluating selected action in the primate striatum European Journal of Neuroscience 34:489-506, 2011.

Muranishi M, Inokawa H, Yamada H, Ueda Y, Matsumoto N, Nakagawa M, Kimura M. Inactivation of the putamen selectively impairs reward history-based action selection. Experimental Brain Research 209(2):235-246, 2011

Inokawa H, Yamada H, Matsumoto N, Muranishi M, Kimura M. Juxtacellular labeling of tonically active neurons and phasically active neurons in the rat striatum. Neuroscience 168(2):395-404,2010

Neuronal encoding of reward value and direction of actions in the primate putamen Hori Y., Minamimoto T. and Kimura M J Neurophysiol 102(6):3530-43, 2009

The Basal Ganglia and the Encoding of Value Doya K., and Kimura M In: Neuroeconomics Decision making and the brain. Eds by Glimcher PW, Camerer CF, Fehr E., Poldrack RA, Elseviewer and Academic Press, pp 407-416, 2009.

What does the habenula tell dopamine neurons? Kimura M, Satoh T, Matsumoto N. Nature Neuroscience 10:677-678, 2007.

Complementary process to response bias in the centromedian nucleus of the thalamus Minamimoto T, Hori Y, and Kimura M Science 308:1798-1801, 2005

Representation of Action-specific Reward Value in the Striatum Samejima K, Ueda Y, Doya K, and Kimura M Science310:1337-1340, 2005

玉川大学 脳科学研究所
(〒194-8610 東京都町田市玉川学園6-1-1)

4.応募者について問い合わせ可能な方1名の氏名、連絡先 (所属、E-



〒194-8610 東京都町田市玉川学園6-1-1
玉川大学 脳科学研究所教授 木村實 宛
E-mail: mkimura@lab.tamagawa.ac.jp

投稿者:木村 實(mkimura@lab.tamagawa.ac.jp)


University of Illinois Medical Center Postdoc募集

We are currently recruiting individuals for post-doctoral fellowships in the area of microRNA biology. Successful candidates will work collaboratively with the principal investigator to conceptualize, initiate and execute research projects. Applicants must have a strong appetite for scientific literature and enjoy tackling challenging problems.

Applicants with a Ph.D. in any area of the life sciences are invited. Applicants must be well organized and possess a genuine interest in scientific inquiry. This is an excellent opportunity to develop world class proficiency in RNA biology and protein biochemistry.
Interested candidates should send their CV to the email address indicated below.

Zain Paroo, Ph.D.
Chicago Biomedical Consortium Investigator
Center for Pharmaceutical Biotechnology
University of Illinois Medical Center
900 South Ashland Ave
Room 3220 MBRB, m/c 870
Chicago, IL

Posted by Zain Paroo(zparoo@uic.edu)


アルバータ大学医学部 ポスドク募集

2011年10月より、Department of Medical Genetics, University of Alberta Faculty of Medicine and Dentistry (アルバータ州エドモントン) にて研究室を立ち上げることになりました横田俊文です。



[採用期間]2011年10月1日以降より3年(雇用契約は原則的に1年更新 となります)。 給与等は大学の規定に従います(健康保険等完備)。
(2) これまでの研究内容と志望動機(1-2枚程度、日本語または英語 )
(3) 推薦者2-3人の氏名と連絡方法

*Efficacy of morpholino systemic exon-skipping in Duchenne dystrophy dogs, Ann Neurol., 2009; 65:667-76.
Yokota T, Lu QL, Partridge T, Kobayashi M, Nakamura A, Takeda S, Hoffman E
* Faculty 1000 exceptional paper (Factor 10) selection
*A renaissance for anti-sense oligonucleotide drugs in neurology: Exon-skipping breaks new ground, Arch. Neurol., 2009;66:32-8
Yokota T, Takeda S, Qi-long Lu, Partridge T, Nakamura A, and Hoffman E
*Cover image selection
Optimizing exon skipping therapies for DMD, Acta Myol. 2007; 26:179-84.
Yokota T (corresponding), Duddy W, Partridge T
Potential of exon skipping therapy for Duchenne Muscular Dystrophy, Expert Opin. Biol. Ther. 2007; 7:831-42
Yokota T (corresponding), Emidio P, Duddy W, Kanneboyina N.
Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as index of muscle regeneration, J Cell Sci. 2006; 119: 2679-87.
Yokota T, Lu QL, Morgan JE, Davies KE, Fisher R, Takeda S, Partridge T

