2019.03.19

Medical University of South Carolinaポスドク募集

Postdoctoral positions in developmental neurobiology and pathophysiology

Charleston, South Carolina
Salary commensurate with qualifications and experience

Postdoctoral scholar positions in neuroscience research are available in an established laboratory that is newly relocated to Medical University of South Carolina. The lab uses mouse genetics and physiological assessment to study several signaling pathways in peripheral nervous system development, coupled with molecular and biochemical approaches to explore underlying mechanisms. Specific ongoing projects address neural progenitor cell migration and fate specification (Tan 2019, submitted; Poltavski, in preparation), axon guidance and refinement (Poltavski 2019 eLife, PMID: 30735130; Manousiouthakis 2014 Nature Commun, PMID: 24875861), and synapse formation and elimination (Tan, in preparation), all of which are relevant to human congenital neurological disorders. Charleston is a vibrant, progressive and inclusive city with a moderate cost of living, tourist attractions, and abundant housing options.

Candidate should contact Dr. Takako Makita directly by email (makita@musc.edu) to discuss these opportunities.


投稿者:Takako Makita(makita@musc.edu)

2019.03.18

Columbia University Medical Centerポスドク募集

Dr. Yuefeng Huangの代理で投稿します。同じDepartment 内のPI(Dr. Yuefeng Huang, Assistant Professor, Department of Microbiology and Immunology, Columbia University Medical Center )がポスドクを募集しています。日本語でのご質問等がありましたら入江 (ki2237@cumc.columbia.edu)までお気軽にお問合せ下さい。

A postdoctoral research scientist position is available immediately in the laboratory of Dr. Yuefeng Huang in the Department of Microbiology & Immunology at Columbia University Medical Center in New York City. The research in Huang lab aims to understand how innate and adaptive lymphocytes respond to pathogens or allergens at mucosal barriers, what the roles of innate lymphoid cells (ILCs) in the multi-layered immune system during host defense and immune disorders, and how ILCs are regulated by the signals from other host cells and commensal microbes. We use a combination of genetic mouse models, high-parameter flow cytometry, tissue confocal imaging, and single-cell analysis approaches. Please refer to our recent publications for further information: Science 2018, 359: 114–119; Nat Immunol 2015, 16: 161–169; J Exp Med 2017, 214:1663-1678; Immunol Rev 2018, 286:160-171; Curr Opin Immunol 2018, 56:76-81.
We are seeking a highly motivated individual holding a PhD degree and with a demonstrated record of scientific productivity. A background in immunology or molecular and cell biology is preferred. Research experiences with mouse models, flow cytometry or confocal imaging are desirable, but not required. Successful candidate will join a dynamic and collaborative environment in Columbia University Medical Center-NewYork Presbyterian Hospital, for both basic and translational research. The university offers great benefits and subsidized housing is available. Interested candidates should send a CV, a cover letter outlining research experience, and contact information for three references to Dr. Yuefeng Huang, yh3102@cumc.columbia.edu.

Posted by Koichiro Irie(ki2237@cumc.columbia.edu)

2019.03.15

イタリア、トリノ大学ポスドク募集

イタリア、トリノ大学でポスドクをしています渡邉と申します。同じセンター内のPI(Dr.Paolo Porporato, Assistant Professor, Molecular Biotechnology Center, University of Turin)がポスドクを募集しています
興味のある方はご連絡ください

POSTDOCTORAL POSITION AVAILBLE IN CANCER METABOLISM

The laboratory of Cancer Metabolism is looking for a motivated Junior Postdoctoral Fellow
to support the research of a recently funded 5-years My First AIRC Grant. The lab is
located at the Molecular Biotechnology Center in Turin, an Institute specialized in
Molecular and Cell Biology with fully equipped state-of-the-art core facilities.
A position is available for a Postdoc in the young team of Dr. Paolo Porporato starting
indicatively on June 1st, 2019. The postdoctoral fellow will conduct a translational project in
the field of cancer metabolism, focused on the role of metabolism in the development of
Cancer Cachexia. Excellent communication skills and ability to work in an international
team are required.

Requirements:
- Holder of a PhD degree in Medical, Pharmaceutical or Biomedical Sciences or related.
- Excellence in Cancer Research, especially biochemistry, molecular biology,
immunohistochemistry.
- Recent practice of in vivo experiments in mice.
- Fluid in spoken and written English.
- Availability to spend a training period abroad

Expertise in either MS-Metabolomics or Zebrafish will be a great plus.

Candidates should submit a motivation letter along with a CV to
paolo.porporato@unito.it
Deadline March 29

投稿者:渡邉美佳(mika.watanabe@unito.it)

2019.03.13

ヴァージニア大学ポスドク募集

Postdoctoral positions are available in the laboratory of Prof. Kodi Ravichandran at University of Virginia (UVA)

University of Virginia, School of Medicine Kodi Ravichandran研究室においてPostdoctoral Fellowを募集しています。

Kodi Ravichandran研究室では死んだ細胞の除去機構を中心に研究を行っています。
体中では古くなった細胞や傷付いた細胞がアポトーシスを起こしており、これらの細胞はマクロファージなどの貪食細胞や近接した上皮細胞・線維芽細胞などによって効率よく除かれています。反対に、貪食機能が低下すると死んだ細胞の蓄積による過度な炎症の誘導から、様々な疾患の原因となります(自己免疫疾患, アテローム性動脈硬化、超大腸炎、網膜変性や腎臓障害など)。Postdoc候補者には、RNA-seqやプロテオミクスを用いて死んだ細胞の新規・除去シグナルの探索と、また、mouse modelを用いてクリアランス機構の破綻と様々な疾病との関係を解明して頂きます。

バイオインフォマッティックス等、大量のデータを視覚的に表現する技能をお持ちの方を探しております。興味のある方はCV (PDF)を添付して下記メールアドレスまで連絡して下さい。ビザの取得や、アメリカ生活のセットアップは、協力致しますのでご安心ください。

研究室業績:
Sanja A et al., Nature Immunol doi: 10.1038
Sho M et al., Nature.2018 doi: 10.1038
Han CZ.et al., Nature.2016 doi: 10.1038/nature20141
Lee CS et al., Immunity.2016 doi: 10.1016/j.immuni.2016.02.005
Poon IK et al., Nature.2014 doi: 10.1038/nature13147
Hochreiter-Hufford AE et al., Nature.2013 doi: 10.1038/nature12135.
Juncadella IJ, et al., Nature.2013 doi: 10.1038/nature11714.
Park D, et al., Nature.2011 doi: 10.1038/nature10340.
Chekeni FB, et al., Nature.2010 doi: 10.1038/nature09413.
Kinchen JM and Ravichandran KS. Nature.2010 doi: 10.1038/nature08853.
Elliott MR, et al., Nature.2010 doi: 10.1038/nature09356

研究室website: http://med.virginia.edu/faculty/faculty-listing/kr4h/

Kodi Ravichandran 研究室, 研究員, 森岡

投稿者:森岡 翔(sm9ss@virginia.edu)


投稿者:Sho Morioka(sm9ss@virginia.edu)