Toshifumi Yokota PhD
Assistant Professor
The Friends of Garret Cumming Research & Muscular Dystrophy Canada
HM Toupin Neurological Science Endowed Research Chair
Department of Medical Genetics
Faculty of Medicine and Dentistry
University of Alberta
Email: toshifumi.yokota アットマーク ualberta.ca

投稿者:横田俊文(toshifumi.yokota アットマーク ualberta.ca)





(1) Tamura et al. Cell. 145:1158 (2011)
(2) Kageyama et al. Curr Opin Cell BIol. 23: 427 (2011)
(3) Zhang et al. Mol. Biol. Cell. 22: 2235 (2011)
(4) Tamura et al. EMBO J. 29: 2875 (2010)
(5) Zhang et al. PNAS. 107: 11829 (2010)
(6) Wakabayashi et al. J. Cell Biol. 186: 805 (2009)
(7) Tamura et al. J. Cell Biol. 185: 1029 (2009)
(8) Tamura et al. J. Cell Biol. 184: 129 (2009)
(9) Cerveny et al. Dev. Cell. 12: 363 (2007)
(10) Jensen and Sesaki. Nat. Cell Biol. 8:1215 (2006)

Hiromi Sesaki, PhD
Assistant Professor

Department of Cell Biology
Johns Hopkins University School of Medicine
109 Hunterian, 725 N. Wolfe Street, Baltimore, MD, USA 21205



MDアンダーソンがんセンター ポスドク募集

本求人は候補者が決定したため募集を打ち切りました。This advertisement was withdrawn because the position has been filled.

The University of Texas MD Anderson Cancer Center, Department of Leukemia, Section of Molecular Hematology and Therapy、Dr Michael Andfeeffの研究室では、ポストドクトラルフェローを募集いたします。仕事内容は、白血病幹細胞と骨髄微小環境の解析、新規治療法の同定と早期臨床試験でのバイオマーカーの解析です。具体的な実験の内容は、動物実験、細胞培養、ウェスタンブロッティング、フローサイトメトリー、PCRなどです。技術よりも、多国籍・多人種のスタッフと気持ちよく働ける協調性と、真面目さ、根気、意欲を重視します。公用語は英語ですが、つたない英語でも懸命に伝えようとする気持ちがあれば、スタッフは好意的に対応してくれます。トランスレーション研究という性質上、臨床経験は必ずしも不利にはなりません。

[応募資格] PhD, MD-PhD 取得者、あるいは取得見込みの方。自分で書いた英語論文(症例報告を含む)が3編以上あることが望ましい。
[赴任時期] 相談に応じます


小島 研介
Kensuke Kojima, MD, PhD.
E-mail: kkojima(*)mdanderson.org 「(*)を@と読み替えてください」


1) MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood. 2005;106:3150-3159.

2) Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood. 2006;108:993-1000.

3) Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006;10:375-388.

4) MEK inhibition enhances nuclear proapoptotic function of p53 in AML cells. Cancer Res. 2007;67:3210-3219.

5) The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML. Leukemia. 2008;22:1728-1736.

6) Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia. Blood. 2008;112:2886-2895.

7) Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 via Mcl-1/Noxa axis. Leukemia. 2010;24:33-43.

8) p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1a-mediated down-regulation of CXCL12. Blood, in press.

投稿者:小島 研介

投稿者:小島 研介(kkojima@mdanderson.org)


テンプル大学医学部心臓血管研究センター Visiting Research Scholar募集

本求人は候補者が決定したため募集を打ち切りました。This advertisement was withdrawn because the position has been filled.

Visiting Research Scholar募集

テンプル大学医学部心臓血管研究センター (Philadelphia, PA)




当研究室にVisiting Research Scholarとして一年留学されれば、遺伝子工学の基礎から応用、細胞生物学的実験、遺伝子改変動物の基礎から応用、免疫組織実験等、研究の基本から応用までを効率よく体験、取得できます。当研究室は2009年に新医学部研究棟10階に移転し、新しい実験室は明るく快適で眺望もすばらしいです。英語については日本人スタッフ現在3名とNative Speakerのスタッフ2名が優しく指導、一年の留学で2年留学者レベルまではいけると確信しています。さらに英文論文作成、投稿、リバイス、学会発表等についても実際の体験と能力アップが可能です。


留学にあたっては私と当ラボスタッフ(日本人3名、アメリカ人1名、オーストラリア人1名 )が 研究面 生活面共に懇切丁寧に面倒を見ます。アパートの決定、セットアップ、銀行口座、車の取得、運転免許取得等も心配はいりません。また電車、地下鉄での通勤も可能です。ご興味を持った方は履歴書(学歴と研究歴/業績、日本語可)を以下にe―mailしてください。(現在の専門分野は問いません。研究実績のすくないかたも歓迎いたします。)また、見学訪問も歓迎いたします。

当研究室は細胞生物学、分子生物学、タンパク工学および遺伝子改変動物を主体とした手法を用いて心血管系の情報伝達と機能解析(atherosclerosis, cardiac and vascular hypertrophy, fibrosis, remodeling, cardiovascular inflammation, endothelial dysfunction, metabolic syndrome, diabetes, diabetic complication)を中心に現在、以下のテーマで研究を行っています(NIH-RO1 funded from NIH HLBI, Established Investigator Award funded from AHA)。

1. Angiotensin II (AT1, G12/13, Rho kinase)
2. ADAM metalloprotease (EGF ligands, EGF receptors, TNF-alpha)
3. Transcriptional repressors
4. Signal cross-talks between vascular/endothelial cytokines and adipokines

江口 暁
Satoru Eguchi, MD. PhD. FAHA
Professor of Physiology
Cardiovascular Research Center
Temple University School of Medicine
e-mail: seguchi@temple.edu(日本語可)


投稿者:江口 暁(seguchi@temple.edu)


UT Southwestern Postdoc募集

Differential Profiling of Ubiquitinome via proteomics
Hamid Mirzaei Lab; UT Southwestern

A postdoctoral position is available immediately to investigate dynamics of ubiquitinome and ubiquitin-like proteomes using modern proteomics technologies. A successful candidate will use a combination of advanced separation techniques such as 2D Gel Electrophoresis (2D-GE) and 2D chromatography in conjunction with advanced mass spectrometry techniques developed in our lab to define and study the dynamics of ubiquitinome. A candidate should be proficient in 2D-GE, chromatography and immunopurification methods. A Solid background in molecular biology is required. Candidates with strong quantitative skills and separation science backgrounds are most highly desired. Previous experience with mass spectrometry is not required but can be a plus. A candidate must be strong in communication- and analytical skills, focused and motivated to succeed, and able to work as a team as well as independently. Salary is commensurate with qualifications and experience (based on UT Southwestern !
scale). The position will be initially available for one year, with the renewal (up to 4-5 years) based on the performance and funding availability. The successful candidate will be encouraged to apply for independent fellowships to gain independent programs for his/her future career path. Email a cover letter (1-2 pages) outlining your research interest and career goal, current curriculum vitae, and a name and e-mail address of three-four referees to:

Dr. Hamid Mirzaei
Assistant Professor of Biochemistry
Director of Proteomics Core Facility
CPRIT Cancer Research Scholar
Department of Biochemistry
T. Boone Pickens Biomedical Building
6001 Forest Park Road, Room ND6.214B
Dallas, TX 75390-9050
Email: Hamid.Mirzaei@UTSouthwestern.edu

Posted by Hamid Mirzaei(Hamid.Mirzaei@UTSouthwestern.edu)


Washington University School of Medicine ポスドク募集

Washington University School of Medicine, USA, Post-doctoral position
Neural Development and Adult Brain Tumors


私がハーバード大学 Brigham and Women's Hospital Neurosurgery に在籍していた際の友人、
Dr. Albert Kim がこのたびセントルイスのワシントン大学医学部に新しくラボを持つことになりました。ワシントン大学医学部は全米医科大学の中でも、常にトップ二位から四位にランクされる優秀な医学部で、研究環境も非常に恵まれています。Dr. Kim は有給のポスドクポジションを募集しており、掲載を依頼されましたので代わりに投稿いたします。神経発生と脳腫瘍幹細胞を基本とする研究室です。