2019.03.12

Beth Israel Deaconess Medical Center Postdoctral Position

A post-doctoral position is available immediately in the Wei lab at Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School. The lab’s major focus is on understanding how aberrant cell signaling pathways including ubiquitination and phosphorylation events drive tumorigenesis. More specifically, the lab explores mechanistically how aberrancies in Ubiquitin E3 ligase APC (Gao et at Nature Cell Biology 11: 397, 2009; Wan et al, Molecular Cell 44: 721, 2011; Wan et al, Developmental Cell 29:377, 2014; Wan et al, Cancer Discovery 7:424, 2017) and SCF or other Cullin-based E3 ligases (Inuzuka et al, Cancer Cell 18:147, 2010; Inuzuka et al, Nature 471:104, 2011; Gao et al, Molecular Cell 44: 290, 2011; Inuzuka et al, Cell 150: 179, 2012; Gan et al, Molecular Cell 59: 917, 2015; Shimizu et al, Science Signaling 2017; Dai et al, Nature Medicine 2017) activities contribute to cell cycle regulation and subsequent tumor formation, as well as how PTEN/Akt/!
mTOR signaling pathway governs tumorigenesis (Liu et al, Nature 508: 541, 2014; Liu et al, Cancer Discovery 5:1194, 2015; Guo et al, Science 353:929, 2016; Wang et al, Nature 545:365). We recently also defined cell cycle-dependent regulation of PD-L1 that provides the rationale for combination therapy of CDK4/6 inhibitor with PD-1 blockade (Zhang et al, Nature 553:91-95, 2018). Future projects in the lab engage the use of biochemistry, molecular biology and genetic approaches, cell culture techniques and potentially mouse modeling. Therefore, energetic applicants with strong experimental background in biochemistry, molecular and cellular biology and/or genetics are encouraged to apply.

Dr. Wei is looking for self-motivated individuals to become involved in the challenging and rewarding environment of the laboratory. If interested, please send your CV/resume and three references to

Wenyi Wei, Ph.D.
Professor
Dept. of Pathology, Harvard Medical School
Beth Israel Deaconess Medical Center
CLS-637, 3 Blackfan Circle
Boston, MA 02115
Phone: (617) 735-2495
Email: wwei2@bidmc.harvard.edu


投稿者:Hiroyuki Inuzuka(hinuzuka@bidmc.harvard.edu)

2019.03.10

オレゴン健康科学大学(OHSU)医学部ポスドクの募集(遺伝性腎疾患遺伝子治療)

Job Title: Postdoctoral Researcher - Gene Therapy for Kidney Diseases Using Adeno-Associated Virus (AAV) Vectors

Oregon Health & Science University(OHSU、オレゴン州ポートランド)中井浩之研究室では、ポスドク研究員を募集しています。当研究室はOregon National Primate Research Centerにも所属しており、学内、学外にわたり幅広い共同研究を行っています。当研究室の主たる研究テーマはadeno-associated virus (AAV、アデノ随伴ウィルス)を用いた遺伝子治療の研究、新しいベクターの開発ですが、マウスおよび大型動物(サルなど)を使った前臨床研究だけでなく、治療に用いるウィルスそのものの分子生物学的研究や、企業とも共同して特定の疾患を対象としたAAVベクター遺伝子治療の臨床応用に向けた研究も行っています。研究室は10数名で、准教授、研究員、ポスドク、大学院生、医学部生、研究補助員、大学生・高校生インターンが様々な研究に取り組んでいます。本募集では、遺伝性腎疾患の遺伝子治療の研究のリードをお願いするポスドクを募集していますが、本研究室では、各種中枢神経系疾患治療、膵ベータ細胞再生医療、先天性代謝異常症の治療をAAVベクターにて行う研究も行っており、それらの分野に意欲的に取り組む意志のある方の応募も歓迎いたします。研究内容は、CRISPRを用いた腎疾患モデルマウスの作成と評価、細胞特異的転写翻訳依存的定向進化法を用いた新規AAVベクターの開発、snRNA-seqとvirus barcode-seqを融合させた網羅的解析法によるAAVベクターの評価、モデルマウスおよびサルを用いた臨床応用に向けた新規AAVベクター遺伝子治療効果の評価です。ポートランドは、アメリカ北西海岸にある全米で最も住んでみたい都市にも選ばれている美しい都市でもあり、2−3年の留学を考えておられる方、あるいは5年もしくはそれ以上アメリカに残って自分の可能性を追求しようと考えておられる方、応募をお待ちしています。