Dr. Kimは、脳神経外科医ですが PhDをもつ大変優秀なサイエンティストでもあります。Cellや Neuron などのトップジャーナルに first author として論文を発表しており、またレジデント時代から独自で研究費をとるなど、活躍しておられました。彼は アメリカ人ですが奥様が日本人で研究者であることから、日本人研究者に対する理解もあり、非常に仕事はしやすいと私は思います。私たちは家族ぐるみで仲良くさせていただいておりました。

希望される方、もしくはご質問のある方は、直接 Dr. Kim にメールもしくは電話でお問い合わせください。もちろん、私宛に送ってくださっても構いませんが、少し時間がかかるかもしれません。


綿谷崇史 Taka.Wataya@utoronto.ca

Washington University School of Medicine, USA, Post-doctoral position

Neural Development and Adult Brain Tumors

A funded postdoctoral position is available in the laboratory of Dr.
Albert H. Kim, Dept of Neurological Surgery, Washington University
School of Medicine, St. Louis, MO beginning late winter/early spring 2012.  The
laboratory has two major research interests: 1) investigation of
molecular mechanisms underlying glial tumor behavior, such as growth
and invasiveness, with an emphasis on the biology of patient-derived
tumor-initiating cells and 2) identification of signaling pathways
controlling fundamental processes in neural development.

M.D. or Ph.D. with expertise in stem cell biology, molecular biology,
and biochemistry with a preference for new graduates or postdocs with
2 or fewer years of experience.

If interested, please email a cover letter, CV, and contact
information for 3 references (kima@wudosis.wustl.edu).

Selected Publications:
A.H. Kim, H. Yano, H. Cho, D. Meyer, B. Monks, B. Margolis, M.J.
Birnbaum, and M.V. Chao. Akt1 regulates a JNK scaffold during
excitotoxic apoptosis. Neuron 35(4): 697-709. 2002.

A.H. Kim and A. Bonni. Thinking within the D box: Initial
identification of Cdh1-APC substrates in the nervous system. Mol Cell
Neurosci. 34(3): 281-7. 2007.

A.H. Kim, S.V. Puram, P.M. Bilimoria, S. Keough, M. Wong, D. Rowitch,
and A. Bonni. A centrosomal Cdc20-APC pathway controls dendrite
morphogenesis in postmitotic neurons. Cell 136(2):322-336. 2009.

Y. Yang, A.H. Kim, T. Yamada, B. Wu, P.M. Bilimoria, Y. Ikeuchi, N. de
la Iglesia, J. Shen, and A. Bonni. A Cdc20-APC ubiquitin signaling
pathway regulates presynaptic differentiation. Science 326:575-8.

S.V. Puram, A.H. Kim, Y. Ikeuchi, A. Riccio, S. Koirala, J.T.
Wilson-Grady, A. Merdes, S.P. Gygi, G. Corfas, and A. Bonni. A Unique
CaMKIIβ Signaling Pathway at the Centrosome Regulates Dendrite
Patterning in the Mammalian Brain. Nat Neurosci 14(8):973-83.

Albert H. Kim, MD, PhD
Assistant Professor of Neurosurgery, Neurology, and Developmental Biology
Washington University School of Medicine
660 S Euclid Ave, Box 8057
St. Louis, MO  63110
Tel: 617-935-2802



金沢医科大学医学部病理学I(腫瘍病理)講座 助教募集


1) 医学部出身者:大学附属病院における病理解剖・CPC(年間20体程度)・病







The Max Planck Institute for Plant Breeding Research ポスドク募集

In the Department of Plant-Microbe Interactions at the Max Planck Institute for Plant Breeding Research (MPIPZ) in Cologne, Germany, a Postdoctoral position in Plant Biology/Molecular Biology
will be available from Jan 1, 2012. This position is based on a Max Planck fellowship and will be initially funded for 2 years (with possible extension).
We seek a motivated candidate with a PhD in plant biology (biology) and extensive knowledge and skills in molecular biology. Experience with Arabidopsis and analysis of genome-wide transcriptional regulatory networks is desirable but not required.
Applicants should have published research results in peer-reviewed high quality journals, demonstrated creativity, independence, high motivation, good communication skills, and the ability to work independently as well as with other members of our research group.
The candidate will work in a project aiming to:
(1) Understand molecular mechanisms underlying the complex nature of the plant immune network using a variety of genetic resources and genomics approaches.
(2) Investigate how plants effectively integrate diverse information to coordinate tuned immune responses in changing environments.
Katagiri F and Tsuda K (2010) Molecular Plant-Microbe Interactions, 23: 1531-1536.
Tsuda K and Katagiri F (2010) Current Opinion in Plant Biology, 13: 459-465.
Sato M et al (2010) PLoS Pathogens, 6: e1001011.
Tsuda K et al (2009) PLoS Genetics, 5: e1000772
Tsuda K et al (2008) The Plant Journal, 53: 763-775
The Max Planck Institute for Plant Breeding Research (MPIPZ) (http://www.mpiz-koeln.mpg.de/) is one of the world’s premier sites committed to research into fundamental processes and training in plant biology. There are four science departments, three independent research groups and specialist support, totaling ~ 400 staff including externally funded positions.
The Max Planck Society is committed to employing more handicapped individuals and especially encourages them to apply.
The Max Planck Society seeks to increase the number of women in those areas where they are under-represented and therefore explicitly encourages women to apply.
Please send your application including (i) a cover letter summarizing your qualifications and your motivation to work on this project, (ii) a CV with a full publication list, and
(iii) names and contacts of three references. The application should be submitted electronically as one file to Dr. Kenichi Tsuda (tsuda@mpipz.mpg.de) before November 1, 2011.
Review of applications will begin immediately and continue until the position is filled.

投稿者:津田 賢一(tsuda@mpipz.mpg.de)


Howard Hughes Medical Institute / University of Washington, Seattle Postdoc募集

Dynamics of cell-cell interactions during plant epidermal development
Keiko Torii Lab; Howard Hughes Medical Institute and University of
Washington, Seattle

Several postdoctoral positions (or a research scientist positions) are available immediately to investigate dynamics of cell-cell interactions during plant epidermal development. We have identified that signal transduction cascades mediated by peptide ligands and receptor kinases controlling proper spacing and patterning of stomata, microscopic valves on the plant epidermis, and further discovered a series of master regulatory transcription factors that make stomata.
A successful candidate will use sophisticated live imaging techniques, such as FRAP, FRET, FLIM, and developing new optical/imaging tools for caging/uncaging signaling components, to investigate and manipulate the dynamics of peptide ligand-receptor mediated signaling and cell-cell interactions leading to functional tissue patterning.

For literature see: Guseman et al. (2010) Development 137, 1731-; Hara et al. (2009) Plant Cell Physiol 50, 1019- ; Pillitteri et al. (2007) Nature 445, 501-;Hara et al. (2007) Genes Dev 15, 1720-; Shpak et al. (2005) Science 309, 290-

A candidate must be proficient in live imaging techniques at tissue-, cellular- or subcellular levels. Solid background in basic molecular biology is required. Candidates with strong quantitative skills and engineering backgrounds are most highly desired. Previous experience in Arabidopsis/plants is not required but can be a plus. A candidate must be strong in communication- and analytical skills, focused and motivated to succeed, and able to work as a team as well as independently. We are also looking for specialists in ChIP-seq/ ChIP-chip assays, and protein phosphorylation/ ubiquitination biochemistry (mass spec, phosphopeptide mapping, etc), So if you have such expertise, you are also welcome!

Salary is commensurate with qualifications and experience (based on University of Washington, NIH or HHMI scale). The position will be initially available for one year, with the renewal (up to 4-5 years) based on the performance and funding availability. The successful candidate will be encouraged to apply for independent fellowships to gain independent programs for his/her future career path. Due to the guideline of the funding agency, priority will be given to candidates within two years of postdoctoral experience. Send a cover letter (1-2 pages) outlining your research interest and career goal, current curriculum vitae, and a name and e-mail address of three-four referees to:

Dr. Keiko Torii
Distinguished Professor of Biology

Howard Hughes Medical Institute
Department of Biology, University of Washington
Box 351800 Seattle, WA 98195-1800

Posted by Keiko Torii(ktorii@u.washington.edu)


University of Texas Southwestern Medical Center Postdoc募集

Molecular Mechanisms of Resistance to Hormonal Therapy for Prostate Cancer

A postdoctoral position is available in the laboratory of Dr. Nima Sharifi in the Division of Hematology/Oncology at UT Southwestern Medical Center.