Job Description:
The lab led by Professor Hiroyuki Nakai, M.D., Ph.D. is seeking a highly motivated and enthusiastic post-doctoral fellow who is willing to lead the project aimed at developing novel AAV vector-mediated gene therapy for renal diseases. The Nakai lab is in the Departments of Molecular & Medical Genetics and Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU) School of Medicine in Portland (Oregon, USA). The lab is also affiliated with the Oregon National Primate Research Center (ONPRC). The successful candidate will join the project where we seek to establish novel mouse models for renal diseases using the CRISPR technology, develop novel AAV vectors using our unpublished technology called TRAnscription/TRAnslation-dependent Directed Evolution (TRADE), comprehensively study novel AAV vectors using AAV Barcode-Seq combined with snRNA-seq, and assess their therapeutic efficacy in animal models for renal diseases.

Required Qualifications:
• Doctoral degree in a relevant field
• Substantial knowledge and expertise in molecular biology and research of renal diseases.
• Ability to perform multiple tasks and prioritize them
• Ability to organize and handle a large quantity of data
• Excellent creative thinking skills
• Excellent verbal and written communication skills
• Strong enthusiasm for AAV and gene therapy research

Salary Range:
$50,004+ Commensurate with experience

How to apply:
Please send a cover letter and C.V. to
Hiroyuki Nakai, M.D., Ph.D.
Professor
Department of Molecular and Medical Genetics
Department of Molecular Microbiology and Immunology
Oregon Health & Science University School of Medicine
Email: nakaih@ohsu.edu

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation, contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.

投稿者:Hiroyuki Nakai(nakaih@ohsu.edu)

2019.03.09

Lewis Katz School of Medicine, Temple Universityポスドク募集

私の所属するLewis Katz School of Medicine, Temple University, Cardiovascular Research Center (Philadelphia)で教授のVictor Rizzo PhDが新たにPostdoctoral Fellow を1名募集致します。この研究では血管病変における情報伝達機構を1. mitochondrial/metabolic phenotype 2. Vascular cell senescenceを中心に研究の予定です。以下の英文広告をご参照ください。
Postdoctoral position

Lewis Katz School of Medicine, Temple University, Cardiovascular Research Center.
Project Title: The role of vascular metabolic phenotype and subsequent senescence in mediating cardiovascular pathophysiology in hypertension and abdominal aortic aneurysm).
Position Type: Postdoctoral Position at an Academic Institution
My laboratory is looking for a post-doctoral fellow (commitment for 2 years or more) to conduct both in vitro and in vivo research experiments focused on the signal transduction mechanisms of vascular disease development (vascular smooth muscle cell and endothelial cell phenotype alteration) using primary culture and mouse models of hypertension and complication, and aortic and cranial aneurysm. Cutting-edge cell biological and biochemical approaches, genetic mouse models, large animal models and human tissue specimens will be employed during the training period. Applicants must have a Ph.D. or M.D. degree. One position is currently available with full financial support (NIH standard) up to 3-4 years.
Preferred Qualifications:
1. Familiarity with at least one of the followings: molecular biology, organelle/cell biology, biochemistry, mouse models, and surgical skills.
2. Publication record in bio/medical journals.
Victor Rizzo, PhD
Professor of Medicine
Temple University School of Medicine
Department of Anatomy and Cell Biology
Independence Blue Cross Cardiovascular Research Center
3500 N. Broad Street
Philadelphia, PA 19140

アットホームで面倒見のよいRizzo先生のラボは現在学生2名の小さなラボですがNIH Grantの獲得に伴って研究者を募集しています。基礎研究を目指す方にも臨床のバックグラウンドの方(腎臓、内分泌、循環器内科、血管,脳外科等)にもおすすめです。
応募締切:該当者が決まり次第締め切ります。
応募あるいは興味、質問のある方はCV (PDF)を添付して下記メールアドレスまで 気軽に連絡してください。よろしくお願いします。
投稿者:河合達男(tuf88636@temple.edu)


投稿者:河合達男(tuf88636@temple.edu)

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