This laboratory is focused on molecular mechanisms of androgen receptor (AR) gain-of-function that lead to resistance to androgen deprivation therapy and the translational relevance thereof. Areas of interest in this laboratory include:

1) Metabolic and genetic changes required for androgen synthesis.
2) Animal models of advanced prostate cancer for translational and therapeutic studies.
3) Defining targets for the development of new pharmacologic therapies.

We have recently discovered that prostate cancer becomes resistant to hormonal therapy by the synthesis of dihydrotestosterone through a pathway that circumvents testosterone, instead requiring 5α-androstanedione, a previously underappreciated intermediate metabolite. This metabolic pathway occurs commonly in all models and patient tumors tested (Chang, et al. Proc Natl Acad Sci USA. 2011 Aug 16;108(33):13728-33). We have also shown that blocking the enzyme 3β-hydroxysteroid dehydrogenase stops the androgen-response from adrenal precursors, validating this as a potential pharmacologic target for the treatment of advanced prostate cancer (Evaul, et al. Endocrinology. 2010. 151(8):3514-20). For further information on our work, refer to the following: http://www4.utsouthwestern.edu/sharifilab/index.html

UT Southwestern Medical Center is the home of four Nobel Laureates, 19 members of the National Academy of Sciences and 18 Members of the Institute of Medicine.

The candidate should hold a doctoral degree with a background in metabolism, cancer biology, or endocrinology. Candidates with an interest in the position should send their cv and contact information for 3 references to:

Nima Sharifi, M.D.
Assistant Professor
Division of Hematology/Oncology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8852


UT Southwestern Medical Center is an Equal Opportunity, Affirmative Action Employer

Posted by Nima Sharifi, M.D.(nima.sharifi@utsouthwestern.edu)


シンシナティ小児病院/シンシナティ大学医学部 ポスドク募集

本求人は候補者が決定したため募集を打ち切りました。This advertisement was withdrawn because the position has been filled.

シンシナティ小児病院/シンシナティ大学医学部 生殖科学部門行川研究室(PI:行川 賢: Satoshi Namekawa)は2009年の9月に開始した新しい研究室です。行川研究室では、マウスを用いて生殖細胞分化におけるエピジェネティック制御の解明を目指しています。特に、性染色体不活性化と精原幹細胞の制御について着目しています。イノベーティブなプロジェクトに挑戦したい意欲的な研究員を募集しています。現在はポスドク2名、テクニシャン1名の少人数の研究室です。

NIHおよびシンシナティ小児病院の規定によります 。
応募資格:上記の研究に興味のある PhD, MD-PhD 取得者、あるいは着任までに取得見込みの方。
応募書類: CV と 推薦者2名以上の連絡先をe-mailで送付して下さい。
宛先:satoshi.namekawa@cchmc.org (日本語可)

Payer B, et. al. Hum Genet 2011 Aug;130(2):265-80.
Ichijima Y, et. al. Genes Dev. 2011 May 1;25(9):959-71.
Namekawa SH, Lee JT. Nat Protoc. 2011 Mar;6(3):270-84.
Namekawa SH, et. al. Mol Cell Biol. 2010 Jul;30(13):3187-205.
Namekawa SH, Lee JT. PLoS Genet. 2009 May;5(5):e1000493.
Namekawa SH, et. al. PNAS 2007 Jun 5;104(23):9730-5.
Namekawa SH, et. al. Curr Biol 2006 Apr 4;16(7):660-7.

Satoshi Namekawa
Assistant Professor
Division of Reproductive Sciences
Cincinnati Children's Hospital Medical Center
Department of Pediatrics
University of Cincinnati College of Medicine
Cincinnati OH
Tel: 513-803-1377
Fax: 513-803-1160

投稿者:Satoshi Namekawa(satoshi.namekawa@cchmc.org)


Dana-Farber Cancer Institute, Brigham and Women's Hospital ポスドク募集

ボストンの Dana-Farber Cancer Institute にある私の病理学・腫瘍学・疫学の研究室でやる気のある研究室員を募集しています。Pathology (特にdiagnostic pathology)あるいはEpidemiologyあるいはBiostatisticsのBackgroundが望ましいです。

ラボでの仕事はいろいろありますが、パラフィン癌組織サンプルの管理とプロセシング、データーベースの管理、免疫組織染色、病理組織解析、DNA・RNA解析、Image Analysis、統計解析、あるいはプログラミングです。もちろんすべての手技をできる人はいませんので、得意な分野・経験を生かしていただきます。ラボの仕事をしながら、統計学とプログラミングを勉強できるのは私の研究室の強みです。

プロジェクトは大腸癌、線腫、膵臓癌、消化器内分泌腫瘍の分子病理疫学(Molecular Pathologic Epidemiology)です。私のラボでは大規模な前向き疫学コホートを使って大腸癌と膵臓癌の様々な分子異常の疫学的病因を研究しています。ハーバード大学公衆衛生大学院とBrigham and Women’s Hospitalではこれまで当初は健康な12万人の女性を34年(Nurses' Health Study、http://www.channing.harvard.edu/nhs/)、5万人の男性を24年(Health Professionals Follow-up Study、http://www.hsph.harvard.edu/hpfs/)追跡して、病気の発生を疫学的に研究してきました。私のラボではこの2つの大規模コホートにおいて追跡中に発生した大腸癌と膵臓癌の癌細胞内の遺伝子の異常、Epigenetic changes (DNAメチル化)、酵素やその他のたんぱく質発現の変化を解析しています。追跡に先立ち、あるいは24年、34年という追跡中に、食べ物、ライフスタイル(運動・肥満度・たばこ・アルコールなど)、薬、家族歴、癌や他の病気の発生、生存状況を記録しています。こうした病因に関するデータは癌やそのほかの疾患の発生に先立って集められているためにバイアスのリスクがより少ないのが、前向きコホート研究の長所です。こうして蓄積された貴重な病因データと癌組織の分子異常、患者の生存状況とを総合的に分析するというのが私のラボの研究内容です。一例としてアスピリンがPTGS2 (COX-2)高発現の大腸癌の発生の防ぐ(New Engl J Med 2007)のに加えてPTGS2(COX-2)高発現の大腸癌による死亡率を下げる(JAMA 2009)、あるいは運動がCTNNB1(b-catenin)低発現の大腸癌による死亡率を下げるという病理疫学データを発表しています(JAMA 2011)。最近、私はこうした研究を新しい多分野融合的科学(Interdisciplinary Science)のパラダイムとして“Molecular Pathological Epidemiology” (MPE)と命名しました(J Natl Cancer Inst 2010; Gut 2011; Nat Rev Clin Oncol 2011)。

その他、Multicenter Collaborative TrialであるCancer and Leukemia Group B (CALGB http://www.calgb.org/)のメンバーとして、大腸癌のBiomarkersを調べています。




Shuji Ogino, MD, PhD, MS(Epidemiology)
Associate Professor of Pathology, Harvard Medical School
Department of Pathology, Brigham and Women's Hospital
Department of Medical Oncology, Dana-Farber Cancer Institute




本求人は募集を打ち切りました。This advertisement was withdrawn.

ペンシルバニア大学医学部病理系専攻の Prof. Mark I. Greeneの研究室でポスドクを募集しております。Greene研究室では、EGFRならびにHER2に関する研究で大きな成果を上げ、癌治療の開発に大きく貢献をして参りました。また最近では、制御性T細胞の分化を制御する転写因子FOXP3に関する研究でも大きな成果を上げております。研究テーマは、EGFRをはじめとした乳がんや前立腺がんの発症に重要な役割をはたす分子の構造解析と、それらの知見にもとづいた新たな薬剤の開発です。タンパク質の構造解析に経験のある方を求めておりますが、免疫学あるいは薬学のバックグランドを持った方でもかまいません。新しい分野に挑戦するチャレンンジ精神にあふれた方を求めています。ボスのMarkは知日家で、これまでも多くの日本人を受け入れてきました。興味のある方は、大谷までお問い合わせください。
参考文献: Zhang G, et al. (2010) PNAS, 107, 732, Zhou Z, et al.(2009) Int Immunopharmacol.,9,518, Samanta A, et al.(2008) PNAS, 105, 14023, Y. Tone et al. Nature Immunol. (2008) 9, 194,

連絡先: 大谷卓也 (Takuya Ohtani)
257 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104



UC Davis Medical Center,Research Technician and Postdoctoral scholar or Senior Research Scientistの募集 

 本求人は候補者が決定したため募集を打ち切りました。This advertisement was withdrawn because the position has been filled.

University of California DavisのMaverakis Labにて新規プロジェクトを立ち上げるために,

The laboratory of Dr. Emanual Maverakis is recruiting one technician and one postdoctoral scholar or senior research scientist.

Research interests include autoimmunity, T cell memory, high-throughput drug screening, high-throughput immunophenotyping, cancer immunotherapy, and T cell repertoire analysis. Specific human diseases of interest include leukemia, lymphoma, melanoma, psoriasis, scleroderma, pyoderma gangrenosum and graft-vs-host disease. Dr. Maverakis also studies animal models of autoimmunity including experimental autoimmune encephalomyelitis.

The laboratory is located in Sacramento California in a beautiful space on the top floor of the Mather Veterans Administration hospital, an official affiliate of the University of California Davis, where Dr. Maverakis is faculty. Below the laboratory is a clinical trials center with inpatient beds funded by the NIH. (Of note, Sacramento is one of the most affordable major California cities to live in. It is located very close to San Francisco and Tahoe).

Dr. Maverakis’s research group is currently preparing several studies for publication. Recent manuscripts have appeared in the J Exp Med, J Clin Invest, PNAS, and Nat Rev Immunol.
Dr. Maverakis is a rising scientist with career awards from the Burroughs Welcome Fund and the Howard Hughes Medical Institute.

Salary support will depend on the specific qualifications of the applicant. Early stage postdoctoral investigators will receive a starting salary of $38,496 /year including an excellent benefit package. Senior postdoctoral fellows and research scientists will also be considered. Applicants wishing to be employed as a research scientist (Assistant Research Professor) should include a one-page summary of their research goals and how they plan to contribute to the Maverakis lab.

The successful applicant for the postdoctoral/senior scientist position will hold a Ph.D., M.D. or equivalent. They will have significant bench research experience, preferably in immunology, cellular biology, molecular biology, biochemistry, biomedical engineering or chemistry.

The successful applicant for the research technician position will hold a B.S. in microbiology, immunology, molecular biology or related field.

Please send a detailed CV, a short statement, and the names of three references electronically to: Dr. Emanual Maverakis via email: emaverakis@ucdavis.edu

Lab website

投稿者:Yoko Ono(yknono@ucdavis.edu)


オンタリオ癌研究所 ポスドク募集



応募資格:博士過程を終了、あるいは終了見込みで、分子生物学,生化学的手法を十分に習得されている方。その他、必要に応じて、マウスモデル、ChIP-sequenceをはじめ、あらゆる手法を用います。独立して研究テーマを推進できる、意欲あふれる方を期待しています。2012年 1-4月頃を予定していますが、採用時期は相談に応じます。興味がある方はご連絡ください。

応募書類:1. 履歴書と発表業績リスト, 2. 推薦者2-3名の連絡先, 3. これまでの研究内容、取得した実験手技と、志望動機をemailでお送りください。

参考:トロントはカナダの東部に位置しオンタリオ湖に面した自然豊かな環境で、Sick Kids Childrens Hospital、Toronto General Hospital、University of Toronto、Mount Sinai Hospital、Ontario Institute of Cancer Research 等の研究施設が集まっており、研究交流も盛んです。

連絡先:Hitoshi Okada

The Campbell Family Cancer Research Institute,
Ontario Cancer Institute、UHN
Department of Medical Biophysics, University of Toronto

E-mail: hokada@uhnres.utoronto.ca (日本語可)

投稿者:岡田 斉(hokada@uhnres.utoronto.ca)

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